CD248+ stromal cells are associated with progressive chronic kidney disease

Kidney International

Volumn 80, Issue 2, 2011, Pages 199-207

  Smith, Stuart W ^a   Eardley, Kevin S ^b   Croft, Adam P ^a   Nwosu, Joel ^c   Howie, Alexander J ^d   Cockwell, Paul ^a,b   Isacke, Clare M ^e   Buckley, Christopher D ^a   Savage, Caroline O S ^a,c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ROYAL SHREWSBURY HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

chronic inflammation; chronic kidney disease; fibroblast; fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD45 ANTIGEN; ENDOSIALIN;

ADULT; AGED; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY BIOPSY; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MYOFIBROBLAST; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; UPREGULATION;

EID: 79959809001     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.103     Document Type: Article

References (36)

1. Strutz F, Zeisberg M. Renal fibroblasts and myofibroblasts in chronic kidney disease. J Am Soc Nephrol 2006; 17: 2992-2998. (Pubitemid 44707759)
2. Goumenos DS, Brown CB, Shortland J et al. Myofibroblasts, predictors of progression of mesangial IgA nephropathy? Nephrol Dial Transplant 1994; 9: 1418-1425. (Pubitemid 24310284)
3. Takeji M, Moriyama T, Oseto S et al. Smooth muscle a-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis. J Biol Chem 2006; 281: 40193-40200. (Pubitemid 46041824)
4. Okada H, Inoue T, Suzuki H et al. Epithelial-mesenchymal transformation of renal tubular epithelial cells in vitro and in vivo. Nephrol Dial Transplant 2000; 15(Suppl 6): 44-46.
5. Strutz FM. EMT and proteinuria as progression factors. Kidney Int 2009; 75: 475-481.
6. Strutz F, Okada H, Lo CW et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 1995; 130: 393-405.
7. Okada H, Danoff TM, Kalluri R et al. Early role of Fsp1 in epithelialmesenchymal transformation. Am J Physiol 1997; 273: F563-F574.
8. Hewitson TD. Renal tubulointerstitial fibrosis: common but never simple. Am J Physiol Renal Physiol 2009; 296: F1239-F1244.
9. Nishitani Y, Iwano M, Yamaguchi Y et al. Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN. Kidney Int 2005; 68: 1078-1085. (Pubitemid 43246424)
10. Ohradanova A, Gradin K, Barathova M et al. Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2. Br J Cancer 2008; 99: 1348-1356.
11. Inoue T, Plieth D, Venkov CD et al. Antibodies against macrophages that overlap in specificity with fibroblasts. Kidney Int 2005; 67: 2488-2493. (Pubitemid 41623414)
12. Eardley KS, Zehnder D, Quinkler M et al. The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease. Kidney Int 2006; 69: 1189-1197.
13. MacFadyen JR, Haworth O, Roberston D et al. Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett 2005; 579: 2569-2575. (Pubitemid 40615660)
14. Simonavicius N, Robertson D, Bax DA et al. Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma. Mod Pathol 2008; 21: 308-315. (Pubitemid 351304285)
15. Christian S, Winkler R, Helfrich I et al. Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. Am J Pathol 2008; 172: 486-494. (Pubitemid 351282034)
16. Rouleau C, Curiel M, Weber W et al. Endosialin protein expression and therapeutic target potential in human solid tumors: sarcoma versus carcinoma. Clin Cancer Res 2008; 14: 7223-7236.
17. Tomkowicz B, Rybinski K, Foley B et al. Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration. Proc Natl Acad Sci USA 2007; 104: 17965-17970. (Pubitemid 350210804)
18. Lax S, Hardie DL, Wilson A et al. The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. Eur J Immunol 2010; 40: 1884-1889.
19. Tomkowicz B, Rybinski K, Sebeck D et al. Endosialin/TEM-1/CD248 regulates pericyte proliferation through PDGF receptor signaling. Cancer Biol Ther 2010; 9: 908-915.
20. Rupp C, Dolznig H, Puri C et al. Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis. Cancer Immun 2006; 6: 10.
21. Nanda A, Karim B, Peng Z et al. Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc Natl Acad Sci USA 2006; 103: 3351-3356. (Pubitemid 43346473)
22. Maia M, de Vriese A, Janssens T et al. CD248 and its cytoplasmic domain: a therapeutic target for arthritis. Arthritis Rheum 2010; 62: 3595-3606.
23. Donadio JV, Grande JP. IgA nephropathy. N Engl J Med 2002; 347: 738-748. (Pubitemid 35203906)
24. Eardley KS, Kubal C, Zehnder D et al. The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease. Kidney Int 2008; 74: 495-504.
25. Lax S, Hardie DL, Wilson A et al. The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. Eur J Immunol 2010; 40: 1884-1889.
26. Lax S, Hou TZ, Jenkinson E et al. CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett 2007; 581: 3550-3556. (Pubitemid 47048202)
27. Watkins NA, Gusnanto A, de Bono B et al. A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood 2009; 113: e1-e9.
28. Conejo-Garcia JR, Buckanovich RJ, Benencia F et al. Vascular leukocytes contribute to tumor vascularization. Blood 2005; 105: 679-681. (Pubitemid 40070752)
29. Iwano M, Plieth D, Danoff TM et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002; 110: 341-350. (Pubitemid 34847966)
30. Zeisberg EM, Potenta SE, Sugimoto H et al. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008; 19: 2282-2287.
31. Okada H, Inoue T, Kanno Y et al. Renal fibroblast-like cells in Goodpasture syndrome rats. Kidney Int 2001; 60: 597-606. (Pubitemid 32678903)
32. Lin SL, Kisseleva T, Brenner DA et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008; 173: 1617-1627.
33. Bohle A, Mackensen-Haen S, von Gise H. Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: a morphometric contribution. Am J Nephrol 1987; 7: 421-433. (Pubitemid 18025635)
34. Grimwood L, Masterson R. Propagation and culture of renal fibroblasts. Methods Mol Biol 2009; 466: 25-37.
35. Howie AJ, Ferreira MA, Adu D. Prognostic value of simple measurement of chronic damage in renal biopsy specimens. Nephrol Dial Transplant 2001; 16: 1163-1169. (Pubitemid 32547370)
36. Robertson D, Savage K, Reis-Filho JS et al. Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue. BMC Cell Biol 2008; 9: 13.