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Volumn 18, Issue 3, 2011, Pages 151-157

Infectious risk in xenotransplantation - What post-transplant screening for the human recipient?

Author keywords

detection methods; porcine endogenous retroviruses (PERV); transpecies transmission; virus safety of xenotransplantation

Indexed keywords

GAG PROTEIN; GLYCOPROTEIN GP 70; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

EID: 79959762066     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2011.00636.x     Document Type: Review
Times cited : (28)

References (60)
  • 1
    • 76649115593 scopus 로고    scopus 로고
    • Genetic modification of pigs as organ donors for xenotransplantation
    • Klymiuk N, Aigner B, Brem G, Wolf E,. Genetic modification of pigs as organ donors for xenotransplantation. Mol Reprod Dev 2010; 77: 209-221.
    • (2010) Mol Reprod Dev , vol.77 , pp. 209-221
    • Klymiuk, N.1    Aigner, B.2    Brem, G.3    Wolf, E.4
  • 4
    • 77954631868 scopus 로고    scopus 로고
    • Xenotransplantation: State of the art of biosafety
    • In: Jansen E.S., Simon J.W., eds., Saarbrücken: VDM-Verlag.
    • Denner J,. Xenotransplantation: state of the art of biosafety. In:, Jansen ES, Simon JW, eds. Xenotransplantation-Ethic, Economic, Social, Cultural and Scientific Background, Vol. 1. Saarbrücken: VDM-Verlag, 2008: 7-79.
    • (2008) Xenotransplantation - Ethic, Economic, Social, Cultural and Scientific Background , vol.1 , pp. 7-79
    • Denner, J.1
  • 5
    • 70349586118 scopus 로고    scopus 로고
    • The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 2: Source pigs
    • Schuurman HJ,. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-chapter 2: source pigs. Xenotransplantation 2009; 16: 215-222.
    • (2009) Xenotransplantation , vol.16 , pp. 215-222
    • Schuurman, H.J.1
  • 6
    • 68749098219 scopus 로고    scopus 로고
    • Porcine circoviruses - Small but powerful
    • Finsterbusch T, Mankertz A,. Porcine circoviruses-small but powerful. Virus Res 2009; 143: 177-183.
    • (2009) Virus Res , vol.143 , pp. 177-183
    • Finsterbusch, T.1    Mankertz, A.2
  • 7
    • 0042868809 scopus 로고    scopus 로고
    • Methods for the exclusion of circoviruses and gammaherpesviruses from pigs
    • Tucker AW, McNeilly F, Meehan B, et al., Methods for the exclusion of circoviruses and gammaherpesviruses from pigs. Xenotransplantation 2003; 10: 343.
    • (2003) Xenotransplantation , vol.10 , pp. 343
    • Tucker, A.W.1    McNeilly, F.2    Meehan, B.3
  • 8
    • 0041866767 scopus 로고    scopus 로고
    • Approaching virus safety in xenotransplantation: A search for unrecognized herpesviruses in pigs
    • DOI 10.1034/j.1399-3089.2003.02074.x
    • Chmielewicz B, Goltz M, Lahrmann KH, Ehlers B,. Approaching virus safety in xenotransplantation: a search for unrecognized herpesviruses in pigs. Xenotransplantation 2003; 10: 349-356. (Pubitemid 36903775)
    • (2003) Xenotransplantation , vol.10 , Issue.4 , pp. 349-356
    • Chmielewicz, B.1    Goltz, M.2    Lahrmann, K.-H.3    Ehlers, B.4
  • 9
    • 0032442114 scopus 로고    scopus 로고
    • Defining appropriate health status and management programs for specific-pathogen-free swine for xenotransplantation
    • DOI 10.1111/j.1749-6632.1998.tb09123.x
    • Swindle MM,. Defining appropriate health status and management programs for specific pathogen-free swine for xenotransplantation. Ann N Y Acad Sci 1998; 862: 111-120. (Pubitemid 29044018)
    • (1998) Annals of the New York Academy of Sciences , vol.862 , pp. 111-120
    • Swindle, M.M.1
  • 12
    • 67651056178 scopus 로고    scopus 로고
    • Porcine endogenous retrovirus and other viruses in xenotransplantation
    • Scobie L, Takeuchi Y,. Porcine endogenous retrovirus and other viruses in xenotransplantation. Curr Opin Organ Transplant 2009; 14: 175-179.
