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Volumn 6, Issue 4, 2011, Pages 315-325

HIV-1 treatment as prevention: The good, the bad, and the challenges

Author keywords

antiretroviral therapy; pre exposure prophylaxis; prevention

Indexed keywords

ABACAVIR; AMPRENAVIR; ATAZANAVIR; DARUNAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ETRAVIRINE; INDINAVIR; LAMIVUDINE; LOPINAVIR; MARAVIROC; NELFINAVIR; NEVIRAPINE; PLACEBO; RALTEGRAVIR; RITONAVIR; SAQUINAVIR; STAVUDINE; TENOFOVIR DISOPROXIL; ZIDOVUDINE;

EID: 79959371227     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0b013e32834788e7     Document Type: Review
Times cited : (74)

References (91)
  • 1
    • 0023938848 scopus 로고
    • Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex
    • Henry K, Chinnock BJ, Quinn RP, et al. Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex. JAMA 1988; 259:3023-3026.
    • (1988) JAMA , vol.259 , pp. 3023-3026
    • Henry, K.1    Chinnock, B.J.2    Quinn, R.P.3
  • 2
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • This study is the first to report the results of a clinical trial demonstrating the effectiveness and safety of a 1%vaginal gel formulation of TDF for the prevention of HIV acquisition in women. Results show that the gel reduces HIV acquisition by an estimated 39% overall and by 54% in women with high gel adherence
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329:1168-1174. This study is the first to report the results of a clinical trial demonstrating the effectiveness and safety of a 1%vaginal gel formulation of TDF for the prevention of HIV acquisition in women. Results show that the gel reduces HIV acquisition by an estimated 39% overall and by 54% in women with high gel adherence.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3
  • 3
    • 78650549662 scopus 로고    scopus 로고
    • Preexposure chemoprophylaxis for HIV prevention in men who have sex with men
    • This study is the first to report the results of a clinical trial demonstrating the efficacy of oral preprophylactic effect (iPREX) in preventing HIV among MSM in Asia and Africa. More information is needed to evaluate possible subclinical effects such as low-level drug resistance as well as potential adjustments in HIV risk behavior among users
    • Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010; 363:2587-2599. This study is the first to report the results of a clinical trial demonstrating the efficacy of oral preprophylactic effect (iPREX) in preventing HIV among MSM in Asia and Africa. More information is needed to evaluate possible subclinical effects such as low-level drug resistance as well as potential adjustments in HIV risk behavior among users.
    • (2010) N Engl J Med , vol.363 , pp. 2587-2599
    • Grant, R.M.1    Lama, J.R.2    Anderson, P.L.3
  • 4
    • 78650872736 scopus 로고    scopus 로고
    • Oral preexposure prophylaxis for HIV: Another arrow in the quiver?
    • Michael NL. Oral preexposure prophylaxis for HIV: another arrow in the quiver? N Engl J Med 2010; 363:2663-2665.
    • (2010) N Engl J Med , vol.363 , pp. 2663-2665
    • Michael, N.L.1
  • 5
    • 77958468743 scopus 로고    scopus 로고
    • Pharmacologic opportunities for HIV prevention
    • Nicol MR, Kashuba AD. Pharmacologic opportunities for HIV prevention. Clin Pharmacol Ther 2010; 88:598-609.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 598-609
    • Nicol, M.R.1    Kashuba, A.D.2
  • 6
  • 7
    • 68449086889 scopus 로고    scopus 로고
    • Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women
    • Dumond JB, Patterson KB, Pecha AL, et al. Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women. J Acquir Immune Defic Syndr 2009; 51:546-553.
    • (2009) J Acquir Immune Defic Syndr , vol.51 , pp. 546-553
    • Dumond, J.B.1    Patterson, K.B.2    Pecha, A.L.3
  • 8
    • 79960357107 scopus 로고    scopus 로고
    • Exposure of extracellular and intracellular tenofovir and emtricitabine in mucosal tissues after a single fixed dose of TDC/FTC: Implications for preexposure HIV prophylaxis (PrEP)
    • Patterson K, Prince H, Kraft E, et al. Exposure of extracellular and intracellular tenofovir and emtricitabine in mucosal tissues after a single fixed dose of TDC/FTC: implications for preexposure HIV prophylaxis (PrEP). In: 18th International AIDS conference; 2010; Vienna, Austria.
    • 18th International AIDS Conference; 2010; Vienna, Austria
    • Patterson, K.1    Prince, H.2    Kraft, E.3
  • 10
    • 46449107370 scopus 로고    scopus 로고
    • Differential extracellular and intracellular concentrations of zidovudine and lamivudine in semen and plasma of HIV-1-infected men
    • Dumond JB, Reddy YS, Troiani L, et al. Differential extracellular and intracellular concentrations of zidovudine and lamivudine in semen and plasma of HIV-1-infected men. J Acquir Immune Defic Syndr 2008; 48:156-162.
