Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls

Redox Report

Volumn 16, Issue 2, 2011, Pages 71-77

  Rybka, Joanna ^a   Kupczyk, Daria ^a   Kedziora Kornatowska, Kornelia ^a   Pawluk, Hanna ^a   Czuczejko, Jolanta ^a   Szewczyk Golec, Karolina ^a   Kozakiewicz, Mariusz ^a   Antonioli, Marco ^b   Carvalho, Livia A ^b   Kedziora, Józef ^a  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; Antioxidant enzymes; Glutathione; Hypertension

Indexed keywords

ANTIOXIDANT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SARTAN DERIVATIVE;

AGED; AGING; ARTICLE; BLOOD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; SEX DIFFERENCE;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANTIOXIDANTS; CASE-CONTROL STUDIES; CATALASE; ERYTHROCYTES; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HUMANS; HYPERTENSION; LIPID PEROXIDATION; MALE; SUPEROXIDE DISMUTASE;

EID: 79959825654     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1179/174329211X13002357050897     Document Type: Article

References (52)

1. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann NY Acad Sci 2006;1067(1):10-21.
2. Asano S, Rice KM, Kakarla S, Katta A, Desai DH, Walker EM, et al. Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat. Redox Rep 2007;12(4):167-180.
3. Zhou H, Huang B, Du J, Wang L. Role of the JAK2/STAT pathway and losartan in human glomerular mesangial cell senescence. Mol Med Rep 2010;3(3):393-398.
4. Rivera J, Sobey CG, Walduck AK, Drummond GR. Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. Redox Rep 2010;15(2):50-63.
5. Vanhoutte PM. Regeneration of the endothelium in vascular injury. Cardiovasc Drugs Ther 2010;24:299-303.
6. Vanhoutte PM, Shimokawa H, Tang EHC, Feletou M. Endothelial dysfunction and vascular disease. Acta Physiol (Oxf) 2009;196(2):193-222.
7. Basso N, Cini R, Pietrelli A, Ferder L, Terragno NA, Inserra F. Protective effect of long-term angiotensin II inhibition. Am J Physiol Heart Circ Physiol 2007;293(3):H1351-H1358.
8. Thomas SR, Witting PK, Drummond GR. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Sig 2008; 10(10):1713-1765.
9. Ceriello A. Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes. Curr Opin Lipidol 2006;17(5):510-518.
10. Weseler AR, Bast A. Oxidative stress and vascular function: implications for pharmacologic treatments. Curr Hypertens Rep 2010;12(3):154-161.
11. de Cavanagh EM, Fraga CG, Ferder L, Inserra F. Enalapril and captopril enhance antioxidant defenses in mouse tissues. Am J Physiol 1997;272(2 Pt 2):R514-R518.
12. Miguel-Carrasco JL, Monserrat MT, Mate A, Vázquez CM. Comparative effects of captopril and l-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats. Eur J Pharmacol 2010 4; 632(1-3):65-72.
13. Khan BV, Sola S, Lauten WB, Natarajan R, Hooper WC, Menon RG, et al. Quinapril, an ACE inhibitor, reduces markers of oxidative stress in the metabolic syndrome. Diabetes Care 2004;27(7):1712-1715.
14. De Cavanagh EMV, Toblli JE, Ferder L, Piotrkowski B, Stella I, Fraga CG, et al. Angiotensin II blockade improves mitochondrial function in spontaneously hypertensive rats. Cell Mol Biol (Noisy-le-grand) 2005;51(6):573-578.
15. Ferder LF, Inserra F, Basso N. Advances in our understanding of aging: role of the renin-angiotensin system. Curr Opin Pharmacol 2002;2(2):189-194.
16. Asselin C, Shi Y, Clément R, Tardif JC, Des Rosiers C. Higher circulating 4-hydroxynonenal-protein thioether adducts correlate with more severe diastolic dysfunction in spontaneously hypertensive rats. Redox Rep 2007;12(1):68-72.
17. Beutler E. Red cell metabolism. In: Beutler E (ed.) A manual of biochemical methods. New York: Grune-Stratton; 1971.
18. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972;247(10):3170-3175.
19. Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952;195(1):133-140.
20. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70(1):158-169.
21. Flohé L, Günzler WA. Assays of glutathione peroxidase. Meth Enzymol 1984;105:114-121.
22. Andersen HR, Nielsen JB, Nielsen F, Grandjean P. Antioxidative enzyme activities in human erythrocytes. Clin Chem 1997;43(4):562-568.
23. Bolzán AD, Bianchi MS, Bianchi NO. Superoxide dismutase, catalase and glutathione peroxidase activities in human blood: influence of sex, age and cigarette smoking. Clin Biochem 1997;30(6):449-454.
24. Mendoza-Núñez VM, Ruiz-Ramos M, Sánchez-Rodríguez MA, Retana-Ugalde R, Muñoz-Sánchez JL. Aging-related oxidative stress in healthy humans. Tohoku J Exp Med 2007;213(3):261-268.
25. Pérez VI, Bokov A, Van Remmen H, Mele J, Ran Q, Ikeno Y, et al. Is the oxidative stress theory of aging dead? Biochim Biophys Acta 2009;1790(10):1005-1014.
