Solid-phase synthesis, thermal denaturation studies, nuclease resistance, and cellular uptake of (oligodeoxyribonucleoside)methylborane phosphine-DNA chimeras

Journal of the American Chemical Society

Volumn 133, Issue 25, 2011, Pages 9844-9854

  Krishna, Heera ^a   Caruthers, Marvin H ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE; BINDING AFFINITIES; CELLULAR UPTAKE; COMPLEMENTARY STRAND; GENE SILENCING; HELA CELL; LOW TOXICITY; MEMBRANE PERMEABILITY; METHYLPHOSPHONATES; NONIONIC; OLIGODEOXYNUCLEOTIDES; PHOSPHONATES; PHYSIOLOGICAL SALINE; POSITIVELY CHARGED; SALT CONCENTRATION; SOLID PHASE SYNTHESIS; THERMAL DENATURATIONS;

BINDING ENERGY; DNA; GENES; GENETIC ENGINEERING; PYROLYSIS; RNA;

PHOSPHORUS COMPOUNDS;

BORANE DERIVATIVE; CARBON; EXODEOXYRIBONUCLEASE III; EXODEOXYRIBONUCLEASE V; METHYLBORANE PHOSPHINE; NUCLEASE; OLIGODEOXYNUCLEOTIDE; PHOSPHATE; PHOSPHORUS; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL TRANSPORT; CHEMICAL BOND; DENATURATION; DRUG UPTAKE; ENZYME STABILITY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; SOLID PHASE SYNTHESIS;

BORANES; CELL LINE; CELL MEMBRANE PERMEABILITY; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA; HUMANS; NUCLEIC ACID HYBRIDIZATION; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959506574     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201314q     Document Type: Article

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