Mesenchymal progenitor cells and their orthopedic applications: Forging a path towards clinical trials

Stem Cells International

Volumn , Issue , 2010, Pages

  He, Tong Chuan ^a,b,c   Shenaq, Deana S ^a   Rastegar, Farbod ^a   Petkovic, Djuro ^a   Zhang, Bing Qiang ^a,b   He, Bai Cheng ^a,b   Chen, Liang ^a,b   Zuo, Guo Wei ^a,b   Luo, Qing ^a,b,c   Shi, Qiong ^a,b   Wagner, Eric R ^a   Huang, Enyi ^a,d   Gao, Yanhong ^a,e   Gao, Jian Li ^a   Kim, Stephanie H ^a   Yang, Ke ^a,f   Bi, Yang ^a,b,c   Su, Yuxi ^a,b,c   Zhu, Gaohui ^a,b,c   Luo, Jinyong ^a,b   Luo, Xiaoji ^a,b   Qin, Jiaqiang ^a,b,c   Reid, Russell R ^a   Luu, Hue H ^a   Haydon, Rex C ^a   more..

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^d CHONGQING UNIVERSITY   (China)

^e XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^f THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; HYDROXYAPATITE; TISSUE SCAFFOLD;

ADIPOSE DERIVED STEM CELL; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BIOMECHANICS; BONE DISEASE; BONE NECROSIS; BONE REMODELING; CARTILAGE INJURY; CELL EXPANSION; CELL LINEAGE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL (TOPIC); DISEASE SEVERITY; FRACTURE NONUNION; GENETIC ENGINEERING; HUMAN; IMPLANT; ISCHEMIC PRECONDITIONING; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLIC BONE DISEASE; MULTIPOTENT STEM CELL; NONHUMAN; OSTEOARTHRITIS; OSTEOGENESIS IMPERFECTA; PRIORITY JOURNAL; REVIEW; TENDON INJURY; TISSUE ENGINEERING; TISSUE REGENERATION; TISSUE REPAIR; TREATMENT INDICATION;

EID: 79959417336     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.4061/2010/519028     Document Type: Review

References (128)

1. Young H. E., Existence of reserve quiescent stem cells in adults, from amphibians to humans Current Topics in Microbiology and Immunology 2003 280 71 109 (Pubitemid 37157941)
2. Buehr M., Meek S., Blair K., Yang J., Ure J., Silva J., McLay R., Hall J., Ying Q.-L., Smith A., Capture of authentic embryonic stem cells from rat blastocysts Cell 2008 135 7 1287 1298
3. Thomson J. A., Embryonic stem cell lines derived from human blastocysts Science 1998 282 5391 1145 1147 (Pubitemid 28516247)
4. Cho M., Lee E. J., Nam H., Yang J.-H., Cho J., Lim J. M., Lee G., Human feeder layer system derived from umbilical cord stromal cells for human embryonic stem cells Fertility and Sterility 2010 93 8 2525 2531
5. Gepstein L., Derivation and potential applications of human embryonic stem cells Circulation Research 2002 91 10 866 876 (Pubitemid 35373586)
6. Lee A. S., Tang C., Cao F., Xie X., Van Der Bogt K., Hwang A., Connolly A. J., Robbins R. C., Wu J. C., Effects of cell number on teratoma formation by human embryonic stem cells Cell Cycle 2009 8 16 2608 2612
7. Hamilton B., Feng Q., Ye M., Welstead G. G., Generation of induced pluripotent stem cells by reprogramming mouse embryonic fibroblasts with a four transcription factor, doxycycline inducible lentiviral transduction system Journal of Visualized Experiments 2009 33
8. Park I.-H., Zhao R., West J. A., Yabuuchi A., Huo H., Ince T. A., Lerou P. H., Lensch M. W., Daley G. Q., Reprogramming of human somatic cells to pluripotency with defined factors Nature 2008 451 7175 141 146
9. Sommer C. A., Stadtfeld M., Murphy G. J., Hochedlinger K., Kotton D. N., Mostoslavsky G., Induced pluripotent stem cell generation using a single lentiviral stem cell cassette Stem Cells 2009 27 3 543 549
10. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 2007 131 5 861 872 (Pubitemid 350138099)
