Determination of unmetabolized folic acid in human plasma using affinity HPLC

American Journal of Clinical Nutrition

Volumn 94, Issue 1, 2011, Pages

  Kalmbach, Renee ^a   Paul, Ligi ^a   Selhub, Jacob ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLIC ACID;

AFFINITY CHROMATOGRAPHY; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROCHEMICAL DETECTION; ERYTHROCYTE; FOLIC ACID BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; MICROBIOLOGICAL EXAMINATION; SENSITIVITY ANALYSIS; STANDARD; VALIDATION PROCESS; VITAMIN METABOLISM;

CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROCHEMICAL TECHNIQUES; ERYTHROCYTES; FOLIC ACID; HUMANS; MICROBIOLOGICAL TECHNIQUES; TETRAHYDROFOLATES;

EID: 79959486754     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.111.013433     Document Type: Conference Paper

References (23)

1. U.S. Food and Drug Administration. Food standards: amendment of standards of identity for enriched cereal grain products to require addition of folic acid. Final Rule. Federal Register 1996;61:8781-97.
2. Eichholzer M, Tonz O, Zimmermann R. Folic acid: a public-health challenge. Lancet 2006;367:1352-61.
3. Yang Q, Botto LD, Erickson JD, et al. Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation 2006;113:1335-43.
4. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340:1449-54. (Pubitemid 29220543)
5. Choumenkovitch SF, Jacques PF, Nadeau MR, Wilson PW, Rosenberg IH, Selhub J. Folic acid fortification increases red blood cell folate concentrations in the Framingham study. J Nutr 2001;131:3277-80. (Pubitemid 33136149)
6. Lewis CJ, Crane NT, Wilson DB, Yetley EA. Estimated folate intakes: data updated to reflect food fortification, increased bioavailability, and dietary supplement use. Am J Clin Nutr 1999;70:198-207. (Pubitemid 29347564)
7. Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Bio-chemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005;82:442-50.
8. Kelly P, McPartlin J, Goggins M, Weir DG, Scott JM. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr 1997;65:1790-5. (Pubitemid 27240695)
9. Sweeney MR, McPartlin J, Weir DG, Daly L, Scott JM. Postprandial serum folic acid response to multiple doses of folic acid in fortified bread. Br J Nutr 2006;95:145-51. (Pubitemid 43250721)
10. Troen AM, Mitchell B, Sorensen B, et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006;136:189-94. (Pubitemid 43156507)
11. Selhub J, Morris MS, Jacques PF. In vitamin B12 deficiency, higher serum folate is associated with increased total homocyteine and methylmalonic acid concentrations. Proc Natl Acad Sci USA 2007;104:19995-20000.
12. Wright AJ, Dainty JR, Finglas PM. Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK. Br J Nutr 2007;98:667-75. (Pubitemid 47487933)
13. Bagley PJ, Selhub J. Analysis of folate form distribution by affinity followed by reversed- phase chromatography with electrical detection. Clin Chem 2000;46:404-11. (Pubitemid 30152268)
14. Horne DW, Patterson D. Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. Clin Chem 1988;34:2357-9. (Pubitemid 19001275)
15. Tamura T, Freeberg LE, Cornwell PE. Inhibition of EDTA of growth of Lactobacillus casei in the folate microbiological assay and its reversal by added manganese or iron. Clin Chem 1990;36:1993.
16. Poo-Prieto R, Haytowitz DB, Holden JM, et al. Use of the affinity/ HPLC method for quantitative estimation of folic acid in enriched cereal-grain products. J Nutr 2006;136:3079-83. (Pubitemid 44878576)
17. Selhub J. Determination of tissue folate composition by affinity chromatography followed by high-pressure ion pair liquid chromatography. Anal Biochem 1989;182:84-93. (Pubitemid 19251284)
18. Hidiroglou N, Camilo ME, Beckenhauer HC, et al. Effect of chronic alcohol ingestion on hepatic folate distribution in the rat. Biochem Pharmacol 1994;47:1561-6. (Pubitemid 24167267)
19. Selhub J, Seyoum E, Pomfret EA, Zeisel SH. Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution. Cancer Res 1991;51:16-21.
20. Varela-Moreiras G, Selhub J. Long-term folate deficiency alters folate content and distribution differentially in rat tissues. J Nutr 1992;122:986-91.
21. Selhub J, Ahmad O, Rosenberg IH. Preparation and use of affinity columns with bovine milk folate-binding protein (FBP) covalently linked to Sepharose 4B. Methods Enzymol 1980;66:686-90.
22. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 1998;95:13217-20. (Pubitemid 28509551)
23. Ghandour H, Bagley PJ, Shemin D, et al. Distribution of plasma folate forms in hemodialysis patients receiving high daily doses of L-folinic or folic acid. Kidney Int 2002;62:2246-9. (Pubitemid 35366182)