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Volumn 13, Issue SUPPL. B, 2011, Pages

Aldosterone blockade: Current research and future trends

Author keywords

Aldosterone blocker; Atrial fibrillation; Eplerenone; Heart failure; Hypertension; Research trends

Indexed keywords

ALDOSTERONE; ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; BR 4628; CALCIUM CHANNEL BLOCKING AGENT; CANRENOIC ACID; CATION EXCHANGE RESIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; FAD 286; LCL 699; MINERALOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR BLOCKING AGENT; OXYGENASE INHIBITOR; PF 03882845; PLACEBO; POLYMER; RECEPTOR BLOCKING AGENT; RLY 5016; SPIRONOLACTONE; UNCLASSIFIED DRUG;

EID: 79959516061     PISSN: 1520765X     EISSN: 15542815     Source Type: Journal    
DOI: 10.1093/eurheartj/sur005     Document Type: Article
Times cited : (8)

References (39)
  • 3
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • DOI 10.1056/NEJM199909023411001
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341:709-717. (Pubitemid 29407370)
    • (1999) New England Journal of Medicine , vol.341 , Issue.10 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 5
    • 65449189741 scopus 로고    scopus 로고
    • Effect of aldosterone antagonism on exercise tolerance, Doppler diastolic function, and quality of life in older women with diastolic heart failure
    • Daniel KR, Wells G, Stewart K, Moore B, Kitzman DW. Effect of aldosterone antagonism on exercise tolerance, Doppler diastolic function, and quality of life in older women with diastolic heart failure. Congest Heart Fail 2009;15:68-74.
    • (2009) Congest Heart Fail , vol.15 , pp. 68-74
    • Daniel, K.R.1    Wells, G.2    Stewart, K.3    Moore, B.4    Kitzman, D.W.5
  • 6
    • 77955444052 scopus 로고    scopus 로고
    • Rationale and design of the aldosterone receptor blockade in diastolic heart failure trial: A double-blind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in patients with symptomatic diastolic heart failure (Aldo-DHF)
    • Edelmann F, Schmidt AG, Gelbrich G, Binder L, Herrmann-Lingen C, Halle M, Hasenfuss G, Wachter R, Pieske B. Rationale and design of the aldosterone receptor blockade in diastolic heart failure trial: a double-blind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in patients with symptomatic diastolic heart failure (Aldo-DHF). Eur J Heart Fail 2010;12:874-882.
    • (2010) Eur J Heart Fail , vol.12 , pp. 874-882
    • Edelmann, F.1    Schmidt, A.G.2    Gelbrich, G.3    Binder, L.4    Herrmann-Lingen, C.5    Halle, M.6    Hasenfuss, G.7    Wachter, R.8    Pieske, B.9
  • 7
    • 0033513989 scopus 로고    scopus 로고
    • Potentially high prevalence of primary aldosteronism in a primary-care population
    • Lim PO, Rodgers P, Cardale K, Watson AD, MacDonald TM. Potentially high prevalence of primary aldosteronism in a primary-care population. Lancet 1999;353:40. (Pubitemid 29037708)
    • (1999) Lancet , vol.353 , Issue.9146 , pp. 40
    • Lim, P.O.1    Rodgers, P.2    Cardale, K.3    Watson, A.D.4    MacDonald, T.M.5
  • 8
    • 0036898286 scopus 로고    scopus 로고
    • Hyperaldosteronism among black and white subjects with resistant hypertension
    • DOI 10.1161/01.HYP.0000040261.30455.B6
    • Calhoun DA, Nishizaka MK, Zaman MA, Thakkar RB, Weissmann P. Hyperaldosteronism among black and white subjects with resistant hypertension. Hypertension 2002;40:892-896. (Pubitemid 35434912)
    • (2002) Hypertension , vol.40 , Issue.6 , pp. 892-896
    • Calhoun, D.A.1    Nishizaka, M.K.2    Zaman, M.A.3    Thakkar, R.B.4    Weissmann, P.5
  • 11
    • 77952395275 scopus 로고    scopus 로고
    • Plasma aldosterone levels are associated with increased cardiovascular mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study
    • Tomaschitz A, Pilz S, Ritz E, Meinitzer A, Boehm BO, Marz W. Plasma aldosterone levels are associated with increased cardiovascular mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Eur Heart J 2010;31:1237-1247.
    • (2010) Eur Heart J , vol.31 , pp. 1237-1247
