Purkinje cell loss is a characteristic of essential tremor

Parkinsonism and Related Disorders

Volumn 17, Issue 6, 2011, Pages 406-409

  Louis, Elan D ^a,b,c   Faust, Phyllis L ^a   Vonsattel, John Paul G ^a  

^a Columbia University ^*  (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c NONE   (United States)

Author keywords

Cerebellum; Essential tremor; Neurodegeneration; Neuropathology; Purkinje cells

Indexed keywords

HARMALINE;

BRAIN DEGENERATION; CELL COUNT; CELL LOSS; CELL SURVIVAL; CEREBELLUM DEGENERATION; DISEASE DURATION; DISEASE SEVERITY; ESSENTIAL TREMOR; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; NERVE DEGENERATION; NEUROANATOMY; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PURKINJE CELL; SHORT SURVEY;

ESSENTIAL TREMOR; HUMANS; NERVE DEGENERATION; PURKINJE CELLS; RESEARCH DESIGN;

EID: 79959351551     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2011.05.004     Document Type: Short Survey

References (12)

1. Rajput A.H., Robinson C.A., Rajput M.L., Rajput A. Cerebellar purkinje cell loss is not pathognomonic of essential tremor. Parkinsonism Relat Disord 2010, Sep 2 [Epub ahead of print].
2. Louis E.D., Faust P.L., Vonsattel J.P., Honig L.S., Rajput A., Robinson C.A., et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 2007, 130:3297-3307.
3. Axelrad J.E., Louis E.D., Honig L.S., Flores I., Ross G.W., Pahwa R., et al. Reduced purkinje cell number in essential tremor: a postmortem study. Arch Neurol 2008, 65:101-107.
4. Burke R.E., Dauer W.T., Vonsattel J.P. A critical evaluation of the braak staging scheme for parkinson's disease. Ann Neurol 2008, 64:485-491.
5. Samuel W., Terry R.D., DeTeresa R., Butters N., Masliah E. Clinical correlates of cortical and nucleus basalis pathology in alzheimer dementia. Arch Neurol 1994, 51:772-778.
6. Louis ED. Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry. Lancet Neurol;9:613-622.
7. Louis E.D. Essential tremors: a family of neurodegenerative disorders?. Arch Neurol 2009, 66:1202-1208.
8. Deuschl G., Elble R. Essential tremor - neurodegenerative or nondegenerative disease towards a working definition of et. Mov Disord 2009, 24:2033-2041.
9. Louis E.D. The shaking palsy, the first forty-five years: a journey through the british literature. Mov Disord 1997, 12:1068-1072.
10. Lorenz D., Deuschl G. Update on pathogenesis and treatment of essential tremor. Curr Opin Neurol 2007, 20:447-452.
11. Rajput A., Robinson C.A., Rajput A.H. Essential tremor course and disability: a clinicopathologic study of 20 cases. Neurology 2004, 62:932-936.
12. Erickson-Davis CR, Faust PL, Vonsattel JP, Gupta S, Honig LS, Louis ED. "Hairy baskets" associated with degenerative purkinje cell changes in essential tremor. J Neuropathol Exp Neurol;69:262-271.