Extensive neck node metastases (N3) in head and neck squamous carcinoma: Is radical treatment warranted?

Otolaryngology - Head and Neck Surgery

Volumn 144, Issue 1, 2011, Pages 29-35

  Jones, Andrew S ^a   Goodyear, Paul W ^a,b   Ghosh, Samit ^a,b   Husband, David ^c   Helliwell, Tim R ^a   Jones, Terry M ^a,b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^c CLATTERBRIDGE CENTRE FOR ONCOLOGY   (United Kingdom)

Author keywords

Head and neck cancer; Multivariate analysis; Neck dissection; Radiotherapy; Regional metastases; Squamous cell carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SPECIFIC SURVIVAL; CANCER SURVIVAL; CANCER THERAPY; CHEMORADIOTHERAPY; CLINICAL TRIAL; FEMALE; HEAD AND NECK CANCER; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; NECK NODE METASTASIS; PROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; SURVIVAL TIME; CANCER STAGING; CARCINOMA; COMPARATIVE STUDY; FOLLOW UP; HEAD AND NECK TUMOR; LYMPH NODE METASTASIS; MORTALITY; MULTIMODALITY CANCER THERAPY; TIME; UNITED KINGDOM;

CARCINOMA; COMBINED MODALITY THERAPY; FOLLOW-UP STUDIES; GREAT BRITAIN; HEAD AND NECK NEOPLASMS; HUMANS; LYMPHATIC METASTASIS; NEOPLASM STAGING; NEOPLASMS, SQUAMOUS CELL; PROSPECTIVE STUDIES; SURVIVAL RATE; TIME FACTORS;

EID: 79959685269     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599810390191     Document Type: Article

References (17)

1. Snow GB, Annyas AA, van Slooten EA, et al. Prognostic factors of neck node metastasis. Clin Otolaryngol. 1982;7:185-192. (Pubitemid 12088842)
2. Mancuso AA, Hanafee WN. Computed Tomography and Magnetic Resonance Imaging of the Head and Neck. 2nd ed. Baltimore, MD: Williams & Wilkins; 1985.
3. Jones AS. Prognosis in mouth cancer: tumour factors. Eur J Cancer B Oral Oncol. 1994;30B:8-15. (Pubitemid 24055768)
4. Violaris NS, O'Neill D, Helliwell TR, et al. Soft tissue cervical metastases of squamous carcinoma of the head and neck. Clin Otolaryngol. 1994;19:394-399. (Pubitemid 24340588)
5. Jones AS, Roland NJ, Field JK, et al. The level of cervical lymph node metastases: their prognostic relevance and relationship with head and neck squamous carcinoma primary sites. Clin Otolaryngol. 1994;19:63-69. (Pubitemid 24081618)
6. Spiro RH, Huvos AG, Wong GY, et al. Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. Am J Surg. 1986;152:345-350. (Pubitemid 16001460)
7. Mendenhall WM, Million RR, Cassisi NJ. Squamous cell carcinoma of the head and neck treated with radiation therapy: the role of neck dissection for clinically positive neck nodes. Int J Radiat Oncol Biol Phys. 1986;12:733-740. (Pubitemid 16033470)
8. Jones AS, Fenton JE, Rafferty M, et al. Treatment of squamous cell carcinoma of the tongue base: irradiation, surgery or palliation. Ann Otol Rhinol Laryngol. 2007;11:92-99. (Pubitemid 46327819)
9. McGuirt WF, McCabe BF. Bilateral radical neck dissection. Arch Otolaryngol. 1980;l06:427-429.
10. Barkley HT Jr, Fletcher GH, Jesse RH, et al. Management of cervical lymph node metastases in squamous cell carcinoma of the tonsillar fossa, base of tongue, supraglottic larynx and hypopharynx. Am J Surg. 1972;124:462-467.
11. Kennedy JT, Kraus CH, Loevy S. The importance of tumor attachment to the carotid artery. Arch Otolaryngol. 1977;103:70.
12. Jones AS, Fenton JE, Husband DJ. The treatment of squamous cell carcinoma of the tonsil with neck node metastases. Head Neck. 2003;25:24-31. (Pubitemid 36007807)
13. Ellis ER, Mendenhall WM, Rao PV, et al. Does node location affect the incidence of distant metastases in head and neck squamous cell carcinoma? Int J Radiat Oncol Biol Phys. 1989;17:293-297. (Pubitemid 19203075)
14. Parsons JT, Mendenhall WM, Cassisi NJ, et al. Neck dissection after twice-a-day radiotherapy: morbidity and recurrence rates. Head Neck. 1989;11:400-404. (Pubitemid 19210519)
15. Northrop MF, Fletcher GR, Jesse RH, et al. Evolution of neck disease in patients with primary squamous cell carcinoma of the oral tongue, floor of mouth, and palatine arch, and clinically positive neck nodes neither fixed nor bilateral. Cancer. 1972;29: 23-30.
16. Keir JA, Whiteside OJH, Winter SC, et al. Outcomes in squamous cell carcinoma with advanced disease. Ann R Coll Surg Engl. 2007;89:703-708. (Pubitemid 47577785)
17. Fletcher GH, MacComb WS, Braun EJ. Analysis of sites and causes of treatment failures in squamous cell carcinomas of the oral cavity. Am J Roentgenol Radium Ther Nucl Med. 1960;83: 405-411.