Nebulized hypertonic saline and recombinant human DNase in the treatment of pulmonary atelectasis in newborns

Pediatrics International

Volumn 53, Issue 3, 2011, Pages 328-331

  Dilmen, Ugur ^a   Karagol, Belma Saygili ^a,b   Oguz, Serife Suna ^a  

^a Zekai Tahir Burak Education and Research Hospital   (Turkey)

^b NONE   (Turkey)

Author keywords

3 hypertonic saline; atelectasis; newborn; recombinant human DNase

Indexed keywords

DORNASE ALFA; SODIUM; SODIUM CHLORIDE;

ARTICLE; ATELECTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; MALE; NEBULIZATION; NEWBORN; OXYGEN SATURATION; PRIORITY JOURNAL; SODIUM BLOOD LEVEL; THORAX RADIOGRAPHY; TREATMENT RESPONSE;

EID: 79959714923     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2010.03245.x     Document Type: Article

References (19)

1. Kuzik BA, Al-Qadhi SA, Kent S, et al,. Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants. J. Pediatr. 2007; 151: 266-70.
2. Tal G, Cesar K, Oron A, Houri S, Ballin A, Mandelberg A,. Hypertonic saline/ epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalizations stay: 2 years experience. IMAJ 2006; 8: 169-73.
3. Erdeve O, Uras N, Atasay B, Arsan S,. Efficacy and safety of nebulized rhDNase as rescue treatment for persistent atelectasis in newborns: Case-series. Croat. Med. J. 2007; 48: 234-9. (Pubitemid 46651030)
4. Mandelberg A, Tal G, Witzling M, et al,. Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis. Chest 2003; 123: 481-7. (Pubitemid 36269434)
5. Wark PAB, McDonald V,. Nebulized hypertonic saline for cystic fibrosis (Cochrane Review). In:, Regnis JA, (ed). The Cochrane Library, 2. Update Software, Oxford, UK, 2001; 284-8.
6. King M, Dasgupta B, Tomkiewicz RP, Brown NE,. Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease. Am. J. Respir. Crit. Care Med. 1997; 156: 173-77. (Pubitemid 27293184)
7. Eng PA, Morton J, Douglass JA, Riedler J, Wilson J, Robertson CF,. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis. Pediatr. Pulmonol. 1996; 21: 77-83. (Pubitemid 26098513)
8. Riedler J, Reade T, Button B, Robertson CF,. Inhaled hypertonic saline increases sputum expectoration in cystic fibrosis. J. Pediatr. Child Health 1996; 32: 48-50. (Pubitemid 26141551)
9. Tomooka LT, Murphy C, Davidson TM,. Clinical study and literature review of nasal irrigation. Laryngoscope 2000; 110: 1189-93. (Pubitemid 30439780)
10. Elkins MR, Robinson M, Rose BR, et al,. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N. Engl. J. Med. 2006; 354: 229-40. (Pubitemid 43113028)
11. Suri R, Grieve R, Normand C, et al,. Effects of hypertonic saline, alternate day and daily rhDNase on healthcare use, costs and outcome in children with cystic fibrosis. Thorax 2002; 57: 841-6. (Pubitemid 35178606)
12. Sarrell E, Tal G, Witzling M, et al,. Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms. Chest 2002; 122: 2015-20. (Pubitemid 36051138)
13. El Hassan NO, Chess PR, Huysman MW, Merkus P, de Longste JC,. Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonates. Pediatrics 2001; 108: 468-70.
14. Kupeli S, Teksam O, Dogru D, Yurdakok M,. Use of recombinant human DNase in a premature infant with recurrent atelectasis. Pediatr. Int. 2003; 45: 584-6. (Pubitemid 37430764)
15. Merkus PJ, de Hoog M, van Gent R, de Jongste JCD,. Nase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis. Eur. Respir. J. 2001; 18: 734-7. (Pubitemid 33040634)
16. Fitzgerald DA, Hilton J, Jepson B, Smith L,. A crossover, randomized, controlled trial of dornase alfa before versus after physiotherapy in cystic fşbrosis. Pediatrics 2005; 116: 549-54.
17. Riethmueller J, Borth-Bruhns T, Kumpf M, et al,. Recombinant human deoxyribonuclease shortens ventilation time in young, mechanically ventilated children. Pediatr. Pulmonol. 2006; 41: 61-6. (Pubitemid 43117369)
18. O'Donnell AE, Barker AF, Ilowite JS, Fick RB,. Treatment of idiopathic bronchiectasis with aerosolized recombinant human DNase 1. rhDNase Study Group. Chest 1998; 113: 1329-34. (Pubitemid 28223825)
19. Hendriks T, de Hoog M, Lequin MH, Devos AS, JFM Merkus P,. DNase and atelectasis in non-cystic fibrosis pediatric patients. Crit. Care 2005; 9: 351-6.