    • (2008) J Acquir Immune Defic Syndr , vol.48 , pp. 156-162
    • Dumond, J.B.1    Reddy, Y.S.2    Troiani, L.3
  • 14
    • 59749098155 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor
    • Fletcher P, Harman S, Azijn H, et al. Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother 2009; 53:487-495.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 487-495
    • Fletcher, P.1    Harman, S.2    Azijn, H.3
  • 16
    • 22944476766 scopus 로고    scopus 로고
    • Pathophysiology of HIV-1 in semen: Current evidence for compartmentalisation and penetration by antiretroviral drugs
    • DOI 10.2174/1570162054368039
    • Chan DJ. Pathophysiology of HIV-1 in semen: current evidence for compartmentalization and penetration by antiretroviral drugs. Current HIV Res 2005; 3:207-222. (Pubitemid 41052422)
    • (2005) Current HIV Research , vol.3 , Issue.3 , pp. 207-222
    • Chan, D.J.1
  • 17
    • 74349122226 scopus 로고    scopus 로고
    • HIV infection in the male genital tract: Consequences for sexual transmission and reproduction
    • Le Tortorec A, Dejucq-Rainsford N. HIV infection in the male genital tract: consequences for sexual transmission and reproduction. Int J Androl 2010; 33:e98-e108.
    • (2010) Int J Androl , vol.33
    • Le Tortorec, A.1    Dejucq-Rainsford, N.2
  • 19
    • 10644234595 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 genomic RNA sequences in the female genital tract and blood: Compartmentalization and intrapatient recombination
    • DOI 10.1128/JVI.79.1.353-363.2005
    • Philpott S, Burger H, Tsoukas C, et al. Human immunodeficiency virus type 1 genomic RNA sequences in the female genital tract and blood: compartmentalization and intrapatient recombination. J Virol 2005; 79:353-363. (Pubitemid 39648389)
    • (2005) Journal of Virology , vol.79 , Issue.1 , pp. 353-363
    • Philpott, S.1    Burger, H.2    Tsoukas, C.3    Foley, B.4    Anastos, K.5    Kitchen, C.6    Weiser, B.7
  • 20
    • 78549279762 scopus 로고    scopus 로고
    • Genital tract HIV-1 RNA shedding among women with below detectable plasma viral load
    • This study determines patterns of genital tract HIV-1-RNA shedding over time among women with suppressed plasma viral load on ART
    • Cu-Uvin S, DeLong AK, Venkatesh KK, et al. Genital tract HIV-1 RNA shedding among women with below detectable plasma viral load. AIDS 2010; 24:2489-2497. This study determines patterns of genital tract HIV-1-RNA shedding over time among women with suppressed plasma viral load on ART.
    • (2010) AIDS , vol.24 , pp. 2489-2497
    • Cu-Uvin, S.1    DeLong, A.K.2    Venkatesh, K.K.3
  • 21
    • 70349758502 scopus 로고    scopus 로고
    • Persistent HIV RNA shedding in semen despite effective antiretroviral therapy
    • Sheth PM, Kovacs C, Kemal KS, et al. Persistent HIV RNA shedding in semen despite effective antiretroviral therapy. AIDS 2009; 23:2050-2053.
    • (2009) AIDS , vol.23 , pp. 2050-2053
    • Sheth, P.M.1    Kovacs, C.2    Kemal, K.S.3
  • 22
    • 76449101531 scopus 로고    scopus 로고
    • Preexisting minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failure
    • This study of the relationship between minority drug-resistant human HIV-1 and virologic failure in treated patients finds that in adherent patients, pre-existing minority Y181C mutants more than triple the risk of virologic failure of first-line efavirenz-based ART
    • Paredes R, Lalama CM, Ribaudo HJ, et al. Preexisting minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failure. J Infect Dis 2010; 201:662-671. This study of the relationship between minority drug-resistant human HIV-1 and virologic failure in treated patients finds that in adherent patients, pre-existing minority Y181C mutants more than triple the risk of virologic failure of first-line efavirenz-based ART.
    • (2010) J Infect Dis , vol.201 , pp. 662-671
    • Paredes, R.1    Lalama, C.M.2    Ribaudo, H.J.3
  • 23
    • 48749086685 scopus 로고    scopus 로고
    • Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naive populations and associate with reduced treatment efficacy
    • Johnson JA, Li JF, Wei X, et al. Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naive populations and associate with reduced treatment efficacy. PLoS Med 2008; 5:e158.