    • Tomaschitz, A.1    Pilz, S.2    Ritz, E.3    Meinitzer, A.4    Boehm, B.O.5    Marz, W.6
  • 12
    • 0142085752 scopus 로고    scopus 로고
    • Effects of Eplerenone, Enalapril, and Eplerenone/Enalapril in Patients With Essential Hypertension and Left Ventricular Hypertrophy: The 4E-Left Ventricular Hypertrophy Study
    • DOI 10.1161/01.CIR.0000091405.00772.6E
    • Pitt B, Reichek N, Willenbrock R, Zannad F, Phillips RA, Roniker B, Kleiman J, Krause S, Burns D, Williams GH. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003;108:1831-1838. (Pubitemid 37296092)
    • (2003) Circulation , vol.108 , Issue.15 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3    Zannad, F.4    Phillips, R.A.5    Roniker, B.6    Kleiman, J.7    Krause, S.8    Burns, D.9    Williams, G.H.10
  • 13
    • 0038673178 scopus 로고    scopus 로고
    • Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension
    • DOI 10.1161/01.HYP.0000067463.13172.EA
    • White WB, Duprez D, St Hillaire R, Krause S, Roniker B, Kuse-Hamilton J, Weber MA. Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension. Hypertension 2003;41:1021-1026. (Pubitemid 36548598)
    • (2003) Hypertension , vol.41 , Issue.5 , pp. 1021-1026
    • White, W.B.1    Duprez, D.2    St. Hillaire, R.3    Krause, S.4    Roniker, B.5    Kuse-Hamilton, J.6    Weber, M.A.7
  • 15
    • 0036330671 scopus 로고    scopus 로고
    • Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients
    • DOI 10.1161/01.HYP.0000025146.19104.FE
    • Krum H, Nolly H, Workman D, He W, Roniker B, Krause S, Fakouhi K. Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients. Hypertension 2002;40:117-123. (Pubitemid 34840085)
    • (2002) Hypertension , vol.40 , Issue.2 , pp. 117-123
    • Krum, H.1    Nolly, H.2    Workman, D.3    He, W.4    Roniker, B.5    Krause, S.6    Fakouhi, K.7
  • 16
    • 33845687252 scopus 로고    scopus 로고
    • High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction
    • DOI 10.1161/CIRCULATIONAHA.106.634626, PII 0000301720061212000009
    • Beygui F, Collet JP, Benoliel JJ, Vignolles N, Dumaine R, Barthelemy O, Montalescot G. High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction. Circulation 2006;114: 2604-2610. (Pubitemid 44967343)
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2604-2610
    • Beygui, F.1    Collet, J.-P.2    Benoliel, J.-J.3    Vignolles, N.4    Dumaine, R.5    Barthelemy, O.6    Montalescot, G.7
  • 17
    • 60749110418 scopus 로고    scopus 로고
    • Aldosterone blockade and left ventricular dysfunction: A systematic review of randomized clinical trials
    • Ezekowitz JA, McAlister FA. Aldosterone blockade and left ventricular dysfunction: a systematic review of randomized clinical trials. Eur Heart J 2009;30:469-477.
    • (2009) Eur Heart J , vol.30 , pp. 469-477
    • Ezekowitz, J.A.1    McAlister, F.A.2
  • 18
    • 62949146402 scopus 로고    scopus 로고
    • Aldosterone and long-term outcome after myocardial infarction: A substudy of the French nationwide Observatoire sur la Prise en charge hospitaliere lEvolution a un an et les caRacteristiques de patients presentant un infArctus du myocarde avec ou sans onde Q (OPERA) study
    • Beygui F, Montalescot G, Vicaut E, Rouanet S, Van Belle E, Baulac C, Degrandsart A, Dallongeville J. Aldosterone and long-term outcome after myocardial infarction: a substudy of the French nationwide Observatoire sur la Prise en charge hospitaliere, lEvolution a un an et les caRacteristiques de patients presentant un infArctus du myocarde avec ou sans onde Q (OPERA) study. Am Heart J 2009;157: 680-687.
    • (2009) Am Heart J , vol.157 , pp. 680-687
    • Beygui, F.1    Montalescot, G.2    Vicaut, E.3    Rouanet, S.4    Van Belle, E.5    Baulac, C.6    Degrandsart, A.7    Dallongeville, J.8
  • 20
    • 0035168937 scopus 로고    scopus 로고
    • Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction
    • DOI 10.1067/mhj.2001.111258
    • Modena MG, Aveta P, Menozzi A, Rossi R. Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction. Am Heart J 2001;141:41-46. (Pubitemid 32061310)
