Prevalence and risk factors of cardiovascular disease (CVD) events among patients with haemophilia: Experience of a single haemophilia treatment centre in the United States (US)

Haemophilia

Volumn 17, Issue 4, 2011, Pages 597-604

  Sharathkumar, A A ^a,b   Soucie, J M ^c   Trawinski, B ^a   Greist, A ^a   Shapiro, A D ^a  

^a INDIANA HEMOPHILIA AND THROMBOSIS CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Cardiovascular disease; Haemophilia A; Haemophilia B

Indexed keywords

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COHORT ANALYSIS; CORONARY ARTERY DISEASE; DIABETES MELLITUS; HEART INFARCTION; HEMOPHILIA A; HEMOPHILIA B; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBESITY; PREVALENCE; PRIORITY JOURNAL; SMOKING; STROKE; UNITED STATES;

ADULT; AGED; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; HEMOPHILIA A; HEMOPHILIA B; HUMANS; LOGISTIC MODELS; MIDDLE AGED; PREVALENCE; RISK FACTORS; UNITED STATES;

EID: 79959520082     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2010.02463.x     Document Type: Article

References (42)

1. Rosamond W, Flegal K, Friday G et al. Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007; 115: e69-171.
2. Rosamond W, Flegal K, Furie K et al. Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008; 117: e25-146.
3. Darby SC, Kan SW, Spooner RJ et al. Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood 2007; 110: 815-25.
4. Plug I, Van Der Bom JG, Peters M et al. Mortality and causes of death in patients with hemophilia, 1992-2001: a prospective cohort study. J Thromb Haemost 2006; 4: 510-6.
5. Jones PK, Ratnoff OD. The changing prognosis of classic hemophilia (factor VIII "deficiency"). Ann Interna Med 1991; 114: 641-8.
6. Mannucci PM, Schutgens RE, Santagostino E et al. How I treat age-related morbidities in elderly persons with hemophilia. Blood 2009; 114: 5256-63.
7. Girolami A, Randi ML, Ruzzon E, Zanon E, Girolami B. Myocardial infarction, other arterial thrombosis and invasive coronary procedures, in hemaophilia B: a critical evaluation of reported cases. J Thromb Thrombolysis 2005; 20: 43-6.
8. Girolami A, Ruzzon E, Fabris F, Varvarikis C, Sartori R, Girolami B. Myocardial infarction and other arterial occlusions in hemophilia A patients. A cardiological evaluation of all 42 cases reported in the literature. Acta Haematol 2006; 116: 120-5.
9. Soucie JM, Nuss R, Evatt B et al. Mortality among males with hemophilia: relations with source of medical care. The Hemophilia Surveillance System Project Investigators. Blood 2000; 96: 437-42.
10. Street A, Hill K, Sussex B, Warner M, Scully MF. Haemophilia and ageing. Haemophilia 2006; 12(Suppl. 3): 8-12.
11. Tuinenburg A, Mauser-Bunschoten EP, Verhaar MC, Biesma DH, Schutgens RE. Cardiovascular disease in participants with hemophilia. J Thromb Haemost 2009; 7: 247-54.
12. Konkle B, Kessler C, Aledort L et al. Emerging clinical concerns in the aging haemophilia participant. Haemophilia 2009; 15: 1197-209.
13. Kulkarni R, Soucie JM, Evatt BL. Prevalence and risk factors for heart disease among males with hemophilia. Am J Hematol 2005; 79: 36-42.
14. Chorba TL, Holman RC, Clarke MJ, Evatt BL. Effects of HIV infection on age and cause of death for persons with hemophilia A in the United States. Am J Hematol 2001; 66: 229-40.
15. Aytaman A, McFarlane SI, Aytaman A, McFarlane SI. Hepatitis C and the risk of cardiovascular disease: an evolving epidemic? Expert Rev Cardiovasc Ther 2006; 4: 439-42.
16. Freiberg MS, Cheng DM, Kraemer KL et al. The association between hepatitis C infection and prevalent cardiovascular disease among HIV-infected individuals. AIDS 2007; 21: 193-7.
17. Goodnough LT, Saito H, Ratnoff OD. Thrombosis or myocardial infarction in congenital clotting factor abnormalities and chronic thrombocytopenias: a report of 21 patients and a review of 50 previously reported cases. Medicine 1983; 62: 248-55.
18. Wong ND, Wong ND. Metabolic syndrome: cardiovascular risk assessment and management. Am J Cardiovasc Drugs 2007; 7: 259-72.
19. Pai JK, Pischon T, Ma J et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 2004; 351: 2599-610.
20. Lloyd-Jones D, Adams R, Carnethon M et al. Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119: e21-181.
