Specific anti-nuclear antibodies in systemic sclerosis patients with and without skin involvement: An extended methodological approach

Rheumatology

Volumn 50, Issue 7, 2011, Pages 1302-1309

  van Praet, Jens T ^a   van Steendam, Katleen ^b   Smith, Vanessa ^a   de Bruyne, Georges ^a   Mimori, Tsuneyo ^c   Bonroy, Carolien ^a   Elewaut, Dirk ^a   Deforce, Dieter ^b   de Keyser, Filip ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anti centromere; Anti nuclear antibodies; Anti RNA polymerase III; Anti topoisomerase I; Disease severity scale; Immunoprecipitation; Systemic sclerosis; Western blotting

Indexed keywords

ANTIBODY; ANTINUCLEAR ANTIBODY; DNA TOPOISOMERASE ANTIBODY; RNA POLYMERASE III ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ARTICLE; FEMALE; HUMAN; IMMUNOASSAY; IMMUNOPRECIPITATION; LINE IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOIMMUNOPRECIPITATION; RNA IMMUNOPRECIPITATION; SCLERODERMA; SYSTEMIC SCLEROSIS; WESTERN BLOTTING;

ADULT; AGED; ALGORITHMS; ANTIBODIES, ANTINUCLEAR; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; RADIOIMMUNOPRECIPITATION ASSAY; SCLERODERMA, LOCALIZED; SCLERODERMA, SYSTEMIC; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX;

EID: 79959392752     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keq446     Document Type: Article

References (26)

1. Denton CP, Black CM, Abraham DJ. Mechanisms and consequences of fibrosis in systemic sclerosis. Nat Clin Pract Rheumatol 2006;2:134-44.
2. LeRoy EC, Black C, Fleischmajer R et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988;15:202-5.
3. LeRoy EC, Medsger TA Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol 2001;28:1573-6.
4. Koenig M, Joyal F, Fritzler MJ et al. Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis. Arthritis heum 2008;58:3902-12.
5. Steen VD. Autoantibodies in systemic sclerosis. Semin Arthritis Rheum 2005;35:35-42.
6. Kuwana M, Kaburaki J, Okano Y, Tojo T, Homma M. Clinical and prognostic associations based on serum antinuclear antibodies in Japanese patients ith systemic sclerosis. Arthritis Rheum 1994;37:75-83.
7. Steen VD, Powell DL, Medsger TA Jr. Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis heum 1988;31:196-203.
8. Smith V, Pizzorni C, De Keyser F et al. Reliability of the qualitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis ohort: a two-centre study. Ann Rheum Dis 2010;69:1092-6.
9. Cutolo M, Sulli A, Pizzorni C, Accardo S. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 000;27:155-60.
10. Medsger TA Jr, Bombardieri S, Czirjak L, Scorza R, Della Rossa A, Bencivelli W. Assessment of disease severity and prognosis. Clin Exp Rheumatol 003;21(3 Suppl. 29): S42-6.
11. Van Praet JT, Vander Cruyssen B, Bonroy C, Smith V, Delanghe J, De Keyser F. Validation of a new screening strategy for anti-extractable nuclear ntigen antibodies. Clin Exp Rheumatol 2009;27:971-6.
12. Fujita Y, Fujii T, Nakashima R, Tanaka M, Mimori T. Aseptic meningitis in mixed connective tissue disease: cytokine and anti-U1RNP antibodies in cerebrospinal fluids from two different cases. Mod Rheumatol 2008;18: 184-8.
13. Hesselstrand R, Scheja A, Shen GQ, Wiik A, Akesson A. The association of antinuclear antibodies with organ involvement and survival in systemic clerosis. Rheumatology 2003;42:534-40.
14. Mitri GM, Lucas M, Fertig N, Steen VD, Medsger TA Jr. A comparison between anti-Th/To- and anticentromere antibody-positive systemic sclerosis patients with limited cutaneous involvement. Arthritis Rheum 2003;48:203-9.
15. Peene I, Meheus L, Veys EM, De Keyser F. Detection and identification of antinuclear antibodies (ANA) in a large and consecutive cohort of serum samples referred for ANA testing. Ann Rheum Dis 2001;60:1131-6.
16. Meheus L, van Venrooij WJ, Wiik A et al. Multicenter validation of recombinant, natural and synthetic antigens used in a single multiparameter assay for the detection of specific anti-nuclear autoantibodies in connective tissue disorders. Clin Exp Rheumatol 1999;17:205-14.
17. Pottel H, Wiik A, Locht H et al. Clinical optimization and multicenter validation of antigen-specific cut-off values on the INNO-LIA ANA update for the detection of autoantibodies in connective tissue disorders. Clin Exp Rheumatol 2004;22:579-88.
18. Meyer O, De Chaisemartin L, Nicaise-Roland P et al. Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study. J Rheumatol 2010;37:125-30.
19. Satoh T, Ishikawa O, Ihn H et al. Clinical usefulness of anti-RNA polymerase III antibody measurement by enzyme-linked immunosorbent assay. heumatology 2009;48:1570-4.
20. Hanke K, Bruckner CS, Dahnrich C et al. Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic clerosis patients. Arthritis Res Ther 2009;11:R22.
21. Kuwana M, Okano Y, Kaburaki J, Tojo T, Medsger TA Jr. Racial differences in the distribution of systemic sclerosis-related serum antinuclear ntibodies. Arthritis Rheum 1994;37:902-6.
22. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum 1980;23:581-90.
23. von Muhlen CA, Tan EM. Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin Arthritis Rheum 1995;24:323-58.
24. Betteridge Z, Gunawardena H, North J, Slinn J, McHugh N. Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia. Rheumatology 2007;46: 1005-8.
25. Bunn CC, Denton CP, Shi-Wen X, Knight C, Black CM. Anti-RNA polymerases and other autoantibody specificities in systemic sclerosis. Br J Rheumatol 1998;37:15-20.
26. Tormey VJ, Bunn CC, Denton CP, Black CM. Anti-fibrillarin antibodies in systemic sclerosis. Rheumatology 2001;40: 1157-62. www.