Paving new paths for neuregulin-1-assisted cardiac regenerative medicine. focus on "improving murine embryonic stem cell differentiation into cardiomyocytes with neuregulin-1: Differential expression of microRNA"

American Journal of Physiology - Cell Physiology

Volumn 301, Issue 1, 2011, Pages

  Lemmens, Katrien ^a   De Keulenaer, Gilles W ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; NEU DIFFERENTIATION FACTOR;

ARTICLE; CARDIAC REGENERATIVE MEDICINE; CELL ASSAY; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL FUNCTION; EMBRYONIC STEM CELL; HEART DEVELOPMENT; HEART FAILURE; HEART MUSCLE CELL; HUMAN; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGENERATIVE MEDICINE; STEM CELL DIFFERENTIATION;

ANIMALS; CELL COMMUNICATION; EMBRYONIC STEM CELLS; HEART; MICE; MICRORNAS; MYOCYTES, CARDIAC; NEUREGULIN-1; ONCOGENE PROTEINS V-ERBB; REGENERATION;

MURINAE;

EID: 79959854751     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00137.2011     Document Type: Article

References (19)

1. Bersell K, Arab S, Haring B, Kühn B. Neuregulin1/ErbB4 signaling induce cardiomyocyte proliferation and repair of heart injury. Cell 138: 257-270, 2009.
2. Brutsaert DL. Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev 83: 59-115, 2003.
3. De Keulenaer GW, Doggen K, Lemmens K. The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy. Circ Res 106: 35-46, 2010.
4. Doggen K, Ray L, Mathieu M, McEntee K, Lemmens K, De Keulenaer GW. Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure. J Mol Cell Cardiol 46: 33-38, 2009.
5. Gao R, Zhang J, Cheng L, Wu X, Dong W, Yang X, Li T, Liu X, Xu Y, Li X, Zhou M. A phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol 55: 1907-1914, 2010.
6. Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, Lemke G. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378: 390-394, 1995.
7. Kuramochi Y, Cote GM, Guo X, Lebrasseur NK, Cui L, Liao R, Sawyer DB. Cardiac endothelial cells regulate reactive oxygen speciesinduced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem 279: 51141-51147, 2004.
8. Kuramochi Y, Guo X, Sawyer DB. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol 41: 228-235, 2006.
9. Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378: 394-398, 1995.
10. Lemmens K, Doggen K, De Keulenaer GW. Activation of the neuregulin/ ErbB system during physiological ventricular remodeling in pregnancy. Am J Physiol Heart Circ Physiol 300: H931-H942, 2011.
11. Lemmens K, Doggen K, De Keulenaer GW. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation 116: 954-960, 2007.
12. Lemmens K, Fransen P, Sys SU, Brutsaert DL, De Keulenaer GW. Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase. Circulation 109: 324-326, 2004.
13. Lemmens K, Segers VFM, Demolder M, De Keulenaer GW. Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk. J Biol Chem 281: 19469-19477, 2006.
14. Liu X, Gu X, Li Z, Li X, Li H, Chang J, Chen P, Jin J, Xi B, Chen D, Lai D, Graham RM, Zhou M. Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol 48: 1438-1447, 2006.
15. Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature 378: 386-390, 1995.
16. Pentassuglia L, Sawyer DB. The role of neuregulin-1beta/ErbB signaling in the heart. Exp Cell Res 315: 627-637, 2009.
17. Segers VF, Lee RT. Protein therapeutics for cardiac regeneration after myocardial infarction. J Cardiovasc Transl Res 3: 469-477, 2010.
18. Sun M, Yan X, Bian Y, Caggiano AO, Morgan JP. Improving murine embryonic stem cell differentiation into cardiomyocytes with neuregulin- 1: differential expression of microRNA. Am J Physiol Cell Physiol (March 30, 2011). doi:10.1152/ajpcell.00141.2010.
19. Zhu WZ, Xie Y, Moyes KW, Gold JD, Askari B, Laflamme MA. Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells. Circ Res 107: 776-786, 2010.