Novel circular, cyclic and acyclic Ψ(CH2O) containing peptide inhibitors of SKI-1/S1P: Synthesis, kinetic and biochemical evaluations

Current Medicinal Chemistry

Volumn 18, Issue 18, 2011, Pages 2770-2782

  Majumdar, S ^a,c   Chen, A ^a   Palmer Smith, H ^a   Basak, A ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c TRIPURA UNIVERSITY   (India)

Author keywords

Circular peptide; Disulfide bridged cyclic peptide; Enzyme inhibitors; Inhibition constant (K i); Intramolecularly quenched fluorogenic peptide; Methylene oxy pseudopeptides; Proprotein processing; Site 1 Protease (S1P); Subtilisin Kexin Isozyme 1 (SKI 1)

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ARGININE; ASPARTIC ACID; CARBENE; CYCLOPEPTIDE; DISULFIDE; ENZYME INHIBITOR; FURIN; GLYCINE; ISOLEUCINE; KEXIN; LEUCINE; LYSINE; MEMBRANE PROTEIN; PHENYLALANINE; PSEUDOPEPTIDE; SERINE; SERINE PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; SUBTILISIN; SUBTILISIN KEXIN ISOZYME 1; THREONINE; TYROSINE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; IC 50; LASSA VIRUS; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CARCINOMA, HEPATOCELLULAR; DRUG EVALUATION; ENZYME INHIBITORS; HEP G2 CELLS; HUMANS; KINETICS; LASSA FEVER; LASSA VIRUS; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES; VIRAL PROTEINS;

EID: 79959332503     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711796011265     Document Type: Article

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