Bleeding after percutaneous endoscopic gastrostomy is linked to serotonin reuptake inhibitors, not aspirin or clopidogrel

Gastrointestinal Endoscopy

Volumn 74, Issue 1, 2011, Pages 22-34.e1

  Richter, James A ^a   Patrie, James T ^b   Richter, Robert P ^a   Henry, Zachary H ^c   Pop, George H ^c   Regan, Kara A ^c   Peura, David A ^a   Sawyer, Robert G ^c   Northup, Patrick G ^a   Wang, Andrew Y ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CITALOPRAM; CLOPIDOGREL; CORTICOSTEROID; DULOXETINE; ENOXAPARIN; ESCITALOPRAM; ESOMEPRAZOLE; FLUOXETINE; FLUVOXAMINE; HEPARIN; HISTAMINE H2 RECEPTOR ANTAGONIST; LANSOPRAZOLE; LOW MOLECULAR WEIGHT HEPARIN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VENLAFAXINE; WARFARIN;

AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MEGADOSE; DRUG WITHDRAWAL; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEMATEMESIS; HIGH RISK PATIENT; HUMAN; HYPOTENSION; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MELENA; PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; POSTOPERATIVE CARE; PREOPERATIVE CARE; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

EID: 79959738331     PISSN: 00165107     EISSN: 10976779     Source Type: Journal    
DOI: 10.1016/j.gie.2011.03.1258     Document Type: Article

References (76)

