Hypersensitivity to pollen panallergens (profilin and polcalcin) detected in vitro and in vivo: A comparative analysis

Journal of Investigational Allergology and Clinical Immunology

Volumn 21, Issue 4, 2011, Pages 323-324

  Asero, R ^a  

^a CLINICA SAN CARLO   (Italy)

Author keywords

Allergens; Calcium binding protein; Pollen; Profilin

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; POLCALCIN; PROFILIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; AGED; ALLERGIC URTICARIA; AMINO ACID ANALYSIS; ARTICLE; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; IMMUNOASSAY; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; POLLEN ALLERGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRICK TEST; PROTEIN DETERMINATION; PROTEIN PURIFICATION; RESPIRATORY TRACT DISEASE; SCHOOL CHILD; SYMPTOM;

ADOLESCENT; ADULT; AGED; ALLERGENS; ANTIGENS, PLANT; CALCIUM-BINDING PROTEINS; CHILD; FEMALE; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; POLLEN; PROFILINS; RHINITIS, ALLERGIC, SEASONAL; SKIN TESTS; YOUNG ADULT;

EID: 79959482979     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Valenta R, Duchene M, Ebner C, Valent P, Sillaber C, Deviller P, Ferreira F, Tejkl M, Edelmann H, Kraft D, Scheiner O. Profilins constitute a novel family of functional plant pan-allergens. J Exp Med. 1992;175:377-85.
2. Asero R, Jimeno L, Barber D. Preliminary results of a SPT study about prevalence and clinical relevance of hypersensitivity to pollen pan-allergens (polcalcin and profilin). J Invest Allergol Clin Immunol. (In press). 2010;20:35-8.
3. Wopfner N, Dissertori O, Ferreira F, Lackner P. Calcium-binding proteins and their role in allerrgic diseases. Immunol Allergy Clin N Am. 2007;27:29-44.
4. Tinghino R, Twardosz A, Barletta B, Puggioni EM, Iacovacci P, Butteroni C, Afferni C, Mari A, Hayek B, Di Felice G, Focke M, Westritschnig K, Valenta R, Pini C. Molecular, structural, and immunologic relationships between different families of recombinant calcium-binding pollen allergens. J Allergy Clin Immunol. 2002;109:314-20.
5. Asturias J.A., Ibarrola I, Fernandez J, Arilla MC, Gonzalez-Rioja R, Martinez A. Pho d 2, a major allergen from date palm pollen, is a profilin: cloning, sequencing, and immunoglobulin E crossreactivity with other profilins. Clin Exp Allergy. 2005;35:374-81.
6. Barber D, de la Torre F, Lombardero M, Antepara I, Colas C, Dávila I, Tabar AI, Vidal C, Villalba M, Salcedo G, Rodríguez R. Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin, and lipid transfer protein panallergens. Clin Exp Allergy. 2009;39:1764-73.
7. Villalta D, Asero R. Sensitization to the pollen panallergen profilin. Is the detection of IgE to multiple homologous proteins from different sources clinically useful? J Invest Allergology Clin Immunol. (In press)