Mechanisms responsible for progesterone's protection against lordosis-inhibiting effects of restraint. I. Role of progesterone receptors

Hormones and Behavior

Volumn 60, Issue 2, 2011, Pages 219-225

  Hassell, James ^a   Miryala, Chandra Suma Johnson ^a   Hiegel, Cindy ^a   Uphouse, Lynda ^a  

^a TEXAS WOMAN'S UNIVERSITY   (United States)

Author keywords

Hormonal priming; Medroxyprogesterone; Ovariectomized female rats; RU486; Stress

Indexed keywords

ESTRADIOL BENZOATE; MEDROXYPROGESTERONE; MIFEPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; IMMOBILIZATION; LORDOSIS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEXUAL BEHAVIOR; STRESS;

ANIMALS; ESTRADIOL; ESTROGENS; FEMALE; HORMONE ANTAGONISTS; MEDROXYPROGESTERONE; MIFEPRISTONE; OVARIECTOMY; POSTURE; PROGESTERONE; PROGESTINS; RATS; RATS, INBRED F344; RECEPTORS, PROGESTERONE; RESTRAINT, PHYSICAL; SEXUAL BEHAVIOR, ANIMAL;

EID: 79959543345     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2011.05.006     Document Type: Article

References (60)

1. Attardi B.J., Burgenson J., Hild S.A., Reel J.R., Blye R.P. CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914. Mol. Cell. Endocrinol. 2002, 188:111-123.
2. Attardi B.J., Burgenson J., Hild S.A., Reel J.R. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J. Steroid Biochem. Mol. Biol. 2004, 88:277-288.
3. Auger A.P. Steroid receptor control of reproductive behavior. Horm. Behav. 2004, 45:168-172.
4. Bannbers, E., Kask, K., Wikstrom, J., Risbrough, V., Sundstrom Poromaa, I., in press. Patients with premenstrual dysphoric disorder have increased startle modulation during anticipation in the late luteal phase period in comparison to control subjects. Psychoneuroendocrinology. DOI: S0306-4530(11)00082-5 [pii]10.1016/j.psyneuen.2011.02.011.
5. Barbaccia M.L. Neurosteroidogenesis: relevance to neurosteroid actions in brain and modulation by psychotropic drugs. Crit. Rev. Neurobiol. 2004, 16:67-74.
6. Bitran D., Purdy R.H., Kellogg C.K. Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function. Pharmacol. Biochem. Behav. 1993, 45:423-428.
7. Blaustein J.D. Neuroendocrine regulation of feminine sexual behavior: lessons from rodent models and thoughts about humans. Annu. Rev. Psychol. 2008, 59:93-118.
8. Brinton R.D., Thompson R.F., Foy M.R., Baudry M., Wang J., Finch C.E., Morgan T.E., Pike C.J., Mack W.J., Stanczyk F.Z., Nilsen J. Progesterone receptors: form and function in brain. Front. Neuroendocrinol. 2008, 29:313-339.
9. Conneely O.M., Mulac-Jericevic B., Lydon J.P. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids 2003, 68:771-778.
10. Dressing G.E., Goldberg J.E., Charles N.J., Schwertfeger K.L., Lange C.A. Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications. Steroids 2011, 76:11-17.
11. Dubrovsky B. Neurosteroids, neuroactive steroids, and symptoms of affective disorders. Pharmacol. Biochem. Behav. 2006, 84:644-655.
12. Erskine M.S. Solicitation behavior in the estrous female rat: a review. Horm. Behav. 1989, 23:473-502.
13. Eser D., Baghai T.C., Schule C., Nothdurfter C., Rupprecht R. Neuroactive steroids as endogenous modulators of anxiety. Curr. Pharm. Des. 2008, 14:3525-3533.
14. Frye C.A. Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse. Pharmacol. Biochem. Behav. 2007, 86:209-219.
15. Frye C.A., Vongher J.M. Progesterone has rapid and membrane effects in the facilitation of female mouse sexual behavior. Brain Res. 1999, 815:259-269.
16. Frye C.A., Bayon L.E., Pursnani N.K., Purdy R.H. The neurosteroids, progesterone and 3alpha,5alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Res. 1998, 808:72-83.
17. Frye C.A., Paris J.J., Rhodes M.E. Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area. Behav. Brain Res. 2008, 193:269-276.
