Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay

Antiviral Research

Volumn 91, Issue 2, 2011, Pages 142-149

  Shiota, Tomoyuki ^a,b   Lixin, Wang ^a   Takayama Ito, Mutsuyo ^a   Iizuka, Itoe ^a,b   Ogata, Momoko ^a   Tsuji, Masanori ^c   Nishimura, Hidekazu ^d   Taniguchi, Shuichi ^c   Morikawa, Shigeru ^a   Kurane, Ichiro ^a   Mizuguchi, Masashi ^b   Saijo, Masayuki ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c SENDAI CITY MEDICAL CENTER   (Japan)

^d TORANOMON HOSPITAL   (Japan)

Author keywords

Acyclovir; Drug resistance; Herpes simplex virus type 1; Rapid antiviral sensitivity assay; Thymidine kinase

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYURIDINE; ACICLOVIR; GANCICLOVIR; RECOMBINANT THYMIDINE KINASE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; DRUG SENSITIVITY; EXPRESSION VECTOR; GENE AMPLIFICATION; HERPES SIMPLEX VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION;

ACYCLOVIR; AMINO ACID SUBSTITUTION; ANIMALS; ANTIVIRAL AGENTS; BROMODEOXYURIDINE; CERCOPITHECUS AETHIOPS; DRUG RESISTANCE, VIRAL; GANCICLOVIR; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HEK293 CELLS; HERPESVIRUS 1, HUMAN; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; PLAQUE ASSAY; RECOMBINANT PROTEINS; THYMIDINE KINASE; VERO CELLS; VIRUS REPLICATION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1;

EID: 79959275069     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2011.05.015     Document Type: Article

References (38)

