A case of hyperammonemia with encephalopathy related to FOLFIRI chemotherapy for advanced colon cancer

Japanese Journal of Cancer and Chemotherapy

Volumn 36, Issue 7, 2009, Pages 1167-1169

  Toyokawa, Akihiro ^a   Nakajima, Takayoshi ^a   Inui, Kyoko ^a   Yamashita, Hironari ^a   Gon, Hidetoshi ^a   Kanemitsu, Kiyonori ^a   Tanaka, Kenichi ^a   Tsukamoto, Tadashi ^a   Hamabe, Yutaka ^a   Ishida, Takeshi ^a  

^a YODOGAWA CHRISTIAN HOSPITAL   (Japan)

Author keywords

5 FU; Colorectal cancer; FOLFIRI chemotherapy; Hyperammonemia

Indexed keywords

AMINO ACID DERIVATIVE; AMINOLEBAN; AMMONIA; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; UNCLASSIFIED DRUG;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ADULT; ADVANCED CANCER; AMMONIA BLOOD LEVEL; ARTICLE; BONE METASTASIS; BRAIN DISEASE; BRAIN METASTASIS; CANCER CHEMOTHERAPY; CANCER INVASION; CANCER SURGERY; CASE REPORT; COLON CANCER; COMA; CONSCIOUSNESS LEVEL; DIFFERENTIAL DIAGNOSIS; EMERGENCY CARE; HUMAN; HYPERAMMONEMIA; LIVER METASTASIS; LUNG METASTASIS; MALE; MULTIPLE CYCLE TREATMENT; PATIENT TRANSPORT; POSTOPERATIVE CARE; SIGMOID; SMALL INTESTINE;

EID: 79959822459     PISSN: 03850684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Tournigand C, André T, Achille E, et al: FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer a randomized GERCOR study. J Clin Oncol 22: 229-237, 2004. (Pubitemid 41095086)
2. Yeh KH and Cheng AL: High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy. Br J Cancer 75: 464-465, 1997.
3. Koenig H and Patel A: Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate. Arch Neurol 23: 155-160, 1970.
4. http://www.info.pmda.go.jp/