Role of rho kinase in the functional and dysfunctional tonic smooth muscles

Trends in Pharmacological Sciences

Volumn 32, Issue 7, 2011, Pages 384-393

  Godoy, Márcio A F De ^a   Rattan, Satish ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALPHOSTIN C; CHELERYTHRINE; FASUDIL; MYOSIN; PROTEIN KINASE C; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GASTROINTESTINAL MOTILITY DISORDER; GENE SILENCING; HUMAN; HYPERTENSION; LOWER ESOPHAGUS SPHINCTER; NEUROPATHIC PAIN; NONHUMAN; PARAINFLUENZA VIRUS INFECTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL VIRUS INFECTION; REVIEW; RNA INTERFERENCE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; SUBRETINAL NEOVASCULARIZATION;

ANIMALS; HUMANS; MUSCLE, SMOOTH; PROTEIN KINASE C; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 79959798427     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2011.03.005     Document Type: Review

References (112)

1. J.C. Ruegg Smooth muscle tone Physiol. Rev. 51 1971 201 248
2. K.M. Harnett Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles Am. J. Physiol. Gastrointest. Liver Physiol. 288 2005 G407 G416
3. K. Golenhofen, and K. Mandrek Phasic and tonic contraction processes in the gastrointestinal tract Dig. Dis. Sci. 9 1991 341 346
4. R. Farre, and D. Sifrim Regulation of basal tone, relaxation, and contraction of the lower esophageal sphincter. Relevance to drug discovery for esophageal disorders Br. J. Pharmacol. 153 2008 858 869 (Pubitemid 351328930)
5. P.J. Culver, and S. Rattan Genesis of anal canal pressures in the opossum Am. J. Physiol. Gastrointest. Liver Physiol. 251 1986 G765 G771
6. R.K. Goyal, and A. Chaudhury Physiology of normal esophageal motility J. Clin. Gastroenterol. 42 2008 610 619 (Pubitemid 351572279)
7. S. Rattan The internal anal sphincter: regulation of smooth muscle tone and relaxation Neurogastroenterol. Motil. 17 2005 50 59 (Pubitemid 40756356)
8. P.C. Johnson The myogenic response F. David, Bohr P. Andrew, Somlyo V. Harvey, Sparks Jr. Handbook of Physiology. The Cardiovascular System. Vascular Smooth Muscle Vol. II, section 2 1980 American Physiological Society 409 442
9. M.J. Davis Myogenic response gradient in an arteriolar network Am. J. Physiol. Heart Circ. Physiol. 264 1993 H2168 H2169
10. E.M. Smolock siRNA knock down of casein kinase 2 increases force and cross-bridge cycling rates in vascular smooth muscle Am. J. Physiol. Cell Physiol. 292 2007 C876 C885
11. S. Rattan Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter Gastroenterology 131 2006 108 116 (Pubitemid 44026500)
12. K.S. Murthy Signaling for contraction and relaxation in smooth muscle of the gut Annu. Rev. Physiol. 68 2006 345 374
13. S. Rattan RhoA/ROCK-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation Gastroenterology 138 2010 13 18
14. K. Hirano Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain Mol. Cell Biochem. 248 2003 105 114 (Pubitemid 36833647)
15. T. Kandabashi Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm Arterioscler. Thromb. Vasc. Biol. 23 2003 2209 2214 (Pubitemid 37532322)
16. S.I.J. Ellenbrock, and J.G. Collard Rho GTPases: functions and association with cancer Clin. Exp. Metastasis 24 2007 657 672 (Pubitemid 50002983)
17. K. Mori Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP J. Biol. Chem. 284 2009 5067 5076
18. J. Bregeon Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells Am. J. Physiol. Cell Physiol. 297 2009 C1062 C1070
19. S. Puetz Regulation of smooth muscle contraction by small GTPases Physiology 24 2009 342 356
20. 2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697 Biochem. J. 389 2005 763 774 (Pubitemid 41121989)
21. K. Sward The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction Curr. Hypertens. Rep. 5 2003 66 72 (Pubitemid 38898934)
22. S. Ayman Receptor-independent activation of Rho-kinase-mediated calcium sensitisation in smooth muscle Br. J. Pharmacol. 139 2003 1532 1538 (Pubitemid 37174668)