11. Yu J., Vodyanik M. A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J. L., Tian S., Nie J., Jonsdottir G. A., Ruotti V., Stewart R., Slukvin I. I., Thomson J. A., Induced pluripotent stem cell lines derived from human somatic cells Science 2007 318 5858 1917 1920
12. Lengner C. J., IPS cell technology in regenerative medicine Annals of the New York Academy of Sciences 2010 1192 1 38 44
13. deBarros A. P. D.N., Takiya C. M., Garzoni L. R., Leal-Ferreira M. L., Dutra H. S., Chiarini L. B., Meirelles M. N., Borojevic R., Rossi M. I.D., Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model PLoS ONE 2010 5 2
14. Jiang Y., Jahagirdar B. N., Reinhardt R. L., Schwartz R. E., Keene C. D., Ortiz-Gonzalez X. R., Reyes M., Lenvik T., Lund T., Blackstad M., Du J., Aldrich S., Lisberg A., Low W. C., Lergaespada D. A., Verfaillie C. M., Pluripotency of mesenchymal stem cells derived from adult marrow Nature 2002 418 6893 41 49 (Pubitemid 34742565)
15. Steinhardt Y., Aslan H., Regev E., Zilberman Y., Kallai I., Gazit D., Gazit Z., Maxillofacial-derived stem cells regenerate critical mandibular bone defect Tissue EngineeringPart A 2008 14 11 1763 1773
16. Bab I., Ashton B. A., Gazit D., Marx G., Williamson M. C., Owen M. E., Kinetics and differentiation of marrow stromal cells in diffusion chambers in vivo Journal of Cell Science 1986 84 139 151
17. Castro-Malaspina H., Gay R. E., Resnick G., Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny Blood 1980 56 2 289 301 (Pubitemid 10043431)
18. Dennis J. E., Charbord P., Origin and differentiation of human and murine stroma Stem Cells 2002 20 3 205 214 (Pubitemid 34507437)
19. Kassem M., Kristiansen M., Abdallah B. M., Mesenchymal stem cells: cell biology and potential use in therapy Basic and Clinical Pharmacology and Toxicology 2004 95 5 209 214 (Pubitemid 39564237)
20. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells Science 1999 284 5411 143 147 (Pubitemid 29282067)
21. Wagner W., Wein F., Seckinger A., Frankhauser M., Wirkner U., Krause U., Blake J., Schwager C., Eckstein V., Ansorge W., Ho A. D., Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood Experimental Hematology 2005 33 11 1402 1416 (Pubitemid 41541969)
22. Friedenstein A. J., Petrakova K. V., Kurolesova A. I., Frolova G. P., Heterotopic of bone marrow.Analysis of precursor cells for osteogenic and hematopoietic tissues Transplantation 1968 6 2 230 247
23. Kuznetsov S. A., Mankani M. H., Bianco P., Robey P. G., Enumeration of the colony-forming units-fibroblast from mouse and human bone marrow in normal and pathological conditions Stem Cell Research 2009 2 1 83 94
24. Deng Z.-L., Sharff K. A., Tang N., Song W.-X., Luo J., Luo X., Chen J., Bennett E., Reid R., Manning D., Xue A., Montag A. G., Luu H. H., Haydon R. C., He T.-C., Regulation of osteogenic differentiation during skeletal development Frontiers in Bioscience 2008 13 6 2001 2021 (Pubitemid 351589231)
25. Luu H. H., Song W.-X., Luo X., Manning D., Luo J., Deng Z.-L., Sharff K. A., Montag A. G., Haydon R. C., He T.-C., Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells Journal of Orthopaedic Research 2007 25 5 665 677 (Pubitemid 46730519)
26. Igura K., Zhang X., Takahashi K., Mitsuru A., Yamaguchi S., Takahashi T. A., Isolation and characterization of mesenchymal progenitor cells from chorionic villi of human placenta Cytotherapy 2004 6 6 543 553 (Pubitemid 40028913)
27. Briquet A., Dubois S., Bekaert S., Dolhet M., Beguin Y., Gothot A., Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages Haematologica 2010 95 1 47 56
28. Mankani M. H., Kuznetsov S. A., Robey P. G., Formation of hematopoietic territories and bone by transplanted human bone marrow stromal cells requires a critical cell density Experimental hematology 2007 35 6 995 1004