    • (2009) Curr Opin Organ Transplant , vol.14 , pp. 175-179
    • Scobie, L.1    Takeuchi, Y.2
  • 13
    • 0042164565 scopus 로고    scopus 로고
    • Swine hepatitis E virus: Cross-species infection and risk in xenotransplantation
    • Meng XJ,. Swine hepatitis E virus: cross-species infection and risk in xenotransplantation. Curr Top Microbiol Immunol 2003; 278: 185-216. (Pubitemid 36950678)
    • (2003) Current Topics in Microbiology and Immunology , vol.278 , pp. 185-216
    • Meng, X.J.1
  • 14
    • 49149109304 scopus 로고    scopus 로고
    • The first Chinese porcine sapovirus strain that contributed to an outbreak of gastroenteritis in piglets
    • Zhang W, Shen Q, Hua X, et al., The first Chinese porcine sapovirus strain that contributed to an outbreak of gastroenteritis in piglets. J Virol 2008; 82: 8239-8240.
    • (2008) J Virol , vol.82 , pp. 8239-8240
    • Zhang, W.1    Shen, Q.2    Hua, X.3
  • 15
    • 67650439331 scopus 로고    scopus 로고
    • Discovery of swine as a host for the Reston ebolavirus
    • Barrette RW, Metwally SA, Rowland JM, et al., Discovery of swine as a host for the Reston ebolavirus. Science 2009; 325: 204-206.
    • (2009) Science , vol.325 , pp. 204-206
    • Barrette, R.W.1    Metwally, S.A.2    Rowland, J.M.3
  • 17
    • 0031054438 scopus 로고    scopus 로고
    • Infection of human cells by an endogenous retrovirus of pigs
    • DOI 10.1038/nm0397-282
    • Patience C, Takeuchi Y, Weiss RA,. Infection of human cells by an endogenous retrovirus of pigs. Nat Med 1997; 3: 282-286. (Pubitemid 27112924)
    • (1997) Nature Medicine , vol.3 , Issue.3 , pp. 282-286
    • Patience, C.1    Takeuchi, Y.2    Weiss, R.A.3
  • 18
    • 36048929469 scopus 로고    scopus 로고
    • Transspecies transmissions of retroviruses: New cases
    • DOI 10.1016/j.virol.2007.07.026, PII S0042682207004977
    • Denner J,. Transspecies transmissions of retroviruses: new cases. Virology 2007; 369: 229-233. (Pubitemid 350087189)
    • (2007) Virology , vol.369 , Issue.2 , pp. 229-233
    • Denner, J.1
  • 19
    • 0034723385 scopus 로고    scopus 로고
    • AIDS as a zoonosis: Scientific and public health implications
    • DOI 10.1126/science.287.5453.607
    • Hahn BH, Shaw GM, De Cock KM, Sharp PM,. AIDS as a zoonosis: scientific and public health implications. Science 2000; 287: 607-614. (Pubitemid 30070900)
    • (2000) Science , vol.287 , Issue.5453 , pp. 607-614
    • Hahn, B.H.1    Shaw, G.M.2    De Cock, K.M.3    Sharp, P.M.4
  • 20
    • 70349587445 scopus 로고    scopus 로고
    • The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 5: Strategies to prevent transmission of porcine endogenous retroviruses
    • Denner J, Schuurman H, Patience C,. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Chapter 5: strategies to prevent transmission of porcine endogenous retroviruses. Xenotransplantation 2009; 16: 239-248.
