Inertial blood plasma separation in a contraction-expansion array microchannel

Applied Physics Letters

Volumn 98, Issue 25, 2011, Pages

  Lee, Myung Gwon ^a   Choi, Sungyoung ^a   Kim, Hee Je ^b   Lim, Hee Kyun ^a,c   Kim, Joon Ho ^c   Huh, Nam ^c   Park, Je Kyun ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c SAMSUNG Electronics   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PLASMA; BLOOD-PLASMA SEPARATION; CUT-OFF VALUE; DRAG FORCES; FORCE BALANCES; LIFT FORCE; LOW ASPECT RATIO;

ASPECT RATIO; DRAG; MICROCHANNELS;

BLOOD;

EID: 79959622809     PISSN: 00036951     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.3601745     Document Type: Article

References (22)

1. M. Toner and D. Irimia, Annu. Rev. Biomed. Eng. 1523-9829 7, 77 (2005). 10.1146/annurev.bioeng.7.011205.135108 (Pubitemid 41174581)
2. J. Moorthy and D. Beebe, Lab Chip 1473-0197 3, 62 (2003). 10.1039/b300450c (Pubitemid 41646561)
3. T. Crowley and V. Pizziconi, Lab Chip 1473-0197 5, 922 (2005). 10.1039/b502930a (Pubitemid 41297845)
4. T. Tachi, N. Kaji, M. Tokeshi, and Y. Baba, Anal. Chem. 0003-2700 81, 3194 (2009). 10.1021/ac802434z
5. V. VanDelinder and A. Groisman, Anal. Chem. 0003-2700 78, 3765 (2006). 10.1021/ac060042r (Pubitemid 43848971)
6. J. Park, K. Cho, C. Chung, D. -C. Han, and J. K. Chang, Proceedings of the 3rd IEEE/EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Kahuku, Oahu, Hawaii, 12-15 May 2005, p. 8.
7. C. Blattert, R. Jurischka, I. Tahhan, A. Schoth, P. Kerth, and W. Menz, Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA, 1-5 September 2004, p. 2627.
8. M. Faivre, M. Abkarian, K. Bickraj, and H. A. Stone, Biorheology 0006-355X 43, 147 (2006).
9. S. Yang, A. Undar, and J. Zahn, Lab Chip 1473-0197 6, 871 (2006). 10.1039/b516401j (Pubitemid 43962794)
10. M. Kersaudy-Kerhoas, D. M. Kavanagh, R. S. Dhariwal, C. J. Campbell, and M. P. Y. Desmulliez, Lab Chip 1473-0197 10, 1587 (2010). 10.1039/b926834k
11. D. Di Carlo, Lab Chip 1473-0197 9, 3038 (2009). 10.1039/b912547g
12. A. A. S. Bhagat, S. S. Kuntaegowdanahalli, and I. Papautsky, Phys. Fluids 1070-6631 20, 101702 (2008). 10.1063/1.2998844
13. B. Chun and A. J. C. Ladd, Phys. Fluids 1070-6631 18, 031704 (2006). 10.1063/1.2176587
14. D. Di Carlo, J. F. Edd, D. Irimia, R. G. Tompkins, and M. Toner, Anal. Chem. 0003-2700 80, 2204 (2008). 10.1021/ac702283m (Pubitemid 351458072)
15. D. Di Carlo, D. Irimia, R. G. Tompkins, and M. Toner, Proc. Natl. Acad. Sci. U.S.A. 0027-8424 104, 18892 (2007). 10.1073/pnas.0704958104
16. A. A. S. Bhagat, S. S. Kuntaegowdanahalli, N. Kaval, C. J. Seliskar, and I. Papautsky, Biomed. Microdevices 1387-2176 12, 187 (2010). 10.1007/s10544-009-9374-9
17. A. A. S. Bhagat, S. S. Kuntaegowdanahalli, and I. Papautsky, Lab Chip 1473-0197 8, 1906 (2008). 10.1039/b807107a
18. J. -S. Park and H. -I. Jung, Anal. Chem. 0003-2700 81, 8280 (2009). 10.1021/ac9005765
19. M. G. Lee, S. Choi, and J. -K. Park, J. Chromatogr., A 0021-9673 1218, 4138 (2011).
20. M. G. Lee, S. Choi, and J. -K. Park, Appl. Phys. Lett. 0003-6951 95, 051902 (2009). 10.1063/1.3194137
21. See supplementary material at http://dx.doi.org/10.1063/1.3601745 E-APPLAB-98-047125 for experimental, ratio of inertial force, Figs. S1 and S2.
22. A. Russom, A. K. Gupta, S. Nagrath, D. Di Carlo, J. F. Edd, and M. Toner, New J. Phys. 1367-2630 11, 075025 (2009). 10.1088/1367-2630/11/7/075025