18. Gellersen B., Fernandes M.S., Brosens J.J. Non-genomic progesterone actions in female reproduction. Hum. Reprod. Update 2009, 15:119-138.
19. Gomez C., Saldivar-Gonzalez A., Delgado G., Rodriguez R. Rapid anxiolytic activity of progesterone and pregnanolone in male rats. Pharmacol. Biochem. Behav. 2002, 72:543-550.
20. Gonzalez-Flores O., Beyer C., Gomora-Arrati P., Garcia-Juarez M., Lima-Hernandez F.J., Soto-Sanchez A., Etgen A.M. A role for Src kinase in progestin facilitation of estrous behavior in estradiol-primed female rats. Horm. Behav. 2010, 58:223-229.
21. Gonzalez-Mariscal G., Gonzalez-Flores O., Beyer C. Intrahypothalamic injection of RU486 antagonizes the lordosis induced by ring A-reduced progestins. Physiol. Behav. 1989, 46:435-438.
22. Hennessy M.B., Zate R., Maken D.S. Social buffering of the cortisol response of adult female guinea pigs. Physiol. Behav. 2008, 93:883-888.
23. Hiroi R., Neumaier J.F. Differential effects of ovarian steroids on anxiety versus fear as measured by open field test and fear-potentiated startle. Behav. Brain Res. 2006, 166:93-100.
24. Ho H.P., Westberg L., Annerbrink K., Olsson M., Melke J., Nilsson S., Baghaei F., Rosmond R., Holm G., Bjorntorp P., Andersch S., Allgulander C., Eriksson E. Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women. Psychoneuroendocrinology 2004, 29:1138-1141.
25. Intlekofer K.A., Petersen S.L. 17beta-estradiol and progesterone regulate multiple progestin signaling molecules in the anteroventral periventricular nucleus, ventromedial nucleus and sexually dimorphic nucleus of the preoptic area in female rats. Neuroscience 2010, 176:86-92.
26. Jarrell J. Studies on the developmental pattern of rat ovarian 3 alpha-hydroxysteroid dehydrogenase: inhibition of the postpubertal activity with medroxyprogesterone acetate in vivo. J. Steroid Biochem. 1984, 21:151-156.
27. Kavaliers M., Wiebe J.P., Galea L.A. Male preference for the odors of estrous female mice is enhanced by the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP). Brain Res. 1994, 646:140-144.
28. Koubovec D., Ronacher K., Stubsrud E., Louw A., Hapgood J.P. Synthetic progestins used in HRT have different glucocorticoid agonist properties. Mol. Cell. Endocrinol. 2005, 242:23-32.
29. Lee T.C., Miller W.L., Auchus R.J. Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes. J. Clin. Endocrinol. Metab. 1999, 84:2104-2110.
30. Lee M.S., Choi H.S., Kwon S.H., Morita K., Her S. Identification of the functional domain of glucocorticoid receptor involved in RU486 antagonism. J. Steroid Biochem. Mol. Biol. 2009, 117:67-73.
31. Leonhardt S.A., Boonyaratanakornkit V., Edwards D.P. Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids 2003, 68:761-770.
32. Mani S.K. Signaling mechanisms in progesterone-neurotransmitter interactions. Neuroscience 2006, 138:773-781.
33. Mani S., Portillo W. Activation of progestin receptors in female reproductive behavior: interactions with neurotransmitters. Front. Neuroendocrinol. 2010, 31:157-171.
34. Mani S.K., Blaustein J.D., Allen J.M., Law S.W., O'Malley B.W., Clark J.H. Inhibition of rat sexual behavior by antisense oligonucleotides to the progesterone receptor. Endocrinology 1994, 135:1409-1414.
35. Mani S.K., Blaustein J.D., O'Malley B.W. Progesterone receptor function from a behavioral perspective. Horm. Behav. 1997, 31:244-255.
36. Mani S.K., Reyna A.M., Chen J.Z., Mulac-Jericevic B., Conneely O.M. Differential response of progesterone receptor isoforms in hormone-dependent and -independent facilitation of female sexual receptivity. Mol. Endocrinol. 2006, 20:1322-1332.
37. Meyer M.E., Pornon A., Ji J.W., Bocquel M.T., Chambon P., Gronemeyer H. Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. EMBO J. 1990, 9:3923-3932.
