Nasal immunization with attenuated Salmonella Typhimurium expressing an MrpA-TetC fusion protein significantly reduces Proteus mirabilis colonization in the mouse urinary tract

Journal of Medical Microbiology

Volumn 60, Issue 7, 2011, Pages 899-904

  Scavone, Paola ^a   Umpiérrez, Ana ^a   Maskell, Duncan J ^b   Zunino, Pablo ^a  

^a INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; LIVE VACCINE; MRPA TETC FUSION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIOPHAGE; BLADDER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IN VIVO STUDY; KIDNEY; MOUSE; MUTANT; NASAL IMMUNIZATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEUS MIRABILIS; SALMONELLA TYPHIMURIUM; URINARY TRACT;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; PROTEUS INFECTIONS; PROTEUS MIRABILIS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SALMONELLA TYPHIMURIUM; URINARY TRACT INFECTIONS; VACCINES, ATTENUATED;

EID: 79959490987     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.030460-0     Document Type: Article

References (24)

1. Bahrani, F. K. & Mobley, H. L. T. (1994). Proteus mirabilis MR/P fimbrial operon: genetic organization, nucleotide sequence, and conditions for expression. J Bacteriol 176, 3412-3419.
2. Bullas, L. R. & Ryu, J. I. (1983). Salmonella typhimurium LT2 strains which are r2 m+ for all three chromosomally located systems of DNA restriction and modification. J Bacteriol 156, 471-474.
3. Bullock, W. O., Fernandez, J. M. & Short, J. M. (1987). XL1-Blue: a high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection. Biotechniques 5, 376-379.
4. Chabalgoity, J. A., Khan, C. M., Nash, A. A. & Hormaeche, C. E. (1996). A Salmonella typhimurium htrA live vaccine expressing multiple copies of a peptide comprising amino acids 8-23 of herpes simplex virus glycoprotein D as a genetic fusion to tetanus toxin fragment C protects mice from herpes simplex virus infection. Mol Microbiol 19, 791-801.
5. Khan, C. M., Villarreal-Ramos, B., Pierce, R. J., Riveau, G., Demarco de Hormaeche, R., McNeill, H., Ali, T., Fairweather, N., Chatfield, S. & other authors (1994). Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella. Proc Natl Acad Sci U S A 91, 11261-11265.
6. Li, X., Lockatell, C. V., Johnson, D. E., Lane, M. C., Warren, J. W. & Mobley, H. L. T. (2004). Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis. Infect Immun 72, 66-75.
7. Mobley, H. L. T. (1997). Vaccines against Escherichia coli and Proteus urinary infections. In New Generation Vaccines, pp. 931-944. Edited by M. M. Levine, G. C. Woodrow, J. B. Kaper & G. S. Cobon. New York: Marcel Dekker.
8. Mobley, H. L. T. & Belas, R. (1995). Swarming and pathogenicity of Proteus mirabilis in the urinary tract. Trends Microbiol 3, 280-284.
9. Nicolle, L. E. (2005). Catheter-related urinary tract infection. Drugs Aging 22, 627-639.
10. Nielubowicz, G. R. & Mobley, H. L. T. (2010). Host-pathogen interactions in urinary tract infection. Nat Rev Urol 7, 430-441.
11. Pellegrino, R., Galvalisi, U., Scavone, P., Sosa, V. & Zunino, P. (2003). Evaluation of Proteus mirabilis structural fimbrial proteins as antigens against urinary tract infections. FEMS Immunol Med Microbiol 36, 103-110.
12. Pickett, T. E., Pasetti, M. F., Galen, J. E., Sztein, M. B. & Levine, M. M. (2000). In vivo characterization of the murine intranasal model for assessing the immunogenicity of attenuated Salmonella enterica serovar Typhi strains as live mucosal vaccines and as live vectors. Infect Immun 68, 205-213.
13. Renegar, K. B., Small, P. A., Jr, Boykins, L. G. & Wright, P. F. (2004). Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract. J Immunol 173, 1978-1986.
14. Roberts, J. A., Fussell, E. N. & Kaack, M. B. (1990). Bacterial adherence to urethral catheters. J Urol 144, 264-269.
15. Roberts, M., Bacon, A., Li, J. & Chatfield, S. (1999). Prior immunity to homologous and heterologous Salmonella serotypes suppresses local and systemic anti-fragment C antibody responses and protection from tetanus toxin in mice immunized with Salmonella strains expressing fragment C. Infect Immun 67, 3810-3815.
16. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
17. Scavone, P., Sosa, V., Pellegrino, R., Galvalisi, U. & Zunino, P. (2004). Mucosal vaccination of mice with recombinant Proteus mirabilis structural fimbrial proteins. Microbes Infect 6, 853-860.
18. Scavone, P., Miyoshi, A., Rial, A., Chabalgoity, A., Langella, P., Azevedo, V. & Zunino, P. (2007). Intranasal immunisation with recombinant Lactococcus lactis displaying either anchored or secreted forms of Proteus mirabilis MrpA fimbrial protein confers specific immune response and induces a significant reduction of kidney bacterial colonisation in mice. Microbes Infect 9, 821-828.
19. Scavone, P., Rial, A., Umpierrez, A., Chabalgoity, A. & Zunino, P. (2009). Effects of the administration of cholera toxin as a mucosal adjuvant on the immune and protective response induced by Proteus mirabilis MrpA fimbrial protein in the urinary tract. Microbiol Immunol 53, 233-240.
20. Stamm, W. E., Martin, S. M. & Bennett, J. V. (1977). Epidemiology of nosocomial infections due to Gram-negative bacilli: aspects relevant to development and use of vaccines. J Infect Dis 136 (Suppl.), S151-S160.
21. Susskind, M. M. & Botstein, D. (1978). Molecular genetics of bacteriophage P22. Microbiol Rev 42, 385-413.
22. Wang, S., Li, Y., Shi, H., Scarpellini, G., Torres-Escobar, A., Roland, K. L. & Curtiss, R., III (2010). Immune responses to recombinant pneumococcal PsaA antigen delivered by a live attenuated Salmonella vaccine. Infect Immun 78, 3258-3271.
23. Warren, J. W., Tenney, J. H., Hoopes, J. M., Muncie, H. L. & Anthony, W. C. (1982). A prospective microbiologic study of bacteriuria in patients with chronic indwelling urethral catheters. J Infect Dis 146, 719-723.
24. Zunino, P., Geymonat, L., Allen, A. G., Legnani-Fajardo, C. & Maskell, D. J. (2000). Virulence of a Proteus mirabilis ATF isogenic mutant is not impaired in a mouse model of ascending urinary tract infection. FEMS Immunol Med Microbiol 29, 137-143.