    • (2008) PLoS Med , vol.5
    • Johnson, J.A.1    Li, J.F.2    Wei, X.3
  • 24
    • 77749306124 scopus 로고    scopus 로고
    • Efficient suppression of minority drugresistant HIV type 1 (HIV-1) variants present at primary HIV-1 infection by ritonavir-boosted protease inhibitor-containing antiretroviral therapy
    • Metzner KJ, Rauch P, von Wyl V, et al. Efficient suppression of minority drugresistant HIV type 1 (HIV-1) variants present at primary HIV-1 infection by ritonavir-boosted protease inhibitor-containing antiretroviral therapy. J Infect Dis 2010; 201:1063-1071.
    • (2010) J Infect Dis , vol.201 , pp. 1063-1071
    • Metzner, K.J.1    Rauch, P.2    Von Wyl, V.3
  • 25
    • 65649096588 scopus 로고    scopus 로고
    • Detection of human immunodeficiency virus (HIV) type 1 M184V and K103N minority variants in patients with primary HIV infection
    • Toni TA, Asahchop EL, Moisi D, et al. Detection of human immunodeficiency virus (HIV) type 1 M184V and K103N minority variants in patients with primary HIV infection. Antimicrob Agents Chemother 2009; 53:1670-1672.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1670-1672
    • Toni, T.A.1    Asahchop, E.L.2    Moisi, D.3
  • 26
    • 77958149391 scopus 로고    scopus 로고
    • HIV-1 populations in semen arise through multiple mechanisms
    • doi: 10.1371/journal.ppat.1001053. This study compared HIV sequences in blood and semen using single gene amplification, a method that allows sensitive discrimination of these biological compartments. The results demonstrated that in some patient, blood and semen harbored similar viral variants, but that considerable divergence was possible. In addition, duplication of variants was observed in semen isolates, emphasizing ongoing viral replication in a closed compartment
    • Anderson JA, Ping LH, Dibben O, et al. HIV-1 populations in semen arise through multiple mechanisms. PLoS Pathog 2010; 6:e1001053. doi: 10.1371/journal.ppat.1001053. This study compared HIV sequences in blood and semen using single gene amplification, a method that allows sensitive discrimination of these biological compartments. The results demonstrated that in some patient, blood and semen harbored similar viral variants, but that considerable divergence was possible. In addition, duplication of variants was observed in semen isolates, emphasizing ongoing viral replication in a closed compartment.
    • (2010) PLoS Pathog , vol.6
    • Anderson, J.A.1    Ping, L.H.2    Dibben, O.3
  • 28
    • 77954757141 scopus 로고    scopus 로고
    • The effect of transmitted HIV-1 drug resistance on pretherapy viral load
    • In this study, the authors demonstrate detection of transmitted variants with drug resistance markers. They note that individuals infected with the M184 V/I variant had lower blood viral load, which they argue reflects a replication fitness cost associated with the mutation
    • Harrison L, Castro H, Cane P, et al. The effect of transmitted HIV-1 drug resistance on pretherapy viral load. AIDS 2010; 24:1917-1922. In this study, the authors demonstrate detection of transmitted variants with drug resistance markers. They note that individuals infected with the M184 V/I variant had lower blood viral load, which they argue reflects a replication fitness cost associated with the mutation.
    • (2010) AIDS , vol.24 , pp. 1917-1922
    • Harrison, L.1    Castro, H.2    Cane, P.3
  • 29
    • 78149499458 scopus 로고    scopus 로고
    • Transmitted drug resistance and type of infection in newly diagnosed HIV-1 individuals in Honduras
    • Murillo W, Paz-Bailey G, Morales S, et al. Transmitted drug resistance and type of infection in newly diagnosed HIV-1 individuals in Honduras. J Clin Virol 2010; 49:239-244.
    • (2010) J Clin Virol , vol.49 , pp. 239-244
    • Murillo, W.1    Paz-Bailey, G.2    Morales, S.3
  • 30
    • 78049365515 scopus 로고    scopus 로고
    • Low prevalence of transmitted drug resistance among newly diagnosed HIV-1 patients in Latvia
    • Balode D, Westman M, Kolupajeva T, et al. Low prevalence of transmitted drug resistance among newly diagnosed HIV-1 patients in Latvia. J Med Virol 2010; 82:2013-2018.
    • (2010) J Med Virol , vol.82 , pp. 2013-2018
    • Balode, D.1    Westman, M.2    Kolupajeva, T.3
  • 31
    • 70449723682 scopus 로고    scopus 로고
    • Transmission of drug-resistant HIV-1 is stabilizing in Europe
    • Vercauteren J, Wensing AM, van de Vijver DA, et al. Transmission of drug-resistant HIV-1 is stabilizing in Europe. J Infect Dis 2009; 200: 1503-1508.
