Endosulfan-induced hepatotoxicity is route of exposure independent in rats

Toxicology and Industrial Health

Volumn 27, Issue 6, 2011, Pages 483-488

  Friday Effiong Uboh, ^a   Ekpo Nya Asuquo, ^a   Mbeh Ubana Eteng, ^a  

^a UNIVERSITY OF CALABAR   (Nigeria)

Author keywords

Endosulfan; hepatotoxicity; histopathology; liver enzymes; route of exposure

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; ENDOSULFAN; LIVER ENZYME;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER TOXICITY; MALE; MICROSCOPY; NONHUMAN; RAT;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CREATINE KINASE; DRUG-INDUCED LIVER INJURY; ENDOSULFAN; ENVIRONMENTAL POLLUTANTS; INHALATION EXPOSURE; INSECTICIDES; LIVER; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

NICOTIANA TABACUM; RATTUS; RATTUS NORVEGICUS;

EID: 79959800208     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233710387011     Document Type: Article

References (37)

1. Ali SS, Shakoori AR (1990) Toxicity of aldrin in rats. Punjab University Journal of Zoology, 5: 1-56.
2. Ali SS, Shakoori AR (1996) Short and long term toxicity of DDT in albino rats: biochemical effects in liver. Punjab University Journal of Zoology, 11: 7-24.
3. Ali SS, Shakoori AR (1999) Hepatotoxicity of lindane (Gamma HCH) in albino rats: short and long term studies. Pakistan Journal of Zoology, 31: 175-185.
4. Bancroft JD, and Stevens A. (1977) Theory and Practice of Histological Techniques. Edinburgh: Churchill Livingstone, 1-15.
5. Blanco-Coronado JL, Repetto M., Ginestal RJ, Vicente JR, Yelamos F., and Lardelli A. (1992) Acute intoxication by endosulfan. Clinical Toxicology, 30(4): 575-583.
6. Boereboom TJ, Van Dijk A., Van Zoonen P., and Meulenbelt J. (1998). Nonaccidental endosulfan intoxication: a case report with toxicokinetic calculations and tissue concentrations. Clinical Toxicology, 36(4): 345-352.
7. Boulecache H., and Spiess C. (1974) Effect of lindane on trout fly (Salmo irideus Gibb). Changes in glycolytic enzymes. Bulletin of the Zoological Society of France, 99: 79-85.
8. Choudhary N., Sharma M., Verma P., and Joshi SC (2003) Hepato and nephrotoxicity in rat exposed to endosulfan. Journal of Environmental Biology, 24: 305-308.
9. Dutta HM, and Arends DA (2003) Effects of endosulfan on brain acetyl-cholinesterase activity in juvenile bluegill sunfish. Environmental Research, 91: 157-162.
10. Fossi MC, Massi A., Lari L., Marsili L., Focardi S., Lionzio C., et al. (1995) Interspecific differences in mixed function oxidase activity in birds: relationship between feeding habits, detoxication activity and organochlorine accumulation. Environmental Pollution, 90: 15-24.
11. Gertig H., and Nowaczyk W. (1975) The influence of lindane on enzymes activity n the tissues of rats on protein rich diet. Polish Journal of Pharmacology and Pharmacy, 27: 529-537.
12. Hargrave BT, Harding GC, Vass WP, Erickson PE, Fowler BR, and Scott V. (1992) Organochlorine pesticides and polychlorinated biphenyls in the Arctic ocean food web. Archives of Environmental Toxicology, 22: 41-54.
13. Junqueira VB, Bainy AC, Arisi AC, Azzalis LA, Simizu K., Pimentel R., et al. (1994) Acute lindane intoxication: a study on lindane tissue concentration and oxidative stress-related parameters in liver and erythrocytes. Journal of Biochemical and Toxicology, 9: 9-15.
14. Junqueira VB, Simizu K., Videla LA, and Barros B. (1986) Dose dependent study of the effects of acute lindane administration on rat liver superoxide anion production, antioxidant enzyme activities, and lipid peroxidation. Toxicology, 41: 193-204.
15. Khuns DB, Kaplan SS, and Basford RE (1986). Hexachlorocyclohexanes, potent stimuli of O2-production and calcium release in human polymorphonuclear leukocytes. Blood, 68: 535-540.
16. Kimbrough RD, Gaines TB, and Linder RE (1971) The ultrastructure of livers of rats fed DDT and dieldrin. Archives of Environmental Health, 22: 460-467.
