Methotrexate treatment in juvenile localized scleroderma: A randomized, double-blind, placebo-controlled trial

Arthritis and Rheumatism

Volumn 63, Issue 7, 2011, Pages 1998-2006

  Zulian, Francesco ^a   Martini, Giorgia ^a   Vallongo, Cristina ^a   Vittadello, Fabio ^a   Falcini, Fernanda ^b   Patrizi, Annalisa ^c   Alessio, Maria ^d   La Torre, Francesco ^e   Podda, Rosa A ^f   Gerloni, Valeria ^g   Cutrone, Mario ^h   Belloni Fortina, Anna ^a   Paradisi, Mauro ⁱ   Martino, Silvana ^j   Perilongo, Giorgio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

^f Cagliari Hospital   (Italy)

^g ISTITUTO ORTOPEDICO GAETANO PINI   (Italy)

^h Children Hospital of Mestre   (Italy)

ⁱ LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^j UNIVERSITY OF TURIN   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; METHOTREXATE; PLACEBO; PREDNISONE;

ADOLESCENT; ALOPECIA; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; HUMAN; INFRARED PHOTOGRAPHY; LIVER TOXICITY; LOCALIZED SCLERODERMA; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SCHOOL CHILD; SCORING SYSTEM; SIDE EFFECT; STRIA; TREATMENT FAILURE; TREATMENT RESPONSE; WEIGHT GAIN;

EID: 79959817059     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30264     Document Type: Article

References (34)