    • (2009) J Infect Dis , vol.200 , pp. 1503-1508
    • Vercauteren, J.1    Wensing, A.M.2    Van De Vijver, D.A.3
  • 32
    • 78049390911 scopus 로고    scopus 로고
    • HIV status in discordant couples in sub-Saharan Africa: A systematic review and meta-analysis
    • This systematic review finds that women are as likely as men to be the index partner in a discordant couple, highlighting the need to focus on both sexes in HIV prevention strategies
    • Eyawo O, de Walque D, Ford N, et al. HIV status in discordant couples in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Infect Dis 2010; 10:770-777. This systematic review finds that women are as likely as men to be the index partner in a discordant couple, highlighting the need to focus on both sexes in HIV prevention strategies.
    • (2010) Lancet Infect Dis , vol.10 , pp. 770-777
    • Eyawo, O.1    De Walque, D.2    Ford, N.3
  • 34
    • 20244368227 scopus 로고    scopus 로고
    • Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda
    • Wawer MJ, Gray RH, Sewankambo NK, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 2005; 191:1402-1409.
    • (2005) J Infect Dis , vol.191 , pp. 1402-1409
    • Wawer, M.J.1    Gray, R.H.2    Sewankambo, N.K.3
  • 35
    • 79959340361 scopus 로고    scopus 로고
    • The contribution of HIV-discordant relationships to new HIV infections in Rakai, Uganda
    • (in press). This research letter presented findings from a secondary analysis of the Rakai Cohort Study in which only a minority of new HIV infections was found to have occurred in the context of a stable HIV-discordant couple relationship
    • Gray R. The contribution of HIV-discordant relationships to new HIV infections in Rakai, Uganda. AIDS (in press). This research letter presented findings from a secondary analysis of the Rakai Cohort Study in which only a minority of new HIV infections was found to have occurred in the context of a stable HIV-discordant couple relationship.
    • AIDS
    • Gray, R.1
  • 42
    • 77953921210 scopus 로고    scopus 로고
    • Combined antiretroviral treatment and heterosexual transmission of HIV-1: Cross sectional and prospective cohort study
    • This article reports findings from a prospective study of 424 serodiscordant couples and finds an HIV seroconversion rate of 0-0.0005 per unprotected intercourse among the 144 couples in which the index partner was on ART. This finding suggests that heterosexual infectivity of HIV-1 in treated individuals may be very low
    • Del Romero J, Castilla J, Hernando V, et al. Combined antiretroviral treatment and heterosexual transmission of HIV-1: cross sectional and prospective cohort study. BMJ 2010; 340:c2205. This article reports findings from a prospective study of 424 serodiscordant couples and finds an HIV seroconversion rate of 0-0.0005 per unprotected intercourse among the 144 couples in which the index partner was on ART. This finding suggests that heterosexual infectivity of HIV-1 in treated individuals may be very low.
    • (2010) BMJ , vol.340
    • Del Romero, J.1    Castilla, J.2    Hernando, V.3
  • 43
    • 77953293984 scopus 로고    scopus 로고
    • Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis
    • Donnell D, Baeten JM, Kiarie J, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 2010; 375:2092-2098.
    • (2010) Lancet , vol.375 , pp. 2092-2098
    • Donnell, D.1    Baeten, J.M.2    Kiarie, J.3
  • 44
    • 70350510210 scopus 로고    scopus 로고
    • Reducing sexual risk behavior among steady heterosexual serodiscordant couples in a testing and counseling program
    • Hernando V, del Romero G, Garcia S, et al. Reducing sexual risk behavior among steady heterosexual serodiscordant couples in a testing and counseling program. Sex Transm Dis 2009; 36:621-628.
    • (2009) Sex Transm Dis , vol.36 , pp. 621-628
    • Hernando, V.1    Del Romero, G.2    Garcia, S.3
  • 45
    • 58149173416 scopus 로고    scopus 로고
    • Sexual transmission of HIV-1 among serodiscordant couples in Porto Alegre, southern Brazil
    • Melo MG, Santos BR, Lira RDC, et al. Sexual transmission of HIV-1 among serodiscordant couples in Porto Alegre, southern Brazil. Sex Transm Dis 2008; 35:912-915.
    • (2008) Sex Transm Dis , vol.35 , pp. 912-915
    • Melo, M.G.1    Santos, B.R.2    Lira, R.D.C.3
  • 46
    • 0027980876 scopus 로고
    • Antiretroviral treatment of men infected with human immunodeficiency virus type 1 reduces the incidence of heterosexual transmission
    • DOI 10.1001/archinte.154.17.1971
    • Musicco M, Lazzarin A, Nicolosi A, et al. Antiretroviral treatment of men infected with human immunodeficiency virus type 1 reduces the incidence of heterosexual transmission. Italian Study Group on HIV Heterosexual Transmission. Arch Intern Med 1994; 154:1971-1976. (Pubitemid 24276382)
    • (1994) Archives of Internal Medicine , vol.154 , Issue.17 , pp. 1971-1976
    • Musicco, M.1    Lazzarin, A.2    Nicolosi, A.3    Gasparini, M.4    Costiglioia, P.5    Arici, C.6    Saracco, A.7
  • 47
    • 79951515595 scopus 로고    scopus 로고
    • HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy
    • Reynolds SJ, Makumbi F, Nakigozi G, et al. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS 2011; 25:473-477.