23. T.P. Woodsome Agonist- and depolarization-induced signals for myosin light chain phosphorylation and force generation of cultured vascular smooth muscle cells J. Cell Sci. 119 2006 1769 1780 (Pubitemid 43811003)
24. Y. Kureishi Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation J. Biol. Chem. 272 1997 12257 12260 (Pubitemid 27203307)
25. M.A.F. De Godoy Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone Gastroenterology 127 2004 127 138 (Pubitemid 38962281)
26. M.A.F. De Godoy, and S. Rattan Autocrine regulation of internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle Am. J. Physiol. Gastrointest. Liver Physiol. 289 2005 G1164 G1175
27. C. Casselbrant Actions by angiotensin II on esophageal contractility in humans Gastroenterology 132 2007 249 260
28. 2 (group I secreted) in the genesis of basal tone in the internal anal sphincter smooth muscle Am. J. Physiol. Gastrointest. Liver Physiol. 293 2007 G979 G986
29. M.A.F. De Godoy COX-1 vs. COX-2 as a determinant of the basal tone in the internal anal sphincter Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G219 G225
30. W.B. Cao Group I secreted PLA2 (sPLA2) and arachidonic acid metabolites in the maintenance of cat LES tone Am. J. Physiol. Gastrointest. Liver Physiol. 40 1999 G585 G598
31. W. Cao Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone Gastroenterology 119 2000 243 252
32. L. Cheng Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle Am. J. Physiol. Gastrointest. Liver Physiol. 288 2005 G787 G797
33. - channels in maintenance of opossum lower esophageal sphincter tone Am. J. Physiol. Gastrointest. Liver Physiol. 279 2000 G1226 G1234
34. S.B. Patil, and K.N. Bitar RhoA- and PKC-α-mediated phosphorylation of MYPT and its association with HSP27 in colonic smooth muscle cells Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G83 G95
35. S. Somara Bioengineered internal anal sphincter derived from isolated human internal anal sphincter smooth muscle cells Gastroenterology 137 2009 53 61
36. C.A. Patel, and S. Rattan RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter J. Pharmacol. Exp. Ther. 321 2007 501 508 (Pubitemid 46628593)
37. S. Rattan 3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylation Am. J. Physiol. Gastrointest. Liver Physiol. 298 2010 G962 G969
38. S.A. Barman RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension Vasc. Health Risk Manage 5 2009 663 671
39. A. Wirth Rho kinase and hypertension Biochim. Biophys. Acta 1802 2010 1276 1284
40. M. Dong Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases Drug Discov. Today 15 2010 622 629
41. Y. Wang ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells Circ. Res. 104 2009 531 540
42. K.P. Nunes RhoA/Rho-kinase and vascular diseases: what is the link? Cell. Mol. Life Sci. 67 2010 3823 3836
43. A.P. Somlyo, and A.V. Somlyo Signal transduction through the RhoA/Rho-kinase pathway in smooth muscle J. Muscle Res. Cell Motil. 25 2004 613 615 (Pubitemid 40562022)
44. T. Leung The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton Mol. Cell Biol. 16 2007 5313 5327
45. 20 (20 kDa regulatory light chain myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit and protein kinase C/CPI-17 pathway Biochem. J. 374 2003 145 155
46. α function using region-specific antibodies J. Biol. Chem. 277 2002 12680 12688
47. K.M. Sanders Regulation of smooth muscle excitation and contraction Neurogastroenterol. Motil. 20 Suppl. 1 2008 39 53 (Pubitemid 351514537)
48. D.J. Hartshorne Myosin light chain phosphatase: subunit composition, interactions and regulation J. Muscle Res. Cell Motil. 19 1998 325 341 (Pubitemid 28253106)
49. M. Koyama Phosphorylation of CPI-17, and inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase FEBS Lett. 475 2000 197 200 (Pubitemid 30408452)
50. T. Kitazawa Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility J. Biol. Chem. 275 2000 9897 9900 (Pubitemid 30202032)
51. M. Amano Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) J. Biol. Chem. 271 1996 20246 20249 (Pubitemid 26281788)