29. Gtherstrm C., Ringdén O., Tammik C., Zetterberg E., Westgren M., Le Blanc K., Immunologic properties of human fetal mesenchymal stem cells American Journal of Obstetrics and Gynecology 2004 190 1 239 245 (Pubitemid 38156354)
30. Le Blanc K., Frassoni F., Ball L., Locatelli F., Roelofs H., Lewis I., Lanino E., Sundberg B., Bernardo M. E., Remberger M., Dini G., Egeler R. M., Bacigalupo A., Fibbe W., Ringdén O., Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study The Lancet 2008 371 9624 1579 1586 (Pubitemid 351626841)
31. Le Blanc K., Tammik C., Rosendahl K., Zetterberg E., Ringdén O., HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells Experimental Hematology 2003 31 10 890 896 (Pubitemid 37211373)
32. Nauta A. J., Westerhuis G., Kruisselbrink A. B., Lurvink E. G. A., Willemze R., Fibbe W. E., Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting Blood 2006 108 6 2114 2120 (Pubitemid 44395028)
33. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F. C., Krause D. S., Deans R. J., Keating A., Prockop D. J., Horwitz E. M., Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 2006 8 4 315 317 (Pubitemid 44269669)
34. Sorrentino A., Ferracin M., Castelli G., Biffoni M., Tomaselli G., Baiocchi M., Fatica A., Negrini M., Peschle C., Valtieri M., Isolation and characterization of CD146+ multipotent mesenchymal stromal cells Experimental Hematology 2008 36 8 1035 1046
35. Sacchetti B., Funari A., Michienzi S., Di Cesare S., Piersanti S., Saggio I., Tagliafico E., Ferrari S., Robey P. G., Riminucci M., Bianco P., Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment Cell 2007 131 2 324 336 (Pubitemid 47592917)
36. Dazzi F., Ramasamy R., Glennie S., Jones S. P., Roberts I., The role of mesenchymal stem cells in haemopoiesis Blood Reviews 2006 20 3 161 171
37. Kadiyala S., Young R. G., Thiede M. A., Bruder S. P., Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro Cell Transplantation 1997 6 2 125 134 (Pubitemid 27188295)
38. Dos Santos F., Andrade P. Z., Boura J. S., Abecasis M. M., Da Silva C. L., Cabral J. M.S., Ex vivo expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and metabolism under hypoxia Journal of Cellular Physiology 2010 223 1 27 35
39. Prahalad A. K., Hock J. M., Proteomic characteristics of ex vvo-enriched adult human bone marrow mononuclear cells in continuous perfusion cultures Journal of Proteome Research 2009 8 4 2079 2089
40. Hernigou P., Mathieu G., Poignard A., Manicom O., Beaujean F., Rouard H., Percutaneous autologous bone-marrow grafting for nonunions. Surgical technique The Journal of Bone and Joint Surgery A 2006 88 supplement, part 2 322 327
41. Hernigou PH., Poignard A., Beaujean F., Rouard H., Percutaneous autologous bone-marrow grafting for nonunions: influence of the number and concentration of progenitor cells Journal of Bone and Joint Surgery A 2005 87 7 1430 1437 (Pubitemid 40917741)
42. Seeger F. H., Tonn T., Krzossok N., Zeiher A. M., Dimmeler S., Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction European Heart Journal 2007 28 6 766 772 (Pubitemid 46439231)
43. Prockop D. J., Marrow stromal cells as stem cells for nonhematopoietic tissues Science 1997 276 5309 71 74 (Pubitemid 27161245)
44. Tondreau T., Lagneaux L., Dejeneffe M., Delforge A., Massy M., Mortier C., Bron D., Isolation of BM mesenchymal stem cells by plastic adhesion or negative selection: phenotype, proliferation kinetics and differentiation potential Cytotherapy 2004 6 4 372 379 (Pubitemid 39214057)