    • (2009) Xenotransplantation , vol.16 , pp. 239-248
    • Denner, J.1    Schuurman, H.2    Patience, C.3
  • 21
    • 0037265712 scopus 로고    scopus 로고
    • Differences in release and determination of subtype of porcine endogenous retroviruses produced by stimulated normal pig blood cells
    • DOI 10.1159/000068120
    • Tacke SJ, Specke V, Denner J,. Differences in release and determination of subtype of porcine endogenous retroviruses produced by stimulated normal pig blood cells. Intervirology 2003; 46: 17-24. (Pubitemid 36173473)
    • (2003) Intervirology , vol.46 , Issue.1 , pp. 17-24
    • Tacke, S.J.1    Specke, V.2    Denner, J.3
  • 22
    • 10044242836 scopus 로고    scopus 로고
    • Determinants of high titer in recombinant porcine endogenous retroviruses
    • DOI 10.1128/JVI.78.24.13871-13879.2004
    • Harrison I, Takeuchi Y, Bartosch B, Stoye JP,. Determinants of high titer in recombinant porcine endogenous retroviruses. J Virol 2004; 78: 13871-13879. (Pubitemid 39612784)
    • (2004) Journal of Virology , vol.78 , Issue.24 , pp. 13871-13879
    • Harrison, I.1    Takeuchi, Y.2    Bartosch, B.3    Stoye, J.P.4
  • 24
    • 47549090956 scopus 로고    scopus 로고
    • Recombinant porcine endogenous retroviruses (PERV-A/C): A new risk for xenotransplantation?
    • Denner J,. Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation? Arch Virol 2008; 153: 1421-1426.
    • (2008) Arch Virol , vol.153 , pp. 1421-1426
    • Denner, J.1
  • 25
    • 79958004118 scopus 로고    scopus 로고
    • Development of sensitive methods for detection of porcine endogenous retrovirus-C (PERV-C) in the genome of pigs
    • Kaulitz D, Mihica D, Dorna J, et al., Development of sensitive methods for detection of porcine endogenous retrovirus-C (PERV-C) in the genome of pigs J Virol Methods (in press) 2011.
    • (2011) J Virol Methods (In Press)
    • Kaulitz, D.1    Mihica, D.2    Dorna, J.3
  • 26
    • 0344405785 scopus 로고    scopus 로고
    • Neutralizing antibodies against conserved domains of p15E of porcine endogenous retroviruses: Basis for a vaccine for xenotransplantation?
    • DOI 10.1016/S0042-6822(02)00140-X
    • Fiebig U, Stephan O, Kurth R, Denner J,. Neutralizing antibodies against conserved domains of p15E of porcine endogenous retroviruses [PERVs]: basis for a vaccine for xenotransplantation? Virology 2003; 307: 406-413. (Pubitemid 36344171)
    • (2003) Virology , vol.307 , Issue.2 , pp. 406-413
    • Fiebig, U.1    Stephan, O.2    Kurth, R.3    Denner, J.4
  • 27
    • 79551686727 scopus 로고    scopus 로고
    • Generation of neutralising antibodies against porcine endogenous retroviruses [PERVs]
    • Kaulitz D, Fiebig U, Eschricht M, et al., Generation of neutralising antibodies against porcine endogenous retroviruses [PERVs]. Virology 2011; 411: 78-86.
    • (2011) Virology , vol.411 , pp. 78-86
    • Kaulitz, D.1    Fiebig, U.2    Eschricht, M.3
  • 28
    • 67651160600 scopus 로고    scopus 로고
    • Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs
    • Ramsoondar J, Vaught T, Ball S, et al., Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs. Xenotransplantation 2009; 16: 164-180.