17. Kurutaş EB, Doran F., and Çıralık H. (2006) The effect of endosulfan on lactic dehydrogenase enzyme system in liver of mus musculus: a histochemical study. European Journal of General Medicine, 3(4): 148-151.
18. Kurutas EB, Doran F., and Varinli S. (2001). The reference value of antioxidant status in erythrocyte and liver Saglıklı erkek farelerde eritrosit ve karaciger antioksidan sistemlerin referans degerleri. Turkish Journal of Veterinary and Animal Sciences, 25: 505-509.
19. Kurutas EB, Tuncer I. (2000) A mouse model for evaluating the induction of liver glucose-6-phosphate dehydrogenase by halothane. Turkish Journal of Veterinary and Animal Sciences, 24: 511-515.
20. Labana S., Bansal RC, and Mahmood A. (1997) Differential effects of Lindane on intestinal functions in normal-fed and malnourished rats. Journal of Pesticide Biochemistry and Physiology, 57: 192-199.
21. Liang HCL, Shertzer HG, and Nebert DW (1992) “Oxidative stress” response in liver of a treated newborn mouse having a 1.2-centimorgan deletion on chromosome 7. Biochemical and Biophysical Research Communications, 182: 1160-1164.
22. Lodha RM, and Saxena V. (1991) Pesticides and environmental pollution. Himanshir publications Udaipur, India, 1: 87-90.
23. Lonsway JA, Byers ME, Dowla HA, Panemangalore M., and Antonious GF (1997) Dermal and respiratory exposure of mixers/sprayers to acephate, methamidophos, and endosulfan during tobacco production. Bulletin of the Environmental Contamination and Toxicology, 59: 179-186.
24. Meany JE, Pocker Y. (1979) The in vivo inactivation of lactate dehydrogenase by organochlorine insecticides. Pesticide Biochemistry and Physiology, 11: 232-242.
25. Nazir A., Shafique M., Kamal F., and Raza TA (2000) Hepatotoxic effects of low dose endosulfan: a duration dependent histological study. Proceeding Shaikh Zayed Postgraduate Medical Institute, 14(2): 77-84.
26. Nichols JW, Larsen CP, Mcdonald ME, Niemi GJ, and Ankley GT (1995) Bioenergetics-based model for accumulation of polychlorinated biphenyls by nesting tree swallow, Tachycineta bicolor. Environmental Science and Technology, 29: 604-612.
27. Omurtag GZ, Tozan A., Şehirli AÖ, and Şener G. (2008) Melatonin protects against endosulfan-induced oxidative tissue damage in rats. Journal of Pineal Research, 44(4): 432-438.
28. Smith AG (1991) Chlorinated hydrocarbon insecticides. In: Hayes WJ Jr, and Laws ER Jr (eds) Handbook of Pesticide Toxicology. New York, NY: Academic Press Inc., 3-6.
29. Thao VUD, Kawano M., and Tatsukawa R. (1993) Persistent organochlorine residues in soils from tropical and subtropical Asian countries. Environmental Pollution, 81: 61-71.
30. Uboh FE, Akpanabiatu MI, Atangwho IJ, Ebong PE, and Umoh IB (2007) Effect of gasoline vapours on serum lipid profile and oxidative stress in hepatocytes of male and female rats. Acta Toxicologica, 15(1): 25-30.
31. Uboh FE, Akpanabiatu MI, Ebong PE, Eyong EU, and Ekaidem IS (2005) Evaluation of to toxicological implications of inhalation exposure to kerosene and petrol fumes in rats. Acta Biological Szegiendiensis, 49(3-4): 19-22.
32. Uboh FE, Akpanabiatu MI, Eteng MU, Ebong PE, and Umoh IB (2008) Toxicological effects of exposure to gasoline vapour in male and female rats. The Internet Journal of Toxicology. 4(2).
33. Uboh FE, Ekaidem IS, Ebong PE, and Umoh IB (2009) Hepatoprotective effect of Vitamin A against Gasoline vapours toxicity in rats. Gastroenterology Research, 2(3): 162-167.
34. Uboh FE, Eteng MU, Ebong PE, and Umoh IB (2010a) Vitamins A and E reverse gasoline vapors-induced hematotoxicity in female rats. Toxicology and Industrial Health, 26(9): 599-566.
35. Uboh FE, Okon IE, and Ekong MB (2010b) Effect of aqueous extract of P. guajava leaves on liver enzymes, histological integrity and hematological indices in rats. Gastroenterology Research, 3(1): 32-38.
36. Winter S., Street B. (1992) Organochlorine compounds in the three step terrestrial food chain. Chemosphere, 24: 1766-1774.
37. Yavuz Y., Yurumez Y., Kücüker H., Ela Y., and Yüksel S. (2007) Two cases of acute endosulfan toxicity. Clinical Toxicology, 45(5): 530-532.