Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase

Journal of Biological Chemistry

Volumn 286, Issue 26, 2011, Pages 23044-23053

  Makarova, Anastasia M ^a   Lebedeva, Tatiana V ^a   Nassar, Taher ^b   Higazi, Abd Al Roof ^a,b   Xue, Jing ^a,c   Carinato, Maria E ^a   Bdeir, Khalil ^a   Cines, Douglas B ^a   Stepanova, Victoria ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c TIANJIN HUANHU HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LUNG INJURY; AIRWAY REMODELING; DENSITY LIPOPROTEINS; ENDOTHELIAL BARRIERS; ENDOTHELIAL PERMEABILITY; IN-VITRO; IN-VIVO; LOW DENSITY LIPOPROTEINS; METHYL ESTERS; MICROVASCULAR; MICROVASCULAR ENDOTHELIAL CELLS; NITRIC-OXIDE SYNTHASE; PROTEIN KINASE A; PULMONARY EDEMA; RECEPTOR-ASSOCIATED PROTEINS; UROKINASE PLASMINOGEN ACTIVATORS (UPA); UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA); VE-CADHERIN;

AMINO ACIDS; BIOLOGICAL ORGANS; BLOOD VESSELS; CHEMICAL ACTIVATION; ENZYME INHIBITION; MONOLAYERS; PHOSPHORYLATION; PROTEINS; PULMONARY DISEASES;

ENDOTHELIAL CELLS;

BETA CATENIN; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MONOCLONAL ANTIBODY; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; UROKINASE; UROKINASE RECEPTOR; VASCULAR ENDOTHELIAL CADHERIN;

ACUTE LUNG INJURY; AIRWAY REMODELING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBRINOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG BLOOD VESSEL; MICROVASCULAR ENDOTHELIAL CELL; MONOLAYER CULTURE; MOUSE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ACUTE LUNG INJURY; ANIMALS; BLOOD-AIR BARRIER; CAPILLARY PERMEABILITY; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; FIBRINOLYSIS; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; MICE; MICE, KNOCKOUT; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; PULMONARY EDEMA; RESPIRATORY MUCOSA; SERPIN E2; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 79959537562     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.210195     Document Type: Article

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