    • (2009) Xenotransplantation , vol.16 , pp. 164-180
    • Ramsoondar, J.1    Vaught, T.2    Ball, S.3
  • 29
    • 40549093335 scopus 로고    scopus 로고
    • Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs
    • DOI 10.1111/j.1399-3089.2008.00442.x
    • Dieckhoff B, Karlas A, Petersen B, et al., Knockdown of porcine endogenous retrovirus [PERV] expression by PERV-specific shRNA in transgenic pigs. Xenotransplantation 2008; 15: 36-45. (Pubitemid 351360240)
    • (2008) Xenotransplantation , vol.15 , Issue.1 , pp. 36-45
    • Dieckhoff, B.1    Petersen, B.2    Kues, W.A.3    Kurth, R.4    Niemann, H.5    Denner, J.6
  • 30
    • 0034752373 scopus 로고    scopus 로고
    • Porcine endogenous retroviruses (PERVs): Generation of specific antibodies, development of an immunoperoxidase assay (IPA) and inhibition by AZT
    • Stephan O, Schwendemann J, Specke V, et al., Porcine endogenous retroviruses (PERVs): generation of specific antibodies, development of an immunoperoxidase assay (IPA) and inhibition by AZT. Xenotransplantation 2010; 8: 310-316.
    • (2010) Xenotransplantation , vol.8 , pp. 310-316
    • Stephan, O.1    Schwendemann, J.2    Specke, V.3
  • 35
    • 0036804768 scopus 로고    scopus 로고
    • Development of a real time quantitative PCR assay for detection of porcine endogenous retrovirus
    • DOI 10.1016/S0166-0934(02)00140-4, PII S0166093402001404
    • Argaw T, Ritzhaupt A, Wilson CA,. Development of a real time quantitative PCR assay for detection of porcine endogenous retrovirus. J Virol Methods 2002; 106: 97-106. (Pubitemid 35279654)
    • (2002) Journal of Virological Methods , vol.106 , Issue.1 , pp. 97-106
    • Argaw, T.1    Ritzhaupt, A.2    Wilson, C.A.3
  • 36
    • 0034720628 scopus 로고    scopus 로고
    • A polymerase chain reaction-based protocol for detection of transmission of pig endogenous retroviruses in pig tohuman xenotransplantation
    • Blusch JH, Roos C, Nitschko H,. A polymerase chain reaction-based protocol for the detection of transmission of pig endogenous retroviruses in pig to human xenotransplantation. Transplantation 2000; 69: 2167-2172. (Pubitemid 30395055)
    • (2000) Transplantation , vol.69 , Issue.10 , pp. 2167-2172
    • Blusch, J.H.1    Roos, C.2    Nitschko, H.3
  • 37
    • 77953737470 scopus 로고    scopus 로고
    • Real-time quantitative polymerase chain reaction with SYBR green i detection for estimating copy numbers of porcine endogenous retrovirus from Chinese miniature pigs
    • Ma Y, Yang Y, Lv M, et al., Real-time quantitative polymerase chain reaction with SYBR green I detection for estimating copy numbers of porcine endogenous retrovirus from Chinese miniature pigs. Transplant Proc 2010; 42: 1949-1952.
