Evaluation of a gene expression microarray-based assay to determine tissue type of origin on a diverse set of 49 malignancies

American Journal of Surgical Pathology

Volumn 35, Issue 7, 2011, Pages 1030-1037

  Beck, Andrew H ^a   Rodriguez Paris, Juan ^a   Zehnder, James ^a   Schrijver, Iris ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

microarray; molecular pathology; tumor of unknown origin

Indexed keywords

ALGORITHM; ARTICLE; CANCER OF UNKNOWN PRIMARY SITE; DNA MICROARRAY; EVALUATION; FEMALE; FROZEN SECTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; METHODOLOGY; NEOPLASM; PREDICTIVE VALUE; REPRODUCIBILITY;

ALGORITHMS; FEMALE; FROZEN SECTIONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; NEOPLASMS; NEOPLASMS, UNKNOWN PRIMARY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS;

EID: 79959668461     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3182178b59     Document Type: Article

References (18)

1. Bridgewater J, van Laar R, Floore A, et al. Gene expression profiling may improve diagnosis in patients with carcinoma of unknown primary. Br J Cancer. 2008;98:1425-1430. (Pubitemid 351543580)
2. Bugat R, Bataillard A, Lesimple T, et al. Summary of the standards, options and recommendations for the management of patients with carcinoma of unknown primary site (2002). Br J Cancer. 2003; 89(suppl 1):S59-S66. (Pubitemid 37076150)
3. DeYoung BR, Wick MR. Immunohistologic evaluation of metastatic carcinomas of unknown origin: an algorithmic approach. Semin Diagn Pathol. 2000;17:184-193. (Pubitemid 30641873)
4. Dumur CI, Lyons-Weiler M, Sciulli C, et al. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn. 2008;10:67-77. (Pubitemid 351184837)
5. Hastie T, Tibshirani R, Friedman JH. The Elements of Statistical Learning: Data Mining, Inference, and Prediction. New York: Springer; 2009.
6. Horlings HM, van Laar RK, Kerst JM, et al. Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary. J Clin Oncol. 2008;26: 4435-4441.
7. Inamura K, Satoh Y, Okumura S, et al. Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas. Am J Surg Pathol. 2005;29: 660-665. (Pubitemid 40577877)
8. Meijer GA, Meuwissen SG, Baak JP. Classification of colorectal adenomas with quantitative pathology. Evaluation of morphometry, stereology, mitotic counts and syntactic structure analysis. Anal Cell Pathol. 1995;9:311-323.
9. Monzon FA, Lyons-Weiler M, Buturovic LJ, et al. Multicenter validation of a 1550-gene expression profile for identification of tumor tissue of origin. J Clin Oncol. 2009;27:2503-2508.
10. Monzon FA, Medeiros F, Lyons-Weiler M, et al. Identification of tissue of origin in carcinoma of unknown primary with a microarray-based gene expression test. Diagn Pathol. 2010;5:3.
11. Pentheroudakis G, Golfinopoulos V, Pavlidis N. Switching benchmarks in cancer of unknown primary: from autopsy to microarray. Eur J Cancer. 2007;43:2026-2036. (Pubitemid 47380362)
12. Pillai R, Deeter R, Rigl CT, et al. Validation and reproducibility of a microarray-based gene expression test for tumor identification in formalin-fixed, paraffin-embedded specimens. J Mol Diagn. 2011; 13:48-56.
13. Singh N. Synchronous tumours of the female genital tract. Histopathology. 2010;56:277-285.
14. Tothill RW, Kowalczyk A, Rischin D, et al. An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin. Cancer Res. 2005;65:4031-4040. (Pubitemid 40775639)
15. van Laar RK, Ma XJ, de Jong D, et al. Implementation of a novel microarray-based diagnostic test for cancer of unknown primary. Int J Cancer. 2009;125:1390-1397.
16. Varadhachary GR, Talantov D, Raber MN, et al. Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation. J Clin Oncol. 2008;26:4442-4448.
17. Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. 5th ed. Philadelphia: Mosby/Elsevier; 2008.
18. Wu AH, Drees JC, Wang H, et al. Gene expression profiles help identify the tissue of origin for metastatic brain cancers. Diagn Pathol. 2010;5:26.