Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Windahl, Sara H ^a   Andersson, Niklas ^a   Börjesson, Anna E ^a   Swanson, Charlotte ^a   Svensson, Johan ^a   Movérare Skrtic, Sofia ^a   Sjögren, Klara ^a   Shao, Ruijin ^a   Lagerquist, Marie K ^a   Ohlsson, Claes ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; STEROID 5ALPHA REDUCTASE 1; TESTOSTERONE; ISOENZYME; MEMBRANE PROTEIN; MESSENGER RNA; PROLACTIN RECEPTOR; SRD5A1 PROTEIN, MOUSE; STEROID 5ALPHA REDUCTASE;

ANDROGEN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; BONE STRUCTURE; CONTROLLED STUDY; CORTICAL BONE; ENZYME ACTIVITY; ENZYME INACTIVATION; FEMALE; GRIP STRENGTH; MALE; MOUSE; MUSCLE STRENGTH; NONHUMAN; ORCHIECTOMY; TRABECULAR BONE; ANIMAL; BLOOD; BODY WEIGHT; BONE; DRUG EFFECT; ENZYME ACTIVATION; FORELIMB; GENE EXPRESSION PROFILING; GENETICS; HAND STRENGTH; METABOLISM; MOUSE MUTANT; ORGAN SIZE; OVARY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VISCERA;

MUS;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; ANDROGENS; ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; ENZYME ACTIVATION; FEMALE; FORELIMB; GENE EXPRESSION PROFILING; HAND STRENGTH; ISOENZYMES; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE STRENGTH; ORCHIECTOMY; ORGAN SIZE; OVARY; RECEPTORS, PROLACTIN; RNA, MESSENGER; TESTOSTERONE; VISCERA;

EID: 79959487515     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021402     Document Type: Article

References (40)