45. Aslan H., Zilberman Y., Kandel L., Liebergall M., Oskouian R. J., Gazit D., Gazit Z., Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells Stem Cells 2006 24 7 1728 1737 (Pubitemid 44474186)
46. Gronthos S., Zannettino A. C. W., A method to isolate and purify human bone marrow stromal stem cells Methods in Molecular Biology 2008 449 45 57
47. Psaltis P. J., Paton S., See F., Arthur A., Martin S., Itescu S., Worthley S. G., Gronthos S., Zannettino A. C.W., Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations Journal of Cellular Physiology 2010 223 2 530 540
48. Muschler G. F., Midura R. J., Connective tissue progenitors: practical concepts for clinical applications Clinical Orthopaedics and Related Research 2002 395 66 80 (Pubitemid 34136658)
49. Vilquin J. T., Rosset P., Mesenchymal stem cells in bone and cartilage repair: current status Regenerative medicine 2006 1 4 589 604
50. Mankani M. H., Kuznetsov S. A., Marshall G. W., Robey P. G., Creation of new bone by the percutaneous injection of human bone marrow stromal cell and HA/TCP suspensions Tissue EngineeringPart A 2008 14 12 1949 1958
51. Tseng S. S., Lee M. A., Reddi A. H., Nonunions and the potential of stem cells in fracture-healing Journal of Bone and Joint Surgery A 2008 90 supplement 1 92 98 (Pubitemid 351329127)
52. Gundle R., Joyner C. J., Triffitt J. T., Human bone tissue formation in diffusion chamber culture in vivo by bone-derived cells and marrow stromal fibroblastic cells Bone 1995 16 6 597 601
53. Bostrom M., Lane J. M., Tomin E., Browne M., Berberian W., Turek T., Smith J., Wozney J., Schildhauer T., Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model Clinical Orthopaedics and Related Research 1996 327 272 282 (Pubitemid 26174996)
54. Kon E., Muraglia A., Corsi A., Bianco P., Marcacci M., Martin I., Boyde A., Ruspantini I., Chistolini P., Rocca M., Giardino R., Cancedda R., Quarto R., Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones Journal of Biomedical Materials Research 2000 49 3 328 337 (Pubitemid 30030478)
55. Arinzeh T. L., Peter S. J., Archambault M. P., Van Den Bos C., Gordon S., Kraus K., Smith A., Kadiyala S., Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect Journal of Bone and Joint Surgery A 2003 85 10 1927 1935 (Pubitemid 37259728)
56. Kuznetsov S. A., Huang K. E., Marshall G. W., Robey P. G., Mankani M. H., Long-term stable canine mandibular augmentation using autologous bone marrow stromal cells and hydroxyapatite/tricalcium phosphate Biomaterials 2008 29 31 4211 4216
57. Mankani M. H., Kuznetsov S. A., Wolfe R. M., Marshall G. W., Robey P. G., In vivo bone formation by human bone marrow stromal cells: reconstruction of the mouse calvarium and mandible Stem Cells 2006 24 9 2140 2149 (Pubitemid 44477139)
58. Mankani M. H., Kuznetsov S. A., Shannon B., Nalla R. K., Ritchie R. O., Qin Y., Robey P. G., Canine cranial reconstruction using autologous bone marrow stromal cells American Journal of Pathology 2006 168 2 542 550 (Pubitemid 43271152)
59. Quarto R., Mastrogiacomo M., Cancedda R., Kutepov S. M., Mukhachev V., Lavroukov A., Kon E., Marcacci M., Repair of large bone defects with the use of autologous bone marrow stromal cells New England Journal of Medicine 2001 344 5 385 386 (Pubitemid 32107654)
60. Marcacci M., Kon E., Moukhachev V., Lavroukov A., Kutepov S., Quarto R., Mastrogiacomo M., Cancedda R., Stem cells associated with macroporous bioceramics for long bone repair: 6- To 7-year outcome of a pilot clinical study Tissue Engineering 2007 13 5 947 955 (Pubitemid 46870419)
