How much do resin-based dental materials release? A meta-analytical approach

Dental Materials

Volumn 27, Issue 8, 2011, Pages 723-747

  Van Landuyt, K L ^a   Nawrot, Tim ^b,c   Geebelen, B ^c   De Munck, J ^a   Snauwaert, J ^c   Yoshihara, K ^a   Scheers, Hans ^c   Godderis, Lode ^c,d   Hoet, P ^c   Van Meerbeek, B ^a  

^a DEPARTMENT OF IMAGING AND PATHOLOGY   (Belgium)

^b HASSELT UNIVERSITY   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d EXTERNAL SERVICE FOR PREVENTION AND PROTECTION AT WORK   (Belgium)

Author keywords

Biocompatibility; Composites; Eluate; Elution; GC; HPLC; Identification; LC; Leaching; MS; Quantity; Release; Resin based dental materials; Systemic toxicity

Indexed keywords

ELUATE; ELUTION; GC; HPLC; LC; MS; QUANTITY; RELEASE; SYSTEMIC TOXICITY;

BIOCOMPATIBILITY; DENTAL MATERIALS; LEACHING; MONOMERS; PHENOLS; RESINS; RESTORATION; TOXICITY;

MATERIALS;

2 HYDROXYETHYL METHACRYLATE; 4,4' ISOPROPYLIDENEDIPHENOL; BIOMEDICAL AND DENTAL MATERIALS; BISPHENOL A BIS(2 HYDROXYPROPYL) ETHER DIMETHACRYLATE; MACROGOL DERIVATIVE; METHACRYLIC ACID DERIVATIVE; PHENOL DERIVATIVE; POLYMETHACRYLIC ACID DERIVATIVE; POLYURETHAN; RESIN; TRIETHYLENE GLYCOL DIMETHACRYLATE; URETHANE DIMETHACRYLATE LUTING RESIN;

CHEMISTRY; DENTAL SURGERY; HUMAN; META ANALYSIS; PHYSICAL CHEMISTRY; POLYMERIZATION; REVIEW; SURFACE PROPERTY; TIME;

BISPHENOL A-GLYCIDYL METHACRYLATE; COMPOSITE RESINS; DENTAL MATERIALS; DENTAL RESTORATION, PERMANENT; HUMANS; METHACRYLATES; PHENOLS; PHYSICOCHEMICAL PHENOMENA; POLYETHYLENE GLYCOLS; POLYMERIZATION; POLYMETHACRYLIC ACIDS; POLYURETHANES; SURFACE PROPERTIES; TIME FACTORS;

EID: 79959708886     PISSN: 01095641     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dental.2011.05.001     Document Type: Review

References (138)

