Transient congenital hypothyroidism due to thyroid-stimulating hormone receptor blocking antibodies: A case series

Annals of Clinical Biochemistry

Volumn 48, Issue 4, 2011, Pages 386-390

  Evans, Carol ^a   Gregory, John W ^b   Barton, John ^c   Bidder, Christopher ^d   Gibbs, John ^e   Pryce, Rebekah ^e   Al Muzaffar, Iyad ^f   Ludgate, Marian ^b   Warner, Justin ^a   John, Rhys ^a   Moat, Stuart J ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c ROYAL GWENT HOSPITAL   (United Kingdom)

^d NEVILL HALL HOSPITAL   (United Kingdom)

^e SINGLETON HOSPITAL   (United Kingdom)

^f ROYAL GLAMORGAN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; PROTIRELIN; TECHNETIUM 99M; THYROGLOBULIN; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY; THYROXINE;

ARTICLE; BILIRUBIN BLOOD LEVEL; BIRTH WEIGHT; CLINICAL ARTICLE; CONGENITAL HYPOTHYROIDISM; DRUG WITHDRAWAL; HUMAN; HUMAN TISSUE; INCIDENCE; INFANT; NEWBORN SCREENING; PLACENTAL TRANSFER; PRIORITY JOURNAL; SCREENING; THYROGLOBULIN BLOOD LEVEL; THYROID FUNCTION; THYROID FUNCTION TEST; THYROTROPIN BLOOD LEVEL;

ANTIBODIES, BLOCKING; CONGENITAL HYPOTHYROIDISM; FEMALE; HUMANS; INFANT; MALE; MATERNAL-FETAL EXCHANGE; PREGNANCY; RECEPTORS, THYROTROPIN; THYROID GLAND; THYROXINE;

EID: 79959895939     PISSN: 00045632     EISSN: 17581001     Source Type: Journal    
DOI: 10.1258/acb.2011.011007     Document Type: Article

References (19)

1. UK Newborn Screening Program Centre. Newborn Blood Spot Screening in the UK Policies and Standards. August 2008. See http://newbornbloodspot.screening.nhs.uk/standards (last checked December 2010)
2. Parks JS, Lin M, Grosse SD, et al. The impact of transient hypothyroidism on the increasing rate of congenital hypothyroidism in the United States. Pediatrics 2010;125:354-63
3. Eugster EA, LeMay D, Zerin M, Pescovitz OH. Definitive diagnosis in children with congenital hypothyroidism. J Pediatr 2004;5:643-7
4. Brown RS, Bellisario RL, Botero D, et al. Incidence of transient congenital hypothyroidism due to maternal thyrotrophin receptor-blocking antibodies in over one million babies. J Clin Endocrinol Metab 1996;81:1147-51
5. Michalek K, Morshed SA, Latif R, Davies TF. TSH receptor antibodies. Autoimmun Rev 2009;9:113-6
6. McKenzie J, Zakarija M. Fetal and neonatal hyperthyroidism and hypothyroidism due to maternal TSH receptor antibodies. Thyroid 1992;2:155-9
7. Vassart G, Dumont JE. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev 1992;13:596-611
8. Kung AWC, Low LCK. Thyrotrophin-blocking receptor antibodies in congenital hypothyroidism. J Pediatr. Child Health 1992;28:50-3
9. Association for Clinical Biochemistry, British Thyroid Foundation. 2006 UK Guidelines for the Use of Thyroid Function Tests. See http://www.acb.org.uk/site/guidelines.asp (last checked November 2010)
10. UK Newborn Screening Program Centre. Newborn Blood Spot Screening in the UK Policies and Standards April 2005 Congenital Hypothyroidism: Initial Clinical Referral Standards. See http://newbornbloodspot.screening.nhs.uk/standards (last checked December 2010)
11. Ilicki A, Larsson A, Karlsson FA. Circulating thyroid antibodies in congenital hypothyroidism. Acta Paeditr Scand 1991;80:805-11
12. Gassner D, Goller R, Stock W, Yoshimura NJ, Sanders J, Rees Smith B. Development of a new automated assay for thyrotropin receptor antibodies on the Elecsys system. Clin Chem 2007;53(Suppl. 6):C-135
13. Evans C, Jordan NJ, Owens G, Bradley D, Ludgate M, John R. Potent thyrotrophin receptor blocking antibodies: a cause of profound congenital hypothyroidism and delayed thyroid development. Eur J Endocrinol 2004;150:265-8
14. Karlsson FA, Dahlberg PA, Ritzen EM. Thyroid blocking antibodies in thyroiditis. Acta Med Scand 1984;215:461-6
15. John R. Response to Newman et al. Facticious increase in thyrotropin in a neonate caused by maternally transmitted interfering substance. Clin Chem 2006;52:1615-6
16. Lazarus JH, John R, Ginsburg J, et al. Transient neonatal hyperthyrotropinaemia: a serum abnormality due to transplacentally acquired antibody to thyroid stimulating hormone. BMJ 1983;286:592-4
17. Newman JD, Bergman PB, Doery JCG, Balazs NDH. Facticious increase in thyrotropin in a neonate caused by a maternally transmitted interfering substance. Clin Chem 2006;52:541-2
18. Jospe N, Berkovitz GD, Corcoran LE, Humphrey RL. Facticious transient neonatal hyperthyrotropinaemia. J Endocrinol Invest 1988;11:129-32
19. Halsall DJ, Fahie-Wilson MN, Hall SK, et al. Macrothyrotropin-IgG complex causes factitious increases in thyroid stimulating hormone screening tests in an neonate and mother. Clin Chem 2006;52:1968-9