61. Ohgushi H., Miyake J., Tateishi T., W., Mesenchymal stem cells and bioceramics: strategies to regenerate the skeleton Novartis Foundation Symposium 2003 249 118 132 (Pubitemid 41329048)
62. Vacanti C. A., Bonassar L. J., Vacanti M. P., Shufflebarger J., Replacement of an avulsed phalanx with tissue-engineered bone New England Journal of Medicine 2001 344 20 1511 1514 (Pubitemid 32429210)
63. Lendeckel S., Jdicke A., Christophis P., Heidinger K., Wolff J., Fraser J. K., Hedrick M. H., Berthold L., Howaldt H.-P., Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report Journal of Cranio-Maxillofacial Surgery 2004 32 6 370 373 (Pubitemid 40045639)
64. Hibi H., Yamada Y., Kagami H., Ueda M., Distraction osteogenesis assisted by tissue engineering in an irradiated mandible: a case report International Journal of Oral and Maxillofacial Implants 2006 21 1 141 147 (Pubitemid 43350999)
65. Kitoh H., Kitakoji T., Tsuchiya H., Mitsuyama H., Nakamura H., Katoh M., Ishiguro N., Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesisa preliminary result of three cases Bone 2004 35 4 892 898 (Pubitemid 39349220)
66. Ueda M., Yamada Y., Ozawa R., Okazaki Y., Clinical case reports of injectable tissue-engineered bone for alveolar augmentation with simultaneous implant placement International Journal of Periodontics and Restorative Dentistry 2005 25 2 129 137 (Pubitemid 40461508)
67. Marsh D., Concepts of fracture union, delayed union, and nonunion Clinical Orthopaedics and Related Research 1998 355 supplement S22 S30
68. Einhorn T. A., Enhancement of fracture-healing Journal of Bone and Joint Surgery A 1995 77 6 940 956
69. Salama R., Weissman S. L., The clinical use of combined xenografts of bone and autologous red marrow. A preliminary report Journal of Bone and Joint Surgery B 1978 60 1 111 115 (Pubitemid 8298419)
70. Connolly J. F., Guse R., Tiedeman J., Dehne R., Autologous marrow injection as a substitute for operative grafting of tibial nonunions Clinical Orthopaedics and Related Research 1991 266 259 270
71. Connolly J. F., Injectable bone marrow preparations to stimulate osteogenic repair Clinical Orthopaedics and Related Research 1995 313 8 18
72. Garg N. K., Gaur S., Sharma S., Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture Acta Orthopaedica Scandinavica 1993 64 6 671 672 (Pubitemid 24032260)
73. Goel A., Sangwan S. S., Siwach R. C., Ali A. M., Percutaneous bone marrow grafting for the treatment of tibial non-union Injury 2005 36 1 203 206 (Pubitemid 39611330)
74. Maneerit J., Meknavin S., Hanpanitkitkan S., Percutaneous versus open bone grafting in the treatment of tibial fractures: a randomized prospective trial Journal of the Medical Association of Thailand 2004 87 9 1034 1040 (Pubitemid 39361406)
75. Wakitani S., Nawata M., Tensho K., Okabe T., Machida H., Ohgushi H., Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees Journal of Tissue Engineering and Regenerative Medicine 2007 1 1 74 79
76. Wakitani S., Imoto K., Yamamoto T., Saito M., Murata N., Yoneda M., Human autologous culture expanded bone marrow-mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees Osteoarthritis and Cartilage 2002 10 3 199 206 (Pubitemid 34189569)
77. Le Blanc K., Gtherstrm C., Ringdén O., Hassan M., McMahon R., Horwitz E., Anneren G., Axelsson O., Nunn J., Ewald U., Nordén-Lindeberg S., Jansson M., Dalton A., strm E., Westgren M., Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta Transplantation 2005 79 11 1607 1614 (Pubitemid 40847594)
78. Horwitz E. M., Gordon P. L., Koo W. K. K., Marx J. C., Neel M. D., McNall R. Y., Muul L., Hofmann T., Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone Proceedings of the National Academy of Sciences of the United States of America 2002 99 13 8932 8937 (Pubitemid 34693661)
