Metabolic control of resting hemispheric cerebral blood flow is oxidative, not glycolytic

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 5, 2011, Pages 1223-1228

  Powers, William J ^a   Videen, Tom O ^b,c   Markham, Joanne ^c   Walter, Vonn ^d   Perlmutter, Joel S ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d IL   (United States)

Author keywords

cerebral blood flow; cerebral glucose metabolism; cerebral oxygen metabolism; flow metabolism coupling; positron emission tomography

Indexed keywords

ADULT; AGED; ARTERIAL OXYGEN TENSION; ARTERIAL PLASMA GLUCOSE; ARTICLE; BLOOD GAS PARAMETERS; BRAIN BLOOD FLOW; BRAIN METABOLISM; CEREBRAL METABOLIC RATE OF OXYGEN; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLYCOLYSIS; HEMISPHERE; HUMAN; MALE; METABOLIC REGULATION; OXIDATION; OXYGEN EXTRACTION FRACTION; PRIORITY JOURNAL; BRAIN; BRAIN CIRCULATION; COMPUTER ASSISTED DIAGNOSIS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; REST; VASCULARIZATION;

GLUCOSE; OXYGEN;

ADULT; AGED; CEREBROVASCULAR CIRCULATION; CEREBRUM; FEMALE; GLUCOSE; GLYCOLYSIS; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MIDDLE AGED; OXYGEN; POSITRON-EMISSION TOMOGRAPHY; REST; YOUNG ADULT;

EID: 79959604280     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.5     Document Type: Article

References (32)