    • (2010) Transplant Proc , vol.42 , pp. 1949-1952
    • Ma, Y.1    Yang, Y.2    Lv, M.3
  • 38
    • 0033609535 scopus 로고    scopus 로고
    • Polymerase chain reaction assays for the diagnosis of infection with the porcine endogenous retrovirus and the detection of pig cells in human and nonhuman recipients of pig xenografts
    • DOI 10.1097/00007890-199907270-00003
    • Switzer WM, Shanmugam V, Chapman L, Heneine W,. Polymerase chain reaction assays for the diagnosis of infection with the porcine endogenous retrovirus and the detection of pig cells in human and nonhuman recipients of pig xenografts. Xenotransplantation 1999; 68: 183-188. (Pubitemid 29360273)
    • (1999) Transplantation , vol.68 , Issue.2 , pp. 183-188
    • Switzer, W.M.1    Shanmugam, V.2    Chapman, L.3    Heneine, W.4
  • 40
    • 0035061912 scopus 로고    scopus 로고
    • Sensitive and specific immunological detection methods for porcine endogenous retroviruses applicable to experimental and clinical xenotransplantation
    • DOI 10.1034/j.1399-3089.2001.00082.x
    • Tacke S, Bodusch K, Berg A, Denner J,. Sensitive and specific detection methods for porcine endogenous retroviruses applicable to experimental and clinical xenotransplantation. Xenotransplantation 2001; 8: 125-135. (Pubitemid 32336222)
    • (2001) Xenotransplantation , vol.8 , Issue.2 , pp. 125-135
    • Tacke, S.J.1    Bodusch, K.2    Berg, A.3    Denner, J.4
  • 42
    • 0033561426 scopus 로고    scopus 로고
    • Development and validation of a western immunoblot assay for detection of antibodies to porcine endogenous retrovirus
    • DOI 10.1097/00007890-199904150-00002
    • Matthews AL, Brown J, Switzer W, et al., Development and validation of a Western immunoblot assay for detection of antibodies to porcine endogenous retrovirus. Transplantation 1999; 67: 939-943. (Pubitemid 29200841)
    • (1999) Transplantation , vol.67 , Issue.7 , pp. 939-943
    • Matthews, A.L.1    Brown, J.2    Switzer, W.3    Folks, T.M.4    Heneine, W.5    Sandstrom, P.A.6
  • 43
    • 0033733755 scopus 로고    scopus 로고
    • Design and validation of immunological tests for the detection of porcine endogenous retrovirus in biological materials
    • Galbraith DN, Kelly HT, Dyke A, et al., Design and validation of immunological tests for the detection of porcine endogenous retrovirus in biological materials. J Virol Methods 2000; 90: 115-124.
    • (2000) J Virol Methods , vol.90 , pp. 115-124
    • Galbraith, D.N.1    Kelly, H.T.2    Dyke, A.3
  • 45
    • 54749140900 scopus 로고    scopus 로고
    • Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study
    • Garkavenko O, Dieckhoff B, Wynyard S, et al., Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study. J Med Virol 2008; 80: 2046-2052.
    • (2008) J Med Virol , vol.80 , pp. 2046-2052
    • Garkavenko, O.1    Dieckhoff, B.2    Wynyard, S.3
  • 47
    • 0038447242 scopus 로고    scopus 로고
    • Vaccinations for adult solid-organ transplant recipients: Current recommendations and protocols
    • DOI 10.1128/CMR.16.3.357-364.2003
    • Duchini A, Goss JA, Karpen S, Pockros PJ,. Vaccinations for adult solid-organ transplant recipients: current recommendations and protocols. Clin Microbiol Rev 2003; 16: 357-364. (Pubitemid 36871311)
    • (2003) Clinical Microbiology Reviews , vol.16 , Issue.3 , pp. 357-364
    • Duchini, A.1    Goss, J.A.2    Karpen, S.3    Pockros, P.J.4
  • 49
    • 38049095101 scopus 로고    scopus 로고
    • Assessment of recent HIV-1 infection by a line immunoassay for HIV-1/2 confirmation
    • Schüpbach J, Gebhardt MD, Tomasik Z, et al., Assessment of recent HIV-1 infection by a line immunoassay for HIV-1/2 confirmation. PLoS Med 2007; 4: e343.
    • (2007) PLoS Med , vol.4
    • Schüpbach, J.1    Gebhardt, M.D.2    Tomasik, Z.3
  • 50
    • 78650893879 scopus 로고    scopus 로고
    • Immunization with the transmembrane protein of a retrovirus, feline leukemia virus: Absence of antigenemia following challenge
    • Langhammer S, Hübner J, Jarrett O, Kurth R, Denner J,. Immunization with the transmembrane protein of a retrovirus, feline leukemia virus: absence of antigenemia following challenge. Antiviral Res 2011; 89: 119-123.
    • (2011) Antiviral Res , vol.89 , pp. 119-123
    • Langhammer, S.1    Hübner, J.2    Jarrett, O.3    Kurth, R.4    Denner, J.5
  • 51
    • 33644923555 scopus 로고    scopus 로고
    • Detection of feline leukemia virus RNA in saliva from naturally infected cats and correlation of PCR results with those of current diagnostic methods
    • Gomes-Keller MA, Gonczi E, Tandon R, et al., Detection of feline leukemia virus RNA in saliva from naturally infected cats and correlation of PCR results with those of current diagnostic methods. J Clin Microbiol 2006; 44: 916-922.