1. T.W. Clarkson, and L. Magos The toxicology of mercury and its chemical compounds Crit Rev Toxicol 36 2006 609 662 (Pubitemid 44396731)
2. D.W. Jones Has dental amalgam been torpedoed and sunk? J Dent Res 87 2008 101 102
3. J. Mutter, J. Naumann, and C. Guethlin Comments on the article "the toxicology of mercury and its chemical compounds" by Clarkson and Magos (2006) Crit Rev Toxicol 37 2007 537 549 (Pubitemid 47174575)
4. W. Geurtsen Biocompatibility of resin-modified filling materials Crit Rev Oral Biol Med 11 2000 333 355
5. K. Sunnegardh-Gronberg, J.W. van Dijken, U. Funegard, A. Lindberg, and M. Nilsson Selection of dental materials and longevity of replaced restorations in Public Dental Health clinics in northern Sweden J Dent 37 2009 673 678
6. H.F. Albers Tooth-colored restorations 9th ed. 2002 BC Decker Inc
7. A. Peutzfeldt Resin composites in dentistry: the monomer systems Eur J Oral Sci 105 1997 97 116 (Pubitemid 127780991)
8. N. Ilie, and R. Hickel Investigations on mechanical behaviour of dental composites Clin Oral Investig 2009
9. F.X. Reichl, M. Seiss, N. Kleinsasser, K. Kehe, K.H. Kunzelmann, and P. Thomas Distribution and excretion of BisGMA in guinea pigs J Dent Res 87 2008 378 380
10. T.M. Gerzina, and W.R. Hume Diffusion of monomers from bonding resin-resin composite combinations through dentine in vitro J Dent 24 1996 125 128 (Pubitemid 126348358)
11. R. Rogalewicz, A. Voelkel, and I. Kownacki Application of HS-SPME in the determination of potentially toxic organic compounds emitted from resin-based dental materials J Environ Monit 8 2006 377 383 (Pubitemid 43385285)
12. W. Marquardt, M. Seiss, R. Hickel, and F.X. Reichl Volatile methacrylates in dental practices J Adhes Dent 11 2009 101 107
13. I. Sideridou, V. Tserki, and G. Papanastasiou Effect of chemical structure on degree of conversion in light-cured dimethacrylate-based dental resins Biomaterials 23 2002 1819 1829 (Pubitemid 34218969)
14. S.H. Park Comparison of degree of conversion for light-cured and additionally heat-cured composites J Prosthet Dent 76 1996 613 618
15. R.H. Halvorson, R.L. Erickson, and C.L. Davidson Energy dependent polymerization of resin-based composite Dent Mater 18 2002 463 469 (Pubitemid 40072248)
16. A.D. Neves, J.A. Discacciati, R.L. Orefice, and M.I. Yoshida Influence of the power density on the kinetics of photopolymerization and properties of dental composites J Biomed Mater Res B: Appl Biomater 72 2005 393 400
17. J.L. Ferracane, and J.R. Condon Rate of elution of leachable components from composite Dent Mater 6 1990 282 287
18. L. Feng, R. Carvalho, and B.I. Suh Insufficient cure under the condition of high irradiance and short irradiation time Dent Mater 25 2009 283 289
19. H. Oysaed, and I.E. Ruyter Water sorption and filler characteristics of composites for use in posterior teeth J Dent Res 65 1986 1315 1318
20. K.J. Soderholm, R. Mukherjee, and J. Longmate Filler leachability of composites stored in distilled water or artificial saliva J Dent Res 75 1996 1692 1699 (Pubitemid 32770415)
21. K.J. Soderholm, M.C. Yang, and I. Garcea Filler particle leachability of experimental dental composites Eur J Oral Sci 108 2000 555 560
22. M. Zhou, J.L. Drummond, and L. Hanley Barium and strontium leaching from aged glass particle/resin matrix dental composites Dent Mater 21 2005 145 155 (Pubitemid 40135742)
23. Y. Finer, and J.P. Santerre The influence of resin chemistry on a dental composite's biodegradation J Biomed Mater Res A 69 2004 233 246 (Pubitemid 38478816)