    • (2011) AIDS , vol.25 , pp. 473-477
    • Reynolds, S.J.1    Makumbi, F.2    Nakigozi, G.3
  • 49
    • 77957309296 scopus 로고    scopus 로고
    • HIV transmission risk among serodiscordant couples: A retrospective study of former plasma donors in Henan, China
    • This article reports findings from a prospective study of 1927 serodiscordant couples. Authors report an HIV incidence rate of 1.71 per 100 person-years in which transmission events are equally distributed among couples whose index case was receiving or was not receiving ART
    • Wang L, Ge Z, Luo J, et al. HIV transmission risk among serodiscordant couples: a retrospective study of former plasma donors in Henan, China. J Acquir Immune Defic Syndr 2010; 55:232-238. This article reports findings from a prospective study of 1927 serodiscordant couples. Authors report an HIV incidence rate of 1.71 per 100 person-years in which transmission events are equally distributed among couples whose index case was receiving or was not receiving ART.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , pp. 232-238
    • Wang, L.1    Ge, Z.2    Luo, J.3
  • 51
    • 77956057163 scopus 로고    scopus 로고
    • Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco
    • This study identified a positive association between decreases in total community viral load - measured as the sum of the most recent viral load of all reported HIV-positive individuals - and the era of expanded ART in San Francisco
    • Das M, Chu PL, Santos GM, et al. Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco. PLoS One 2010; 5:e11068. This study identified a positive association between decreases in total community viral load - measured as the sum of the most recent viral load of all reported HIV-positive individuals - and the era of expanded ART in San Francisco.
    • (2010) PLoS One , vol.5
    • Das, M.1    Chu, P.L.2    Santos, G.M.3
  • 53
    • 1642506098 scopus 로고    scopus 로고
    • Decline in HIV infectivity following the introduction of highly active antiretroviral therapy
    • DOI 10.1097/00002030-200401020-00010
    • Porco TC, Martin JN, Page-Shafer KA, et al. Decline in HIV infectivity following the introduction of highly active antiretroviral therapy. AIDS 2004; 18:81-88. (Pubitemid 38402321)
    • (2004) AIDS , vol.18 , Issue.1 , pp. 81-88
    • Porco, T.C.1    Martin, J.N.2    Page-Shafer, K.A.3    Cheng, A.4    Chadebois, E.5    Grant, R.M.6    Osmond, D.H.7
  • 54
    • 4344646287 scopus 로고    scopus 로고
    • Decreased HIV transmission after a policy of providing free access to highly active antiretroviral therapy in Taiwan
    • Fang CT, Hsu HM, Twu SJ, et al. Decreased HIV transmission after a policy of providing free access to highly active antiretroviral therapy in Taiwan. J Infect Dis 2004; 190:879-885.
    • (2004) J Infect Dis , vol.190 , pp. 879-885
    • Fang, C.T.1    Hsu, H.M.2    Twu, S.J.3
  • 56
    • 33746512140 scopus 로고    scopus 로고
    • The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic
    • DOI 10.1016/S0140-6736(06)69162-9, PII S0140673606691629
    • Montaner JS, Hogg R, Wood E, et al. The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet 2006; 368:531-536. (Pubitemid 44142776)
    • (2006) Lancet , vol.368 , Issue.9534 , pp. 531-536
    • Montaner, J.S.1    Hogg, R.2    Wood, E.3    Kerr, T.4    Tyndall, M.5    Levy, A.R.6    Harrigan, P.R.7
  • 57
    • 77956056661 scopus 로고    scopus 로고
    • Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: A population-based study
    • Using mathematical models to analyze HIV surveillance data in British Columbia, the authors of this study claimed evidence of strong population-level associations among expanded ART coverage, decreased population viral load, and fewer annual HIV diagnoses between 1996 and 2009
    • Montaner JS, Lima VD, Barrios R, et al. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet 2010; 376:532-539. Using mathematical models to analyze HIV surveillance data in British Columbia, the authors of this study claimed evidence of strong population-level associations among expanded ART coverage, decreased population viral load, and fewer annual HIV diagnoses between 1996 and 2009.
    • (2010) Lancet , vol.376 , pp. 532-539
    • Montaner, J.S.1    Lima, V.D.2    Barrios, R.3
  • 58
    • 78649491674 scopus 로고    scopus 로고
    • Is antiretroviral therapy modifying the HIV epidemic?