1. Riggs BL, Khosla S, Melton LJ 3rd, (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23: 279-302.
2. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, et al. (2004) Androgens and bone. Endocr Rev 25: 389-425.
3. Venken K, De Gendt K, Boonen S, Ophoff J, Bouillon R, et al. (2006) Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model. J Bone Miner Res 21: 576-585.
4. Arts J, Kuiper GG, Janssen JM, Gustafsson J-Å, Lowik CW, et al. (1997) Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138: 5067-5070.
5. Nilsson LO, Boman A, Sävendahl L, Grigelioniene G, Ohlsson C, et al. (1999) Demonstration of estrogen receptor-beta immunoreactivity in human growth plate cartilage. J Clin Endocrinol Metab 84: 370-373.
6. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T, (1997) Expression of estrogen receptor beta in rat bone. Endocrinology 138: 4509-4512.
7. Vidal O, Kindblom LG, Ohlsson C, (1999) Expression and localization of estrogen receptor-beta in murine and human bone. J Bone Miner Res 14: 923-929.
8. Windahl SH, Norgård M, Kuiper GG, Gustafsson J-Å, Andersson G, (2000) Cellular distribution of estrogen receptor beta in neonatal rat bone. Bone 26: 117-121.
9. Callewaert F, Venken K, Ophoff J, De Gendt K, Torcasio A, et al. (2009) Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha. FASEB J 23: 232-240.
10. Mellström D, Vandenput L, Mallmin H, Holmberg AH, Lorentzon M, et al. (2008) Older men with low serum estradiol and high serum SHBG have an increased risk of fractures. J Bone Miner Res 23: 1552-1560.
11. Moverare S, Venken K, Eriksson AL, Andersson N, Skrtic S, et al. (2003) Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice. Proc Natl Acad Sci U S A 100: 13573-13578.
12. Sims NA, Clement-Lacroix P, Minet D, Fraslon-Vanhulle C, Gaillard-Kelly M, et al. (2003) A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice. J Clin Invest 111: 1319-1327.
13. Vandenput L, Ohlsson C, (2009) Estrogens as regulators of bone health in men. Nat Rev Endocrinol 5: 437-443.
14. Windahl SH, Vidal O, Andersson G, Gustafsson J-Å, Ohlsson C, (1999) Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice. J Clin Invest 104: 895-901.
15. Deslypere JP, Young M, Wilson JD, McPhaul MJ, (1992) Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene. Mol Cell Endocrinol 88: 15-22.
16. Kaufman M, Pinsky L, (1983) The dissociation of testosterone- and 5 alpha-dihydrotestosterone-receptor complexes formed within cultured human genital skin fibroblasts. J Steroid Biochem 18: 121-125.
17. Kaufman M, Pinsky L, Trifiro M, Lumbroso R, Sabbaghian N, et al. (1993) Kinetic evidence for a unique testosterone-receptor complex in 5 alpha-reductase sufficient genital skin fibroblasts and the effects of 5 alpha-reductase deficiency on its formation. J Steroid Biochem Mol Biol 45: 467-476.
18. Kovacs WJ, Griffin JE, Weaver DD, Carlson BR, Wilson JD, (1984) A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA-binding state. J Clin Invest 73: 1095-1104.
19. Wilson EM, French FS, (1976) Binding properties of androgen receptors. Evidence for identical receptors in rat testis, epididymis, and prostate. J Biol Chem 251: 5620-5629.
20. Mahendroo MS, Cala KM, Hess DL, Russell DW, (2001) Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes. Endocrinology 142: 4652-4662.
21. Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, et al. (2010) SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142: 203-217.
22. Langlois VS, Zhang D, Cooke GM, Trudeau VL, (2010) Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase. Gen Comp Endocrinol 166: 489-497.
23. Russell DW, Wilson JD, (1994) Steroid 5 alpha-reductase: two genes/two enzymes. Annu Rev Biochem 63: 25-61.
24. Stiles AR, Russell DW, (2010) SRD5A3: A surprising role in glycosylation. Cell 142: 196-198.
25. Uemura M, Tamura K, Chung S, Honma S, Okuyama A, et al. (2008) Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci 99: 81-86.
26. Mahendroo MS, Russell DW, (1999) Male and female isoenzymes of steroid 5alpha-reductase. Rev Reprod 4: 179-183.
27. Mahendroo MS, Cala KM, Russell DW, (1996) 5 alpha-reduced androgens play a key role in murine parturition. Mol Endocrinol 10: 380-392.
28. Issa S, Schnabel D, Feix M, Wolf L, Schaefer HE, et al. (2002) Human osteoblast-like cells express predominantly steroid 5alpha-reductase type 1. J Clin Endocrinol Metab 87: 5401-5407.
29. Schweikert HU, Rulf W, Niederle N, Schafer HE, Keck E, et al. (1980) Testosterone metabolism in human bone. Acta Endocrinol (Copenh) 95: 258-264.
30. Van Der Eerden BC, Van De Ven J, Lowik CW, Wit JM, Karperien M, (2002) Sex steroid metabolism in the tibial growth plate of the rat. Endocrinology 143: 4048-4055.
31. Mahendroo MS, Porter A, Russell DW, Word RA, (1999) The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol 13: 981-992.
32. Ohlsson C, Mohan S, Sjogren K, Tivesten Å, Isgaard J, et al. (2009) The role of liver-derived insulin-like growth factor-I. Endocr Rev 30: 494-535.
33. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 95: 2536-2559.
34. Storer TW, Woodhouse L, Magliano L, Singh AB, Dzekov C, et al. (2008) Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men. J Am Geriatr Soc 56: 1991-1999.
35. Olsen NJ, Olson G, Viselli SM, Gu X, Kovacs WJ, (2001) Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 142: 1278-1283.
36. Tivesten Å, Moverare-Skrtic S, Chagin A, Venken K, Salmon P, et al. (2004) Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats. J Bone Miner Res 19: 1833-1839.
37. Mahendroo MS, Cala KM, Landrum DP, Russell DW, (1997) Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess. Mol Endocrinol 11: 917-927.
38. Goodarzi MO, Shah NA, Antoine HJ, Pall M, Guo X, et al. (2006) Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women. J Clin Endocrinol Metab 91: 4085-4091.
39. Vidal O, Lindberg MK, Hollberg K, Baylink DJ, Andersson G, et al. (2000) Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci U S A 97: 5474-5479.
40. Jablonka-Shariff A, Ravi S, Beltsos AN, Murphy LL, Olson LM, (1999) Abnormal estrous cyclicity after disruption of endothelial and inducible nitric oxide synthase in mice. Biol Reprod 61: 171-177.