24. P.J. Koin, A. Kilislioglu, M. Zhou, J.L. Drummond, and L. Hanley Analysis of the degradation of a model dental composite J Dent Res 87 2008 661 665
25. J.P. Santerre, L. Shajii, and H. Tsang Biodegradation of commercial dental composites by cholesterol esterase J Dent Res 78 1999 1459 1468 (Pubitemid 32507636)
26. J.C. Atkinson, F. Diamond, F. Eichmiller, R. Selwitz, and G. Jones Stability of bisphenol A, triethylene-glycol dimethacrylate, and bisphenol A dimethacrylate in whole saliva Dent Mater 18 2002 128 135 (Pubitemid 40072288)
27. L. Shajii, and J.P. Santerre Effect of filler content on the profile of released biodegradation products in micro-filled bis-GMA/TEGDMA dental composite resins Biomaterials 20 1999 1897 1908 (Pubitemid 29421706)
28. G. Schmalz The biocompatibility of non-amalgam dental filling materials Eur J Oral Sci 106 1998 696 706 (Pubitemid 128737077)
29. H.R. Stanley Effects of dental restorative materials: local and systemic responses reviewed J Am Dent Assoc 124 1993 76 80
30. M. Goldberg, and ORE-FDI working group Biocompatibility or cytotoxic effects of dental composites 1st ed. 2009 Coxmoor Publishing Company Oxford, UK
31. K. Alanko, P. Susitaival, R. Jolanki, and L. Kanerva Occupational skin diseases among dental nurses Contact Dermatitis 50 2004 77 82 (Pubitemid 38657360)
32. D. Arenholt-Bindslev Environmental aspects of dental filling materials Eur J Oral Sci 106 1998 713 720 (Pubitemid 128737079)
33. E. Sandberg, G. Bergenholtz, C. Eklund, and U.I. Dahlgren HEMA bound to self-protein promotes auto-antibody production in mice J Dent Res 81 2002 633 636
34. A. Schedle, U. Ortengren, N. Eidler, M. Gabauer, and A. Hensten Do adverse effects of dental materials exist? What are the consequences, and how can they be diagnosed and treated? Clin Oral Implants Res 18 Suppl 3 2007 232 256
35. M.G. Brackett, S. Bouillaguet, P.E. Lockwood, S. Rotenberg, J.B. Lewis, and R.L. Messer In vitro cytotoxicity of dental composites based on new and traditional polymerization chemistries J Biomed Mater Res B: Appl Biomater 81 2007 397 402 (Pubitemid 46685106)
36. J. Emmler, M. Seiss, H. Kreppel, F.X. Reichl, R. Hickel, and K. Kehe Cytotoxicity of the dental composite component TEGDMA and selected metabolic by-products in human pulmonary cells Dent Mater 24 2008 1670 1675
37. J. Engelmann, V. Janke, J. Volk, G. Leyhausen, N. Von Neuhoff, and B. Schlegelberger Effects of BisGMA on glutathione metabolism and apoptosis in human gingival fibroblasts in vitro Biomaterials 25 2004 4573 4580 (Pubitemid 38561144)
38. G. Nocca, F. De Palma, A. Minucci, P. De Sole, G.E. Martorana, and C. Calla Alterations of energy metabolism and glutathione levels of HL-60 cells induced by methacrylates present in composite resins J Dent 35 2007 187 194
39. L. Stanislawski, M. Lefeuvre, K. Bourd, E. Soheili-Majd, M. Goldberg, and A. Perianin TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species J Biomed Mater Res A 66 2003 476 482 (Pubitemid 37517192)
40. R. Datar, F.A. Rueggeberg, G.B. Caughman, J.C. Wataha, J. Lewis, and G.S. Schuster Effects of subtoxic concentrations of benzoyl peroxide on cell lipid metabolism J Biomed Mater Res A 71 2004 685 692 (Pubitemid 39578683)
41. D. Arenholt-Bindslev, V. Breinholt, A. Preiss, and G. Schmalz Time-related bisphenol-A content and estrogenic activity in saliva samples collected in relation to placement of fissure sealants Clin Oral Investig 3 1999 120 125