    • (2006) J Clin Microbiol , vol.44 , pp. 916-922
    • Gomes-Keller, M.A.1    Gonczi, E.2    Tandon, R.3
  • 52
    • 77949428222 scopus 로고    scopus 로고
    • Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation
    • Denner J,. Detection of a gammaretrovirus, XMRV, in the human population: open questions and implications for xenotransplantation. Retrovirology 2010; 7: 16.
    • (2010) Retrovirology , vol.7 , pp. 16
    • Denner, J.1
  • 53
    • 78650982482 scopus 로고    scopus 로고
    • Chronic fatigue syndrome. Studies point to possible contamination in XMRV findings
    • Kaiser J,. Chronic fatigue syndrome. Studies point to possible contamination in XMRV findings. Science 2011; 331: 17.
    • (2011) Science , vol.331 , pp. 17
    • Kaiser, J.1
  • 54
    • 78650289504 scopus 로고    scopus 로고
    • Contamination of clinical specimens with MLV-encoding nucleic acids: Implications for XMRV and other candidate human retroviruses
    • Smith RA,. Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses. Retrovirology 2010; 7: 112.
    • (2010) Retrovirology , vol.7 , pp. 112
    • Smith, R.A.1
  • 55
    • 78650290583 scopus 로고    scopus 로고
    • Disease-associated XMRV sequences are consistent with laboratory contamination
    • Hué S, Gray ER, Gall A, et al., Disease-associated XMRV sequences are consistent with laboratory contamination. Retrovirology 2010; 7: 111.
    • (2010) Retrovirology , vol.7 , pp. 111
    • Hué, S.1    Gray, E.R.2    Gall, A.3
  • 56
    • 78650258862 scopus 로고    scopus 로고
    • An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV
    • Sato E, Furuta RA, Miyazawa T,. An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV. Retrovirology 2010; 7: 110.
    • (2010) Retrovirology , vol.7 , pp. 110
    • Sato, E.1    Furuta, R.A.2    Miyazawa, T.3
  • 57
    • 70450273189 scopus 로고    scopus 로고
    • Lack of evidence for XMRV in prostate cancer biopsies from German patients
    • Hohn O, Krause H, Barbarotto P, et al., Lack of evidence for XMRV in prostate cancer biopsies from German patients. Retrovirology 2009; 6: 92.
    • (2009) Retrovirology , vol.6 , pp. 92
    • Hohn, O.1    Krause, H.2    Barbarotto, P.3
  • 58
    • 76349095580 scopus 로고    scopus 로고
    • Can human viruses infect porcine xenografts?
    • Millard AL, Mueller NJ,. Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6.
    • (2010) Xenotransplantation , vol.17 , pp. 6
    • Millard, A.L.1    Mueller, N.J.2
  • 59
    • 77955900381 scopus 로고    scopus 로고
    • Efficiency of porcine endothelial cell infection with human cytomegalovirus depends on both virus tropism and endothelial cell vascular origin
    • Millard AL, Häberli L, Sinzger C, et al., Efficiency of porcine endothelial cell infection with human cytomegalovirus depends on both virus tropism and endothelial cell vascular origin. Xenotransplantation 2010; 17: 274.
    • (2010) Xenotransplantation , vol.17 , pp. 274
    • Millard, A.L.1    Häberli, L.2    Sinzger, C.3
  • 60
    • 77954630631 scopus 로고    scopus 로고
    • Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C
    • Karlas A, Irgang M, Votteler J, et al., Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C. Ann Transplant 2010; 15: 45.
    • (2010) Ann Transplant , vol.15 , pp. 45
    • Karlas, A.1    Irgang, M.2    Votteler, J.3


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