1. M.J. Zuckerman, W.K. Hirota, and D.G. Adler ASGE guideline: the management of low-molecular-weight heparin and nonaspirin antiplatelet agents for endoscopic procedures Gastrointest Endosc 61 2005 189 194 (Pubitemid 40261064)
2. W. Luman, K.R. Kwek, and K.L. Loi Percutaneous endoscopic gastrostomy - indications and outcome of our experience at the Singapore General Hospital Singapore Med J 42 2001 460 465 (Pubitemid 33622429)
3. G.D. Schapiro, and S.A. Edmundowicz Complications of percutaneous endoscopic gastrostomy Gastrointest Endosc Clin N Am 6 1996 409 422 (Pubitemid 26116048)
4. S. Juul-Moller, N. Edvardsson, and B. Jahnmatz Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group Lancet 340 1992 1421 1425
5. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients BMJ 324 2002 71 86
6. D.L. Bhatt, K.A. Fox, and W. Hacke Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events N Engl J Med 354 2006 1706 1717
7. The SALT Collaborative Group Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events Lancet 338 1991 1345 1349
8. Steering Committee of the Physicians' Health Study Research Group Final report on the aspirin component of the ongoing Physicians' Health Study N Engl J Med 321 1989 129 135
9. S.B. King 3rd, T. Aversano, and W.L. Ballard ACCF/AHA/SCAI 2007 update of the clinical competence statement on cardiac interventional procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Training J Am Coll Cardiol 50 2007 82 108
10. J. Weil, D. Colin-Jones, and M. Langman Prophylactic aspirin and risk of peptic ulcer bleeding BMJ 310 1995 827 830
11. J. Hallas, M. Dall, and A. Andries Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study BMJ 333 2006 726
12. L. Laine Review article: gastrointestinal bleeding with low-dose aspirinwhat's the risk? Aliment Pharmacol Ther 24 2006 897 908 (Pubitemid 44326371)
13. A. Lanas, L.A. Garcia-Rodriguez, and M.T. Arroyo Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations Gut 55 2006 1731 1738 (Pubitemid 44893570)
14. C.D. Mulrow, J.W. Williams Jr, and E. Chiquette Efficacy of newer medications for treating depression in primary care patients Am J Med 108 2000 54 64 (Pubitemid 30058278)
15. F. Kapczinski, M.S. Lima, and J.S. Souza Antidepressants for generalized anxiety disorder Cochrane Database Syst Rev 2003 CD003592
16. J.H. Greist, J.W. Jefferson, and K.A. Kobak Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder A meta-analysis Arch Gen Psychiatry 52 1995 53 60
17. D.J. Stein, J.C. Ipser, and S. Seedat Pharmacotherapy for post traumatic stress disorder (PTSD) Cochrane Database Syst Rev 2006 CD002795
18. R. Moynihan Drug spending in North America rose by 11% in 2003 BMJ 328 2004 727
19. S. MacGillivray, B. Arroll, and S. Hatcher Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis BMJ 326 2003 1014
20. F.J. de Abajo, L.A. Rodriguez, and D. Montero Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study BMJ 319 1999 1106 1109 (Pubitemid 29494721)
21. C. van Walraven, M.M. Mamdani, and P.S. Wells Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study BMJ 323 2001 655 658 (Pubitemid 32897004)
22. S. Wessinger, M. Kaplan, and L. Choi Increased use of selective serotonin reuptake inhibitors in patients admitted with gastrointestinal haemorrhage: a multicentre retrospective analysis Aliment Pharmacol Ther 23 2006 937 944
23. L. Opatrny, J.A. Delaney, and S. Suissa Gastro-intestinal haemorrhage risks of selective serotonin receptor antagonist therapy: a new look Br J Clin Pharmacol 66 2008 76 81 (Pubitemid 351822152)
24. J.D. Lewis, B.L. Strom, and A.R. Localio Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity Pharmacoepidemiol Drug Saf 17 2008 328 335 (Pubitemid 351566348)
25. X. Vidal, L. Ibanez, and L. Vendrell Risk of upper gastrointestinal bleeding and the degree of serotonin reuptake inhibition by antidepressants: a case-control study Drug Saf 31 2008 159 168 (Pubitemid 351158526)
26. F.J. de Abajo, and L.A. Garcia-Rodriguez Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents Arch Gen Psychiatry 65 2008 795 803 (Pubitemid 351957705)
27. L.E. Targownik, J.M. Bolton, and C.J. Metge Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding Am J Gastroenterol 104 2009 1475 1482
28. M. Dall, O.B. Schaffalitzky de Muckadell, and A.T. Lassen An association between selective serotonin reuptake inhibitor use and serious upper gastrointestinal bleeding Clin Gastroenterol Hepatol 7 2009 1314 1321
29. S.O. Dalton, C. Johansen, and L. Mellemkjaer Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study Arch Intern Med 163 2003 59 64 (Pubitemid 36091601)
30. D.W. Gunzberger, and D. Martinez Adverse vascular effects associated with fluoxetine Am J Psychiatry 149 1992 1751
31. V.B. Pai, and M.W. Kelly Bruising associated with the use of fluoxetine Ann Pharmacother 30 1996 786 788 (Pubitemid 26243926)
32. M. Smith, and D. Robinson Sertraline and vaginal bleeding - a possible association J Am Geriatr Soc 50 2002 200 201 (Pubitemid 34053046)
33. F. Abad-Santos, A.J. Carcas, and C. F-Capitan Retroperitoneal haematoma in a patient treated with acenocoumarol, phenytoin and paroxetine Clin Lab Haematol 17 1995 195 197
34. Acquired abnormalities of platelet function N Engl J Med 324 1991 1670 1672
35. I.M. van Haelst, T.C. Egberts, and J.H. Doodeman Use of serotonergic antidepressants and bleeding risk in orthopedic patients Anesthesiology 112 2010 631 636
36. K.L. Movig, M.W. Janssen, and J. de Waal Malefijt Relationship of serotonergic antidepressants and need for blood transfusion in orthopedic surgical patients Arch Intern Med 163 2003 2354 2358 (Pubitemid 37310197)
37. N. Li, N.H. Wallen, and M. Ladjevardi Effects of serotonin on platelet activation in whole blood Blood Coagul Fibrinolysis 8 1997 517 523 (Pubitemid 28023394)