21. World Health Organization. (PDF). Technical report series 894: Obesity: preventing and managing the global epidemic. Geneva: World Health Organization, 2000. ISBN 92-4-120894-5.
22. Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: US Department of Health and Human Services, Centers for Disease Control and Prevention, 20052006.
23. Foley CJ, Nichols L, Jeong K, Moore CG, Ragni MV. Coronary atherosclerosis and cardiovascular mortality in hemophilia. J Thromb Haemost 2010; 8: 208-11.
24. Walsh M, Macgregor D, Stuckless S, Barrett B, Kawaja M, Scully MF. Health-related quality of life in a cohort of adult participants with mild hemophilia A. J Thromb Haemost 2008; 6: 755-61.
25. Gerberding JC, Crudder SO, Soucie JM. The Report on the Universal Data Collection Program. Atlanta, Georgia: Division of Hereditary Blood Disorders, National Center on Birth Defects and Development Disabilities, Centers for Disease Control and Prevention, 2005.
26. Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003-2006. JAMA 2008; 299: 2401-5.
27. Hofstede FG, Fijnvandraat K, Plug I, Kamphuisen PW, Rosendaal FR, Peters M. Obesity: a new disaster for haemophilic patients? A nationwide survey. Haemophilia 2008; 14: 1035-8.
28. Kenchaiah S, Evans JC, Levy D et al. Obesity and the risk of heart failure. N Engl J Med 2002; 347: 305-13.
29. Meigs JB, Wilson PWF, Fox CS et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006; 91: 2906-12.
30. Wilson PW. Diabetes mellitus and coronary heart disease. Endocrinol Metab Clin North Am 2001; 30: 857-81.
31. Wilson PWF, Kannel WB. Obesity, diabetes, and risk of cardiovascular disease in the elderly. Am J Geriatr Cardiol 2002; 11: 119-23.
32. Kavey RE, Daniels SR, Lauer RM et al. American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. Circulation 2003; 107: 1562-6.
33. Morris PJ, Morris PJ. Physical activity recommendations for children and adolescents with chronic disease. Curr Sports Med Rep 2008; 7: 353-8.
34. Rosendaal FR, Briet E, Stibbe J et al. Haemophilia protects against ischaemic heart disease: a study of risk factors. Br J Haematol 1990; 75: 525-30.
35. Rosendaal FR, Varekamp I, Smit C et al. Mortality and causes of death in Dutch haemophiliacs, 1973-86. Br J Haematol 1989; 71: 71-6.
36. Triemstra M, Rosendaal FR, Smit C, Van der Ploeg HM, Briet E. Mortality in patients with hemophilia. Changes in a Dutch population from 1986 to 1992 and 1973 to 1986. Ann Intern Med 1995; 123: 823-7.
37. Smith Sehdev AE, Hutchins GM. Problems with proper completion and accuracy of the cause-of-death statement. Arch of Intern Med 2001; 161: 277-84.
38. Khallou-Laschet J, Caligiuri G, Tupin E et al. Role of the intrinsic coagulation pathway in atherogenesis assessed in hemophilic apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2005; 25: e123-6.
39. Sramek A, Reiber JH, Gerrits WB, Rosendaal FR. Decreased coagulability has no clinically relevant effect on atherogenesis: observations in individuals with a hereditary bleeding tendency. Circulation 2001; 104: 762-7.
40. Medical and Scientific Advisory Council of the National Hemophilia Foundation. Recommendation #132 - Standards and Criteria for the Care of Persons with Congenital Bleeding Disorders (Revised April 2002). Available at: .
41. Redberg RF, Benjamin EJ, Bittner V et al. ACCF/AHA 2009 performance measures for primary prevention of cardiovascular disease in adults: a report of the American College of Cardiology Foundation/American Heart Association task force on performance measures (writing committee to develop performance measures for primary prevention of cardiovascular disease): developed in collaboration with the American Academy of Family Physicians; American Association of Cardiovascular and Pulmonary Rehabilitation; and Preventive Cardiovascular Nurses Association: endorsed by the American College of Preventive Medicine, American College of Sports Medicine, and Society for Women's Health Research. Circulation 2009; 120: 1296-336.
42. Eyre H, Kahn R, Robertson RM et al. Preventing cancer, cardiovascular disease, and diabetes: a common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association. Diabetes Care 2004; 27: 1812-24.