Portfolio management in early stage drug discovery - A traveler's guide through uncharted territory

Drug Discovery Today

Volumn 16, Issue 13-14, 2011, Pages 609-618

  Betz, Ulrich A K ^a  

^a Merck Serono GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

COST; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG RESEARCH; MANAGEMENT; REVIEW;

DRUG DESIGN; DRUG DISCOVERY; DRUG INDUSTRY; EFFICIENCY, ORGANIZATIONAL; HUMANS; RESEARCH;

EID: 79959742183     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.04.012     Document Type: Review

References (34)

1. S.M. Paul How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discov. 9 2010 203 214
2. F.J. Cohen Macro trends in pharmaceutical innovation Nat. Rev. Drug Discov. 4 2005 78 84 (Pubitemid 40109592)
3. B. Munos Lessons from 60 years of pharmaceutical innovation Nat. Rev. Drug Discov. 8 2009 959 968
4. J. Malek The path to smart R&D Pharmaceut. Executive November 2003 70 80
5. F. Sams-Dodd Optimizing the discovery organization for innovation Drug Discov. Today 10 2005 1049 1056 (Pubitemid 41074143)
6. H.M. Markowitz Portfolio selection J. Fin. 7 1952 77 91
7. Boston Consulting Group BCG Growth Share Matrix 1968 http://www.bcg.com/ about-bcg/history/history-1968.aspx
8. Scientific Management at Merck: An interview with CFO Judy Lewent Harv. Bus. Rev. January-February 1994
9. P. Sharpe, and T. Keelin How SmithKline Beecham makes better resource-allocation decisions Harv. Bus. Rev. March-April 1998
10. M. Pandey Investment decisions for pharmaceutical R&D projects Drug Discov. Today 21 2003 968 971
11. S. Senn Some statistical issues in project prioritization in the pharmaceutical industry Stat. Med. 15 1996 2689 2702 (Pubitemid 27011051)
12. S. Hartz, and J. John Contribution of economic evaluation to decision making in early phases of product development: a methodological and empirical review Int. J. Technol. Assess. Health Care 24 2008 465 472
13. H.J. Federsel An unbalanced portfolio Drug News Perspect. 22 2009 287 292
14. M. Edwards Managing the health of early-stage discovery Nat. Rev. Drug Discov. 12 2011 171 172
15. R. Balachandra, and J.A. Raelin When to kill that R&D project Res. Manage. 27 1984 30 33
16. S.J. Macdonald, and P.W. Smith Lead optimization in 12 months? True confessions of a chemistry team Drug Discov. Today 15 2001 947 953 (Pubitemid 32799252)
17. J.F. Pritchard Making better drugs: decision gates in non-clinical drug development Nat. Rev. Drug Discov. 2 2003 542 553 (Pubitemid 37361746)
18. G.E. Blau Managing a portfolio of interdependent new product candidates in the pharmaceutical industry J. Prod. Innov. Manag. 21 2004 227 245
19. M. Wehling Assessing the translatability of drug projects: what needs to be scored to predict success? Nat. Rev. Drug Discov. 8 2009 541 546
20. J.R. Moore, and N.R. Baker An analytical approach to scoring model design - application to research and development project selection IEEE Trans. Eng. Manage. 16 1969 90 98
21. M.J. Cooper An evaluation system for project selection Res. Manage. 21 1978 29 33
22. G. Lockett Modelling a research portfolio using AHP: a group decision process R&D Manage. 16 1986 151 160
23. J.F. Bard An interactive approach to R&D project selection and termination IEEE Trans. Eng. Manage. 35 1988 139 146
24. C.M. Mottley, and R.D. Newton The selection of projects for industrial research Oper. Res. 7 1959 740 751
25. A.G. Lockett, and A.E. Gear Representation and analysis of multi-stage problems in R&D Manage. Sci. 19 1973 947 960
26. T.L. Saaty The Analytical Hierarchy Process 1981 McGraw Hill
27. V.L. Smith Constructivist and ecological rationality in economics Am. Econ. Rev. 93 2003 465 508 (Pubitemid 38799563)
28. J. Giles Wisdom of the crowd Nature 438 2005 281
29. V. Aurentz Revitalizing portfolio decision-making at Merck Serono S.A. - Geneva J. Com. Biotechnol. 17 1 2011 24 36
30. R. Evans Portfolio analysis and R&D decision making Nat. Rev. Drug Discov. 8 2009 189 190
31. P. Cuatrecasas Drug discovery in jeopardy J. Clin. Invest. 116 2006 2837 2842 (Pubitemid 44684465)
32. P. Cuatrecasas An audience with Pedro Cuatrecasas Nat. Rev. Drug Discov. 8 2009 446
33. G. Pinchot Intrapreneuring in Action - A Handbook for Business Innovation 1999 Berret-Koehler Publishers, Inc.
34. F.L. Douglas The case for entrepreneurship in R&D in the pharmaceutical industry Nat. Rev. Drug Discov. 9 2010 683 689