    • (2001) American Heart Journal , vol.141 , Issue.1 , pp. 41-46
    • Modena, M.G.1    Aveta, P.2    Menozzi, A.3    Rossi, R.4
  • 21
    • 77957955333 scopus 로고    scopus 로고
    • Rationale for an early aldosterone blockade in acute myocardial infarction and design of the ALBATROSS trial
    • Beygui F, Vicaut E, Ecollan P, Machecourt J, Van Belle E, Zannad F, Montalescot G. Rationale for an early aldosterone blockade in acute myocardial infarction and design of the ALBATROSS trial. Am Heart J 2010;160:642-648.
    • (2010) Am Heart J , vol.160 , pp. 642-648
    • Beygui, F.1    Vicaut, E.2    Ecollan, P.3    MacHecourt, J.4    Van Belle, E.5    Zannad, F.6    Montalescot, G.7
  • 22
    • 0035887191 scopus 로고    scopus 로고
    • Effect of successful electrical cardioversion on serum aldosterone in patients with persistent atrial fibrillation
    • DOI 10.1016/S0002-9149(01)01905-1, PII S0002914901019051
    • Goette A, Hoffmanns P, Enayati W, Meltendorf U, Geller JC, Klein HU. Effect of successful electrical cardioversion on serum aldosterone in patients with persistent atrial fibrillation. Am J Cardiol 2001;88: 906-909, A908. (Pubitemid 32995932)
    • (2001) American Journal of Cardiology , vol.88 , Issue.8 , pp. 906-909
    • Goette, A.1    Hoffmanns, P.2    Enayati, W.3    Meltendorf, U.4    Geller J.Christoph5    Klein, H.U.6
  • 25
    • 0030809598 scopus 로고    scopus 로고
    • Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion
    • DOI 10.1016/S0008-6363(97)00097-7, PII S0008636397000977
    • Sun Y, Ramires FJ, Weber KT. Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion. Cardiovasc Res 1997;35:138-147. (Pubitemid 27374751)
    • (1997) Cardiovascular Research , vol.35 , Issue.1 , pp. 138-147
    • Sun, Y.1    Ramires, F.J.A.2    Weber, K.T.3
  • 26
    • 77957606840 scopus 로고    scopus 로고
    • Effects of selective mineralocorticoid receptor antagonism on atrial ion currents and early ionic tachycardia-induced electrical remodelling in rabbits
    • Laszlo R, Bentz K, Konior A, Eick C, Schreiner B, Kettering K, Schreieck J. Effects of selective mineralocorticoid receptor antagonism on atrial ion currents and early ionic tachycardia-induced electrical remodelling in rabbits. Naunyn Schmiedebergs Arch Pharmacol 2010;382:347-356.
    • (2010) Naunyn Schmiedebergs Arch Pharmacol , vol.382 , pp. 347-356
    • Laszlo, R.1    Bentz, K.2    Konior, A.3    Eick, C.4    Schreiner, B.5    Kettering, K.6    Schreieck, J.7
  • 27
    • 73549118782 scopus 로고    scopus 로고
    • Agents with antialdosterone properties should be the preferred diuretics for reducing hypertension related atrial fibrillation
    • Jolobe OM. Agents with antialdosterone properties should be the preferred diuretics for reducing hypertension related atrial fibrillation. Eur J Intern Med 2010;21:55.
    • (2010) Eur J Intern Med , vol.21 , pp. 55
    • Jolobe, O.M.1
  • 28
    • 34247157767 scopus 로고    scopus 로고
    • Spironolactone Reduced Arrhythmia and Maintained Magnesium Homeostasis in Patients With Congestive Heart Failure
    • DOI 10.1016/j.cardfail.2006.11.015, PII S1071916406012589
    • Gao X, Peng L, Adhikari CM, Lin J, Zuo Z. Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure. J Card Fail 2007;13:170-177. (Pubitemid 46591953)
    • (2007) Journal of Cardiac Failure , vol.13 , Issue.3 , pp. 170-177
    • Gao, X.1    Peng, L.2    Adhikari, C.M.3    Lin, J.4    Zuo, Z.5
  • 29
    • 2342511544 scopus 로고    scopus 로고
    • Vascular synthesis of aldosterone: Role in hypertension
    • DOI 10.1016/j.mce.2003.10.012, PII S0303720703003836
    • Takeda Y. Vascular synthesis of aldosterone: role in hypertension. Mol Cell Endocrinol 2004;217:75-79. (Pubitemid 38596631)
    • (2004) Molecular and Cellular Endocrinology , vol.217 , Issue.1-2 , pp. 75-79
    • Takeda, Y.1
  • 30
    • 77953749176 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: Comparison with the 11beta-hydroxylase inhibitor metyrapone