38. Ogawa S., Olazabal U.E., Parhar I.S., Pfaff D.W. Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone receptor immunoreactivity in female rat. J. Neurosci. 1994, 14:1766-1774.
39. Pazol K., Northcutt K.V., Wilson M.E., Wallen K. Medroxyprogesterone acetate acutely facilitates and sequentially inhibits sexual behavior in female rats. Horm. Behav. 2006, 49:105-113.
40. Pfaff D. Hormone-driven mechanisms in the central nervous system facilitate the analysis of mammalian behaviours. J. Endocrinol. 2005, 184:447-453.
41. Picazo O., Fernandez-Guasti A. Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test. Brain Res. 1995, 680:135-141.
42. Pluchino N., Luisi M., Lenzi E., Centofanti M., Begliuomini S., Freschi L., Ninni F., Genazzani A.R. Progesterone and progestins: effects on brain, allopregnanolone and beta-endorphin. J. Steroid Biochem. Mol. Biol. 2006, 102:205-213.
43. Pluchino N., Cubeddu A., Giannini A., Merlini S., Cela V., Angioni S., Genazzani A.R. Progestogens and brain: an update. Maturitas 2009, 62:349-355.
44. Pridjian G., Schmit V., Schreiber J. Medroxyprogesterone acetate: receptor binding and correlated effects on steroidogenesis in rat granulosa cells. J. Steroid Biochem. 1987, 26:313-319.
45. Reddy D.S., O'Malley B.W., Rogawski M.A. Anxiolytic activity of progesterone in progesterone receptor knockout mice. Neuropharmacology 2005, 48:14-24.
46. Selman P.J., Wolfswinkel J., Mol J.A. Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog. Steroids 1996, 61:133-137.
47. Shively C.A., Bethea C.L. Cognition, mood disorders, and sex hormones. ILAR J. 2004, 45:189-199.
48. Sodersten P. Estradiol-progesterone interactions in the reproductive behavior of female rats. Current Topics in Neuroendocrinology: Actions of Progesterone on the Brain 1981, 141-174. Springer-Verlag, New York. D. Ganten, D. Pfaff (Eds.).
49. Solomon M.B., Herman J.P. Sex differences in psychopathology: of gonads, adrenals and mental illness. Physiol. Behav. 2009, 97:250-258.
50. Starkey N.J., Bridges N.J. The effects of acute, chronic and withdrawn progesterone in male and female Mongolian gerbils (Meriones unguiculatus) in two tests of anxiety. Behav. Brain Res. 2010, 207:490-499.
51. Taylor R.N., Savouret J.F., Vaisse C., Vigne J.L., Ryan I., Hornung D., Seppala M., Milgrom E. Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells. J. Clin. Endocrinol. Metab. 1998, 83:4006-4012.
52. Tetel M.J. Nuclear receptor coactivators: essential players for steroid hormone action in the brain and in behaviour. J. Neuroendocrinol. 2009, 21:229-237.
53. Tetel M.J., Auger A.P., Charlier T.D. Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior. Front. Neuroendocrinol. 2009, 30:328-342.
54. Truitt W., Harrison L., Guptarak J., White S., Hiegel C., Uphouse L. Progesterone attenuates the effect of the 5-HT1A receptor agonist, 8-OH-DPAT, and of mild restraint on lordosis behavior. Brain Res. 2003, 974:202-211.
55. Uphouse L., Caldarola-Pastuszka M., Montanez S. Intracerebral actions of the 5-HT1A agonists, 8-OH-DPAT and buspirone and of the 5-HT1A partial agonist/antagonist, NAN-190, on female sexual behavior. Neuropharmacology 1992, 31:969-981.
56. Uphouse L., Hiegel C., Perez E., Guptarak J. Serotonin receptor involvement in effects of restraint on female rat lordosis behavior. Pharmacol. Biochem. Behav. 2007, 86:631-636.
57. White S., Uphouse L. Estrogen and progesterone dose-dependently reduce disruptive effects of restraint on lordosis behavior. Horm. Behav. 2004, 45:201-208.
58. Zar J. Biostatistical Analysis 1999, Prentice Hall, Englewood Cliffs, New Jersey.
59. Zhang S., Jonklaas J., Danielsen M. The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids 2007, 72:600-608.
60. Zheng P. Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Prog. Neurobiol. 2009, 89:134-152.