26. Paravicini T, Touyz R. Redox signaling in hypertension. Cardiovasc Res 2006;71(2):247-258.
27. Pierce GL, Larocca TJ. Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults? J Physiol (Lond) 2008;586(Pt 11):2673-2674.
28. Simic DV, Mimic-Oka J, Pljesa-Ercegovac M, Savic-Radojevic A, Opacic M, Matic D, et al. Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension. J Hum Hypertens 2005;20(2):149-155.
29. Kaminsky Y, Suslikov A, Kosenko E. Specific and pronounced impacts of lisinopril and lisinopril plus simvastatin on erythrocyte antioxidant enzymes. J Clin Pharmacol 2010;50(2):180-187.
30. Lacy F, Kailasam MT, O'Connor DT, Schmid-Schönbein GW, Parmer RJ. Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity. Hypertension 2000;36(5):878-874.
31. Yang H, Zhou L, Wang Z, Roberts LJ, Lin X, Zhao Y, et al. Overexpression of antioxidant enzymes inApoE-deficient mice suppresses benzo(a)pyrene-accelerated atherosclerosis. Atherosclerosis 2009;207(1):51-58.
32. Pedro-Botet J, Covas MI, Martín S, Rubiés-Prat J. Decreased endogenous antioxidant enzymatic status in essential hypertension. J Hum Hypertens 2000;14(6):343-345.
33. Russo C, Olivieri O, Girelli D, Faccini G, Zenari ML, Lombardi S, et al. Anti-oxidant status and lipid peroxidation in patients with essential hypertension. J. Hypertens 1998;16(9):1267-1271.
34. Ceballos-Picot I, Trivier JM, Nicole A, Sinet PM, Thevenin M. Age-correlated modifications of copper-zinc superoxide dismutase and glutathione-related enzyme activities in human erythrocytes. Clin Chem 1992;38(1):66-70.
35. Inal ME, Kanbak G, Sunal E. Antioxidant enzyme activities and malondialdehyde levels related to aging. Clin Chim Acta 2001; 305(1-2):75-80.
36. Habif S, Mutaf I, Turgan N, Onur E, Duman C, Ozmen D, et al. Age and gender dependent alterations in the activities of glutathione related enzymes in healthy subjects. Clin Biochem 2001; 34(8):667-671.
37. Erden-Inal M, Sunal E, Kanbak G. Age-related changes in the glutathione redox system. Cell Biochem Funct 2002;20(1):61-66.
38. Andriollo-Sanchez M, Hininger-Favier I, Meunier N, Venneria E, O'Connor JM, Maiani G, et al. Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. Eur J Clin Nutr 2005;59(Suppl. 2):S58-S62.
39. Hernanz A, Fernández-Vivancos E, Montiel C, Vazquez JJ, Arnalich F. Changes in the intracellular homocysteine and glutathione content associated with aging. Life Sci 2000;67(11): 1317-1324.
40. de Cavanagh EMV. Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine. AJP: Regul Integr Comp Physiol 2006;290(6): R1616-R1625.
41. Ng ESM, Kubes P. The physiology of S-nitrosothiols: carrier molecules for nitric oxide. Can J Physiol Pharmacol 2003;81(8): 759-764.
42. Uppu RM, Nossaman BD, Greco AJ, Fokin A, Murthy SN, Fonseca VA, et al. Cardiovascular effects of peroxynitrite. Clin Exp Pharmacol Physiol 2007;34(9):933-937.
43. Xu A, Vita JA, Keaney JF. Ascorbic acid and glutathione modulate the biological activity of S-nitrosoglutathione. Hypertension 2000;36(2):291-295.
44. Siems WG, Capuozzo E, Verginelli D, Salerno C, Crifò C, Grune T. Inhibition of NADPH oxidase-mediated superoxide radical formation in PMA-stimulated human neutrophils by 4-hydroxynonenal-binding to -SH and -NH2 groups. Free Radic Res 1997;27(4):353-358.
45. Romeo AA, Capobianco JA, English AM. Superoxide dismutase targets NO from GSNO to Cysbeta93 of oxyhemoglobin in concentrated but not dilute solutions of the protein. J Am Chem Soc 2003;125(47):14370-14378.
46. Rauhala P, Andoh T, Chiueh CC. Neuroprotective properties of nitric oxide and S-nitrosoglutathione. Toxicol Appl Pharmacol 2005;207(Suppl. 2):91-95.
47. Hogg N. The biochemistry and physiology of S-nitrosothiols. Annu Rev Pharmacol Toxicol 2002;42:585-600.
48. González-Sánchez MI, Manjabacas MC, García-Carmona F, Valero E. Mechanism of acetaminophen oxidation by the peroxidase-like activity of methemoglobin. Chem Res Toxicol 2009;22(11):1841-1850.
49. Umbreit J. Methemoglobin-It's not just blue: a concise review. Am J Hematol 2007;82(2):134-144.
50. Da Silva AP, Marinho C, Gonçalves MC, Monteiro C, Laires MJ, Falcão LM, et al. Decreased erythrocyte activity of methemoglobin and glutathione reductases may explain agerelated high blood pressure. Rev Port Cardiol 2010;29(3): 403-412.
51. Laterreur J, English AM. Hemoglobin S-nitrosation on oxygenation of nitrite/deoxyhemoglobin incubations is attenuated by methemoglobin. J Inorg Biochem 2007;101(11-12): 1827-1835.
52. Lang CA, Mills BJ, Lang HL, Liu MC, Usui WM, Richie J, et al. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. J Lab Clin Med 2002;140(6):413-417.