42. Y. Nomura, W. Teshima, T. Kawahara, N. Tanaka, H. Ishibashi, and M. Okazaki Genotoxicity of dental resin polymerization initiators in vitro J Mater Sci Mater Med 17 2006 29 32 (Pubitemid 43042225)
43. N.H. Kleinsasser, B.C. Wallner, U.A. Harreus, T. Kleinjung, M. Folwaczny, and R. Hickel Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (COMET) assay J Dent 32 2004 229 234 (Pubitemid 38328465)
44. A. Bakopoulou, D. Mourelatos, A.S. Tsiftsoglou, N.P. Giassin, E. Mioglou, and P. Garefis Genotoxic and cytotoxic effects of different types of dental cement on normal cultured human lymphocytes Mutat Res 672 2009 103 112
45. A. Bakopoulou, D. Mourelatos, A.S. Tsiftsoglou, E. Mioglou, and P. Garefis Sister-chromatid exchange, chromosomal aberrations and delays in cell-cycle kinetics in human lymphocytes induced by dental composite resin eluates Mutat Res 649 2008 79 90 (Pubitemid 350235302)
46. H. Schweikl, and G. Schmalz Triethylene glycol dimethacrylate induces large deletions in the HPRT gene of V79 cells Mutat Res 438 1999 71 78 (Pubitemid 29015753)
47. H. Schweikl, G. Spagnuolo, and G. Schmalz Genetic and cellular toxicology of dental resin monomers J Dent Res 85 2006 870 877 (Pubitemid 44578595)
48. H. Darmani, and A.S. Al Hiyasat The effects of BIS-GMA and TEG-DMA on female mouse fertility Dent Mater 22 2006 353 358 (Pubitemid 43375068)
49. J.B. Lewis, F.A. Rueggeberg, C.A. Lapp, J.W. Ergle, and G.S. Schuster Identification and characterization of estrogen-like components in commercial resin-based dental restorative materials Clin Oral Investig 3 1999 107 113
50. H. Tarumi, S. Imazato, M. Narimatsu, M. Matsuo, and S. Ebisu Estrogenicity of fissure sealants and adhesive resins determined by reporter gene assay J Dent Res 79 2000 1838 1843 (Pubitemid 32489349)
51. H. Wada, H. Tarumi, S. Imazato, M. Narimatsu, and S. Ebisu In vitro estrogenicity of resin composites J Dent Res 83 2004 222 226 (Pubitemid 41713779)
52. S. Schwengberg, H. Bohlen, N. Kleinsasser, K. Kehe, M. Seiss, and U.I. Walther In vitro embryotoxicity assessment with dental restorative materials J Dent 33 2005 49 55 (Pubitemid 40093562)
53. C. Klaassen Casarett and Doul's toxicology: the basic science of poisons 7th ed. 2008 The MacGrew Hill Company
54. N. Olea, R. Pulgar, P. Perez, F. Olea-Serrano, A. Rivas, and A. Novillo-Fertrell Estrogenicity of resin-based composites and sealants used in dentistry Environ Health Perspect 104 1996 298 305 (Pubitemid 26123084)
55. Y. Finer, and J.P. Santerre Influence of silanated filler content on the biodegradation of bisGMA/TEGDMA dental composite resins J Biomed Mater Res A 81 2007 75 84 (Pubitemid 46435455)
56. D. Nathanson, P. Lertpitayakun, M.S. Lamkin, M. Edalatpour, and L.L. Chou In vitro elution of leachable components from dental sealants J Am Dent Assoc 128 1997 1517 1523 (Pubitemid 127454978)
57. E. Komurcuoglu, S. Olmez, and N. Vural Evaluation of residual monomer elimination methods in three different fissure sealants in vitro J Oral Rehabil 32 2005 116 121 (Pubitemid 40187457)
58. W. Spahl, H. Budzikiewicz, and W. Geurtsen Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry J Dent 26 1998 137 145 (Pubitemid 128392124)
59. W. Geurtsen, W. Spahl, K. Muller, and G. Leyhausen Aqueous extracts from dentin adhesives contain cytotoxic chemicals J Biomed Mater Res 48 1999 772 777
60. W. Geurtsen, W. Spahl, and G. Leyhausen Variability of cytotoxicity and leaching of substances from four light-curing pit and fissure sealants J Biomed Mater Res 44 1999 73 77 (Pubitemid 28544087)
