The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking

Blood

Volumn 117, Issue 23, 2011, Pages 6371-6374

  Fraser, Steven R ^a   Booth, Nuala A ^a   Mutch, Nicola J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ANTIPLASMIN; BLOOD CLOTTING FACTOR 13; DIMER; FIBRIN; NEUTRALIZING ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMER; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR;

ARTICLE; FIBRINOLYSIS; HUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; THROMBUS;

EID: 79959486796     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-02-333203     Document Type: Article

References (20)

1. Mockros LF, Roberts WW, Lorand L. Viscoelastic properties of ligation-inhibited fibrin clots. Biophys Chem. 1974;2(2):164-169.
2. Shen L, Lorand L. Contribution of fibrin stabilization to clot strength. Supplementation of factor XIII-deficient plasma with the purified zymogen. J Clin Invest. 1983;71(5):1336-1341. (Pubitemid 13098922)
3. Anwar R, Miloszewski KJ. Factor XIII deficiency. Br J Haematol. 1999;107(3):468-484.
4. Koseki-Kuno S, Yamakawa M, Dickneite G, Ichinose A. Factor XIII A subunit-deficient mice developed severe uterine bleeding events and subsequent spontaneous miscarriages. Blood. 2003;102(13):4410-4412. (Pubitemid 37494103)
5. Chen R, Doolittle RF. - cross-linking sites in human and bovine fibrin. Biochemistry. 1971;10(24): 4487-4491.
6. McKee PA, Mattock P, Hill RL. Subunit structure of human fibrinogen, soluble fibrin, and crosslinked insoluble fibrin. Proc Natl Acad Sci U S A. 1970;66(3):738-744.
7. Siebenlist KR, Mosesson MW. Progressive crosslinking of fibrin gamma chains increases resistance to fibrinolysis. J Biol Chem. 1994;269(45): 28414-28419. (Pubitemid 24354586)
8. Sakata Y, Aoki N. Significance of cross-linking of alpha 2-plasmin inhibitor to fibrin in inhibition of fibrinolysis and in hemostasis. J Clin Invest. 1982;69(3):536-542. (Pubitemid 12184949)
9. Sakata Y, Aoki N. Cross-linking of alpha 2-plasmin inhibitor to fibrin by fibrin-stabilizing factor. J Clin Invest. 1980;65(2):290-297. (Pubitemid 10159859)
10. Kimura S, Aoki N. Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor. J Biol Chem. 1986; 261(33):15591-15595. (Pubitemid 17208788)
11. Ritchie H, Robbie LA, Kinghorn S, Exley R, Booth NA. Monocyte plasminogen activator inhibitor 2 (PAI-2) inhibits u-PA-mediated fibrin clot lysis and is cross-linked to fibrin. Thromb Haemost. 1999;81(1):96-103. (Pubitemid 29041657)
12. Valnickova Z, Enghild JJ. Human procarboxypeptidase U, or thrombin-activable fibrinolysis inhibitor, is a substrate for transglutaminases. Evidence for transglutaminase-catalyzed crosslinking to fibrin. J Biol Chem. 1998;273(42): 27220-27224. (Pubitemid 28500432)
13. Mutch NJ, Koikkalainen JS, Fraser SR, et al. Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis. J Thromb Haemost. 2010;8(9): 2017-2024.
14. Mutch NJ, Thomas L, Moore NR, Lisiak KM, Booth NA. TAFIa, PAI-1 and alpha2-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots. J Thromb Haemost. 2007;5(4): 812-817. (Pubitemid 46563582)
15. Freund KF, Doshi KP, Gaul SL, et al. Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation. Biochemistry. 1994;33(33):10109-10119. (Pubitemid 24286091)
16. Favier R, Aoki N, de Moerloose P. Congenital alpha(2)-plasmin inhibitor deficiencies: a review. Br J Haematol. 2001;114(1):4-10. (Pubitemid 32702626)
17. Lee KN, Jackson KW, Christiansen VJ, Chung KH, McKee PA. A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion. Blood. 2004;103(10):3783-3788. (Pubitemid 38596296)
18. Ryan EA, Mockros LF, Stern AM, Lorand L. Influence of a natural and a synthetic inhibitor of factor XIIIa on fibrin clot rheology. Biophys J. 1999; 77(5):2827-2836. (Pubitemid 29519525)
19. Ryan EA, Mockros LF, Weisel JW, Lorand L. Structural origins of fibrin clot rheology. Biophys J. 1999;77(5):2813-2826. (Pubitemid 29519524)
20. Tamaki T, Aoki N. Cross-linking of alpha 2-plasmin inhibitor and fibronectin to fibrin by fibrinstabilizing factor. Biochim Biophys Acta. 1981; 661(2):280-286. (Pubitemid 12233437)