52. M. Eto Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle FEBS Lett. 410 1997 356 360 (Pubitemid 27304096)
53. 2+ sensitization in rabbit smooth muscle J. Physiol. (Lond.) 546 2003 879 889 (Pubitemid 36204521)
54. M. Eto Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors J. Biol. Chem. 284 2009 35273 35277
55. T. Wang Carbachol-induced rabbit bladder smooth muscle contraction: roles of protein kinase C and Rho kinase Am. J. Physiol. Renal Physiol. 297 2009 F1534 F1542
56. 2β in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals J. Biol. Chem. 285 2010 8628 8638
57. N. Kim Distinct kinases are involved in contraction of cat esophageal and lower esophageal sphincter smooth muscles Am. J. Physiol. Cell Physiol. 287 2004 C384 C394
58. 3 Am. J. Physiol. Gastrointest. Liver Physiol. 260 1991 G537 G542
59. S.M. Sims Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone J. Pharmacol. Exp. Ther. 327 2008 178 186
60. S.Y. Park Paticipation of Rho-associated kinase in electrical stimulated and acetylcholine-induced contraction of feline esophageal smooth muscle Eur. J. Pharmacol. 607 2009 220 225
61. C.A. Patel, and S. Rattan Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle Am. J. Physiol. Gastrointest. Liver Physiol. 291 2006 G830 G837
62. C.A. Patel, and S. Rattan Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 G1747 G1756
63. S. Rattan, and C.A. Patel Selectivity of Rho kinase inhibitors in the spontaneously tonic smooth muscle Am. J. Physiol. Gastrointest. Liver Physiol. 294 2008 G687 G693
64. 2+-independent contractions induced by phorbol-12,13-dibutyrate Clin. Exp. Pharmacol. Physiol. 36 2009 256 261
65. + sensitization in the bovine cerebral artery: unimportant role for protein kinase C Circ. Res. 91 2002 112 119 (Pubitemid 34827221)
66. N. Baeyens Identification of functional implication of a rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery Am. J. Physiol. Cell Physiol. 299 2010 C1530 C1540
67. L. Xiao ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK J. Biol. Chem. 284 2010 29365 29375
68. M. Hashish Surgical implantation of a bioengineered internal anal sphincter J. Ped. Surg. 45 2010 52 58
69. A. Wald Clinical practice. Fecal incontinence in adults N. Engl. J. Med. 356 2007 1648 1655 (Pubitemid 46631674)
70. S.S. Rao, and S. Singh Clinical utility of colonic and anorectal manometry in chronic constipation J. Clin. Gastroenterol. 44 2010 597 609
71. C.P. Gibbons Role of constipation and anal hypertonia in the pathogenesis of haemorrhoids Br. J. Surg. 75 1988 656 660
72. R. Farouk Sustained internal sphincter hypertonia with chronic anal fissure Dis. Colon Rectum. 37 1994 424 429 (Pubitemid 24149674)
73. M. Madalinski, and L. Kalinowski Novel options for the pharmacological treatment of chronic anal fissure - role of botulinum toxin Curr. Clin. Pharmacol. 4 2009 47 52
74. S. Kuribayashi Mechanism of gastroesophageal reflux in patients with obstructive sleep apnea syndrome Neurogastroenterol. Motil. 22 2010 611-e172
75. R.K. Mittal, and D.H. Balaban The esophagogastric junction N. Engl. J. Med. 336 1997 924 932 (Pubitemid 27137194)
76. J.E. Richter Achalasia - an update J. Neurogastroenterol. Motil. 16 2010 232 242
77. M.A.F. De Godoy H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter Gastroenterology 132 2007 1401 1409
78. N. Arber Activation of c-K-ras mutations in human gastrointestinal tumors Gastroenterology 118 2000 1045 1050 (Pubitemid 30346981)
79. P. van Duijvendijk A prospective evaluation of anorectal function after total mesorectal excision in patients with a rectal carcinoma Surgery 133 2003 56 65 (Pubitemid 36183126)
80. S. Rattan Involvement of rho and rho-associated kinase in sphincteric smooth muscle contraction by angiotensin II Exp. Biol. Med. 228 2003 972 981 (Pubitemid 37163251)
81. S. Rattan Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles Life Sci. 70 2002 2147 2164 (Pubitemid 34219465)