61. M. Stefova, V. Ivanova, and I. Muratovska Identification and quantification of Bis-GMA and Teg-DMA released from dental materials by HPLC J Liq Chromatogr Relat Technol 28 2005 289 295 (Pubitemid 40139444)
62. A. Hamid, A. Okamoto, M. Iwaku, and W.R. Hume Component release from light-activated glass ionomer and compomer cements J Oral Rehabil 25 1998 94 99 (Pubitemid 128704905)
63. K. Kawai, and T. Takaoka Fluoride, hydrogen ion and HEMA release from light-cured GIC restoratives Am J Dent 15 2002 149 152
64. S. Imazato, D. Horikawa, K. Ogata, Y. Kinomoto, and S. Ebisu Responses of MC3T3-E1 cells to three dental resin-based restorative materials J Biomed Mater Res A 76 2006 765 772 (Pubitemid 47233485)
65. K. Moharamzadeh, R. Van Noort, I.M. Brook, and A.M. Scutt HPLC analysis of components released from dental composites with different resin compositions using different extraction media J Mater Sci Mater Med 18 2007 133 137 (Pubitemid 46046725)
66. K. Sutton, D. Abrams, T. Jones, F. Sheldon, and F. Song Methods for meta-analysis in medical research 2000 Wiley New York
67. V.B. Michelsen, G. Moe, R. Skalevik, E. Jensen, and H. Lygre Quantification of organic eluates from polymerized resin-based dental restorative materials by use of GC/MS J Chromatogr B: Anal Technol Biomed Life Sci 850 2007 83 91 (Pubitemid 46618148)
68. A. Manabe, S. Kaneko, S. Numazawa, K. Itoh, M. Inoue, and H. Hisamitsu Detection of bisphenol-A in dental materials by gas chromatography-mass spectrometry Dent Mater J 19 2000 75 86
69. O. Polydorou, R. Trittler, E. Hellwig, and K. Kummerer Elution of monomers from two conventional dental composite materials Dent Mater 23 2007 1535 1541 (Pubitemid 350018865)
70. O. Polydorou, A. Konig, E. Hellwig, and K. Kummerer Long-term release of monomers from modern dental-composite materials Eur J Oral Sci 117 2009 68 75
71. M. Pelka, W. Distler, and A. Petschelt Elution parameters and HPLC-detection of single components from resin composite Clin Oral Investig 3 1999 194 200
72. S.A. Mazzaoui, M.F. Burrow, M.J. Tyas, F.R. Rooney, and R.J. Capon Long-term quantification of the release of monomers from dental resin composites and a resin-modified glass ionomer cement J Biomed Mater Res 63 2002 299 305 (Pubitemid 34521331)
73. U. Ortengren, H. Wellendorf, S. Karlsson, and I.E. Ruyter Water sorption and solubility of dental composites and identification of monomers released in an aqueous environment J Oral Rehabil 28 2001 1106 1115 (Pubitemid 33754564)
74. O. Polydorou, M. Hammad, A. Konig, E. Hellwig, and K. Kummerer Release of monomers from different core build-up materials Dent Mater 25 2009 1090 1095
75. R. Pulgar, M.F. Olea-Serrano, A. Novillo-Fertrell, A. Rivas, P. Pazos, and V. Pedraza Determination of bisphenol A and related aromatic compounds released from bis-GMA-based composites and sealants by high performance liquid chromatography Environ Health Perspect 108 2000 21 27 (Pubitemid 30064091)
76. N. Hofmann, J. Renner, B. Hugo, and B. Klaiber Elution of leachable components from resin composites after plasma arc vs standard or soft-start halogen light irradiation J Dent 30 2002 223 232 (Pubitemid 40433433)
77. I. Sideridou, V. Tserki, and G. Papanastasiou Study of water sorption, solubility and modulus of elasticity of light-cured dimethacrylate-based dental resins Biomaterials 24 2003 655 665 (Pubitemid 35346395)
