Inactivity-induced diaphragm dysfunction and mitochondria-targeted antioxidants: New concepts in critical care medicine

Critical Care Medicine

Volumn 39, Issue 7, 2011, Pages 1844-1845

  Levine, Sanford ^a   Budak, Murat T ^a   Dierov, Jamil ^a   Singhal, Sunil ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

contractile dysfunction; diaphragm disuse atrophy; humans; mechanical ventilation; mitochondria targeted antioxidants; myofiber atrophy; oxidative stress

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ACTIN; ANTIOXIDANT; ATROGIN 1; CALPAIN 1; CALPAIN 2; CALPAIN 3; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITO Q; MUSCLE PROTEIN; MUSCLE RING FINGER 1 PROTEIN; MYOSIN; MYOSIN HEAVY CHAIN; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; SZETO SCHILLER PEPTIDE 31; TROLOX C; UNCLASSIFIED DRUG;

ARTIFICIAL VENTILATION; DIAPHRAGM; DIAPHRAGM DISEASE; DISEASE ASSOCIATION; DRUG EFFECT; EDITORIAL; ELECTROMYOGRAPHY; ENZYME ACTIVITY; HUMAN; IMMOBILIZATION; INACTIVITY INDUCED DIAPHRAGM DYSFUNCTION; INTENSIVE CARE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MUSCLE ATROPHY; NERVE STIMULATION; NONHUMAN; OXIDATIVE STRESS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHRENIC NERVE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THORAX PRESSURE; TRANSDIAPHRAGMATIC PRESSURE; VENTILATOR INDUCED DIAPHRAGM DYSFUNCTION; VENTILATOR INDUCED LUNG INJURY;

EID: 79959675499     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31821e85ca     Document Type: Editorial

References (18)

1. Falk DJ, Deruisseau KC, Van Gammeren DL, et al: Mechanical ventilation promotes redox status alterations in the diaphragm. J Appl Physiol 2006; 101:1017-1024 (Pubitemid 44497543)
2. McClung JM, Kavazis AN, Whidden MA, et al: Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. J Physiol 2007; 585:203-215 (Pubitemid 350131113)
3. Powers SK, Shanely RA, Coombes JS, et al: Mechanical ventilation results in progressive contractile dysfunction in the diaphragm. J Appl Physiol 2002; 92:1851-1858 (Pubitemid 34666410)
4. Whidden MA, Smuder AJ, Wu M, et al: Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm. J Appl Physiol 2010; 108: 1376-1382
5. Levine S, Nguyen T, Taylor N, et al: Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008; 358:1327-1335 (Pubitemid 351468409)
6. Levine S, Biswas C, Dierov J, et al: Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse. Am J Respir Crit Care Med 2011; 183:483-490
7. Jaber S, Petrof BJ, Jung B, et al: Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med 2011; 183: 364-371
8. Callahan LA, Supinski GS: Diaphragm weakness and mechanical ventilation-What's the critical issue? Crit Care 2010; 14:187
9. Ottenheijm CA, van Hees HW, Heunks LM, et al: Titin-based mechanosensing and signaling: Role in diaphragm atrophy during unloading? Am J Physiol Lung Cell Mol Physiol 2011; 300:L161-L166
10. Hussain SN, Mofarrahi M, Sigala I, et al: Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy. Am J Respir Crit Care Med 2010; 182:1377-1386
11. Betters JL, Criswell DS, Shanely RA, et al: Trolox attenuates mechanical ventilationinduced diaphragmatic dysfunction and proteolysis. Am J Respir Crit Care Med 2004; 170:1179-1184 (Pubitemid 39577375)
12. Kavazis AN, Talbert EE, Smuder AJ, et al: Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production. Free Radic Biol Med 2009; 46:842-850
13. Powers SK, Hudson MB, Nelson WB, et al: Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness. Crit Care Med 2011; 39: 1749-1759
14. Smith RA, Murphy MP: Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci 2010; 1201: 96-103
15. Szeto HH: Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents. AAPS J 2006; 8:E521-E531
16. Agten A, Maes K, Smuder A, et al: NAcetylcysteine protects the rat diaphragm from the decreased contractility associated with controlled mechanical ventilation. Crit Care Med 2011; 39:777-782
17. Vassilakopoulos T, Petrof BJ: Ventilatorinduced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004; 169:336-341
18. Ayas NT, McCool FD, Gore R, et al: Prevention of human diaphragm atrophy with short periods of electrical stimulation. Am J Respir Crit Care Med 1999; 159:2018-2020 (Pubitemid 29275079)