메뉴 건너뛰기




Volumn 16, Issue 1, 2011, Pages 41-50

Studying therapy response and resistance in mouse models for BRCA1-deficient breast cancer

Author keywords

BRCA1; Genetically engineered mouse models; PARP inhibitors; Platinum drugs; Therapy resistance

Indexed keywords

BEVACIZUMAB; BRCA1 PROTEIN; BRCA2 PROTEIN; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOUBLE STRANDED DNA; ERLOTINIB; GEMCITABINE; GLYCOPROTEIN P; INIPARIB; LETROZOLE; MIFEPRISTONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NIMUSTINE; OLAPARIB; PROTEIN P53; PROTEIN P53 BINDING PROTEIN 53BP1; SUNITINIB; TARIQUIDAR; UNCLASSIFIED DRUG; VELIPARIB;

EID: 79959597157     PISSN: 10833021     EISSN: 15737039     Source Type: Journal    
DOI: 10.1007/s10911-011-9199-z     Document Type: Article
Times cited : (19)

References (93)
  • 1
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8(5):R76.
    • (2007) Genome Biol , vol.8 , Issue.5
    • Herschkowitz, J.I.1    Simin, K.2    Weigman, V.J.3    Mikaelian, I.4    Usary, J.5    Hu, Z.6
  • 4
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • DOI 10.1038/nrc1457
    • Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer. 2004;4(10):814-9. (Pubitemid 39331153)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 6
    • 77954712322 scopus 로고    scopus 로고
    • BRCA1 16 years later: Risk-associated BRCA1 mutations and their functional implications
    • Linger RJ, Kruk PA. BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications. FEBS J. 2010;277(15):3086-96.
    • (2010) FEBS J , vol.277 , Issue.15 , pp. 3086-3096
    • Linger, R.J.1    Kruk, P.A.2
  • 8
    • 75149189204 scopus 로고    scopus 로고
    • BRCA1 and its toolbox for the maintenance of genome integrity
    • Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol. 2010;11 (2):138-48.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , Issue.2 , pp. 138-148
    • Huen, M.S.1    Sy, S.M.2    Chen, J.3
  • 9
    • 33749000596 scopus 로고    scopus 로고
    • The role of BRCA1 in transcriptional regulation and cell cycle control
    • DOI 10.1038/sj.onc.1209872, PII 1209872
    • Mullan PB, Quinn JE, Harkin DP. The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene. 2006;25(43):5854-63. (Pubitemid 44453441)
    • (2006) Oncogene , vol.25 , Issue.43 , pp. 5854-5863
    • Mullan, P.B.1    Quinn, J.E.2    Harkin, D.P.3
  • 11
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • DOI 10.1038/ng0296-191
    • Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 1996;12(2):191-4. (Pubitemid 26051301)
    • (1996) Nature Genetics , vol.12 , Issue.2 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 13
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 1996;10(14):1835-43. (Pubitemid 26272388)
    • (1996) Genes and Development , vol.10 , Issue.14 , pp. 1835-1843
    • Liu, C.-Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.-H.5
  • 14
    • 0026935108 scopus 로고
    • Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome
    • Smith SA, Easton DF, Evans DG, Ponder BA. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome. Nat Genet. 1992;2(2):128-31.
    • (1992) Nat Genet , vol.2 , Issue.2 , pp. 128-131
    • Smith, S.A.1    Easton, D.F.2    Evans, D.G.3    Ponder, B.A.4
  • 16
    • 58349094961 scopus 로고    scopus 로고
    • High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors
    • Manie E, Vincent-Salomon A, Lehmann-Che J, Pierron G, Turpin E, Warcoin M, et al. High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. Cancer Res. 2009;69(2):663-71.
