Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors

Molecules

Volumn 16, Issue 6, 2011, Pages 4681-4694

  Li, Shang ^a,b,c   Yao, Hequan ^a   Xu, Jinyi ^a   Jiang, Sheng ^b,c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF TECHNOLOGY   (China)

^c GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

Author keywords

Biological evaluation; Histone deacetylase inhibitor; Largazole; Natural products; Total synthesis

Indexed keywords

DEPSIPEPTIDE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; LARGAZOLE; THIAZOLE DERIVATIVE;

CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; METABOLISM; REVIEW; SYNTHESIS;

DEPSIPEPTIDES; ENZYME ACTIVATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; THIAZOLES;

EID: 79959603291     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16064681     Document Type: Review

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