A "conditionally essential" nutrient, L-carnitine, as a primary suspect in endometriosis

Fertility and Sterility

Volumn 95, Issue 8, 2011, Pages 2759-2760

  Vassiliadis, Simon ^a   Athanassakis, Irene ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

caloric restriction; Endometriosis; L carnitine; prostaglandins

Indexed keywords

CARNITINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDOMETACIN; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; PROSTAGLANDIN; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ARTICLE; BODY WEIGHT; CALORIC RESTRICTION; CYTOKINE PRODUCTION; ENDOMETRIOSIS; FEMALE INFERTILITY; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOSURVEILLANCE; NONHUMAN; PERITONEAL FLUID; PRIORITY JOURNAL; SEX RATIO; WEIGHT GAIN;

ALPROSTADIL; AMINO ACIDS, ESSENTIAL; ANIMALS; CARNITINE; CYTOKINES; DIETARY SUPPLEMENTS; DINOPROSTONE; ENDOMETRIOSIS; FEMALE; FERTILITY; HUMANS; MICE; RISK ASSESSMENT; RISK FACTORS;

EID: 79959719762     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.04.091     Document Type: Article

References (29)

1. Alesci S, Manoli I, Costello R, Coates P, Gold PW, Chrousos GP, Blackman MR (eds). Proceedings of the conference, Carnitine: the science behind a conditionally essential nutrient. Ann N Y Acad Sci 2004;1033:1-197.
2. W. Gulewitsch, and R. Krimberg Zur Kenntnis der Extractivstoffe der Muskeln Z Physiol Chem 45 1905 326 328
3. H. Karlic, and A. Lohninger Supplementation of L-carnitine in athletes: does it make sense? Nutrition 20 2004 709 715 (Pubitemid 38798089)
4. R. Crayhon Carnitine may benefit athletes J Am Coll Nutr 17 1998 649 650
5. Proceedings of the 4th Pan-Hellenic Endometriosis Congress, October 16-17, 2010, Heraklion, Greece. In: Rombauts L (ed). World Endometriosis Society e-Journal 2010;12(5):8.
6. R.M. Anson, Z. Guo, R. de Cabo, T. Iyun, M. Rios, and A. Hagepanos Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake Proc Natl Acad Sci U S A 100 2003 6216 6220 (Pubitemid 36576956)
7. R.S. Sohal, and R. Weindruch Oxidative stress, caloric restriction and aging Science 273 1996 59 63 (Pubitemid 26255420)
8. T.A. Wadden, R.V. Considine, G.D. Foster, D.A. Anderson, D.B. Sarwer, and J.S. Caro Short- and long-term changes in serum leptin in dieting obese women: effects of caloric restriction and weight loss J Clin Endocrinol Metab 83 1998 214 218 (Pubitemid 28498338)
9. N. Guayerbas, M. Puerto, V.M. Víctor, J. Miquel, and M. de la Fuente Leukocyte function and life span in a murine model of premature immunosenescence Exp Gerontol 37 2002 249 256 (Pubitemid 34073541)
10. I. Messaoudi, M. Fischer, J. Warner, B. Park, J. Mattison, and D.K. Ingram Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates Aging Cell 7 2008 908 919 (Pubitemid 352751535)
11. C.M. Weyand, J.W. Fulbright, and J.J. Goronzy Immunosenescence, autoimmunity, and rheumatoid arthritis Exp Gerontol 38 2003 833 841 (Pubitemid 36957956)
12. L. Vecchiet, F. di Lisa, G. Pieralisi, P. Ripari, R. Menab, and M.A. Giamberardino Influence of L-carnitine administration on maximal physical exercise Eur J Applied Physiol Occup Physiol 61 1990 486 490
13. G. Cavallini, A.P. Ferraretti, L. Gianaroli, G. Biagiotti, and G. Vitali Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia J Androl 25 2004 761 770 (Pubitemid 39096312)
14. M. Costa, D. Canale, M. Filicori, S. d'lddio, and A. Lenzi L-carnitine in idiopathic asthenozoospermia: a multicenter study Andrologia 26 1994 155 159 (Pubitemid 24192033)
15. E. Dionyssopoulou, S. Vassiliadis, A. Evangeliou, E.E. Koumantakis, and I. Athanassakis Constitutive or induced elevated levels of L-carnitine correlate with the cytokine and cellular profile of endometriosis J Reprod Immunol 65 2005 159 170 (Pubitemid 40461933)
16. M.-Y. Wu, and H.-N. Ho The role of cytokines in endometriosis Am J Reprod Immunol 49 2003 285 296 (Pubitemid 36581967)
17. K. Furuya, M. Murakami, N. Makimura, H. Matsuda, K. Ikou, and K. Saito Immunological and endocrinological studies on lymphocyte subpopulation and medical treatment for infertility in patients with endometriosis Mol Cell Endocrinol 202 2003 195 199 (Pubitemid 36593412)
18. M. Menon, B.N. Jaroslow, and R. Koesterer The decline of cell-mediated immunity in aging mice J Gerontol 29 1974 499 505
19. H.J. Cohen Biology of aging as related to cancer Cancer 74 Suppl 7 1994 2092 2100 (Pubitemid 24304380)
20. L. Balducci, and W.B. Ershler Cancer and ageing: a nexus at several levels Nat Rev Cancer 5 2005 655 662 (Pubitemid 41081391)
21. S. Vassiliadis Premature immunosenescence impairs immune surveillance allowing the endometriotic stem cell to migrate: the cytokine profile as a common denominator J Endometriosis 2 2010 7 18
22. S. Vassiliadis Can incapacitation of the mesenchymal endometriotic stem cell via the fortification of the immune system lead to the eradication of endometriosis? J Endometriosis 3 2011 1 7
23. I. Matalliotakis, I. Athanassakis, M. Neonaki, A. Goumenou, S. Vassiliadis, and E. Koumantakis The possible antiinflammatory role of circulating human leukocyte antigen levels in women with endometriosis after treatment with danazol and leuprorelin acetate depot Med Inflamm 10 2001 75 80 (Pubitemid 32522163)
24. L. Papadimitriou, I. Morianos, V. Michailidou, E. Dionyssopoulou, S. Vassiliadis, and I. Athanassakis Characterization of intracellular HLA-DR, DM and DO profile in K562 and HL-60 leukemic cells Mol Immunol 45 2008 3965 3973
25. A. Kauppila, J. Puolakka, and O. Ylikorkala Prostaglandin biosynthesis inhibitors and endometriosis Prostaglandins 18 1979 655 661 (Pubitemid 10204320)
26. W.L. Smith, and D.L. Dewitt Prostaglandin endoperoxide H synthases-1 and -2 Adv Immunol 62 1996 167 215 (Pubitemid 26250630)
27. Tselekidou A, Athanassakis I. PGE1 versus PGE2: protective rather than inducing agent for endometriosis [abstract]. Second European Congress of Immunology, Berlin, 2009. Eur J Immunol 2009;PA14/18:S120.
28. E. Dionyssopoulou, E. Anagnostaki, A. Tselekidou, S. Vassiliadis, and I. Athanassakis Establishment or aggravation of endometriosis by L-carnitine: the role of PGE1 and PGE2 in the endometriosis-induction process A. Arici, I. Matalliotakis, Endometriosis-adenomyosis 2011 PM Publications Greece
29. M.H. Wu, C.W. Lu, P.C. Chuang, and S.J. Tsai Prostaglandin E2: the master of endometriosis? Exp Biol Med 235 2010 668 677