79. Flanigan D. C., Harris J. D., Trinh T. Q., Siston R. A., Brophy R. H., Prevalence of chondral defects in athletes' kneesa systematic review Medicine Science in Sports Exercise 2010 42 10 1795 1801
80. O'Hara B. P., Urban J. P. G., Maroudas A., Influence of cyclic loading on the nutrition of articular cartilage Annals of the Rheumatic Diseases 1990 49 7 536 539 (Pubitemid 20225408)
81. Bedi A., Feeley B. T., Williams 3rd. R. J., Management of articular cartilage defects of the knee The Journal of Bone and Joint Surgery A 2010 92 4 994 1009
82. Brittberg M., Autologous chondrocyte implantation-Technique and long-term follow-up Injury 2008 39 supplement 1 40 49 (Pubitemid 351296056)
83. Minas T., Autologous chondrocyte implantation for focal chondral defects of the knee Clinical Orthopaedics and Related Research 2001 391, supplement S349 S361
84. Horas U., Pelinkovic D., Herr G., Aigner T., Schnettler R., Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial Journal of Bone and Joint Surgery A 2003 85 2 185 192 (Pubitemid 36538777)
85. Erggelet C., Kreuz P. C., Mrosek E. H., Schagemann J. C., Lahm A., Ducommun P. P., Ossendorf C., Autologous chondrocyte implantation versus ACI using 3D-bioresorbable graft for the treatment of large full-thickness cartilage lesions of the knee Archives of Orthopaedic and Trauma Surgery 2009 1 8
86. Kreuz P. C., Mller S., Ossendorf C., Kaps C., Erggelet C., Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results Arthritis Research and Therapy 2009 11 2, article R33
87. Ossendorf C., Kaps C., Kreuz P. C., Burmester G. R., Sittinger M., Erggelet C., Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results Arthritis Research and Therapy 2007 9, article R41
88. Manfredini M., Zerbinati F., Gildone A., Faccini R., Autologous chondrocyte implantation: a comparison between an open periosteal-covered and an arthroscopic matrix-guided technique Acta Orthopaedica Belgica 2007 73 2 207 218
89. Ashton B. A., Allen T. D., Howlett C. R., Eaglesom C. C., Hattori A., Owen M., Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo Clinical Orthopaedics and Related Research 1980 151 294 307
90. Kuroda R., Usas A., Kubo S., Corsi K., Peng H., Rose T., Cummins J., Fu F. H., Huard J., Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells Arthritis and Rheumatism 2006 54 2 433 442 (Pubitemid 43228617)
91. Meyer E. G., Buckley C. T., Thorpe S. D., Kelly D. J., Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression Journal of Biomechanics 2010 43 13 2516 2523
92. Vinardell T., Thorpe S. D., Buckley C. T., Kelly D. J., Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model Annals of Biomedical Engineering 2009 37 12 2556 2565
93. Wakitani S., Mitsuoka T., Nakamura N., Toritsuka Y., Nakamura Y., Horibe S., Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports Cell Transplantation 2004 13 5 595 600 (Pubitemid 39557438)
94. Black L. L., Gaynor J., Gahring D., Adams C., Aron D., Harman S., Gingerich D. A., Harman R., Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial Veterinary Therapeutics 2007 8 4 272 284 (Pubitemid 351419393)
95. Murphy J. M., Fink D. J., Hunziker E. B., Barry F. P., Stem cell therapy in a caprine model of osteoarthritis Arthritis and Rheumatism 2003 48 12 3464 3474 (Pubitemid 37531912)
96. Erices A., Conget P., Minguell J. J., Mesenchymal progenitor cells in human umbilical cord blood British Journal of Haematology 2000 109 1 235 242 (Pubitemid 30340601)
