Diet-induced hypercholesterolemia impaired testicular steroidogenesis in mice through the renin-angiotensin system

General and Comparative Endocrinology

Volumn 173, Issue 1, 2011, Pages 15-19

  Martínez Martos, José M ^a   Arrazola, Marce ^a   Mayas, María D ^a   Carrera González, María P ^a   García, María J ^a   Ramírez Expósito, María J ^a  

^a UNIVERSITY OF JAÉN   (Spain)

Author keywords

Aminopeptidase A; Aminopeptidase B; Aminopeptidase N; Hypercholesterolemia; Steroidogenesis; Testicular renin angiotensin system; Testosterone

Indexed keywords

AMINOPEPTIDASE B; ANDROGEN; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ASPARTYL AMINOPEPTIDASE; CHOLESTEROL; GLUTAMYL AMINOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; TESTOSTERONE;

ANDROGEN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; HYPERCHOLESTEROLEMIA; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK FACTOR; STEROIDOGENESIS; TESTIS DISEASE; TESTOSTERONE BLOOD LEVEL;

EID: 79959876168     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2011.04.015     Document Type: Article

References (24)

1. Albiston A.L., McDowall S.G., Matsacos D., Sim P., Clune E., Mustafa T., Lee J., Mendelsohn F.A., Simpson R.J., Connolly L.M., Chai S.Y. Evidence that the angiotensin IV (at(4)) receptor is the enzyme insulin-regulated aminopeptidase. J. Biol. Chem. 2001, 276:48623-48626.
2. Alexandersen P., Haarbo J., Byrjalsen I., Lawaetz H., Christiansen C. Natural androgens inhibit male atherosclerosis: a study in castrated cholesterol-fed rabbits. Circ. Res. 1999, 84:813-819.
3. Barrett A.J., Rawlings N.D., Woessner J.F. Handbook of Proteolytic Enzymes 1998, Londres, Academic Press.
4. Bhasin S., Herbst K. Testosterone and atherosclerosis progression in men. Diabetes Care 2003, 26:1929-1931.
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
6. De la chica S., Cortes -Denia P., Ramirez-Exposito M.J., Arias de saavedra J.M., Sanchez-Agesta R., Perez M.C., Martinez-Martos J.M. Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis. Fertil. Steril. 2007, 88:1171-1175.
7. De la chica S., Cortes -Denia P., Ramirez-Exposito M.J., Arias de saavedra J.M., Sanchez-Agesta R., Perez M.C., Martinez-Martos J.M. In vivo administration of doxazosin in rats highly decreases serum circulating levels of testosterone through a mechanism involving the testicular renin-angiotensin system. Int. J. Androl. 2007, 31:364-370.
8. Dufau M.L., Khanum A., Tsai-Morris C.H. Multistep regulation of leydig cell function. J. Steroid Biochem. 1987, 27:343-350.
9. Feng Y., Zhu Y., Chen X., Sha J., Fan L., Chen Q. Effects of diet-induced hypercholesterolemia on testosterone-regulated protein expression in mice liver. J. Nanosci. Nanotechnol. 2005, 5:1273-1276.
10. Fyhrquist F., Saijonmaa O. Renin-angiotensin system revisited. J. Intern. Med. 2008, 264:224-236.
11. Garcia M.J., Martinez-Martos J.M., Mayas M.D., Carrera M.P., Ramirez-Exposito M.J. Hormonal status modifies renin-angiotensin system-regulating aminopeptidases and vasopressin-degrading activity in the hypothalamus-pituitary-adrenal axis of male mice. Life Sci. 2003, 73:525-538.
12. Keller S.R., Scott H.M., Mastick C.C., Aebersold R., Lienhard G.E. Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from glut4 vesicles. J. Biol. Chem. 1995, 270:23612-23618.
13. Khanum A., Dufau M.L. Angiotensin ii receptors and inhibitory actions in leydig cells. J. Biol. Chem. 1988, 263:5070-5074.
14. Naruse M., Naruse K., Kurimoto F., Sakurai H., Yoshida S., Toma H., Ishii T., Obana K., Demura H., Inagami T T., et al. Evidence for the existence of des-asp1-angiotensin II in human uterine and adrenal tissues. J. Clin. Endocrinol. Metab. 1985, 61:480-483.
15. Nathan L., Shi W., Dinh H., Mukherjee T.K., Wang X., Lusis A.J., Chaudhuri G. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc. Natl. Acad. Sci. USA 2001, 98:3589-3593.
16. Pandey K.N., Maki M., Inagami T. Detection of rennin mRNA in mouse testis by hybridization with rennin cDNA probe. Biochem. Biophys. Res. Commun. 1984, 125:662-667.
17. Pandey K.N., Inagami T. Regulation of rennin angiotensins by gonadotropic hormones in cultured murine Leydig tumor cells. Release of angiotensin but not renin. J. Biol. Chem. 1986, 261:3934-3938.
18. Parmentier M., Inagami T., Pochet R., Desclin J.C. Pituitary-dependent renin-like immunoreactivity in the rat testis. Endocrinology 1983, 112:1318-1323.
19. Reaux A., Fournie-Zaluski M.C., Llorens-Cortes C. Angiotensin III: a central regulator of vasopressin release and blood pressure. Trends Endocrinol. Metab. 2001, 12:157-162.
20. Ruiz-Ortega M., Esteban V., Egido J. The regulation of the inflammatory response through nuclear factor-kappaβ pathway by angiotensin IV extends the role of the renin angiotensin system in cardiovascular diseases. Trends Cardiovasc. Med. 2007, 17:19-25.
21. Savoia C., Schiffrin E.L. Inflammation in hypertension. Curr. Opin. Nephrol. Hypertens. 2006, 15:152-158.
22. Tanaka M., Nakaya S., Kumai T., Watanabe M., Matsumoto N., Kobayashi S. Impaired testicular function in rats with diet-induced hypercholesterolemia and/or streptozotocin-induced diabetes mellitus. Endocr. Res. 2001, 27:109-117.
23. Ward P.E., Benter I.F., Dick L., Wilk S. Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M. Biochem. Pharmacol. 1990, 40:1725-1732.
24. Wilk S., Wilk E., Magnusson R.P. Purification, characterization and cloning of a cytosolic aspartyl aminopeptidase. J. Biol. Chem. 1998, 273:15961-15970.