Is RAD51 135G>C polymorphism really associated with breast cancer in general population? Biased design and results lead to inappropriate conclusion

Breast Cancer Research and Treatment

Volumn 128, Issue 1, 2011, Pages 297-300

  Yu, Ke Da ^a   Li, Bin ^a   Zhou, Ying ^a   Shao, Zhi Ming ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; RAD51 PROTEIN;

BREAST CANCER; BREAST CARCINOGENESIS; CANCER RISK; CANCER SUSCEPTIBILITY; GENE MUTATION; GENETIC ASSOCIATION; HETEROZYGOTE; HUMAN; LETTER; POPULATION RESEARCH; PRIORITY JOURNAL; RAD51 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

EID: 79959276021     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1402-9     Document Type: Letter

References (20)

1. LB Gao XM Pan LJ Li WB Liang Y Zhu LS Zhang YG Wei M Tang L Zhang 2011 RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies Breast Cancer Res Treat 125 827 835 10.1007/s10549-10010-10995-10548 20640595 10.1007/s10549-010-0995-8 1:CAS:528:DC%2BC3MXhtVelsLw%3D
2. H Sun J Bai F Chen Y Jin Y Yu L Jin S Fu 2011 RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22, 399 subjects Breast Cancer Res Treat 125 157 161 20454923 10.1007/s10549-010-0922-z
3. Z Wang H Dong Y Fu H Ding 2010 RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26, 444 subjects Breast Cancer Res Treat 124 765 769 20396943 10.1007/s10549-010-0885-0 1:CAS:528:DC%2BC3cXhtlyrsrjL
4. Yu KD, Yang C, Fan L, Chen AX, Shao ZM (2010) RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies. Breast Cancer Res Treat (in press). doi: 10.1007/s10549-10010-10937-10545
5. GW Zhou J Hu XD Peng Q Li 2011 RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis Breast Cancer Res Treat 125 529 535 20623332 10.1007/s10549-010-1031-8 1:CAS:528:DC%2BC3cXhsFCqt73N
6. PH Lu MB Chen W Shen C Li MY Wu GQ Tao 2011 New conflicting results obtained in the subgroup analysis of RAD51 135G>C polymorphism and breast cancer risk Breast Cancer Res Treat. 126 265 266 10.1007/s10549-10010-11267- 10543 21110082 10.1007/s10549-010-1267-3
7. KD Yu AX Chen LX Qiu L Fan C Yang ZM Shao 2010 XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37, 369 subjects Breast Cancer Res Treat 123 219 225 20127279 10.1007/s10549-010-0753-y 1:CAS:528:DC%2BC3cXoslektrw%3D
8. KD Yu AX Chen ZM Shao 2010 No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis Breast Cancer Res Treat 122 853 858 20076999 10.1007/s10549-010-0738-x 1:CAS:528:DC%2BC3cXoslehsbk%3D
9. LX Qiu C Mao L Yao KD Yu P Zhan B Chen HG Liu H Yuan J Zhang K Xue XC Hu 2010 XRCC3 5′-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis Breast Cancer Res Treat 122 489 493 20049524 10.1007/s10549-009-0726-1 1:CAS:528:DC%2BC3cXnsFymu70%3D
10. KD Yu GH Di L Fan AX Chen C Yang ZM Shao 2010 Lack of an association between a functional polymorphism in the interleukin-6 gene promoter and breast cancer risk: a meta-analysis involving 25, 703 subjects Breast Cancer Res Treat 122 483 488 20043205 10.1007/s10549-009-0706-5 1:CAS:528:DC%2BC3cXnsFymtbk%3D
11. KD Yu AX Chen C Yang LX Qiu L Fan WH Xu ZM Shao 2010 Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis Breast Cancer Res Treat 122 251 257 20033767 10.1007/s10549-009-0688-3 1:CAS:528:DC%2BC3cXntlKls70%3D
12. T Walsh MC King 2007 Ten genes for inherited breast cancer Cancer Cell 11 103 105 17292821 10.1016/j.ccr.2007.01.010 1:CAS:528:DC%2BD2sXitVartLw%3D (Pubitemid 46209856)
13. SC Lymberis PK Parhar E Katsoulakis SC Formenti 2004 Pharmacogenomics and breast cancer Pharmacogenomics 5 31 55 14683419 10.1517/phgs.5.1.31.25686 1:CAS:528:DC%2BD2cXhvF2rtbc%3D (Pubitemid 38088479)
14. WF Li Z Hu NY Rao CG Song B Zhang MZ Cao FX Su YS Wang PQ He GH Di KW Shen J Wu JS Lu JM Luo XY Liu J Zhou L Wang L Zhao YB Liu WT Yuan L Yang ZZ Shen W Huang ZM Shao 2008 The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified Breast Cancer Res Treat 110 99 109 17851763 10.1007/s10549-007-9708-3 1:CAS:528:DC%2BD1cXmslyjsrg%3D (Pubitemid 351793864)
15. AC Antoniou OM Sinilnikova J Simard M Leone M Dumont SL Neuhausen JP Struewing D Stoppa-Lyonnet L Barjhoux DJ Hughes I Coupier M Belotti C Lasset V Bonadona YJ Bignon TR Rebbeck T Wagner HT Lynch SM Domchek KL Nathanson JE Garber J Weitzel SA Narod G Tomlinson OI Olopade A Godwin C Isaacs A Jakubowska J Lubinski J Gronwald B Gorski T Byrski T Huzarski S Peock M Cook C Baynes A Murray M Rogers PA Daly H Dorkins RK Schmutzler B Versmold C Engel A Meindl N Arnold D Niederacher H Deissler AB Spurdle X Chen N Waddell N Cloonan T Kirchhoff K Offit E Friedman B Kaufmann Y Laitman G Galore G Rennert F Lejbkowicz L Raskin IL Andrulis E Ilyushik H Ozcelik P Devilee MP Vreeswijk MH Greene SA Prindiville A Osorio J Benitez M Zikan CI Szabo O Kilpivaara H Nevanlinna U Hamann F Durocher A Arason FJ Couch DF Easton G Chenevix-Trench 2007 RAD51 135G->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies Am J Hum Genet 81 1186 1200 17999359 10.1086/522611 1:CAS:528:DC%2BD2sXhtl2ju77P (Pubitemid 350211449)
16. Yu KD, Yang C, Fan L, Chen AX, Shao ZM (2010) RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies. Breast Cancer Res Treat (in press)
17. H Sun J Bai F Chen Y Jin Y Yu L Jin S Fu 2011 RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22, 399 subjects Breast Cancer Res Treat 125 157 161 20454923 10.1007/s10549-010-0922-z
18. Z Wang H Dong Y Fu H Ding 2010 RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26, 444 subjects Breast Cancer Res Treat 124 765 769 20396943 10.1007/s10549-010-0885-0 1:CAS:528:DC%2BC3cXhtlyrsrjL
19. GW Zhou J Hu XD Peng Q Li 2011 RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis Breast Cancer Res Treat 125 529 535 20623332 10.1007/s10549-010-1031-8 1:CAS:528:DC%2BC3cXhsFCqt73N
20. LB Gao XM Pan LJ Li WB Liang Y Zhu LS Zhang YG Wei M Tang L Zhang 2011 RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies Breast Cancer Res Treat 125 827 835 20640595 10.1007/s10549-010-0995-8 1:CAS:528:DC%2BC3MXhtVelsLw%3D