Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired Glucose-Insulin homeostasis with ADCY5 in Asian Indians

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Vasan, Senthil K ^a,b   Neville, Matt J ^c   Antonisamy, Belavendra ^b   Samuel, Prasanna ^b   Fall, Caroline H ^d   Geethanjali, Finney S ^b   Thomas, Nihal ^b   Raghupathy, Palany ^b   Brismar, Kerstin ^a   Karpe, Fredrik ^b,c,e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b CHRISTIAN MEDICAL COLLEGE   (India)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; ADENYLATE CYCLASE; ADENYLYL CYCLASE TYPE V; CCNL1 PROTEIN, HUMAN; CYCLINE;

ADCY5 GENE; ADULT; ANTHROPOMETRY; ARTICLE; BIRTH WEIGHT; CCNL1 GENE; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INDIAN; INSULIN BLOOD LEVEL; INSULIN METABOLISM; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; CAUCASIAN; ETHNIC GROUP; GENETIC PREDISPOSITION; GENETICS; HOMEOSTASIS; INDIA; METABOLISM;

ADENYLATE CYCLASE; ADULT; ANTHROPOMETRY; BIRTH WEIGHT; BLOOD GLUCOSE; CYCLINS; DIABETES MELLITUS, TYPE 2; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HOMEOSTASIS; HUMANS; INDIA; INSULIN; MALE;

EID: 79959349040     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021331     Document Type: Article

References (25)

1. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, et al. (2010) Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 42: 430-5.
2. Sachdev HPS, (1997) Low birth weight in south asia. In: Gillepspie S, editors. Malnutrition in South Asia: A regional profile New York NY: United Nations Children Fund pp. 23-50.
3. Kinare AS, Chinchwadkar MC, Natekar AS, Coyaji KJ, Wills AK, et al. (2010) Patterns of fetal growth in a rural Indian cohort and comparison with a Western European population: data from the Pune maternal nutrition study. J Ultrasound Med 29: 215-23.
4. Whincup PH, Kaye SJ, Owen CG, Huxley R, Cook DG, et al. (2008) Birth weight and risk of type 2 diabetes: a systematic review. JAMA 300: 2886-97.
5. Hattersley AT, Tooke JE, (1999) The fetal insulin hypothesis: an alternative explanation of the association of low birth weight with diabetes and vascular disease. Lancet 353: 1789-92.
6. Barker DJ, (2007) The origins of the developmental origins theory. J Intern Med 261: 412-7.
7. Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, et al. (2009) Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes 58: 1428-33.
8. Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, et al. (2007) Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A 104: 15040-4.
9. Edghill EL, Bingham C, Slingerland AS, Minton JA, Noordam C, et al. (2006) Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic development. Diabet Med 23: 1301-6.
10. Babenko AP, Polak M, Cavé H, Busiah K, Czernichow P, et al. (2006) Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med 355: 456-66.
11. Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, et al. (2007) Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. 80 Am J Hum Genet: 1150-61.
12. Weedon MN, Frayling TM, Shields B, Knight B, Turner T, et al. (2005) Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 54: 576-81.
13. Vaessen N, Janssen JA, Heutink P, Hofman A, Lamberts SW, et al. (2002) Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight. Lancet 23; 359: 1036-7.
14. Lindsay RS, Hanson RL, Wiedrich C, Knowler WC, Bennett PH, et al. (2003) The insulin gene variable number tandem repeat class I/III polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in the Pima population. 52 Diabetes: 187-93.
15. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42: 105-16.
16. Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, et al. (2010) Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. Diabetologia 53: 1908-16.
17. Antonisamy B, Raghupathy P, Christopher S, Richard J, Rao PS, et al. (2009) Cohort Profile: the 1969-73 Vellore birth cohort study in South India. 38 Int J Epidemiol.: 663-69.
18. Raghupathy P, Antonisamy B, Geethanjali FS, Saperia J, Leary SD, et al. (2010) Glucose tolerance, insulin resistance and insulin secretion in young south Indian adults; relationships to parental size, neonatal size and childhood body mass index. Diabetes Research Clin Pract 87: 283-92.
19. Durnin JVGA, Womersley, (1974) Body fat assessed from total body density and its estimation from skin fold thickness; measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32: 77-97.
20. Kuriyan R, Petracchi C, Ferro-Luzzi A, Shetty PS, Kurpad AV, (1998) Validation of expedient methods for measuring body composition in Indian adults. Indian J Med Res 107: 37-45.
21. Leary S, Fall C, Osmond C, Lovel H, Campbell D, et al. (2006) Geographical variation in neonatal phenotype. Acta Obstet Gynecol Scand 85: 1080-9.
22. Harding S, Rosato MG, Cruickshank JK, (2004) Lack of change in birthweights of infants by generational status among Indian, Pakistani, Bangladeshi, Black Caribbean, and Black African mothers in a British cohort study. Int J Epidemiol 33: 1279-85.
23. Dhawan S, (1995) Birth weights of infants of first generation Asian women in Britain compared with second generation Asian women. BMJ 311: 86-8.
24. Reich D, Thangaraj K, Patterson N, Price AL, Singh L, (2009) Reconstructing Indian population history. Nature 461: 489-94.
25. Chauhan G, Spurgeon CJ, Tabassum R, Bhaskar S, Kulkarni SR, et al. (2010) Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes 59 (8): 2068-2074.