CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease

Journal of Clinical Immunology

Volumn 31, Issue 2, 2011, Pages 240-244

  Kuo, Ho Chang ^a,b   Liang, Chi Di ^a   Yu, Hong Ren ^a,b   Wang, Chih Lu ^c   Lin, I Chun ^b   Liu, Chieh An ^a   Chang, Jen Chieh ^a,d   Lee, Chiu Ping ^a   Chang, Wei Chiao ^e,f   Yang, Kuender D ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c Po Jen Hospital   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

coronary artery lesions; CTLA 4; Kawasaki disease

Indexed keywords

ACETYLSALICYLIC ACID; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA; IMMUNOGLOBULIN;

ARTICLE; CHILD; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; INFANT; MAJOR CLINICAL STUDY; MALE; MUCOCUTANEOUS LYMPH NODE SYNDROME; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; SEX DIFFERENCE; SINGLE DRUG DOSE; TREATMENT RESPONSE;

ALLELES; ANTIGENS, CD; CHILD; CHILD, PRESCHOOL; CORONARY ARTERY DISEASE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; MALE; MUCOCUTANEOUS LYMPH NODE SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS;

EID: 79959706212     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-010-9484-4     Document Type: Article

References (31)

1. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. 1974;54:271-6.
2. Wang CL, Wu YT, Liu CA, Kuo HC, Yang KD. Kawasaki disease: infection, immunity and genetics. Pediatr Infect Dis J. 2005;24:998-1004. (Pubitemid 41689607)
3. Burns JC, Glode MP. Kawasaki syndrome. Lancet. 2004;364:533-44. (Pubitemid 39070416)
4. Park YW, Han JW, Park IS, Kim CH, Cha SH, Ma JS, et al. Kawasaki disease in Korea, 2003-2005. Pediatr Infect Dis J. 2007;26:821-3.
5. Huang WC, Huang LM, Chang IS, Chang LY, Chiang BL, Chen PJ, et al. Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics. 2009;123:e401-5.
6. Nakamura Y, Yashiro M, Uehara R, Oki I, Kayaba K, Yanagawa H. Increasing incidence of Kawasaki disease in Japan: nationwide survey. Pediatr Int. 2008;50:287-90. (Pubitemid 351781496)
7. Liang CD, Kuo HC, Yang KD, Wang CL, Ko SF. Coronary artery fistula associated with Kawasaki disease. Am Heart J. 2009;157:584-8.
8. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 2004;114:1708-33.
9. Soylemezoglu O, Peru H, Gonen S, Cetinyurek A, Ozkaya O, Bakkaloglu S, et al. CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-Schonlein purpura. Pediatr Nephrol. 2008;23:1239-44.
10. Yang KD, Liu CA, Chang JC, Chuang H, Ou CY, Hsu TY, et al. Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases. Clin Exp Allergy. 2004;34:32-7.
11. Chang JC, Liu CA, Chuang H, Ou CY, Hsu TY, Huang EY, et al. Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels. Pediatr Allergy Immunol. 2004;15:506-12. (Pubitemid 40030117)
12. Momin S, Flores S, Angel BB, Codner DE, Carrasco PE, Perez-Bravo F. Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes. Diabetes Res Clin Pract. 2009;83:289-94.
13. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003;423:506-11. (Pubitemid 36648570)
14. Kristiansen OP, Larsen ZM, Pociot F. CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity? Genes Immun. 2000;1:170-84.
15. Munthe-Kaas MC, Carlsen KH, Helms PJ, Gerritsen J, Whyte M, Feijen M, et al. CTLA-4 polymorphisms in allergy and asthma and the TH1/TH2 paradigm. J Allergy Clin Immunol. 2004;114:280-7. (Pubitemid 39119025)
16. Kuo HC, Wang CL, Liang CD, Yu HR, Chen HH, Wang L, et al. Persistent monocytosis after intravenous immunoglobulin therapy correlated with the development of coronary artery lesions in patients with Kawasaki disease. J Microbiol Immunol Infect. 2007;40:395-400.
17. Kuo HC, Yang KD, Liang CD, Bong CN, Yu HR, Wang L, et al. The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease. Pediatr Allergy Immunol. 2007;18:354-9. (Pubitemid 46961750)
18. Kuo HC, Wang CL, Liang CD, Yu HR, Huang CF, Wang L, et al. Association of lower eosinophil-related T helper 2 (Th2) cytokines with coronary artery lesions in Kawasaki disease. Pediatr Allergy Immunol. 2009;20:266-72.
19. Akagi T, Rose V, Benson LN, Newman A, Freedom RM. Outcome of coronary artery aneurysms after Kawasaki disease. J Pediatr. 1992;121:689-94.
20. Shulman ST, De Inocencio J, Hirsch R. Kawasaki disease. Pediatr Clin North Am. 1995;42:1205-22.
21. Yang KD, Ou CY, Chang JC, Chen RF, Liu CA, Liang HM, et al. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clin Immunol. 2007;120:842-8. (Pubitemid 47531851)
22. Hirao J, Hibi S, Andoh T, Ichimura T. High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease. Int Arch Allergy Immunol. 1997;112:152-6. (Pubitemid 27039179)
23. Furukawa S, Matsubara T, Motohashi T, Sasai K, Nakachi S, Umezawa Y, et al. Increased expression of Fc epsilon R2/CD23 on peripheral blood B lymphocytes and serum IgE levels in Kawasaki disease. Int Arch Allergy Appl Immunol. 1991;95:7-12.
24. Furuno K, Yuge T, Kusuhara K, Takada H, Nishio H, Khajoee V, et al. CD25+CD4+ regulatory T cells in patients with Kawasaki disease. J Pediatr. 2004;145:385-90. (Pubitemid 39165689)
25. Matsubara T, Anwar R, Fujiwara M, Ichiyama T, Furukawa S. CTLA-4 (CD152) expression in peripheral blood T cells in Kawasaki disease. Clin Exp Immunol. 2003;132:169-73. (Pubitemid 36418920)
26. Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. J Immunol. 2001;165:6606-11.
27. Maurer M, Loserth S, Kolb-Maurer A, Ponath A, Wiese S, Kruse N, et al. A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1 +49) alters T-cell activation. Immunogenetics. 2002;54:1-8. (Pubitemid 34492947)
28. Ahmed S, Ihara K, Kanemitsu S, Nakashima H, Otsuka T, Tsuzaka K, et al. Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population. Rheumatology (Oxford). 2001;40:662-7.
29. Lee YJ, Huang FY, Lo FS, Wang WC, Hsu CH, Kao HA, et al. Association of CTLA4 gene A-G polymorphism with type 1 diabetes in Chinese children. Clin Endocrinol (Oxford). 2000;52:153-7.
30. Onouchi Y, Gunji T, Burns JC, Shimizu C, Newburger JW, Yashiro M, et al. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet. 2008;40:35-42.
31. Burgner D, Davila S, Breunis WB, Ng SB, Li Y, Bonnard C, et al. A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease. PLoS Genet. 2009;5:e1000319.