78. J.L. Ferracane Elution of leachable components from composites J Oral Rehabil 21 1994 441 452
79. G. Schmalz, and D. Arentholt-Bindslev Biocompatibility of dental materials 2008 Springer Berlin, Heidelberg
80. W. Geurtsen Substances released from dental resin composites and glass ionomer cements Eur J Oral Sci 106 1998 687 695 (Pubitemid 128737076)
81. R. Rogalewicz, K. Batko, and A. Voelkel Identification of organic extractables from commercial resin-modified glass-ionomers using HPLC-MS J Environ Monit 8 2006 750 758 (Pubitemid 44024884)
82. V.B. Michelsen, G. Moe, M.B. Strom, E. Jensen, and H. Lygre Quantitative analysis of TEGDMA and HEMA eluted into saliva from two dental composites by use of GC/MS and tailor-made internal standards Dent Mater 24 2008 724 731 (Pubitemid 351626153)
83. M. Braden, and G.J. Pearson Analysis of aqueous extract from filled resins J Dent 9 1981 141 143
84. S.Y. Lee, E.H. Greener, and H.J. Mueller Effect of food and oral simulating fluids on structure of adhesive composite systems J Dent 23 1995 27 35
85. S.Y. Lee, E.H. Greener, and D.L. Menis Detection of leached moieties from dental composites in fluids simulating food and saliva Dent Mater 11 1995 348 353
86. J. Timbrell Principles of biochemical toxicology 3rd ed. 2000 Taylors & Francis
87. V.B. Michelsen, H. Lygre, R. Skalevik, A.B. Tveit, and E. Solheim Identification of organic eluates from four polymer-based dental filling materials Eur J Oral Sci 111 2003 263 271 (Pubitemid 37465519)
88. N.M. Mohsen, R.G. Craig, and C.T. Hanks Cytotoxicity of urethane dimethacrylate composites before and after aging and leaching J Biomed Mater Res 39 1998 252 260 (Pubitemid 28060358)
89. J. Durner, W. Spahl, J. Zaspel, H. Schweikl, R. Hickel, and F.X. Reichl Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient Dent Mater 26 2010 91 99
90. L.R. Thompson, E.G. Miller, and W.H. Bowles Leaching of unpolymerized materials from orthodontic bonding resin J Dent Res 61 1982 989 992
91. J.C. Wataha, F.A. Rueggeberg, C.A. Lapp, J.B. Lewis, P.E. Lockwood, and J.W. Ergle In vitro cytotoxicity of resin-containing restorative materials after aging in artificial saliva Clin Oral Investig 3 1999 144 149
92. H.M. Kopperud, M. Schmidt, and I.S. Kleven Elution of substances from a silorane-based dental composite Eur J Oral Sci 118 2010 100 102
93. E.C. Munksgaard, A. Peutzfeldt, and E. Asmussen Elution of TEGDMA and BisGMA from a resin and a resin composite cured with halogen or plasma light Eur J Oral Sci 108 2000 341 345
94. A. Hamid, and W.R. Hume A study of component release from resin pit and fissure sealants in vitro Dent Mater 13 1997 98 102 (Pubitemid 127683574)
95. A.S. Al Hiyasat, H. Darmani, and M.M. Milhem Cytotoxicity evaluation of dental resin composites and their flowable derivatives Clin Oral Investig 9 2005 21 25 (Pubitemid 40425132)
96. S.Y. Lee, H.M. Huang, C.Y. Lin, and Y.H. Shih Leached components from dental composites in oral simulating fluids and the resultant composite strengths J Oral Rehabil 25 1998 575 588
97. L. Kanerva, M.L. Henriks-Eckerman, R. Jolanki, and T. Estlander Plastics/acrylics: material safety data sheets need to be improved Clin Dermatol 15 1997 533 546 (Pubitemid 27315172)
98. M. Noda, H. Komatsu, and H. Sano HPLC analysis of dental resin composites components J Biomed Mater Res 47 1999 374 378
99. J. Durner, H. Kreppel, J. Zaspel, H. Schweikl, R. Hickel, and F.X. Reichl The toxicokinetics and distribution of 2-hydroxyethyl methacrylate in mice Biomaterials 30 2009 2066 2071