    • author reply 1825
    • Shelton JD, Cohen M, Barnhart M, Hallett T. Is antiretroviral therapy modifying the HIV epidemic? Lancet 2010; 376:1824-1825; author reply 1825.
    • (2010) Lancet , vol.376 , pp. 1824-1825
    • Shelton, J.D.1    Cohen, M.2    Barnhart, M.3    Hallett, T.4
  • 59
    • 78649491674 scopus 로고    scopus 로고
    • Is antiretroviral therapy modifying the HIV epidemic?
    • ·] on the association between ART coverage and community HIV viral load. Safer injection practices among IDUs is also highlighted as a likely confounder that could lead to overestimation of the association between expanded ART on lowered HIV incidence in British Columbia
    • ·] on the association between ART coverage and community HIV viral load. Safer injection practices among IDUs is also highlighted as a likely confounder that could lead to overestimation of the association between expanded ART on lowered HIV incidence in British Columbia.
    • (2010) Lancet , vol.376 , pp. 1824
    • Grulich, A.E.1    Wilson, D.P.2
  • 60
    • 0037025122 scopus 로고    scopus 로고
    • HIV incidence on the increase among homosexual men attending an Amsterdam sexually transmitted disease clinic: Using a novel approach for detecting recent infections
    • DOI 10.1097/00002030-200207050-00001
    • Dukers NHTM, Spaargaren J, Geskus RB, et al. HIV incidence on the increase among homosexual men attending an Amsterdam sexually transmitted disease clinic: using a novel approach for detecting recent infections. AIDS 2002; 16:F19-F24. (Pubitemid 34722061)
    • (2002) AIDS , vol.16 , Issue.10
    • Dukers, N.H.T.M.1    Spaargaren, J.2    Geskus, R.B.3    Beijnen, J.4    Coutinho, R.A.5    Fennema, H.S.A.6
  • 62
    • 79951515760 scopus 로고    scopus 로고
    • Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: A 25-year prospective cohort study
    • This cohort study reports ongoing HIV-1 transmission among MSM in Amsterdam, particularly following increases in sexual risk behavior from 1996 onwards
    • Jansen IA, Geskus RB, Davidovich U, et al. Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study. AIDS 2011; 25:493-501. This cohort study reports ongoing HIV-1 transmission among MSM in Amsterdam, particularly following increases in sexual risk behavior from 1996 onwards.
    • (2011) AIDS , vol.25 , pp. 493-501
    • Jansen, I.A.1    Geskus, R.B.2    Davidovich, U.3
  • 63
    • 77949558370 scopus 로고    scopus 로고
    • Per-contact probability of HIV transmission in homosexual men in Sydney during the era of HAART
    • A longitudinal cohort study of homosexual men in Australia found little difference in the per-contact probability of HIV transmission before and after widespread uptake of ART in HIV-infected men. The authors hypothesize that untreated STIs or unprotected sex during acute infection may partially explain the persistence of transmission even with high ART coverage
    • Jin F, Jansson J, Law M. Per-contact probability of HIV transmission in homosexual men in Sydney during the era of HAART. AIDS 2010; 24:907-913. A longitudinal cohort study of homosexual men in Australia found little difference in the per-contact probability of HIV transmission before and after widespread uptake of ART in HIV-infected men. The authors hypothesize that untreated STIs or unprotected sex during acute infection may partially explain the persistence of transmission even with high ART coverage.
    • (2010) AIDS , vol.24 , pp. 907-913
    • Jin, F.1    Jansson, J.2    Law, M.3
  • 65
    • 48749117983 scopus 로고    scopus 로고
    • Estimation of HIV incidence in the United States
    • Hall HI, Song R, Rhodes P, et al. Estimation of HIV incidence in the United States. JAMA 2008; 300:520-529.
    • (2008) JAMA , vol.300 , pp. 520-529
    • Hall, H.I.1    Song, R.2    Rhodes, P.3
  • 66
    • 77957155418 scopus 로고    scopus 로고
    • Population-based HIV-1 incidence in France, 2003-08: A modelling analysis
    • This analysis uses a stratified extrapolation model to estimate population incidence of HIV in France. Findings suggest that overall incidence in France is decreasing, but remains comparatively high among MSM
    • Le Vu S, Le Strat Y, Barin F, et al. Population-based HIV-1 incidence in France, 2003-08: a modelling analysis. Lancet Infect Dis 2010; 10:682-687. This analysis uses a stratified extrapolation model to estimate population incidence of HIV in France. Findings suggest that overall incidence in France is decreasing, but remains comparatively high among MSM.