1. Zulian F, Vallongo C, Woo P, Russo R, Ruperto N, Harper J, et al, for the Juvenile Scleroderma Working Group of the Pediatric Rheumatology European Society (PRES). Localized scleroderma in childhood is not just a skin disease. Arthritis Rheum 2005; 52: 2873-81. (Pubitemid 41369118)
2. Laxer R, Zulian F,. Localized scleroderma. Curr Opin Rheumatol 2006; 18: 606-13. (Pubitemid 44607414)
3. Orzechowski NM, Davis DM, Mason TG III, Crowson CS, Reed AM,. Health-related quality of life in children and adolescents with juvenile localized scleroderma. Rheumatology (Oxford) 2009; 48: 670-2.
4. Uziel Y, Feldman B, Krafchik B, Yeung R, Laxer RL,. Methotrexate and corticosteroid therapy for pediatric localized scleroderma. J Pediatr 2000; 136: 91-5. (Pubitemid 30468564)
5. Fitch P, Rettig P, Burnham J, Finkel T, Yan A, Akin E, et al. Treatment of pediatric localized scleroderma with methotrexate. J Rheumatol 2006; 33: 609-14. (Pubitemid 43334587)
6. Weibel L, Sampaio MC, Visentin MT, Howell KJ, Woo P, Harper JI,. Evaluation of methotrexate and corticosteroids for the treatment of localized scleroderma (morphoea) in children. Br J Dermatol 2006; 155: 1013-20. (Pubitemid 44564513)
7. Cox D, O'Regan G, Collins S, Byrne A, Irvine A, Watson R,. Juvenile localised scleroderma: a retrospective review of response to systemic treatment. Ir J Med Sci 2008; 177: 343-6.
8. Christen-Zaech S, Hakim MD, Afsar FS, Paller AS,. Pediatric morphea (localized scleroderma): review of 136 patients. J Am Acad Dermatol 2008; 59: 385-96.
9. Segal R, Yaron M, Tartakovsky B,. Methotrexate: mechanism of action in rheumatoid arthritis. Semin Arthritis Rheum 1990; 20: 190-200.
10. Ihn H, Sato S, Fujimoto M, Kikuchi K, Takehara K,. Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma. Arch Dermatol Res 1995; 287: 193-7.
11. Barrera P, Haagsma CJ, Boerbooms AM, Van Riel PL, Borm GF, Van De Putte LB, et al. Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists: longitudinal evaluation in patients with rheumatoid arthritis. Br J Rheumatol 1995; 34: 747-55.
12. Rose CD, Fawcett PT, Gibney K, Doughty RA, Singsen BH,. Serial measurements of soluble interleukin-2 receptor levels (sIL2-R) in children with rheumatoid arthritis treated with oral methotrexate. Ann Rheum Dis 1994; 53: 471-4. (Pubitemid 24252496)
13. Seyger MM, Van den Hoogen FH, Van Vlijmen-Willems IM, Van De Kerkof PC, De Jong EM,. Localized and systemic scleroderma show different histological response to methotrexate therapy. J Pathol 2001; 193: 511-6. (Pubitemid 32266821)
14. Ruperto N, Ravelli A, Pistorio A, Malattia C, Viola S, Cavuto S, et al, Paediatric Rheumatology International Trials Organisation. The Italian version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). Clin Exp Rheumatol 2001; 19: S91-5. (Pubitemid 33730195)
15. Singh G, Athreya BH, Fries JF, Goldsmith DP,. Measurement of health status in children with juvenile rheumatoid arthritis. Arthritis Rheum 1994; 37: 1761-9. (Pubitemid 24371878)
16. Martini G, Murray KJ, Howell KJ, Harper J, Woo P, Zulian F, et al. Juvenile-onset localized scleroderma activity detection by infrared thermography. Rheumatology (Oxford) 2002; 41: 1178-82. (Pubitemid 35203548)
17. Zulian F, Meneghesso D, Grisan E, Vittadello F, Belloni-Fortina A, Pigozzi B, et al. A new computerized method for the assessment of skin lesions in localized scleroderma. Rheumatology (Oxford) 2007; 46: 856-60. (Pubitemid 47064263)
18. Dytoc M, I Kossintseva, Ting P,. First case series on the use of calcipotriol-betamethasone diproprionate for morphoea. Br J Dermatol 2007; 157: 615-8. (Pubitemid 47256106)
19. Joly P, Bamberger N, Crickx B, Befaich S,. Treatment of severe forms of localized scleroderma with oral corticosteroids: follow-up study on 17 patients. Arch Dermatol 1994; 130: 664-5.
20. 3 (calcitriol) in seven children. Pediatr Dermatol 1999; 19: 53-8. (Pubitemid 29102635)
21. Cunningham BB, Landells ID, Langman C, Sailer DE, Paller AS,. Topical calcipotriene for morphea/linear scleroderma. J Am Acad Dermatol 1998; 39: 211-5. (Pubitemid 28367331)
22. Hulshof MM, Bavinck JN, Bergman W, Masclee AA, Heickendorff L, Breedveld FC, et al. Double-blind, placebo-controlled study of oral calcitriol for the treatment of localized and systemic scleroderma. J Am Acad Dermatol 2000; 43: 1017-23.
23. Kroft EB, Groeneveld TJ, Seyger MM, De Jong EM,. Efficacy of topical tacrolimus 0.1% in active plaque morphea: randomized, double-blind, emollient-controlled pilot study. Am J Clin Dermatol 2009; 10: 181-7.
24. Hunzelmann N, Anders S, Gierlbeck G, Hein R, Herrmann K, Albrecht M, et al. Double-blind, placebo-controlled study of intralesional interferon Î for the treatment of localized scleroderma. J Am Acad Dermatol 1997; 36: 433-5. (Pubitemid 27131967)
25. Kerscher M, Volkenandt M, Gruss C, Reuther T, von Kobyletzki G, Freitag M, et al. Low-dose UVA1 phototherapy for treatment of localized scleroderma. J Am Acad Dermatol 1998; 38: 21-6. (Pubitemid 28100460)
26. Kreuter A, Gambichler T, Avermaete A, Jansen T, Hoffmann M, Hoffmann K, et al. Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea. Pediatr Dermatol 2001; 18: 241-5. (Pubitemid 32567879)
27. Kreuter A, Gambichler T, Breuckmann F, Rotterdam S, Freitag M, Stuecker M, et al. Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma. Arch Dermatol 2005; 141: 847-52. (Pubitemid 41058065)
28. Kroft EB, Creemers MC, Van den Hoogen FH, Boezeman JB, De Jong EM,. Effectiveness, side-effects and period of remission after treatment with methotrexate in localized scleroderma and related sclerotic skin diseases: an inception cohort study. Br J Dermatol 2009; 160: 1075-82.
29. Li SC, Feldman BM, Higgins GC, Haines KA, Punaro MG, O'Neil KM,. Treatment of pediatric localized scleroderma: results of a survey of North American pediatric rheumatologists. J Rheumatol 2010; 37: 175-81.
30. Stewart CF, Christensen ML, Evans RP,. Influence of concomitant aspirin or prednisone on methotrexate synovial fluid concentration. J Pharmacol Exp Ther 1987; 243: 131-7. (Pubitemid 17162708)
31. Lafforgue P, Monjanel-Mouterde S, Durand A, Catalin J, Acquaviva PC,. Is there an interaction between low dose of corticosteroids and methotrexate in patients with rheumatoid arthritis? A pharmacokinetic study in 33 patients. J Rheumatol 1993; 20: 26-7.
32. Arkachaisri T, Pino S,. Localized Scleroderma Severity Index and global assessments: a pilot study of outcome instruments [published erratum appears in J Rheumatol 2009;36:2136]. J Rheumatol 2008; 35: 650-7. (Pubitemid 351500061)
33. Weibel L, Howell KJ, Visentin MT, Rudiger A, Denton CP, Zulian F, et al. Laser Doppler flowmetry for assessing localized scleroderma in children. Arthritis Rheum 2007; 56: 3489-95. (Pubitemid 47585445)
34. Li SC, Liebling MS, Haines KA,. Ultrasonography is a sensitive tool for monitoring localized scleroderma. Rheumatology (Oxford) 2007; 46: 1316-9. (Pubitemid 47244508)