100. U. Ortengren, S. Langer, A. Goransson, and T. Lundgren Influence of pH and time on organic substance release from a model dental composite: a fluorescence spectrophotometry and gas chromatography/mass spectrometry analysis Eur J Oral Sci 112 2004 530 537 (Pubitemid 39627035)
101. A.U. Yap, H.K. Lee, and R. Sabapathy Release of methacrylic acid from dental composites Dent Mater 16 2000 172 179
102. O.A. Kazantsev, K.V. Shirshin, A.P. Sivokhin, S.V. Tel'nov, I.V. Zhiganov, and A.E. Kuznetsov Hydrolysis of 2-hydroxyethyl methacrylate in concentrated aqueous solutions Russ J Appl Chem 76 2003 1296 1298
103. K.L. Van Landuyt, J. Snauwaert, J. De Munck, M. Peumans, Y. Yoshida, and A. Poitevin Systematic review of the chemical composition of contemporary dental adhesives Biomaterials 28 2007 3757 3785 (Pubitemid 47053932)
104. H. Oysaed, I.E. Ruyter, and K. Sjovik I. Release of formaldehyde from dental composites J Dent Res 67 1988 1289 1294
105. S. Kitamura, T. Suzuki, S. Sanoh, R. Kohta, N. Jinno, and K. Sugihara Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds Toxicol Sci 84 2005 249 259 (Pubitemid 40542284)
106. Y. Imai, and T. Komabayashi Elution of bisphenol A from composite resin: a model experiment Dent Mater J 19 2000 133 138
107. A.S. Al Hiyasat, H. Darmani, and A.M. Elbetieha Leached components from dental composites and their effects on fertility of female mice Eur J Oral Sci 112 2004 267 272 (Pubitemid 38834412)
108. K.J. Soderholm, and A. Mariotti BIS-GMA-based resins in dentistry: are they safe? J Am Dent Assoc 130 1999 201 209
109. G. Schmalz, A. Preiss, and D. Arenholt-Bindslev Bisphenol-A content of resin monomers and related degradation products Clin Oral Investig 3 1999 114 119
110. J.P. Myers, F.S. vom Saal, B.T. Akingbemi, K. Arizono, S. Belcher, and T. Colborn Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A Environ Health Perspect 117 2009 309 315
111. E.Y. Fung, N.O. Ewoldsen, G.H. St Jr., D.B. Marx, C.L. Miaw, and C. Siew Pharmacokinetics of bisphenol A released from a dental sealant J Am Dent Assoc 131 2000 51 58
112. P. Perez, R. Pulgar, F. Olea-Serrano, M. Villalobos, A. Rivas, and M. Metzler The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups Environ Health Perspect 106 1998 167 174 (Pubitemid 28177096)
113. D.A. Crain, M. Eriksen, T. Iguchi, S. Jobling, H. Laufer, and G.A. LeBlanc An ecological assessment of bisphenol-A: evidence from comparative biology Reprod Toxicol 24 2007 225 239 (Pubitemid 47386027)
114. A. Azarpazhooh, and P.A. Main Is there a risk of harm or toxicity in the placement of pit and fissure sealant materials? A systematic review J Can Dent Assoc 74 2008 179 183
115. European Union; 2010. www.bispenol-a-europe.org.
116. B.M. Thomson, P.R. Grounds, and Bisphenol A in canned foods in New Zealand: an exposure assessment Food Addit Contam 22 2005 65 72 (Pubitemid 40352709)
117. W.K. Onn, L.L. Woon, and S.H. Leng Dietary exposure assessment of infants to bisphenol A from the use of polycarbonate baby milk bottles Food Addit Contam 22 2005 280 288
118. European Union Risk Assessment Report: 4,4′-Isopropylidenediphenol (Bisphenol-A); 2010.
119. H. Darmani, A.S. Al Hiyasat, and M.M. Milhem Cytotoxicity of dental composites and their leached components Quintessence Int 38 2007 789 795