38. N. Hergovich, M. Aigner, and H.G. Eichler Paroxetine decreases platelet serotonin storage and platelet function in human beings Clin Pharmacol Ther 68 2000 435 442
39. D. Halperin, and G. Reber Influence of antidepressants on hemostasis Dialogues Clin Neurosci 9 2007 47 59 (Pubitemid 46607130)
40. A. Helin-Salmivaara, T. Huttunen, and J.M. Gronroos Risk of serious upper gastrointestinal events with concurrent use of NSAIDs and SSRIs: a case-control study in the general population Eur J Clin Pharmacol 63 2007 403 408 (Pubitemid 46399132)
41. M.A. Anderson, T. Ben-Menachem, and S.I. Gan Management of antithrombotic agents for endoscopic procedures Gastrointest Endosc 70 2009 1060 1070
42. D.L. Bhatt, J. Scheiman, and N.S. Abraham ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents J Am Coll Cardiol 52 2008 1502 1517
43. J.L. Ponsky, and M.W. Gauderer Percutaneous endoscopic gastrostomy: a nonoperative technique for feeding gastrostomy Gastrointest Endosc 27 1981 9 11 (Pubitemid 11137279)
44. C.R. Mehta, and N.R. Patel Exact logistic regression: theory and examples Stat Med 14 1995 2143 2160
45. L.M. Bjerre, and J. LeLorier Expressing the magnitude of adverse effects in case-control studies: "the number of patients needed to be treated for one additional patient to be harmed" BMJ 320 2000 503 506 (Pubitemid 30173128)
46. I. Iakovou, T. Schmidt, and E. Bonizzoni Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents JAMA 293 2005 2126 2130 (Pubitemid 40617065)
47. S. Derry, and Y.K. Loke Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis BMJ 321 2000 1183 1187
48. H.C. Diener, J. Bogousslavsky, and L.M. Brass Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial Lancet 364 2004 331 337
49. P.J. Roderick, H.C. Wilkes, and T.W. Meade The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials Br J Clin Pharmacol 35 1993 219 226 (Pubitemid 23074044)
50. A.J. Hui, R.M. Wong, and J.Y. Ching Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases Gastrointest Endosc 59 2004 44 48 (Pubitemid 38095506)
51. H.S. Kim, T.I. Kim, and W.H. Kim Risk factors for immediate postpolypectomy bleeding of the colon: a multicenter study Am J Gastroenterol 101 2006 1333 1341 (Pubitemid 43830002)
52. M.S. Sawhney, N. Salfiti, and D.B. Nelson Risk factors for severe delayed postpolypectomy bleeding Endoscopy 40 2008 115 119 (Pubitemid 351292212)
53. C.K. Hui, K.C. Lai, and M.F. Yuen Does withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding? Aliment Pharmacol Ther 16 2002 929 936
54. D.B. Nelson, and M.L. Freeman Major hemorrhage from endoscopic sphincterotomy: risk factor analysis J Clin Gastroenterol 19 1994 283 287 (Pubitemid 24371048)
55. N. Hussain, R. Alsulaiman, and P. Burtin The safety of endoscopic sphincterotomy in patients receiving antiplatelet agents: a case-control study Aliment Pharmacol Ther 25 2007 579 584
56. M. Singh, N. Mehta, and U.K. Murthy Postpolypectomy bleeding in patients undergoing colonoscopy on uninterrupted clopidogrel therapy Gastrointest Endosc 71 2010 998 1005
57. S. Friedland, D. Sedehi, and R. Soetikno Colonoscopic polypectomy in anticoagulated patients World J Gastroenterol 15 2009 1973 1976
58. J.R. Vane Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Nat New Biol 231 1971 232 235
59. P. Savi, P. Nurden, and A.T. Nurden Clopidogrel: a review of its mechanism of action Platelets 9 1998 251 255 (Pubitemid 28312689)
60. J.W. Burch, N. Stanford, and P.W. Majerus Inhibition of platelet prostaglandin synthetase by oral aspirin J Clin Invest 61 1978 314 319 (Pubitemid 8280401)
61. P.J. Sharis, C.P. Cannon, and J. Loscalzo The antiplatelet effects of ticlopidine and clopidogrel Ann Intern Med 129 1998 394 405 (Pubitemid 28402795)
62. J.D. Douketis, P.B. Berger, and A.S. Dunn The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 299S 339S (Pubitemid 351894915)
63. O. Ruthmann, A. Seitz, and S. Richter Percutaneous endoscopic gastrostomy Complications with and without anticoagulation Chirurg 81 2010 247 254
64. J.P. Collet, F. Himbet, and P.G. Steg Myocardial infarction after aspirin cessation in stable coronary artery disease patients Int J Cardiol 76 2000 257 258
65. E. Ferrari, M. Benhamou, and P. Cerboni Coronary syndromes following aspirin withdrawal: a special risk for late stent thrombosis J Am Coll Cardiol 45 2005 456 459 (Pubitemid 40186800)
66. K. Senior Aspirin withdrawal increases risk of heart problems Lancet 362 2003 1558
67. D.S. Bachman Discontinuing chronic aspirin therapy: another risk factor for stroke? Ann Neurol 51 2002 137 138 (Pubitemid 34027990)
68. Effexor Revised label FDA approved on 01/06/2010 http://www.accessdata. fda.gov/drugsatfda-docs/label/2010/020151s056s057lbl.pdf Accessed June 14, 2010
69. Paxil Revised label FDA approved on 08/07/2009 http://www.accessdata.fda. gov/drugsatfda-docs/label/2009/020031s05920710s023lbl.pdf Accessed June 14, 2010
70. Prozac Revised label FDA approved on 06/22/2009 http://www.accessdata. fda.gov/drugsatfda-docs/label/2009/018936s089lbl.pdf Accessed June 14, 2010
71. Zoloft Revised label FDA approved on 01/30/2009 http://www.accessdata. fda.gov/drugsatfda-docs/label/2009/019839s070,020990s032lbl.pdf Accessed June 14, 2010
72. Lexapro Revised label FDA approved on 03/09/2009 http://www.accessdata. fda.gov/drugsatfda-docs/label/2009/021323s030s031,021365s021s022lbl.pdf Accessed June 14, 2010
73. V.L. Serebruany, R.F. Suckow, and T.B. Cooper Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression Am J Psychiatry 162 2005 1165 1170 (Pubitemid 40770700)
74. A. Sarma, and M.K. Horne 3rd Venlafaxine-induced ecchymoses and impaired platelet aggregation Eur J Haematol 77 2006 533 537 (Pubitemid 44690802)
75. B.E. Leonard The comparative pharmacology of new antidepressants J Clin Psychiatry 54 Suppl 1993 3 15 discussion 16-7 (Pubitemid 23277305)
76. G.D. Tollefson, and S.L. Holman How long to onset of antidepressant action Int Clin Psychopharmacol 9 1994 245 250