    • (2010) Lancet Infect Dis , vol.10 , pp. 682-687
    • Le Vu, S.1    Le Strat, Y.2    Barin, F.3
  • 67
    • 77951822950 scopus 로고    scopus 로고
    • Treatment to prevent transmission of HIV-1
    • Cohen MS, Gay CL. Treatment to prevent transmission of HIV-1. Clin Infect Dis 2010; 50 (Suppl 3):S85-S95.
    • (2010) Clin Infect Dis , vol.50 , Issue.SUPPL. 3
    • Cohen, M.S.1    Gay, C.L.2
  • 68
    • 79951749480 scopus 로고    scopus 로고
    • Introduction to recent developments in HIV epidemic modeling
    • Wilson DP, Garnett GP. Introduction to recent developments in HIV epidemic modeling. Curr Opin HIV AIDS 2011; 6:91-93.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 91-93
    • Wilson, D.P.1    Garnett, G.P.2
  • 69
    • 79951770250 scopus 로고    scopus 로고
    • Modelling the impact of treatment with individual antiretrovirals
    • Cambiano V, Phillips AN. Modelling the impact of treatment with individual antiretrovirals. Curr Opin HIV AIDS 2011; 6:124-130.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 124-130
    • Cambiano, V.1    Phillips, A.N.2
  • 70
    • 58149097694 scopus 로고    scopus 로고
    • Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: A mathematical model
    • Granich RM, Gilks CF, Dye C, et al. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009; 373:48-57.
    • (2009) Lancet , vol.373 , pp. 48-57
    • Granich, R.M.1    Gilks, C.F.2    Dye, C.3
  • 71
    • 47649111041 scopus 로고    scopus 로고
    • Relation between HIV viral load and infectiousness: A model-based analysis
    • DOI 10.1016/S0140-6736(08)61115-0, PII S0140673608611150
    • Wilson DP, Law MG, Grulich AE, et al. Relation between HIV viral load and infectiousness: a model-based analysis. Lancet 2008; 372:314-320. (Pubitemid 352020440)
    • (2008) The Lancet , vol.372 , Issue.9635 , pp. 314-320
    • Wilson, D.P.1    Law, M.G.2    Grulich, A.E.3    Cooper, D.A.4    Kaldor, J.M.5
  • 72
    • 0035816364 scopus 로고    scopus 로고
    • Modelling the effect of combination antiretroviral treatments on HIV incidence
    • DOI 10.1097/00002030-200107060-00011
    • Law MG, Prestage G, Grulich A, et al. Modelling the effect of combination antiretroviral treatments on HIV incidence. AIDS 2001; 15:1287-1294. (Pubitemid 32592362)
    • (2001) AIDS , vol.15 , Issue.10 , pp. 1287-1294
    • Law, M.G.1    Prestage, G.2    Grulich, A.3    Van De, V.P.4    Kippax, S.5
  • 73
    • 78249246666 scopus 로고    scopus 로고
    • Evaluating the cost-effectiveness of preexposure prophylaxis (PrEP) and its impact on HIV-1 transmission in South Africa
    • doi: 10.1371/journal.pone.0013646. This study models the potential impact of pre-exposure prophylaxis in averting new infections in South Africa and estimates a range in cost from $12 500 to $20 000 per infection averted, depending on the level of ART coverage and baseline incidence
    • Pretorius C, Stover J, Bollinger L, et al. Evaluating the cost-effectiveness of preexposure prophylaxis (PrEP) and its impact on HIV-1 transmission in South Africa. PLoS One 2010; 5:e13646. doi: 10.1371/journal. pone.0013646. This study models the potential impact of pre-exposure prophylaxis in averting new infections in South Africa and estimates a range in cost from $12 500 to $20 000 per infection averted, depending on the level of ART coverage and baseline incidence.
    • (2010) PLoS One , vol.5
    • Pretorius, C.1    Stover, J.2    Bollinger, L.3
  • 74
    • 77955689297 scopus 로고    scopus 로고
    • Test and treat DC: Forecasting the impact of a comprehensive HIV strategy in Washington DC
    • This study applies a mathematical model to estimate the potential impact of an expanded HIV test and treat program in Washington, District of Columbia. The authors find that an intensive test and treat program - although expected to yield substantial benefits to individual patients - cannot be expected to stop the epidemic in Washington, District of Columbia, a finding that holds important implications for ongoing 'test and treat' strategies
    • Walensky RP, Paltiel AD, Losina E, et al. Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC. Clin Infect Dis 2010; 51:392-400. This study applies a mathematical model to estimate the potential impact of an expanded HIV test and treat program in Washington, District of Columbia. The authors find that an intensive test and treat program - although expected to yield substantial benefits to individual patients - cannot be expected to stop the epidemic in Washington, District of Columbia, a finding that holds important implications for ongoing 'test and treat' strategies.