120. Y. Zhang, and J. Xu Effect of immersion in various media on the sorption, solubility, elution of unreacted monomers, and flexural properties of two model dental composite compositions J Mater Sci Mater Med 19 2008 2477 2483
121. R.T. Morrison, and R.N. Boyd Organic chemistry 3rd ed. 1973 Allyn and Bacon Boston
122. J.L. Ferracane Hygroscopic and hydrolytic effects in dental polymer networks Dent Mater 22 2006 211 222 (Pubitemid 43199610)
123. A.R. Benetti, E. Asmussen, E.C. Munksgaard, M. Dewaele, A. Peutzfeldt, and G. Leloup Softening and elution of monomers in ethanol Dent Mater 25 2009 1007 1013
124. M.H. Tabatabaee, H. Mahdavi, S. Zandi, and M.J. Kharrazi HPLC analysis of eluted monomers from two composite resins cured with LED and halogen curing lights J Biomed Mater Res B: Appl Biomater 88 2009 191 196
125. S. Imazato, D. Horikawa, M. Nishida, and S. Ebisu Effects of monomers eluted from dental resin restoratives on osteoblast-like cells J Biomed Mater Res B: Appl Biomater 88 2009 378 386
126. G. Palmer, H.M. Anstice, and G.J. Pearson The effect of curing regime on the release of hydroxyethyl methacrylate (HEMA) from resin-modified glass-ionomer cements J Dent 27 1999 303 311
127. A. Nalcaci, N. Ulusoy, and O. Atakol Time-based elution of TEGDMA and BisGMA from resin composite cured with LED, QTH and high-intensity QTH lights Oper Dent 31 2006 197 203 (Pubitemid 43633128)
128. O. Polydorou, A. Konig, E. Hellwig, and K. Kummerer Uthethane dimethacrylate: a molecule that may cause confusion in dental research J Biomed Mater Res B: Appl Biomater 91 2009 1 4
129. W. Geurtsen, W. Spahl, and G. Leyhausen Residual monomer/additive release and variability in cytotoxicity of light-curing glass-ionomer cements and compomers J Dent Res 77 1998 2012 2019 (Pubitemid 32770502)
130. H.J. Moon, Y.K. Lee, B.S. Lim, and C.W. Kim Effects of various light curing methods on the leachability of uncured substances and hardness of a composite resin J Oral Rehabil 31 2004 258 264
131. O. Polydorou, J. Beiter, A. Konig, E. Hellwig, and K. Kummerer Effect of bleaching on the elution of monomers from modern dental composite materials Dent Mater 25 2009 254 260
132. V. Miletic, A. Santini, and I. Trkulja Quantification of monomer elution and carbon-carbon double bonds in dental adhesive systems using HPLC and micro-Raman spectroscopy J Dent 37 2009 177 184
133. A.U. Yap, V.T. Han, M.S. Soh, and K.S. Siow Elution of leachable components from composites after LED and halogen light irradiation Oper Dent 29 2004 448 453 (Pubitemid 39090795)
134. I.D. Sideridou, and D.S. Achilias Elution study of unreacted Bis-GMA, TEGDMA, UDMA, and Bis-EMA from light-cured dental resins and resin composites using HPLC J Biomed Mater Res B: Appl Biomater 74 2005 617 626 (Pubitemid 40917733)
135. K. Tanaka, M. Taira, H. Shintani, K. Wakasa, and M. Yamaki Residual monomers (TEGDMA and Bis-GMA) of a set visible-light-cured dental composite resin when immersed in water J Oral Rehabil 18 1991 353 362
136. T. Eliades, G. Eliades, W.A. Brantley, and W.M. Johnston Residual monomer leaching from chemically cured and visible light-cured orthodontic adhesives Am J Orthod Dentofacial Orthop 108 1995 316 321
137. J.G. Kim, and C.M. Chung Elution from light-cured dental composites: comparison of trimethacrylate and dimethacrylate as base monomers J Biomed Mater Res B: Appl Biomater 72 2005 328 333
138. M. Vakiparta, M. Puska, and P.K. Vallittu Residual monomers and degree of conversion of partially bioresorbable fiber-reinforced composite Acta Biomater 2 2006 29 37 (Pubitemid 43348742)