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Volumn 16, Issue 6, 2011, Pages 5159-5167

Inhibitory activity of flavonoids against class I phosphatidylinositol 3-kinase isoforms

Author keywords

Flavonoid; Phosphatidylinositol 3 kinase; Structure activity relationship

Indexed keywords

ENZYME INHIBITOR; FLAVONOID; ISOENZYME; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE;

EID: 79959623768     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16065159     Document Type: Article
Times cited : (27)

References (24)
  • 1
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • DOI 10.1038/42648
    • Toker, A.; Cantley, L.C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997, 387, 673-676. (Pubitemid 27270600)
    • (1997) Nature , vol.387 , Issue.6634 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 2
    • 50149101312 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase inhibitors: Promising drug candidates for cancer therapy
    • Kong, D.; Yamori, T. Phosphatidylinositol 3-kinase inhibitors: Promising drug candidates for cancer therapy. Cancer Sci. 2008, 99, 1734-1740.
    • (2008) Cancer Sci. , vol.99 , pp. 1734-1740
    • Kong, D.1    Yamori, T.2
  • 6
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira, S.M.; Stauffer, F.; Brueggen, J.; Furet, P.; Schnell, C.; Fritsch, C.; Brachmann, S.; Chene, P.; De Pover, A.; Schoemaker, K.; et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol. Cancer Ther. 2008, 7, 1851-1863.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3    Furet, P.4    Schnell, C.5    Fritsch, C.6    Brachmann, S.7    Chene, P.8    De Pover, A.9    Schoemaker, K.10
  • 7
    • 52449106253 scopus 로고    scopus 로고
    • The identification of 2-(1H-indazol-4-yl)-6-(4- methanesulfonyl- piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
    • Folkes, A.J.; Ahmadi, K.; Alderton, W.K.; Alix, S.; Baker, S.J.; Box, G.; Chuckowree, I.S.; Clarke, P.A.; Depledge, P.; Eccles, S.A.; et al. The identification of 2-(1H-indazol-4-yl)-6-(4- methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J. Med. Chem. 2008, 51, 5522-5532.
    • (2008) J. Med. Chem. , vol.51 , pp. 5522-5532
    • Folkes, A.J.1    Ahmadi, K.2    Alderton, W.K.3    Alix, S.4    Baker, S.J.5    Box, G.6    Chuckowree, I.S.7    Clarke, P.A.8    Depledge, P.9    Eccles, S.A.10
  • 8
    • 70349391226 scopus 로고    scopus 로고
    • Advances in development of phosphatidylinositol 3-kinase inhibitors
    • Kong, D.; Yamori, T. Advances in development of phosphatidylinositol 3-kinase inhibitors. Curr. Med. Chem. 2009, 16, 2839-2854.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 2839-2854
    • Kong, D.1    Yamori, T.2
  • 9
    • 34548189038 scopus 로고    scopus 로고
    • ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms
    • DOI 10.1111/j.1349-7006.2007.00580.x
    • Kong, D.; Yamori, T. ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci. 2007, 98, 1638-1642. (Pubitemid 47308463)
    • (2007) Cancer Science , vol.98 , Issue.10 , pp. 1638-1642
    • Kong, D.1    Yamori, T.2
  • 10
    • 61349194402 scopus 로고    scopus 로고
    • Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor
    • Kong, D.; Okamura, M.; Yoshimi, H.; Yamori, T. Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor. Eur. J. Cancer 2009, 45, 857-865.
    • (2009) Eur. J. Cancer , vol.45 , pp. 857-865
    • Kong, D.1    Okamura, M.2    Yoshimi, H.3    Yamori, T.4
  • 11
    • 58149294243 scopus 로고    scopus 로고
    • Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase
    • Kong, D.; Yaguchi, S.; Yamori, T. Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase. Biol. Pharm. Bull. 2009, 32, 297-300.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 297-300
    • Kong, D.1    Yaguchi, S.2    Yamori, T.3
  • 13
    • 77949484879 scopus 로고    scopus 로고
    • Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39
    • Kong, D.; Dan, S.; Yamazaki, K.; Yamori, T. Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39. Eur. J. Cancer 2010, 46, 1111-1121.
    • (2010) Eur. J. Cancer , vol.46 , pp. 1111-1121
    • Kong, D.1    Dan, S.2    Yamazaki, K.3    Yamori, T.4
  • 16
    • 33748324543 scopus 로고    scopus 로고
    • Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver
    • Peluso, M.R. Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. Exp. Biol. Med. (Maywood) 2006, 231, 1287-1299. (Pubitemid 44330564)
    • (2006) Experimental Biology and Medicine , vol.231 , Issue.8 , pp. 1287-1299
    • Peluso, M.R.1
  • 17
    • 0031708667 scopus 로고    scopus 로고
    • Effect of plant flavonoids on immune and inflammatory cell function
    • Middleton, E., Jr. Effect of plant flavonoids on immune and inflammatory cell function. Adv. Exp. Med. Biol. 1998, 439, 175-182. (Pubitemid 28429016)
    • (1998) Advances in Experimental Medicine and Biology , vol.439 , pp. 175-182
    • Middleton Jr., E.1
  • 18
    • 77957597727 scopus 로고    scopus 로고
    • Discovery of phosphatidylinositol 3-kinase inhibitory compounds from the Screening Committee of Anticancer Drugs (SCADS) library
    • Kong, D.; Yamazaki, K.; Yamori, T. Discovery of phosphatidylinositol 3-kinase inhibitory compounds from the Screening Committee of Anticancer Drugs (SCADS) library. Biol. Pharm. Bull. 2010, 33, 1600-1604.
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 1600-1604
    • Kong, D.1    Yamazaki, K.2    Yamori, T.3
  • 19
    • 33847239467 scopus 로고    scopus 로고
    • PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond?
    • Rommel, C.; Camps, M.; Ji, H. PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond? Nat. Rev. Immunol. 2007, 7, 191-201.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 191-201
    • Rommel, C.1    Camps, M.2    Ji, H.3
  • 22
    • 0034534704 scopus 로고    scopus 로고
    • Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form
    • DOI 10.1211/0022357001777621
    • Akao, T.; Kawabata, K.; Yanagisawa, E.; Ishihara, K.; Mizuhara, Y.; Wakui, Y.; Sakashita, Y.; Kobashi, K. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J. Pharm. Pharmacol. 2000, 52, 1563-1568. (Pubitemid 32058657)
    • (2000) Journal of Pharmacy and Pharmacology , vol.52 , Issue.12 , pp. 1563-1568
    • Akao, T.1    Kawabata, K.2    Yanagisawa, E.3    Ishihara, K.4    Mizuhara, Y.5    Wakui, Y.6    Sakashita, Y.7    Kobashi, K.8
  • 24
    • 0035150315 scopus 로고    scopus 로고
    • Human nutrition and metabolism: Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice
    • Erlund, I.; Meririnne, E.; Alfthan, G.; Aro, A. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J. Nutr. 2001, 131, 235-241. (Pubitemid 32115362)
    • (2001) Journal of Nutrition , vol.131 , Issue.2 , pp. 235-241
    • Erlund, I.1    Meririnne, E.2    Alfthan, G.3    Aro, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.