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 663-671
    • Manie, E.1    Vincent-Salomon, A.2    Lehmann-Che, J.3    Pierron, G.4    Turpin, E.5    Warcoin, M.6
  • 18
    • 0036895886 scopus 로고    scopus 로고
    • Molecular classification of breast carcinomas by comparative genomic hybridization: A specific somatic genetic profile for BRCA1 tumors
    • Wessels LF, van Welsem T, Hart AA, van't Veer LJ, Reinders MJ, Nederlof PM. Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors. Cancer Res. 2002;62(23):7110-7. (Pubitemid 35424107)
    • (2002) Cancer Research , vol.62 , Issue.23 , pp. 7110-7117
    • Wessels, L.F.A.1    Van Welsem, T.2    Hart, A.A.M.3    Van'T Veer, L.J.4    Reinders, M.J.T.5    Nederlof, P.M.6
  • 19
    • 85011938244 scopus 로고    scopus 로고
    • An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinumbased chemotherapy in HER2-negative breast cancer patients
    • Dec 6 [Epub ahead of print]
    • Vollebergh MA, Lips EH, Nederlof PM, Wessels LF, Schmidt MK, van Beers EH, et al. An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinumbased chemotherapy in HER2-negative breast cancer patients. Ann Oncol. 2010 Dec 6. [Epub ahead of print]
    • (2010) Ann Oncol
    • Vollebergh, M.A.1    Lips, E.H.2    Nederlof, P.M.3    Wessels, L.F.4    Schmidt, M.K.5    Van Beers, E.H.6
  • 23
    • 62449131093 scopus 로고    scopus 로고
    • Supervised risk predictor of breast cancer based on intrinsic subtypes
    • Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol. 2009;27(8):1160-7.
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1160-1167
    • Parker, J.S.1    Mullins, M.2    Cheang, M.C.3    Leung, S.4    Voduc, D.5    Vickery, T.6
  • 25
    • 65649151690 scopus 로고    scopus 로고
    • Survival outcomes for patients with metastatic triple-negative breast cancer: Implications for clinical practice and trial design
    • Kassam F, Enright K, Dent R, Dranitsaris G, Myers J, Flynn C, et al. Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design. Clin Breast Cancer. 2009;9(1):29-33.
    • (2009) Clin Breast Cancer , vol.9 , Issue.1 , pp. 29-33
    • Kassam, F.1    Enright, K.2    Dent, R.3    Dranitsaris, G.4    Myers, J.5    Flynn, C.6
  • 26
    • 0035874894 scopus 로고    scopus 로고
    • Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation
    • Moynahan ME, Cui TY, Jasin M. Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation. Cancer Res. 2001;61(12):4842-50. (Pubitemid 32691900)
    • (2001) Cancer Research , vol.61 , Issue.12 , pp. 4842-4850
    • Moynahan, M.E.1    Cui, T.Y.2    Jasin, M.3
  • 27
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol. 2008;26 (22):3785-90.
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3785-3790
    • Ashworth, A.1
  • 28
    • 34547100275 scopus 로고    scopus 로고
    • The resurgence of platinum-based cancer chemotherapy
    • DOI 10.1038/nrc2167, PII NRC2167
    • Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer. 2007;7(8):573-84. (Pubitemid 47106628)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.8 , pp. 573-584
    • Kelland, L.1
  • 30
    • 75749143502 scopus 로고    scopus 로고
    • Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy
    • Byrski T, Gronwald J, Huzarski T, Grzybowska E, Budryk M, Stawicka M, et al. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol. 2010;28(3):375-9.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 375-379
    • Byrski, T.1    Gronwald, J.2    Huzarski, T.3    Grzybowska, E.4    Budryk, M.5    Stawicka, M.6
  • 33
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361(2):123-34.
    • (2009) N Engl J Med , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 34
    • 77954032829 scopus 로고    scopus 로고
    • Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
    • Fong PC, Yap TA, Boss DS, Carden CP, Mergui-Roelvink M, Gourley C, et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol. 2010;28 (15):2512-9.
    • (2010) J Clin Oncol , vol.28 , Issue.15 , pp. 2512-2519
    • Fong, P.C.1    Yap, T.A.2    Boss, D.S.3    Carden, C.P.4    Mergui-Roelvink, M.5    Gourley, C.6
  • 35
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet. 2010;376(9737):245-51.
    • (2010) Lancet , vol.376 , Issue.9737 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3    Friedlander, M.4    Powell, B.5    Bell-Mcguinn, K.M.6
  • 36
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet. 2010;376(9737):235-44.
    • (2010) Lancet , vol.376 , Issue.9737 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3    Domchek, S.M.4    Audeh, M.W.5    Weitzel, J.N.6
  • 37
    • 78751629661 scopus 로고    scopus 로고
    • BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors
    • author reply e565-6
    • Veeck J, Ropero S, Setien F, Gonzalez-Suarez E, Osorio A, Benitez J, et al. BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. J Clin Oncol. 2010;28(29):e563-4; author reply e565-6.
