Effect of inhibition of Notch signal on pulmonary vascular remodeling induced by angiotensin II

Chinese Journal of Contemporary Pediatrics

Volumn 13, Issue 6, 2011, Pages 503-508

  Qiao, Li Na ^a   Xu, Hong Bo ^a   Shi, Kun ^a   Zhou, Tong Fu ^a   Hua, Yi Min ^a   Liu, Han Min ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Angiotensin; Notch signal; Pulmonary; Rats; Vascular remodeling

Indexed keywords

ANGIOTENSIN II; CASPASE 3; CYCLINE; GAMMA SECRETASE INHIBITOR; MESSENGER RNA; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR;

AIRWAY REMODELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL WALL; CELL PROLIFERATION; NONHUMAN; POLYMERASE CHAIN REACTION; PULMONARY ARTERY; PULMONARY VASCULAR DISEASE; RAT;

ANGIOTENSIN II; ANIMALS; DIPEPTIDES; PROLIFERATING CELL NUCLEAR ANTIGEN; PULMONARY ARTERY; RATS; RATS, WISTAR; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 79959808156     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms[J]. Circ Res, 2006, 99(7): 675-691. (Pubitemid 44498302)
2. Chan SY, Loscalzo J. Pathogenic mechanisms of pulmonary arterial hypertension[J]. J Mol Cell Cardiol, 2008, 44(1): 14-30.
3. Hofmann JJ, Iruela-Arispe ML. Notch signaling in blood vessels: who is talking to whom about what?[J]. Circ Res, 2007, 100(11): 1556-1568.
4. Ehebauer M, Hayward P, Arias AM. Notch, a universal arbiter of cell fate decision[J]. Science, 2006, 314(5804): 1414-1415. (Pubitemid 44871939)
5. Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O'Brien C, et al. Notch and vascular smooth muscle cell phenotype[J]. Cir Res, 2008, 103(12): 1370-1382.
6. Kurpinski K, Lam H, Chu J, Wang A, Kim A, Tsay E, et al. Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells[J]. Stem Cell, 2010, 28(4): 734-742.
7. Kennard S, Liu H, Lilly B. Transforming growth factor-beta (TGF-1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression[J]. J Biol Chem, 2008, 283(3): 1324-1333.
8. Hellström M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, et al. D114 signalling through Notch1 regulates formation of tip cells during angiogenesis[J]. Nature, 2007, 445(7129): 776-780.
9. Morrow D, Sweeney C, Birney YA, Guha S, Collins N, Cummins PM, et al. Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo[J]. Am J Physiol CeU Physiol, 2007, 292(1): C488-C496.
10. McKie PM, Cataliotti A, Boerrigter G, Chen HH, Sangaralingham SJ, Martin FL, et al. A novel atrial natriuretic peptide based therapeutic in experimental angiotensin II mediated acute hypertension [J]. Hypertension, 2010, 56(6): 1152-1159.
11. Bradford CN, Ely DR, Raizada MK. Targeting the vasoprotective axis of the renin-angiotensin system: a novel strategic approach to pulmonary hypertensive therapy[J]. Curr Hypertens Rep, 2010, 12(4): 212-219.
12. Shenoy V, Ferreira AJ, Qi Y, Fraga-Silva RA, Díez-Freire C, Dooies A, et al. The angiotensin-converting enzyme 2/angiogenesis-( 1-7 )/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension[J]. Am J Respir Crit Care Med, 2010, 182(8): 1065-1072.
13. Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, et al. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibition DAPT (N-[N-(3,5-Difluorophenacetyl)-L- alanyl]-S-phenylglycinet-Butyl ester)[J]. J Biol Chem, 2006, 281(21): 14670-14676. (Pubitemid 43855171)
14. Nelson BR, Hartman BH, Georgi SA, Lan MS, Reh TA. Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells[J]. Dev Biol, 2007, 304(2): 479-498. (Pubitemid 46527560)