97. Lee O. K., Kuo T. K., Chen W.-M., Lee K.-D., Hsieh S.-L., Chen T.-H., Isolation of multipotent mesenchymal stem cells from umbilical cord blood Blood 2004 103 5 1669 1675 (Pubitemid 38268958)
98. Lee K., Chan C. K., Patil N., Goodman S. B., Cell therapy for bone regeneration-bench to bedside Journal of Biomedical Materials Research-Part B Applied Biomaterials 2009 89 1 252 263
99. Hernigou P., Bernaudin F., Reinert P., Kuentz M., Vernant J. P., Bone-marrow transplantation in sickle-cell disease. Effect on osteonecrosis: a case report with a four-year follow-up Journal of Bone and Joint Surgery A 1997 79 11 1726 1730 (Pubitemid 27508533)
100. Hernigou P., Beaujean F., Treatment of osteonecrosis with autologous bone marrow grafting Clinical Orthopaedics and Related Research 2002 405 14 23 (Pubitemid 36008240)
101. Cabral W. A., Milgrom S., Letocha A. D., Moriarty E., Marini J. C., Biochemical screening of type I collagen in osteogenesis imperfecta: detection of glycine substitutions in the amino end of the alpha chains requires supplementation by molecular analysis Journal of Medical Genetics 2006 43 8 685 690 (Pubitemid 44214907)
102. Galicka A., Wolczynski S., Gindzienski A., Comparative studies of osteoblast and fibroblast type I collagen in a patient with osteogenesis imperfecta type IV Journal of Pathology 2002 196 2 235 237 (Pubitemid 34110906)
103. Sarafova A. P., Choi H., Forlino A., Gajko A., Cabral W. A., Tosi L., Reing C. M., Marini J. C., Three novel type I collagen mutations in osteogenesis imperfecta type IV probands are associated with discrepancies between electrophoretic migration of osteoblast and fibroblast collagen Human Mutation 1998 11 5 395 403 (Pubitemid 28196640)
104. Shapiro J. R., Sponsellor P. D., Osteogenesis imperfecta: questions and answers Current Opinion in Pediatrics 2009 21 6 709 716
105. Glorieux F. H., Bishop N. J., Plotkin H., Chabot G., Lanoue G., Travers R., Cyclic administration of pamidronate in children with severe osteogenesis imperfecta New England Journal of Medicine 1998 339 14 947 952 (Pubitemid 28455096)
106. Roldn E. J. A., Pasqualini T., Plantalech L., Bisphosphonates in children with osteogenesis imperfecta may improve bone mineralization but not bone strength. Report of two patients Journal of Pediatric Endocrinology and Metabolism 1999 12 4 555 559 (Pubitemid 29334736)
107. Pereira R. F., O'Hara M. D., Laptev A. V., Halford K. W., Pollard M. D., Class R., Simon D., Livezey K., Prockop D. J., Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta Proceedings of the National Academy of Sciences of the United States of America 1998 95 3 1142 1147 (Pubitemid 28124926)
108. Horwitz E. M., Prockop D. J., Gordon P. L., Koo W. W. K., Fitzpatrick L. A., Neel M. D., McCarville M. E., Orchard P. J., Pyeritz R. E., Brenner M. K., Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta Blood 2001 97 5 1227 1231 (Pubitemid 32183743)
109. Young R. G., Butler D. L., Weber W., Caplan A. I., Gordon S. L., Fink D. J., Use of mesenchymal stem cells in a collagen matrix for achilles tendon repair Journal of Orthopaedic Research 1998 16 4 406 413 (Pubitemid 28427689)
110. Crovace A., Lacitignola L., deSiena R., Rossi G., Francioso E., Cell therapy for tendon repair in horses: an experimental study Veterinary Research Communications 2007 31 supplement 1 281 283 (Pubitemid 47244324)
111. Ouyang H. W., Goh J. C. H., Thambyah A., Teoh S. H., Lee E. H., Knitted poly-lactide-co-glycolidescaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit achilles tendon Tissue Engineering 2003 9 3 431 439 (Pubitemid 36736126)