    • (2010) J Clin Oncol , vol.28 , Issue.29
    • Veeck, J.1    Ropero, S.2    Setien, F.3    Gonzalez-Suarez, E.4    Osorio, A.5    Benitez, J.6
  • 39
    • 79151476662 scopus 로고    scopus 로고
    • Triple negative breast cancer: Unmet medical needs
    • Pal SK, Childs BH, Pegram M. Triple negative breast cancer: unmet medical needs. Breast Cancer Res Treat. 2011;125(3):627-36.
    • (2011) Breast Cancer Res Treat , vol.125 , Issue.3 , pp. 627-636
    • Pal, S.K.1    Childs, B.H.2    Pegram, M.3
  • 40
    • 77958479034 scopus 로고    scopus 로고
    • Treatment options for patients with triple-negative breast cancer
    • Santana-Davila R, Perez EA. Treatment options for patients with triple-negative breast cancer. J Hematol Oncol. 2010;3:42.
    • (2010) J Hematol Oncol , vol.3 , pp. 42
    • Santana-Davila, R.1    Perez, E.A.2
  • 41
    • 33748331308 scopus 로고    scopus 로고
    • The mighty mouse: Genetically engineered mouse models in cancer drug development
    • DOI 10.1038/nrd2110, PII NRD2110
    • Sharpless NE, Depinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov. 2006;5(9):741-54. (Pubitemid 44323701)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.9 , pp. 741-754
    • Sharpless, N.E.1    DePinho, R.A.2
  • 42
    • 33745240353 scopus 로고    scopus 로고
    • Cross-Species Oncogenomics in Cancer Gene Identification
    • DOI 10.1016/j.cell.2006.06.018, PII S0092867406007768
    • Peeper D, Berns A. Cross-species oncogenomics in cancer gene identification. Cell. 2006;125(7):1230-3. (Pubitemid 43929103)
    • (2006) Cell , vol.125 , Issue.7 , pp. 1230-1233
    • Peeper, D.1    Berns, A.2
  • 43
    • 77955895963 scopus 로고    scopus 로고
    • Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
    • Lim E, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, et al. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 2010;12(2):R21.
    • (2010) Breast Cancer Res , vol.12 , Issue.2
    • Lim, E.1    Wu, D.2    Pal, B.3    Bouras, T.4    Asselin-Labat, M.L.5    Vaillant, F.6
  • 44
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov. 2004;3(8):711-5. (Pubitemid 39173511)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.8 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 45
    • 66349136558 scopus 로고    scopus 로고
    • Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice
    • Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, et al. Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proc Natl Acad Sci USA. 2009;106(17):7022-7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.17 , pp. 7022-7027
    • Wu, M.1    Jung, L.2    Cooper, A.B.3    Fleet, C.4    Chen, L.5    Breault, L.6
  • 46
    • 58749103524 scopus 로고    scopus 로고
    • From human to mouse and back: 'Tumorgraft' models surge in popularity
    • Garber K. From human to mouse and back: 'tumorgraft' models surge in popularity. J Natl Cancer Inst. 2009;101(1):6-8.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.1 , pp. 6-8
    • Garber, K.1
  • 48
    • 77957987999 scopus 로고    scopus 로고
    • Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation
    • de Plater L, Lauge A, Guyader C, Poupon MF, Assayag F, de Cremoux P, et al. Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation. Br J Cancer. 2010;103(8):1192-200.
    • (2010) Br J Cancer , vol.103 , Issue.8 , pp. 1192-1200
    • De Plater, L.1    Lauge, A.2    Guyader, C.3    Poupon, M.F.4    Assayag, F.5    De Cremoux, P.6
  • 49
    • 70449346284 scopus 로고    scopus 로고
    • Preclinical mousemodels for BRCA1-associated breast cancer
    • Drost RM, Jonkers J. Preclinical mousemodels for BRCA1-associated breast cancer. Br J Cancer. 2009;101(10):1651-7.
