Quantitative determination of hederagenin in rat plasma and cerebrospinal fluid by ultra fast liquid chromatography-tandem mass spectrometry method

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 21, 2011, Pages 1973-1979

  Yang, Xuemei ^a   Li, Guoliang ^a   Chen, Lingyun ^a   Zhang, Cong ^a   Wan, Xinxiang ^a   Xu, Jiangping ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Fructus akebiae; Hederagenin; Pharmacokinetic; Plasma and CSF; UFLC MS MS

Indexed keywords

AMMONIUM ACETATE; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEMS; CEREBRO SPINAL FLUIDS; CONCENTRATION RANGES; ETHYL ACETATES; FRUCTUS AKEBIAE; GRADIENT ELUTION; HEDERAGENIN; LINEAR CALIBRATION CURVE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MOBILE PHASE; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PROTEIN PRECIPITATION; QUANTITATIVE DETERMINATIONS; RAT PLASMA; RELATIVE ERRORS; RELATIVE STANDARD DEVIATIONS; SAMPLE PRETREATMENT; UFLC-MS/MS; ULTRA-FAST;

ACETONITRILE; AMMONIUM COMPOUNDS; BODY FLUIDS; BRAIN; ELECTROSPRAY IONIZATION; LIQUIDS; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; PLASMAS; PRECIPITATION (CHEMICAL); RATS; VOLATILE FATTY ACIDS;

LIQUID CHROMATOGRAPHY;

ACETIC ACID; ACETONITRILE; AMMONIUM ACETATE; HEDERAGENIN; METHANOL; OLEANOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DRUG DETERMINATION; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; RAT; TANDEM MASS SPECTROMETRY;

ACANTHACEAE; ANIMALS; CHEMICAL PRECIPITATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUGS, CHINESE HERBAL; LINEAR MODELS; MALE; METHANOL; OLEANOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 79959363144     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.05.029     Document Type: Article

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