    • (2010) Clin Infect Dis , vol.51 , pp. 392-400
    • Walensky, R.P.1    Paltiel, A.D.2    Losina, E.3
  • 75
    • 78751631897 scopus 로고    scopus 로고
    • The cost-effectiveness and population outcomes of expanded HIV screening and antiretroviral treatment in the United States
    • This article applies a dynamic mathematical model to perform a cost-effectiveness model of expanded ART, HIV screening, and behavioral interventions. The authors suggest that expanded screening and treatment offers a substantial public health impact, but are insufficient to reduce the US HIV epidemic without substantial reductions in risk behavior
    • Long EF, Brandeau ML, Owens DK. The cost-effectiveness and population outcomes of expanded HIV screening and antiretroviral treatment in the United States. Ann Intern Med 2010; 153:778-789. This article applies a dynamic mathematical model to perform a cost-effectiveness model of expanded ART, HIV screening, and behavioral interventions. The authors suggest that expanded screening and treatment offers a substantial public health impact, but are insufficient to reduce the US HIV epidemic without substantial reductions in risk behavior.
    • (2010) Ann Intern Med , vol.153 , pp. 778-789
    • Long, E.F.1    Brandeau, M.L.2    Owens, D.K.3
  • 79
    • 47049122773 scopus 로고    scopus 로고
    • HIV - Infected patients under HAART without any other sexually transmitted infection do not transmit HIV by sexual intercourse
    • Vernazza P, Hirschel B, Bernasconi E, Flepp M. HIV - infected patients under HAART without any other sexually transmitted infection do not transmit HIV by sexual intercourse. Bull Med Suisse 2008; 89:165-169.
    • (2008) Bull Med Suisse , vol.89 , pp. 165-169
    • Vernazza, P.1    Hirschel, B.2    Bernasconi, E.3    Flepp, M.4
  • 80
    • 78649879210 scopus 로고    scopus 로고
    • Frequency and determinants of unprotected sex among HIV-infected persons: The Swiss HIV cohort study
    • Hasse B, Ledergerber B, Hirschel B, et al. Frequency and determinants of unprotected sex among HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis 2010; 51:1314-1322.
    • (2010) Clin Infect Dis , vol.51 , pp. 1314-1322
    • Hasse, B.1    Ledergerber, B.2    Hirschel, B.3
  • 81
    • 78649812833 scopus 로고    scopus 로고
    • HIV treatment as prevention and 'The Swiss Statement': In for a dime, in for a dollar?
    • Cohen MS. HIV treatment as prevention and 'The Swiss Statement': in for a dime, in for a dollar? Clin Infect Dis 2010; 51:1323-1324.
    • (2010) Clin Infect Dis , vol.51 , pp. 1323-1324
    • Cohen, M.S.1
  • 82
    • 77956326236 scopus 로고    scopus 로고
    • HIV-1 subtype C-infected individuals maintaining high viral load as potential targets for the 'test-and-treat' approach to reduce HIV transmission
    • Novitsky V, Wang R, Bussmann H, et al. HIV-1 subtype C-infected individuals maintaining high viral load as potential targets for the 'test-and-treat' approach to reduce HIV transmission. PLoS One 2010; 5:e10148.
    • (2010) PLoS One , vol.5
    • Novitsky, V.1    Wang, R.2    Bussmann, H.3
  • 88
    • 79959331175 scopus 로고    scopus 로고
    • The contribution of early HIV infection to HIV spread in Lilongwe, Malawi: Implications for transmission prevention strategies
    • abstract FRLBC105
    • Powers K, Ghani A, Miller W, et al. The contribution of early HIV infection to HIV spread in Lilongwe, Malawi: implications for transmission prevention strategies. In: International AIDS Conference; 2010; Vienna, abstract FRLBC105, 2010.
    • (2010) International AIDS Conference; 2010; Vienna
    • Powers, K.1    Ghani, A.2    Miller, W.3
  • 90
    • 80052782429 scopus 로고    scopus 로고
    • Continued high risk sexual behavior following diagnosis with acute HIV infection in South Africa and Malawi: Implications for prevention
    • in press
    • Pettifor A, Macphail C, Corneli A, et al. Continued high risk sexual behavior following diagnosis with acute HIV infection in South Africa and Malawi: implications for prevention. AIDS Behav (in press).
    • AIDS Behav
    • Pettifor, A.1    Macphail, C.2    Corneli, A.3
  • 91
    • 79959352553 scopus 로고    scopus 로고
    • Acute HIV infection: Basic, clinical and public health perspectives
    • Forthcoming
    • Cohen MS, Shaw G, Haynes B, McMicael A. Acute HIV infection: basic, clinical and public health perspectives. New Engl J Med. Forthcoming 2011.
    • (2011) New Engl J Med
    • Cohen, M.S.1    Shaw, G.2    Haynes, B.3    McMicael, A.4


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