    • (2009) Br J Cancer , vol.101 , Issue.10 , pp. 1651-1657
    • Drost, R.M.1    Jonkers, J.2
  • 50
    • 33749007676 scopus 로고    scopus 로고
    • Mouse models of BRCA1 and BRCA2 deficiency: Past lessons, current understanding and future prospects
    • DOI 10.1038/sj.onc.1209871, PII 1209871
    • Evers B, Jonkers J. Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene. 2006;25(43):5885-97. (Pubitemid 44453444)
    • (2006) Oncogene , vol.25 , Issue.43 , pp. 5885-5897
    • Evers, B.1    Jonkers, J.2
  • 51
    • 0030924656 scopus 로고    scopus 로고
    • Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
    • Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 1997;11 (10):1226-41. (Pubitemid 27235356)
    • (1997) Genes and Development , vol.11 , Issue.10 , pp. 1226-1241
    • Ludwig, T.1    Chapman, D.L.2    Papaioannou, V.E.3    Efstratiadis, A.4
  • 54
    • 0034946638 scopus 로고    scopus 로고
    • Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
    • DOI 10.1038/90108
    • Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, et al. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001;28 (3):266-71. (Pubitemid 32626030)
    • (2001) Nature Genetics , vol.28 , Issue.3 , pp. 266-271
    • Xu, X.1    Qiao, W.2    Linke, S.P.3    Cao, L.4    Li, W.-M.5    Furth, P.A.6    Harris, C.C.7    Deng, C.-X.8
  • 55
    • 77956218241 scopus 로고    scopus 로고
    • BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    • Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell. 2010;7(3):403-17.
    • (2010) Cell Stem Cell , vol.7 , Issue.3 , pp. 403-417
    • Molyneux, G.1    Geyer, F.C.2    Magnay, F.A.3    McCarthy, A.4    Kendrick, H.5    Natrajan, R.6
  • 56
    • 0033106326 scopus 로고    scopus 로고
    • 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • DOI 10.1016/S1097-2765(00)80466-9
    • Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999;3(3):389-95. (Pubitemid 29290679)
    • (1999) Molecular Cell , vol.3 , Issue.3 , pp. 389-395
    • Xu, X.1    Weaver, Z.2    Linke, S.P.3    Li, C.4    Gotay, J.5    Wang, X.-W.6    Harris, C.C.7    Ried, T.8    Deng, C.-X.9
  • 57
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med. 2009;15(8):907-13.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 907-913
    • Lim, E.1    Vaillant, F.2    Wu, D.3    Forrest, N.C.4    Pal, B.5    Hart, A.H.6
  • 58
    • 77955797447 scopus 로고    scopus 로고
    • Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers
    • Holstege H, van Beers E, Velds A, Liu X, Joosse SA, Klarenbeek S, et al. Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. BMC Cancer. 2010;10:455.
    • (2010) BMC Cancer , vol.10 , pp. 455
    • Holstege, H.1    Van Beers, E.2    Velds, A.3    Liu, X.4    Joosse, S.A.5    Klarenbeek, S.6
  • 59
    • 37849030476 scopus 로고    scopus 로고
    • Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: The national Israeli study of ovarian cancer
    • Chetrit A, Hirsh-Yechezkel G, Ben-David Y, Lubin F, Friedman E, Sadetzki S. Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer. J Clin Oncol. 2008;26(1):20-5.
    • (2008) J Clin Oncol , vol.26 , Issue.1 , pp. 20-25
    • Chetrit, A.1    Hirsh-Yechezkel, G.2    Ben-David, Y.3    Lubin, F.4    Friedman, E.5    Sadetzki, S.6
  • 62
    • 37549020704 scopus 로고    scopus 로고
    • Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
    • Saal LH, Gruvberger-Saal SK, Persson C, Lovgren K, Jumppanen M, Staaf J, et al. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet. 2008;40(1):102-7.
    • (2008) Nat Genet , vol.40 , Issue.1 , pp. 102-107
    • Saal, L.H.1    Gruvberger-Saal, S.K.2    Persson, C.3    Lovgren, K.4    Jumppanen, M.5    Staaf, J.6
  • 65
    • 75749088216 scopus 로고    scopus 로고
    • BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
    • Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen-Steijger P, et al. BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A. Breast Cancer Res. 2009;11(4): R63.
    • (2009) Breast Cancer Res , vol.11 , Issue.4
    • Puppe, J.1    Drost, R.2    Liu, X.3    Joosse, S.A.4    Evers, B.5    Cornelissen-Steijger, P.6
  • 67
    • 67650432118 scopus 로고    scopus 로고
    • Validated germline-competent embryonic stem cell lines from nonobese diabetic mice
    • Nichols J, Jones K, Phillips JM, Newland SA, Roode M, Mansfield W, et al. Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat Med. 2009;15 (7):814-8.