    • Rigel DF, Fu F, Beil M, Hu CW, Liang G, Jeng AY. Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. J Pharmacol Exp Ther 2010;334:232-243.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 232-243
    • Rigel, D.F.1    Fu, F.2    Beil, M.3    Hu, C.W.4    Liang, G.5    Jeng, A.Y.6
  • 31
    • 64949189157 scopus 로고    scopus 로고
    • Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
    • Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown NJ. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int 2009;75:936-944.
    • (2009) Kidney Int , vol.75 , pp. 936-944
    • Lea, W.B.1    Kwak, E.S.2    Luther, J.M.3    Fowler, S.M.4    Wang, Z.5    Ma, J.6    Fogo, A.B.7    Brown, N.J.8
  • 33
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with LCI699: A proof-of-concept study in patients with primary aldosteronism
    • Amar L, Azizi M, Menard J, Peyrard S, Watson C, Plouin PF. Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 2010;56: 831-838.
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3    Peyrard, S.4    Watson, C.5    Plouin, P.F.6
  • 35
    • 79959528137 scopus 로고    scopus 로고
    • New oral potassium binder lowers potassium levels in patients with heart failure and heart failure with chronic kidney disease
    • Stockholm, Sweden, August 28-September 1
    • Montalescot G. New oral potassium binder lowers potassium levels in patients with heart failure and heart failure with chronic kidney disease. Presented at: European Society of Cardiology, Stockholm, Sweden, August 28-September 1, 2010.
    • (2010) European Society of Cardiology
    • Montalescot, G.1
  • 36
    • 53549085406 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 2008;10:933-989.
    • (2008) Eur J Heart Fail , vol.10 , pp. 933-989
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3    McMurray, J.J.4    Ponikowski, P.5    Poole-Wilson, P.A.6    Stromberg, A.7    Van Veldhuisen, D.J.8    Atar, D.9    Hoes, A.W.10    Keren, A.11    Mebazaa, A.12    Nieminen, M.13    Priori, S.G.14    Swedberg, K.15
  • 37
    • 65549154913 scopus 로고    scopus 로고
    • 2009 focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation
    • Jessup M, Abraham WT, Casey DE, Feldman AM, Francis GS, Ganiats TG, Konstam MA, Mancini DM, Rahko PS, Silver MA, Stevenson LW, Yancy CW. 2009 focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009;119:1977-2016.
    • (2009) Circulation , vol.119 , pp. 1977-2016
    • Jessup, M.1    Abraham, W.T.2    Casey, D.E.3    Feldman, A.M.4    Francis, G.S.5    Ganiats, T.G.6    Konstam, M.A.7    Mancini, D.M.8    Rahko, P.S.9    Silver, M.A.10    Stevenson, L.W.11    Yancy, C.W.12
  • 38
    • 57349189353 scopus 로고    scopus 로고
    • Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology
    • ESC Committee for Practice Guidelines (CPG)
    • Van de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C, Crea F, Falk V, Fillippatos G, Fox K, Huber K, Kastrati A, Rosengren A, Steg PG, Tubaro M, Verheugt F, Weidinger F, Weis M; ESC Committee for Practice Guidelines (CPG). Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008; 29:2909-2945.
    • (2008) Eur Heart J , vol.29 , pp. 2909-2945
    • Van De Werf, F.1    Bax, J.2    Betriu, A.3    Blomstrom-Lundqvist, C.4    Crea, F.5    Falk, V.6    Fillippatos, G.7    Fox, K.8    Huber, K.9    Kastrati, A.10    Rosengren, A.11    Steg, P.G.12    Tubaro, M.13    Verheugt, F.14    Weidinger, F.15    Weis, M.16
  • 39
    • 34547772153 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary sydromes
    • Task Force for Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of European Society of Cardiology
    • Task Force for Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of European Society of Cardiology, Bassard JP, Hamm CW, Ardissino D, Boersma E, Budaj A, Fernández-Avilés F, Fox KA, Hasdai D, Ohman EM, Wallentin L, Wihns W. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary sydromes. Eur Heart J 2007;28:1598-1660.
    • (2007) Eur Heart J , vol.28 , pp. 1598-1660
    • Bassard Jp, H.1


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