Placental abruption and perinatal mortality with preterm delivery as a mediator: Disentangling direct and indirect effects

American Journal of Epidemiology

Volumn 174, Issue 1, 2011, Pages 99-108

  Ananth, Cande V ^a   Vanderweele, Tyler J ^b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

abruptio placentae; bias (epidemiology); causal model; gestational age; perinatal mortality

Indexed keywords

CHILD LABOR; EPIDEMIOLOGY; MATERNAL HEALTH; MORTALITY RISK; PREGNANCY; SENSITIVITY ANALYSIS; SPATIOTEMPORAL ANALYSIS;

ARTICLE; CONFOUNDING VARIABLE; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; METHODOLOGY; NEWBORN; PERINATAL MORTALITY; PREMATURE LABOR; RISK ASSESSMENT; RISK FACTOR; SOLUTIO PLACENTAE; UNITED STATES;

ABRUPTIO PLACENTAE; ADULT; CONFIDENCE INTERVALS; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; MATHEMATICAL COMPUTING; ODDS RATIO; PERINATAL MORTALITY; PREGNANCY; PREMATURE BIRTH; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SURVIVAL RATE; UNITED STATES;

UNITED STATES;

EID: 79959656404     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwr045     Document Type: Article

References (42)

1. Robins JM, Greenland S. Identifiability and exchangeability for direct and indirect effects. Epidemiology. 1992;3(2):143-155.
2. Pearl J. Direct and indirect effects. In: Breese JS, Koller D, eds. Proceedings of the 17th Conference in Uncertainty in Artificial Intelligence. San Francisco, CA: Morgan Kaufmann Publishers, Inc; 2001:411-420.
3. VanderWeele TJ,Vansteelandt S. Conceptual issues concerning mediation, interventions and composition. Stat Interface-Spec Issue Mental Health Soc Behav Sci. 2009;2:457-468.
4. VanderWeele TJ. Bias formulas for sensitivity analysis for direct and indirect effects. Epidemiology. 2010;21(4):540-551.
5. Vanderweele TJ, Vansteelandt S. Odds ratios for mediation analysis for a dichotomous outcome. Am J Epidemiol. 2010; 172(12):1339-1348.
6. Judd CM, Kenny DA. Process analysis: estimating mediation in treatment evaluations. Eval Rev. 1981;5(6):602-619.
7. Cole SR, Hernán MA. Fallibility in estimating direct effects. Int J Epidemiol. 2002;31(1):163-165. (Pubitemid 34284920)
8. Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol. 2006;108(4):1005-1016. (Pubitemid 44498264)
9. Ananth CV, Savitz DA,Williams MA. Placental abruption and its association with hypertension and prolonged rupture of membranes: a methodologic review and meta-analysis. Obstet Gynecol. 1996;88(2):309-318. (Pubitemid 26250312)
10. Rasmussen S, Irgens LM, Bergsjo P, et al. The occurrence of placental abruption in Norway 1967-1991. Acta Obstet Gynecol Scand. 1996;75(3):222-228. (Pubitemid 26105276)
11. Ananth CV, Smulian JC, Demissie K, et al. Placental abruption among singleton and twin births in the United States: risk factor profiles. Am J Epidemiol. 2001;153(8):771-778. (Pubitemid 32319704)
12. Ananth CV, Oyelese Y, Yeo L, et al. Placental abruption in the United States, 1979 through 2001: temporal trends and potential determinants. Am J Obstet Gynecol. 2005;192(1): 191-198. (Pubitemid 40164241)
13. Ananth CV, Berkowitz GS, Savitz DA, et al. Placental abruption and adverse perinatal outcomes. JAMA. 1999; 282(17):1646-1651. (Pubitemid 29513971)
14. Ananth CV, Wilcox AJ. Placental abruption and perinatal mortality in the United States. Am J Epidemiol. 2001;153(4): 332-337. (Pubitemid 32144558)
15. Rasmussen S, Irgens LM, Bergsjo P, et al. Perinatal mortality and case fatality after placental abruption in Norway 1967-1991. Acta Obstet Gynecol Scand. 1996;75(3):229-234. (Pubitemid 26105277)
16. Raymond EG, Mills JL. Placental abruption. Maternal risk factors and associated fetal conditions. Acta Obstet Gynecol Scand. 1993;72(8):633-639. (Pubitemid 23359459)
17. Rosen T, Schatz F, Kuczynski E, et al. Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes. J Matern Fetal Neonatal Med. 2002;11(1):11-17.
18. Gargano JW, Holzman CB, Senagore PK, et al. Evidence of placental haemorrhage and preterm delivery. BJOG. 2010; 117(4):445-455.