    • (2009) Nat Med , vol.15 , Issue.7 , pp. 814-818
    • Nichols, J.1    Jones, K.2    Phillips, J.M.3    Newland, S.A.4    Roode, M.5    Mansfield, W.6
  • 68
    • 15544381256 scopus 로고    scopus 로고
    • Prevention and management of hereditary breast cancer
    • DOI 10.1200/JCO.2005.10.035
    • Narod SA, Offit K. Prevention and management of hereditary breast cancer. J Clin Oncol. 2005;23(8):1656-63. (Pubitemid 46211420)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.8 , pp. 1656-1663
    • Narod, S.A.1    Offit, K.2
  • 70
  • 72
    • 33845315093 scopus 로고    scopus 로고
    • Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist
    • DOI 10.1126/science.1130471
    • Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science. 2006;314(5804):1467-70. (Pubitemid 44871955)
    • (2006) Science , vol.314 , Issue.5804 , pp. 1467-1470
    • Poole, A.J.1    Li, Y.2    Kim, Y.3    Lin, S.-C.J.4    Lee, W.-H.5    Lee, E.Y.-H.P.6
  • 73
    • 73949137350 scopus 로고    scopus 로고
    • Studying drug resistance using genetically engineered mouse models for breast cancer
    • Rottenberg S, Pajic M, Jonkers J. Studying drug resistance using genetically engineered mouse models for breast cancer. Methods Mol Biol. 2010;596:33-45.
    • (2010) Methods Mol Biol , vol.596 , pp. 33-45
    • Rottenberg, S.1    Pajic, M.2    Jonkers, J.3
  • 74
    • 52449111109 scopus 로고    scopus 로고
    • Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
    • Evers B, Drost R, Schut E, de Bruin M, van der Burg E, Derksen PW, et al. Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin. Clin Cancer Res. 2008;14(12):3916-25.
    • (2008) Clin Cancer Res , vol.14 , Issue.12 , pp. 3916-3925
    • Evers, B.1    Drost, R.2    Schut, E.3    De Bruin, M.4    Van Der Burg, E.5    Derksen, P.W.6
  • 75
    • 79951819983 scopus 로고    scopus 로고
    • Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts
    • Kortmann UK, McAlpine JN, Xue H, Guan J, Ha G, Tully S, et al. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. Clin Cancer Res.
    • Clin Cancer Res
    • Kortmann, U.K.1    McAlpine, J.N.2    Xue, H.3    Guan, J.4    Ha, G.5    Tully, S.6
  • 77
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci USA. 2008;105(44):17079-84.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.44 , pp. 17079-17084
    • Rottenberg, S.1    Jaspers, J.E.2    Kersbergen, A.3    Van Der Burg, E.4    Nygren, A.O.5    Zander, S.A.6
  • 78
    • 76749114340 scopus 로고    scopus 로고
    • Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase i inhibitor topotecan
    • Zander SA,KersbergenA, van der Burg E, deWater N, van Tellingen O, Gunnarsdottir S, et al. Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. Cancer Res. 2010;70(4):1700-10.
    • (2010) Cancer Res , vol.70 , Issue.4 , pp. 1700-1710
    • Sakersbergena, Z.1    Van Der Burg, E.2    Dewater, N.3    Van Tellingen, O.4    Gunnarsdottir, S.5
  • 79
    • 74949093142 scopus 로고    scopus 로고
    • A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors
    • Evers B, Schut E, van der Burg E, Braumuller TM, Egan DA, Holstege H, et al. A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors. Clin Cancer Res. 2010;16(1):99-108.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 99-108
    • Evers, B.1    Schut, E.2    Van Der Burg, E.3    Braumuller, T.M.4    Egan, D.A.5    Holstege, H.6
  • 80
    • 70350034147 scopus 로고    scopus 로고
    • Eleven years disease-free: Role of chemotherapy in metastatic BRCA2-related breast cancer
    • Huang F, Kushner YB, Langleben A, Foulkes WD. Eleven years disease-free: role of chemotherapy in metastatic BRCA2-related breast cancer. Nat Rev Clin Oncol. 2009;6(8):488-92.