112. Harris M. T., Butler D. L., Boivin G. P., Florer J. B., Schantz E. J., Wenstrup R. J., Mesenchymal stem cells used for rabbit tendon repair can form ectopic bone and express alkaline phosphatase activity in constructs Journal of Orthopaedic Research 2004 22 5 998 1003 (Pubitemid 39145116)
113. Schliephake H., Weich H. A., Dullin C., Gruber R., Frahse S., Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid-an experimental study in rats Biomaterials 2008 29 1 103 110 (Pubitemid 47599661)
114. Luo J., Gene therapy for bone regeneration Current Gene Therapy 2005 5 2 167 179 (Pubitemid 40439587)
115. Breyer B., Jiang W., Cheng H., Zhou L., Paul R., Feng T., He T. C., Adenoviral vector-mediated gene transfer for human gene therapy Current gene therapy 2001 1 2 149 162
116. Ghosh S. S., Gopinath P., Ramesh A., Adenoviral vectors: a promising tool for gene therapy Applied Biochemistry and Biotechnology 2006 133 1 9 29 (Pubitemid 43780431)
117. Baltzer A. W. A., Lattermann C., Whalen J. D., Wooley P., Weiss K., Grimm M., Ghivizzani S. C., Robbins P. D., Evans C. H., Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene Gene Therapy 2000 7 9 734 739 (Pubitemid 30255754)
118. Park J., Ries J., Gelse K., Kloss F., von der Mark K., Wiltfang J., Neukam F. W., Schneider H., Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes Gene Therapy 2003 10 13 1089 1098 (Pubitemid 36850231)
119. Tang N., Song W.-X., Luo J., Luo X., Chen J., Sharff K. A., Bi Y., He B.-C., Huang J.-Y., Zhu G.-H., Su Y.-X., Jiang W., Tang M., He Y., Wang Y., Chen L., Zuo G.-W., Shen J., Pan X., Reid R. R., Luu H. H., Haydon R. C., He T.-C., BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/ -catenin signalling Journal of Cellular and Molecular Medicine 2009 13 8 B 2448 2464
120. Lind M., Bnger C., Orthopaedic applications of gene therapy International Orthopaedics 2005 29 4 205 209 (Pubitemid 41125316)
121. Balyasnikova I. V., Franco-Gou R., Michael Mathis J., Lesniak M. S., Genetic modification of mesenchymal stem cells to express a single-chain antibody against EGFRvIII on the cell surface Journal of Tissue Engineering and Regenerative Medicine 2010 4 4 247 258
122. Duffy G. P., D'Arcy S., Ahsan T., Nerem R. M., O'Brien T., Barry F., Mesenchymal stem cells overexpressing ephrin-B2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential Tissue EngineeringPart A 2010 16 9 2755 2768
123. Sheyn D., Pelled G., Zilberman Y., Talasazan F., Frank J. M., Gazit D., Gazit Z., Nonvirally engineered porcine adipose tissue-derived stem cells: use in posterior spinal fusion Stem Cells 2008 26 4 1056 1064
124. Gheisari Y., Soleimani M., Azadmanesh K., Zeinali S., Multipotent mesenchymal stromal cells: optimization and comparison of five cationic polymer-based gene delivery methods Cytotherapy 2008 10 8 815 823
125. Hoffmann A., Pelled G., Turgeman G., Eberle P., Zilberman Y., Shinar H., Keinan-Adamsky K., Winkel A., Shahab S., Navon G., Gross G., Gazit D., Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells Journal of Clinical Investigation 2006 116 4 940 952
126. Jacobsen L. B., Calvin S. A., Colvin K. E., Wright M., FuGENE 6 transfection reagent: the gentle power Methods 2004 33 2 104 112 (Pubitemid 38569655)
127. Hoffmann A., Czichos S., Kaps C., Bchner D., Mayer H., Zilberman Y., Turgeman G., Pelled G., Gross G., Gazit D., The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2 Journal of Cell Science 2002 115, part 4 769 781 (Pubitemid 34196337)
128. Slater B. J., Kwan M. D., Gupta D. M., Panetta N. J., Longaker M. T., Mesenchymal cells for skeletal tissue engineering Expert Opinion on Biological Therapy 2008 8 7 885 893 (Pubitemid 352007001)