Comparison of characteristics of natural autoantibodies against myeloperoxidase and anti-myeloperoxidase autoantibodies from patients with microscopic polyangiitis

Rheumatology

Volumn 50, Issue 7, 2011, Pages 1236-1243

  Xu, Peng Cheng ^a   Cui, Zhao ^a   Chen, Min ^a   Hellmark, Thomas ^b   Zhao, Ming Hui ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b Department of Nephrology   (Sweden)

Author keywords

Anti neutrophil cytoplasm antibodies; Microscopic polyangitis; Myeloperoxidase; Natural autoantibodies; Vasculitis

Indexed keywords

AUTOANTIBODY; CERULOPLASMIN; EPITOPE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; MYELOPEROXIDASE; NATURAL AUTOANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; REACTIVE OXYGEN METABOLITE; RHODAMINE; UNCLASSIFIED DRUG;

ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAVY CHAIN; HUMAN; HUMAN CELL; MICROSCOPIC POLYANGIITIS; NEUTROPHIL; OXIDATION; PATHOGENESIS; PLASMA; PRIORITY JOURNAL; RESPIRATORY BURST; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOANTIBODIES; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MICROSCOPIC POLYANGIITIS; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; REFERENCE VALUES; SAMPLING STUDIES;

EID: 79959415700     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ker085     Document Type: Article

References (27)

1. Bansal PJ, Tobin MC. Neonatal microscopic polyangiitis secondary to transfer of maternal myeloperoxidaseantineutrophil cytoplasmic antibody resulting in neonatal pulmonary hemorrhage and renal involvement. Ann Allergy Asthma Immunol 2004;93:398-401.
2. Xiao H, Heeringa P, Hu P et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J lin Invest 2002;110:955-63.
3. Czarnocka B, Ruf J, Ferrand M, Carayon P, Lissitzky S. Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid disease. FEBS Lett 1985;190:147-52.
4. Tse WY, Nash GB, Hewins P, Savage CO, Adu D. ANCA induced neutrophil F-actin polymerization: Implications for microvascular inflammation. idney Int 2005;67:130-9.
5. Griffin SV, Chapman PT, Lianos EA, Lockwood CM. The inhibition of myeloperoxidase by ceruloplasmin can be reversed by anti-myeloperoxidase ntibodies. Kidney Int 1999;55:917-25.
6. Cui Z, Zhao MH, Segelmark M, Hellmark T. Natural autoantibodies to myeloperoxidase, proteinase3 and the glomerular basement membrane are present n normal individuals. Kidney Int 2010;78:590-7.
7. Coutinho A, Kazatchkine MD, Avrameas S. Natural autoantibodies. Curr Opin Immunol 1995;7:812-8.
8. Cui Z, Wang HY, Zhao MH. Natural autoantibodies against glomerular basement membrane exist in normal human sera. Kidney Int 2006;69:894-9.
9. Zhao MH, Lockwood CM. A comprehensive method to purify three major ANCA antigens: proteinase 3, myeloperoxidase and bactericidal/permeability increasing protein from human neutrophil granule acid extract. J Immunol Methods 1996;197:121-30.
10. Xu PC, Chen M, Cui Z, Zhao MH. Influence of myeloperoxidase by anti-myeloperoxidase antibodies and its association with the disease activity in icroscopic polyangiitis. Rheumatology 2010;49:2068-75.
11. Van Rossum AP, van der Geld YM, Limburg PC, Kallenberg CG. Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to eutrophils. Kidney Int 2005;68:537-41.
12. Kettritz R, Schreiber A, Luft FC, Haller H. Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic ntibodies. J Am Soc Nephrol 2001;12:37-46.
13. Falk RJ, Becker M, Terrell R, Jennette JC. Anti-myeloperoxidase autoantibodies react with native but not denatured myeloperoxidase. Clin Exp Immunol 992; 89:274-8.
14. Erdbrügger U, Hellmark T, Bunch DO et al. Mapping of myeloperoxidase epitopes recognized by MPO-ANCA using human-mouse MPO chimers. idney Int 2006;69: 1799-805.
15. Suzuki K, Kobayashi S, Yamazaki K et al. Analysis of risk epitopes of anti-neutrophil antibody MPO-ANCA in vasculitis in Japanese population. icrobiol Immunol 2007;51:1215-20.
16. Avrameas S, Ternynck T. The natural autoantibodies system: between hypotheses and facts. Mol Immunol 1993;30:1133-42.
17. Lin W, Chen M, Zhao MH. Follow-up of avidity and titer of anti-myeloperoxidase antibodies in sera from patients with primary ANCA-associated asculitis. Autoimmunity 2009; 42:198-202.
18. Gao Y, Chen M, Ye H, Guo XH, Zhao MH, Wang HY. Follow-up of avidity and titre of anti-myeloperoxidase antibodies in sera from patients with ropylthiouracil-induced vasculitis. Clin Endocrinol 2007; 66:543-7.
19. Gueirard P, Delpech A, Gilbert D, Godin M, Le Loet X, Tron F. Anti-myeloperoxidase antibodies: immunological characteristics and clinical associations. Autoimmun 1991;4:517-27.
20. Kokolina E, Noël LH, Nusbaum P et al. Isotype and affinity of anti-myeloperoxidase autoantibodies in systemic vasculitis. Kidney Int 1994;46:177-84.
21. Gao Y, Ye H, Yu F, Guo XH, Zhao MH. Anti-myeloperoxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis. Clin Immunol 2005;117:87-93.
22. Segelmark M, Wieslander J. IgG subclasses of antineutrophil cytoplasmic antibodies (ANCA). Nephrol Dial Transplant 1993;8:696-702.
23. Liu LJ, Chen M, Yu F, Zhao MH, Wang HY. IgG subclass distribution, affinity of anti-myeloperoxidase antibodies in sera from patients with Wegener's granulomatosis and microscopic polyangiitis. Nephrology 2008;13: 629-35.
24. Esnault VL, Jayne DR, Weetman AP, Lockwood CM. IgG subclass distribution and relative functional affinity of antimyeloperoxidase antibodies in systemic vasculitis at presentation and during follow-up. Immunology 1991;74: 714-8.
25. Jarius S, Eichhorn P, Albert MH et al. Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFalpha-dependent and Fc-receptor-independent way. Blood 2007;109:4376-82.
26. Jayne DR, Chapel H, Adu D et al. Intravenous immunoglobulin for ANCA-associated systemic vasculitis with persistent disease activity. Q J Med 000;93:433-9.
27. Pall AA, Varagunam M, Adu D et al. Anti-idiotypic activity against anti-myeloperoxidase antibodies in pooled human immunoglobulin. Clin Exp Immunol 994;95:257-62.