Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia

Journal of Pediatric Hematology/Oncology

Volumn 33, Issue 5, 2011, Pages 339-343

  Ansari, Saqib H ^a   Shamsi, Tahir S ^a   Ashraf, Mushtaq ^a   Perveen, Kousar ^a   Farzana, Tasneem ^a   Bohray, Muneera ^a   Erum, Sajida ^a   Mehboob, Tabassum ^a  

^a National Institute of Blood Disease and Bone Marrow Transplantation   (Pakistan)

Author keywords

thalassemia major; Hydroxyurea; transfusion volume

Indexed keywords

HYDROXYUREA;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ALOPECIA; ARTICLE; BETA THALASSEMIA; BLOOD CELL COUNT; BONE MARROW SUPPRESSION; CHILD; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DRUG EFFICACY; DRUG ERUPTION; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSURIA; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HALLUCINATION; HUMAN; INTERVENTION STUDY; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; OLIGURIA; OUTCOME ASSESSMENT; POLYURIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PRURITUS; SCHOOL CHILD; SIDE EFFECT; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT RESPONSE;

ADOLESCENT; BETA-THALASSEMIA; CHILD; CHILD, PRESCHOOL; ERYTHROCYTE TRANSFUSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROXYUREA; INFANT; MALE; NUCLEIC ACID SYNTHESIS INHIBITORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79959830632     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31821b0770     Document Type: Article

References (20)

1. Weatherall DJ, Clegg JB. The Thalassemia Syndromes. 4th ed. Oxford: Blackwell Science; 2001:288-289.
2. Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann NY Acad Sci. 1998;850:251-269. (Pubitemid 28369766)
3. Ahmed S, Saleem M, Modell B, et al. Screening extended families for genetic hemoglobin disorders in Pakistan. N Engl J Med. 2010;347:1162-1168.
4. Annual report of health services in Pakistan. Rawalpindi: Ministry of Health. Government of Pakistan. 1997.
5. Perrine SP. Fetal globin induction-can it cure b-thalassemia? Hematology Am Soc Hematol Educ Program. 2005;38-44.
6. Rodgers GP, Sauntharajah Y. Advances in experimental treatment of b-thalassemia. Expert Opin Invest Drugs. 2001; 10:925-934.
7. Fucharoen S, Siritanaratkul N, Winichagoon P, et al. Hydroxyurea increases hemoglobin F levels and improves the effectiveness of erythropoiesis in b-thalassemia/hemoglobin E disease. Blood. 1996;87:887-892. (Pubitemid 26043518)
8. Italia KY, Jijina FJ, Merchant R et al. Response to hydroxyurea in b thalassemia major and intermedia: Experience in western India. Clin Chim Acta. 2009;407:10-15.
9. Letvin NLDC, Linch P, Bearssky KW, et al. Augmentation of fetal hemoglobin production in anemic monkeys by hydroxyurea. N Engl J Med. 1984;310:317-323.
10. Miller BA, Platt O, Hope S, et al. Influence of hydroxyurea on fetal hemoglobin production in vitro. Blood. 1987;70: 1824-1829. (Pubitemid 18055631)
11. Fibach E, Burke LP, Schechter AN, et al. Hydroxyurea increases fetal hemoglobin in cultured erythroid cells derived from normal individuals and patients with sickle cell anemia. Blood. 1993;81:1630-1635. (Pubitemid 23083845)
12. Zeng YT, Huang SZ, Ren ZR, et al. Hydroxyurea therapy in b-thalassemia intermedia: Improvement in hematological parameters due to enhanced b-globin synthesis. Br J Haematol. 1995;90:557-563.
13. Olivieri NF. Reactivation of fetal hemoglobin in patients with b-thalassemia. Semin Hematol. 1996;33:24-42. (Pubitemid 26064766)
14. Arruda VR, Lima CSP, Saad STO, et al. Successful use of hydroxyurea in b-thalassemia major. N Engl J Med. 1997; 336:964. (Pubitemid 27137206)
15. Bradai M, Abad MT, Pissard S, et al. Hydroxyurea can eliminate transfusion requirements in children with severe b-thalassemia. Blood. 2003;104:114-117.
16. Yavarian M, Karimi M, Bakker E, et al. Response to hydroxyurea treatment in Iranian transfusion-dependent b-thalassemia patients. Haematologica. 2004;89:1172-1178. (Pubitemid 39390440)
17. Ansari SH, Shamsi TH, Siddiqui FJ, et al. Efficacy of hydroxyurea in reduction of pack red cell transfusion requirement among children having b-thalassemia major: Karachi HU Trial. J Pediatr Hematol Oncol. 2007;29:743-746. (Pubitemid 350071221)
18. Bianchi N, Zuccato C, Lampronti I, et al. Fetal hemoglobin inducers from the natural world: A novel approach for identification of drugs for the treatment of b-thalassemia and sickle-cell anemia. Evid Based Complement Alternat Med. 2007;6:1-11.
19. Dixit A, Chatterjee TC, Mishra P et al. Hydroxyurea in thalassemia intermedia-a promising therapy. Ann Hematol. 2005;84:441-446. (Pubitemid 40867920)
20. Charache S, Terrin MI, Moore RD, et al. Effect of hydroxyurea on frequency of painful crisis in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332:1317-1322.