Clinical potential of zinc in prophylaxis of the common cold

Expert Review of Respiratory Medicine

Volumn 5, Issue 3, 2011, Pages 301-303

  Singh, Meenu ^a   Das, Rashmi Ranjan ^b  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

clinical trial; immunity; micronutrient; rhinovirus; upper respiratory tract infection

Indexed keywords

ANTIBIOTIC AGENT; ASCORBIC ACID; GLUCONATE ZINC; ZINC; ZINC SULFATE;

BLOOD DISEASE; CELLULAR IMMUNITY; CLINICAL TRIAL; COMMON COLD; COMORBIDITY; DRUG EFFECT; DRUG MECHANISM; GASTROINTESTINAL SYMPTOM; HUMAN; HUMORAL IMMUNITY; NAUSEA; PROPHYLAXIS; REVIEW; RISK FACTOR;

EID: 79959701958     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.11.29     Document Type: Review

References (19)

1. Simasek M, Blandino DA. Treatment of the common cold. Am. Fam. Physician 75(4), 515-520 (2007
2. Fendrick AM, Monto AS, Nightengale B, Sarnes M. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch. Intern. Med. 163(4), 487-494 (2003 (Pubitemid 36244917)
3. Turner RB. The treatment of rhinovirus infections: progress and potential. Antiviral Res. 49(1), 1-14 (2001 (Pubitemid 32146574)
4. Korant BD, Kaurer JC, Butterworth BE. Zinc ions inhibit replication of rhinoviruses. Nature 248(449), 588-590 (1974
5. Bates J, McClain CJ. The effect of severe zinc deficiency on serum levels of albumin, transferrin, and prealbumin in man. Am. J. Clin. Nutr. 34(9), 1655-1660 (1981 (Pubitemid 12245257)
6. Golden MHN, Jackson AA, Golden BE. Effect of zinc on thymus of recently malnourished children. Lancet 2(8047), 1057-1059 (1977 (Pubitemid 8206874)
7. Mathe G, Blazsek I, Gil-Delgado MA et al. The effect of zinc on normal and neoplastic T-lymphocyte proliferation. Med. Oncol. Tumor Pharmacother. 2(3), 203-210 (1985 (Pubitemid 16245675)
8. Rocklin RE, Haberek-Davidson A. Histamine activates suppressor cells in vitro using a coculture technique. J. Clin. Immunol. 1(1), 73-79 (1981 (Pubitemid 12064722)
9. Cohen S, Tyrrell DAJ, Smith AP. Psychological stress and susceptibility to the common cold. N. Eng. J. Med. 325(9), 606-612 (1991
10. Beisel WR, Pekarek RS, Wannemaker RW Jr. Homeostatic mechanisms affecting plasma zinc levels in acute stress. In: Trace Elements in Human Health and Disease (Volume 1Prasad AS, Oberleas D (EdsAcademic Press, NY, USA, 87-106 (1976
11. Al-Nakib W, Higgins PG, Barrow I, Batsone G, Tyrell DA. Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. J. Antimicrob. Chemother. 20(6), 893-901 (1987 (Pubitemid 18033973)
12. McElroy BH, Miller SP. Effectiveness of zinc gluconate glycine lozenges (Cold-Eeze) against the common cold in school-aged subjects: a retrospective chart review. Am. J. Ther. 9(6), 472-475 (2002
13. McElroy BH, Miller SP. An open-label, single-center, Phase IV clinical study of the effectiveness of zinc gluconate glycine lozenges (Cold-Eeze) in reducing the duration and symptoms of the common cold in school-aged subjects. Am. J. Ther. 10(5), 324-329 (2003
14. Takkouche B, Regueira-Mendez C, Garcia-Closas R, Figueiras A, Gestal-Otero JJ. Intake of vitamin C and zinc and risk of common cold: a cohort study. Epidemiology 13(1), 38-44 (2002 (Pubitemid 34031508)
15. Kurugöl Z, Akilli M, Bayram N, Koturoglu G. The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children. Acta Paediatr. 95(10), 1175-1181 (2006 (Pubitemid 44423179)
16. Vakili R, Vahedian M, Khodaei GH, Mahmoudi M. Effects of zinc supplementation in occurrence and duration of common cold in school aged children during cold season: a double-blind placebocontrolled trial. Iran. J. Pediatr. 19(4), 376-380 (2009
17. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst. Rev. 2, CD001364 (2011
18. Chandra RK. Excessive intake of zinc impairs immune responses. JAMA 252(11), 1443-1446 (1984 (Pubitemid 14037009)
19. Sandstead HH. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Am. J. Clin. Nutr. 61(3 Suppl.), 621S-624S (1995).