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.8 , pp. 488-492
    • Huang, F.1    Kushner, Y.B.2    Langleben, A.3    Foulkes, W.D.4
  • 82
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    • DOI 10.1158/0008-5472.CAN-08-0088
    • Swisher EM, Sakai W, Karlan BY, Wurz K, Urban N, Taniguchi T. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res. 2008;68(8):2581-6. (Pubitemid 351556255)
    • (2008) Cancer Research , vol.68 , Issue.8 , pp. 2581-2586
    • Swisher, E.M.1    Sakai, W.2    Karlan, B.Y.3    Wurz, K.4    Urban, N.5    Taniguchi, T.6
  • 84
    • 70349178444 scopus 로고    scopus 로고
    • Therapeutic options for triplenegative breast cancers with defective homologous recombination
    • Jaspers JE, Rottenberg S, Jonkers J. Therapeutic options for triplenegative breast cancers with defective homologous recombination. Biochim Biophys Acta. 2009;1796(2):266-80.
    • (2009) Biochim Biophys Acta , vol.1796 , Issue.2 , pp. 266-280
    • Jaspers, J.E.1    Rottenberg, S.2    Jonkers, J.3
  • 85
    • 77953270903 scopus 로고    scopus 로고
    • Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
    • Ishida S, McCormick F, Smith-McCune K, Hanahan D. Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell. 2010;17(6):574-83.
    • (2010) Cancer Cell , vol.17 , Issue.6 , pp. 574-583
    • Ishida, S.1    McCormick, F.2    Smith-Mccune, K.3    Hanahan, D.4
  • 86
    • 44849143103 scopus 로고    scopus 로고
    • Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors
    • Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN, et al. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res. 2008;68 (9):3243-50.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3243-3250
    • Shafee, N.1    Smith, C.R.2    Wei, S.3    Kim, Y.4    Mills, G.B.5    Hortobagyi, G.N.6
  • 87
    • 0030981170 scopus 로고    scopus 로고
    • 5-6 early embryonic lethality by p53 or p21 null mutation
    • DOI 10.1038/ng0797-298
    • Hakem R, de la Pompa JL, Elia A, Potter J, Mak TW. Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat Genet. 1997;16(3):298-302. (Pubitemid 27280216)
    • (1997) Nature Genetics , vol.16 , Issue.3 , pp. 298-302
    • Hakem, R.1    De La Pompa, J.L.2    Elia, A.3    Potter, J.4    Mark, T.W.5
  • 88
    • 68949221567 scopus 로고    scopus 로고
    • A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
    • Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, et al. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell. 2009;35(4):534-41.
    • (2009) Mol Cell , vol.35 , Issue.4 , pp. 534-541
    • Cao, L.1    Xu, X.2    Bunting, S.F.3    Liu, J.4    Wang, R.H.5    Cao, L.L.6
  • 89
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol. 2010;17(6):688-95.
    • (2010) Nat Struct Mol Biol , vol.17 , Issue.6 , pp. 688-695
    • Bouwman, P.1    Aly, A.2    Escandell, J.M.3    Pieterse, M.4    Bartkova, J.5    Van Der Gulden, H.6
  • 90
    • 77950958141 scopus 로고    scopus 로고
    • 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    • Bunting SF, Callen E, Wong N, Chen HT, Polato F, Gunn A, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 2010;141 (2):243-54.
    • (2010) Cell , vol.141 , Issue.2 , pp. 243-254
    • Bunting, S.F.1    Callen, E.2    Wong, N.3    Chen, H.T.4    Polato, F.5    Gunn, A.6
  • 92
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • DOI 10.1038/35102167
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105-11. (Pubitemid 33041634)
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 93
    • 77956985875 scopus 로고    scopus 로고
    • Tumor-initiating cells are not enriched in cisplatinsurviving BRCA1;p53-deficient mammary tumor cells in vivo
    • Pajic M, Kersbergen A, van Diepen F, Pfauth A, Jonkers J, Borst P, et al. Tumor-initiating cells are not enriched in cisplatinsurviving BRCA1;p53-deficient mammary tumor cells in vivo. Cell Cycle. 2010;9(18):3780-91.
    • (2010) Cell Cycle , vol.9 , Issue.18 , pp. 3780-3791
    • Pajic, M.1    Kersbergen, A.2    Van Diepen, F.3    Pfauth, A.4    Jonkers, J.5    Borst, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.