1. Aldea C., Alvarez C.P., Folgueira L., Delgado R., Otero J.R. Rapid detection of herpes simplex virus DNA in genital ulcers by real-time PCR using SYBR green I dye as the detection signal. J. Clin. Microbiol. 2002, 40:1060-1062.
2. Bestman-Smith J., Schmit I., Papadopoulou B., Boivin G. Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues. J. Virol. 2001, 75:3105-3110.
3. Boivin G., Erice A., Crane D.D., Dunn D.L., Balfour H.H. Acyclovir susceptibilities of herpes simplex virus strains isolated from solid organ transplant recipients after acyclovir or ganciclovir prophylaxis. Antimicrob. Agents. Chemother. 1993, 37:357-359.
4. Chen Y., Scieux C., Garrait V., Socie G., Rocha V., Molina J.M., Thouvenot D., Morfin F., Hocqueloux L., Garderet L., Esperou H., Selimi F., Devergie A., Leleu G., Aymard M., Morinet F., Gluckman E., Ribaud P. Resistant herpes simplex virus type 1 infection: an emerging concern after allogeneic stem cell transplantation. Clin. Infect. Dis. 2000, 31:927-935.
5. Collins P., Ellis M.N. Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir. J. Med. Virol. 1993, (Suppl. 1):58-66.
6. Collins P., Appleyard G., Oliver N.M. Sensitivity of herpes virus isolates from acyclovir clinical trials. Am. I. Med. 1982, 73:380-382.
7. Collins P., Larder B.A., Oliver N.M., Kemp S., Smith I.W., Darby G. Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir. J. Gen. Virol. 1989, 70(Pt 2):375-382.
8. Danve-Szatanek C., Aymard M., Thouvenot D., Morfin F., Agius G., Bertin I., Billaudel S., Chanzy B., Coste-Burel M., Finkielsztejn L., Fleury H., Hadou T., Henquell C., Lafeuille H., Lafon M.E., Le Faou A., Legrand M.C., Maille L., Mengelle C., Morand P., Morinet F., Nicand E., Omar S., Picard B., Pozzetto B., Puel J., Raoult D., Scieux C., Segondy M., Seigneurin J.M., Teyssou R., Zandotti C. Surveillance network for herpes simplex virus resistance to antiviral drugs: 3-year follow-up. J. Clin. Microbiol. 2004, 42:242-249.
9. Erlich K.S., Jacobson M.A., Koehler J.E., Follansbee S.E., Drennan D.P., Gooze L., Safrin S., Mills J. Foscarnet therapy for severe acyclovir-resistant herpes simplex virus type-2 infections in patients with the acquired immunodeficiency syndrome (AIDS). An uncontrolled trial. Ann. Intern. Med. 1989, 110:710-713.
10. Field H.J. Herpes simplex virus antiviral drug resistance-current trends and future prospects. J. Clin. Virol. 2001, 21:261-269.
11. Field H.J., Darby G. Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo. Antimicrob. Agents Chemother. 1980, 17:209-216.
12. Gaudreau A., Hill E., Balfour H.H., Erice A., Boivin G. Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients. J. Infect. Dis. 1998, 178:297-303.
13. Graham D., Larder B.A., Inglis M.M. Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide. J. Gen. Virol. 1986, 67(Pt 4):753-758.
14. Greiner M., Sohr D., Gobel P. A modified ROC analysis for the selection of cut-off values and the definition of intermediate results of serodiagnostic tests. J. Immunol. Methods 1995, 185:123-132.
15. Hill E.L., Hunter G.A., Ellis M.N. In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 1991, 35:2322-2328.
16. Hwang C.B., Chen H.J. An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase. Gene 1995, 152:191-193.
17. Lazarus H.M., Belanger R., Candoni A., Aoun M., Jurewicz R., Marks L. Intravenous penciclovir for treatment of herpes simplex infections in immunocompromised patients: results of a multicenter, acyclovir-controlled trial. The penciclovir immunocompromised study group. Antimicrob. Agents Chemother. 1999, 43:1192-1197.
18. McLaren C., Ellis M.N., Hunter G.A. A colorimetric assay for the measurement of the sensitivity of herpes simplex viruses to antiviral agents. Antiviral Res. 1983, 3:223-234.
19. Morfin F., Souillet G., Bilger K., Ooka T., Aymard M., Thouvenot D. Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients. J. Infect. Dis. 2000, 182:290-293.
20. Morfin F., Thouvenot D., Aymard M., Souillet G. Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene. J. Med. Virol. 2000, 62:247-250.
21. Morfin F., Bilger K., Boucher A., Thiebaut A., Najioullah F., Bleyzac N., Raus N., Bosshard S., Aymard M., Michallet M., Thouvenot D. HSV excretion after bone marrow transplantation: a 4-year survey. J. Clin. Virol. 2004, 30:341-345.
22. Nugier F., Colin J.N., Aymard M., Langlois M. Occurrence and characterization of acyclovir-resistant herpes simplex virus isolates: report on a two-year sensitivity screening survey. J. Med. Virol. 1992, 36:1-12.
23. Parker A.C., Craig J.I., Collins P., Oliver N., Smith I. Acyclovir-resistant herpes simplex virus infection due to altered DNA polymerase. Lancet 1987, 2:1461.
24. Pottage J.C., Kessler H.A. Herpes simplex virus resistance to acyclovir: clinical relevance. Infect. Agents Dis. 1995, 4:115-124.
25. Pramod N.P., Thyagarajan S.P., Mohan K.V., Anandakannan K. Acyclovir resistance in herpes simplex virus isolates from keratitis cases: an analysis from a developing country. Microbiol. Immunol. 2000, 44:241-247.
26. Sacks S.L., Wanklin R.J., Reece D.E., Hicks K.A., Tyler K.L., Coen D.M. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?. Ann. Intern. Med. 1989, 111:893-899.
27. Safrin S., Elbeik T., Phan L., Robinson D., Rush J., Elbaggari A., Mills J. Correlation between response to acyclovir and foscarnet therapy and in vitro susceptibility result for isolates of herpes simplex virus from human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 1994, 38:1246-1250.
28. Sahli R., Andrei G., Estrade C., Snoeck R., Meylan P.R. A rapid phenotypic assay for detection of acyclovir-resistant varicella-zoster virus with mutations in the thymidine kinase open reading frame. Antimicrob. Agents Chemother. 2000, 44:873-878.
29. Saijo M., Suzutani T., Yoshida I. Effects of acyclovir, oxetanocin-G, and carbocyclic oxetanocin-G in combinations on the replications of herpes simplex virus type 1 and type 2 in Vero cells. Tohoku J. Exp. Med. 1992, 167:57-68.
30. Saijo M., Suzutani T., Murono K., Hirano Y., Itoh K. Recurrent aciclovir-resistant herpes simplex in a child with Wiskott-Aldrich syndrome. Br. J. Dermatol. 1998, 139:311-314.
31. Saijo M., Suzutani T., Itoh K., Hirano Y., Murono K., Nagamine M., Mizuta K., Niikura M., Morikawa S. Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus. J. Med. Virol. 1999, 58:387-393.
32. Saijo M., Suzutani T., De Clercq E., Niikura M., Maeda A., Morikawa S., Kurane I. Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain. Antiviral Res. 2002, 56:253-262.
33. Saijo M., Yasuda Y., Yabe H., Kato S., Suzutani T., De Clercq E., Niikura M., Maeda A., Kurane I., Morikawa S. Bone marrow transplantation in a child with Wiskott-Aldrich syndrome latently infected with acyclovir-resistant (ACV(r)) herpes simplex virus type 1: emergence of foscarnet-resistant virus originating from the ACV(r) virus. J. Med. Virol. 2002, 68:99-104.
34. Saijo M., Suzutani T., Mizuta K., Kurane I., Morikawa S. Characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons. Arch. Virol. 2008, 153:303-314.
35. Stranska R., Schuurman R., Nienhuis E., Goedegebuure I.W., Polman M., Weel J.F., Wertheim-Van Dillen P.M., Berkhout R.J., van Loon A.M. Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization. J. Clin. Virol. 2005, 32:7-18.
36. Summers W.C., Raksin P. A method for selection of mutations at the tdk locus in Escherichia coli. J. Bacteriol. 1993, 175:6049-6051.
37. Suzutani T., Saijo M., Nagamine M., Ogasawara M., Azuma M. Rapid phenotypic characterization method for herpes simplex virus and Varicella-Zoster virus thymidine kinases to screen for acyclovir-resistant viral infection. J. Clin. Microbiol. 2000, 38:1839-1844.
38. Wade J.C., Newton B., McLaren C., Flournoy N., Keeney R.E., Meyers J.D. Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: a double-blind trial. Ann. Intern. Med. 1982, 96:265-269.