Lack of association of small-colony-variant Staphylococcus aureus strains with long-term use of azithromycin in patients with cystic fibrosis

Journal of Clinical Microbiology

Volumn 49, Issue 7, 2011, Pages 2772-2773

  Green, Nicole ^a   Burns, Jane L ^b   Mayer Hamblett, Nicole ^b   Kloster, Margaret ^b   Lands, Larry C ^c   Anstead, Michael ^d   Ratjen, Felix ^e   Saiman, Lisa ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF KENTUCKY   (United States)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN;

ANTIBIOTIC RESISTANCE; BACTERIAL STRAIN; BACTERIUM CULTURE; CYSTIC FIBROSIS; DRUG RESPONSE; HUMAN; LETTER; LONG TERM CARE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; SMALL COLONY VARIANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ADOLESCENT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CHILD; CYSTIC FIBROSIS; HUMANS; PHENOTYPE; PLACEBOS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TREATMENT OUTCOME;

STAPHYLOCOCCUS AUREUS;

EID: 79959816024     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00835-11     Document Type: Letter

References (4)

1. Besier, S., et al. 2008. The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. Antimicrob. Agents Chemother. 52:2183-2189.
2. Prunier, A. L., et al. 2003. High rate of macrolide resistance in Staphylococcus aureus strains from patients with cystic fibrosis reveals high proportions of hypermutable strains. J. Infect. Dis. 187:1709-1716.
3. Saiman, L., et al. 2010. Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa. JAMA 303:1707-1715.
4. Von Eiff, C., G. Peters, and K. Becker. 2006. The small colony variant (SCV) concept-the role of staphylococcal SCVs in persistent infections. Injury 37(Suppl. 2):S26-S33.