19. Salafia CM, López-Zeno JA, Sherer DM, et al. Histologic evidence of old intrauterine bleeding is more frequent in prematurity. Am J Obstet Gynecol. 1995;173(4):1065-1070.
20. Clark SL. Placenta previa and abruptio placentae. In: Creasy RK, Resnik R, eds. Maternal Fetal Medicine. Philadelphia, PA: WB Saunders Company; 2004:715-717.
21. Naeye RL. Causes of perinatal mortality in the US Collaborative Perinatal Project. JAMA. 1977;238(3):228-229. (Pubitemid 8154088)
22. Naeye RL, Tafari N, Marboe CC. Perinatal death due to abruptio placentae in an African city. Acta Obstet Gynecol Scand. 1979;58(1):37-40. (Pubitemid 9110846)
23. Hernán MA. A definition of causal effect for epidemiological research. J Epidemiol Community Health. 2004;58(4):265-271. (Pubitemid 38406475)
24. Rubin DB. Formal modes of statistical inference for causal effects. J Stat Plan Infer. 1990;25(3):279-292.
25. VanderWeele TJ. Controlled direct and mediated effects: definition, identification and bounds. Scand J Stat. Advance Access: December 22, 2010. (DOI: 10.1111/j.1467-9469. 2010.00722.x).
26. Kaufman JS, MacLehose RF, Kaufman S. A further critique of the analytic strategy of adjusting for covariates to identify biologic mediation [electronic article]. Epidemiol Perspect Innov. 2004;1(1):4.
27. Spiegelman D, Hertzmark E. Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol. 2005; 162(3):199-200. (Pubitemid 41373523)
28. Valeri L, VanderWeele TJ. Technical Report: Extending the Baron and Kenny Mediation Analysis to Allow for Exposure- Mediator Interactions: SAS and SPSS Macros. Boston, MA: Harvard School of Public Health; 2010.
29. Ananth CV, Oyelese Y, Srinivas N, et al. Preterm premature rupture of membranes, intrauterine infection, and oligohydramnios: risk factors for placental abruption. Obstet Gynecol. 2004;104(1):71-77. (Pubitemid 40458907)
30. McElrath TF, Hecht JL, Dammann O, et al. Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification. ELGAN Study Investigators. Am J Epidemiol. 2008;168(9):980-989.
31. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000; 342(20):1500-1507. (Pubitemid 30318275)
32. Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75-84.
33. Taffel SM, Ventura SJ, Gay GA. Revised US. certificate of birth-new opportunities for research on birth outcome. Birth. 1989;16(4):188-193.
34. Taffel S, Johnson D, Heuser R. A method of imputing length of gestation on birth certificates. Vital Health Stat 2. 1982; 93:1-11.
35. Ananth CV. Menstrual versus clinical estimate of gestational age dating in the United States: temporal trends and variability in indices of perinatal outcomes. Paediatr Perinat Epidemiol. 2007;21(suppl 2):22-30. (Pubitemid 47347804)
36. Joseph KS, Huang L, Liu S, et al. Reconciling the high rates of preterm and postterm birth in the United States. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. Obstet Gynecol. 2007;109(4):813-822.
37. Ananth CV, Getahun D, Peltier MR, et al. Placental abruption in term and preterm gestations: evidence for heterogeneity in clinical pathways. Obstet Gynecol. 2006; 107(4):785-792.
38. Ananth CV, Oyelese Y, Prasad V, et al. Evidence of placental abruption as a chronic process: associations with vaginal bleeding early in pregnancy and placental lesions. Eur J Obstet Gynecol Reprod Biol. 2006;128(1-2): 15-21. (Pubitemid 44322019)
39. Elsasser DA, Ananth CV, Prasad V, et al. Diagnosis of placental abruption: relationship between clinical and histopathological findings. New Jersey-Placental Abruption Study Investigators. Eur J Obstet Gynecol Reprod Biol. 2010;148(2):125-130.
40. Joseph KS. Theory of obstetrics: the fetuses-at-risk approach as a causal paradigm. J Obstet Gynaecol Can. 2004;26(11): 953-960.
41. Basso O, Wilcox AJ, Weinberg CR. Birth weight and mortality: causality or confounding? Am J Epidemiol. 2006;164(4):303-311. (Pubitemid 44297336)
42. Hernández-Díaz S, Schisterman EF, Hernán MA. The birth weight "paradox" uncovered? Am J Epidemiol. 2006; 164(11):1115-1120.