1. Altman DI, Lich LL, Powers WJ (1991) Brief inhalation method to measure cerebral oxygen extraction fraction with PET: accuracy determination under pathologic conditions. J Nucl Med 32:1738-41
2. Coles JP, Fryer TD, Bradley PG, Nortje J, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK (2006) Intersubject variability and reproducibility of 15O PET studies. J Cereb Blood Flow Metab 26:48-57 (Pubitemid 41818069)
3. Filipek PA, Richelme C, Kennedy DN, Caviness Jr VS (1994) The young adult human brain: an MRI-based morphometric analysis. Cereb Cortex 4:344-60 (Pubitemid 24228840)
4. Fiorelli M, Duboc D, Mazoyer BM, Blin J, Eymard B, Fardeau M, Samson Y (1992) Decreased cerebral glucose utilization in myotonic dystrophy. Neurology 42:91-4
5. Fox J (2002) Bootstrapping regression models: appendix to an R and S-plus companion to applied regression. http://cran.r-project.org/doc/contrib/Fox- Companion/ appendix-bootstrapping.pdf
6. Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462-4
7. Gottstein U, Bernsmeier A, Sedlmeyer I (1963) Der Kohlenhydratstoffweehsel des menschlichen Gehirns bei Schlafmittelvergiftung. Klin Wschr 41:943-8
8. Herscovitch P (2002) Cerebral physiologic measurements with PET. In: Positron Emission Tomography (Valk PE, Bailey DL, Townsend DW, Maisey MN, eds), New York: Springer-Verlag, pp 283-307
9. Herscovitch P, Markham J, Raichle ME (1983) Brain blood flow measured with intravenous H215O. I. Theory and error analysis. J Nucl Med 24:782-9 (Pubitemid 14234678)
10. Ito H, Kanno I, Kato C, Sasaki T, Ishii K, Ouchi Y, Iida A, Okazawa H, Hayashida K, Tsuyuguchi N, Ishii K, Kuwabara Y, Senda M (2004) Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan. Eur J Nucl Med Mol Imaging 31:635-43 (Pubitemid 38647901)
11. Lammertsma AA, Brooks DJ, Frackowiak RS, Beaney RP, Herold S, Heather JD, Palmer AJ, Jones T (1987) Measurement of glucose utilisation with [18F]2-fluoro-2-deoxy-D-glucose: a comparison of different analytical methods. J Cereb Blood Flow Metab 7:161-72 (Pubitemid 17060473)
12. 0h C, Sastre J, Bousser MG (1983) Coupling between regional blood flow and oxygen utilization in the normal human brain. A study with positron tomography and oxygen 15. Arch Neurol 40:230-6 (Pubitemid 13161434)
13. Lindauer U, Leithner C, Kaasch H, Rohrer B, Foddis M, Fuchtemeier M, Offenhauser N, Steinbrink J, Royl G, Kohl-Bareis M, Dirnagl U (2010) Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation. J Cereb Blood Flow Metab 30:757-68
14. Madsen PL, Hasselbalch SG, Hagemann LP, Olsen KS, Bulow J, Holm S, Wildschiodtz G, Paulson OB, Lassen NA (1995) Persistent resetting of the cerebral oxygen/ glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab 15:485-91
15. Madsen PL, Holm S, Herning M, Lassen NA (1993) Average blood flow and oxygen uptake in the human brain during resting wakefulness: a critical appraisal of the Kety-Schmidt technique. J Cereb Blood Flow Metab 13:646-55 (Pubitemid 23187508)
16. Martin WR, Powers WJ, Raichle ME (1987) Cerebral blood volume measured with inhaled C15O and positron emission tomography. J Cereb Blood Flow Metab 7:421-6 (Pubitemid 18035534)
17. Mintun MA, Raichle ME, Martin WR, Herscovitch P (1984) Brain oxygen utilization measured with O-15 radio-tracers and positron emission tomography. J Nucl Med 25:177-87 (Pubitemid 14187475)
18. Mosconi L, Tsui WH, Rusinek H, De Santi S, Li Y, Wang GJ, Pupi A, Fowler J, de Leon MJ (2007) Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease. Eur J Nucl Med Mol Imaging 34:1467-79 (Pubitemid 47312590)
19. Nemoto EM, Yao L, Yonas H, Darby JM (1994) Compart-mentation of whole brain blood flow and oxygen and glucose metabolism in monkeys. J Neurosurg Anesthe-siol 6:170-4 (Pubitemid 24198712)
20. Powers WJ, Dagogo-Jack S, Markham J, Larson KB, Dence CS (1995) Cerebral transport and metabolism of 1-11C-D-glucose during stepped hypoglycemia. Ann Neurol 38:599-609
21. Powers WJ, Hirsch IB, Cryer PE (1996) Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological brain activation. Am J Physiol 270:H554-9
22. Powers WJ, Videen TO, Markham J, Black KJ, Golchin N, Perlmutter JS (2008) Cerebral mitochondrial metabolism in early Parkinson's disease. J Cereb Blood Flow Metab 28:1754-60
23. Powers WJ, Videen TO, Markham J, McGee-Minnich L, Antenor-Dorsey JV, Hershey T, Perlmutter JS (2007) Selective defect of in vivo glycolysis in early Hunting-ton's disease striatum. Proc Natl Acad Sci USA 104:2945-9 (Pubitemid 46327983)
24. R Development Core Team (2010) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, 2010. http:// www.R-project.org
25. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL (2001) A default mode of brain function. Proc Natl Acad Sci USA 98:676-82 (Pubitemid 32105102)
26. Raichle ME, Martin WR, Herscovitch P, Mintun MA, Markham J (1983) Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. J Nucl Med 24:790-8 (Pubitemid 14234679)
27. Scheinberg P, Stead EA (1949) The cerebral blood flow in male subjects as measured by the nitrous oxide technique: normal values for blood flow, oxygen utilization, glucose utilization and peripheral resistance, with observations on the effect of tilting and anxiety. J Clin Invest 28:1163-71
28. Sokoloff L (1981) Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed Proc 40:2311-6 (Pubitemid 11036104)
29. Videen TO, Dunford-Shore JE, Diringer MN, Powers WJ (1999) Correction for partial volume effects in regional blood flow measurements adjacent to hemato-mas in humans with intracerebral hemorrhage: implementation and validation. J Comput Assist Tomogr 23:248-56 (Pubitemid 29138502)
30. Videen TO, Perlmutter JS, Herscovitch P, Raichle ME (1987) Brain blood volume, flow, and oxygen utilization measured with 15O radiotracers and positron emission tomography: revised metabolic computations. J Cereb Blood Flow Metab 7:513-6 (Pubitemid 18035540)
31. Vlassenko AG, Rundle MM, Raichle ME, Mintun MA (2006) Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratio. Proc Natl Acad Sci USA 103:1964-9 (Pubitemid 43228801)
32. Woods RP, Mazziotta JC, Cherry SR (1993) MRI-PET registration with automated algorithm. J Comput Assist Tomogr 17:536-46 (Pubitemid 23206731)