82. E. Zizer Loss of Lsc/p115 protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice Gastroenterology 139 2010 1344 1354
83. C.D. Wells Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor J. Biol. Chem. 276 2001 28897 28905
84. H. Ohtsu Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II Arterioscler. Thromb. Vasc. Biol. 25 2005 1831 1836 (Pubitemid 41243450)
85. S.-S. Bolz Sphingosin kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase Circulation 108 2003 342 347 (Pubitemid 36899027)
86. N.I. Gokina Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity J. Appl. Physiol. 98 2004 1940 1948
87. Y. Mukai Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension FASEB J. 15 2001 1062 1064
88. M. Asano, and Y. Nomura Comparison of inhibitory effects of Y-27632, a Rho kinase inhibitor, in strips of small and large mesenteric arteries from spontaneously hypertensive and normotensive Wistar-Kyoto rats Hypertension Res. 26 2003 97 106 (Pubitemid 36193104)
89. S. Chrissobolis, and C.G. Sobey Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension - comparison with protein kinase C Circ. Res. 88 2001 774 779 (Pubitemid 32429972)
90. D.S. Weber, and R.C. Webb Enhanced relaxation to the rho-kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats Pharmacology 63 2001 129 133 (Pubitemid 34701642)
91. T. Seko Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle Circ. Res. 92 2003 411 418 (Pubitemid 36298201)
92. T.M. Seasholtz Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats Circ. Res. 89 2001 488 495 (Pubitemid 34132642)
93. N. Moriki RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats Hypertension Res. 27 2004 263 270 (Pubitemid 38594398)
94. P.D. Zamore RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals Cell 101 2000 25 33
95. K.A. Harvey Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation Mol. Cell. Biochem. 342 2010 7 19
96. Y-W.E. Chang RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility Cancer Res. 66 2006 11700 11708 (Pubitemid 46094182)
97. A. Fire Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
98. J.R. Kennerdell, and R.W. Carthew Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway Cell 95 1998 1017 1026 (Pubitemid 29019053)
99. S.M. Elbashir Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498 (Pubitemid 32494397)
100. A.K. Vaishnaw A status report on RNAi therapeutics Silence 1 2010 1 13
101. S.J. Reich Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model Mol. Vis. 9 2003 210 216 (Pubitemid 38097589)
102. A.S. Herard siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo Neurobiol. Aging 27 2005 1740 1750 (Pubitemid 44572585)
103. D.R. Thakker siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain Mol. Psychiatry 10 2005 782 789 (Pubitemid 41129051)
104. G. Dorn siRNA relieves chronic neuropathic pain Nucleic Acids Res. 32 2004 e49
105. V. Bitko Inhibition of respiratory viruses by nasally administered siRNA Nat. Med. 11 2005 50 55 (Pubitemid 40215837)
106. Y. Mizuno Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo Am. J. Physiol. Cell Physiol. 295 2008 C358 C364
107. Y.J. Han Regulation of myosin light chain kinase expression by angiotensin II in hypertension Am. J. Hypertens. 21 2008 860 865
108. W.-Y. Hu Involvement of ras-regulated myosin light chain phosphorylation in the captopril effects in spontaneously hypertensive rats Am. J. Hypertens. 20 2007 53 61 (Pubitemid 46019849)
109. O. Ogut, and F. Brozovich The potential role of MLC phosphatase and MAPK signaling in the pathogenesis of vascular dysfunction in heart failure J. Cell. Mol. Med. 12 2008 2158 2164
110. M.C. Payne Dynamic changes in expression of myosin phosphatase in a model of portal hypertension Am. J. Physiol. Heart Circ. Physiol. 286 2004 H1801 H1810
111. S. Dakshinamurti Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17 Ped. Pulmonol. 40 2005 398 407 (Pubitemid 41546902)
112. J. Belik Myosin light chain phosphatase and kinase abnormalities in fetal sheep pulmonary hypertension Pediatr. Res. 43 1998 57 61 (Pubitemid 28069168)