Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment

Blood

Volumn 117, Issue 24, 2011, Pages 6489-6497

  Cook, Brandoch D ^a   Liu, Susanna ^a   Evans, Todd ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; ERYTHROID KRUPPEL LIKE FACTOR; SMAD1 PROTEIN; SMAD2 PROTEIN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR RUNX1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYOID BODY; HEMANGIOBLAST; HEMATOPOIESIS; MESODERM; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 79959262615     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-10-312389     Document Type: Article

References (33)

1. McGrath KE, Palis J. Hematopoiesis in the yolk sac: more than meets the eye. Exp Hematol. 2005;33(9):1021-1028. (Pubitemid 41225425)
2. Lacaud G, Keller G, Kouskoff V. Tracking mesoderm formation and specification to the hemangioblast in vitro. Trends Cardiovasc Med. 2004; 14(8):314-317. (Pubitemid 41110610)
3. Soderberg SS, Karlsson G, Karlsson S. Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling. Ann N Y Acad Sci. 2009;1176:55-69.
4. Winnier G, Blessing M, Labosky PA, Hogan BL. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995;9(17):2105-2116.
5. Kishigami S, Mishina Y. BMP signaling and early embryonic patterning. Cytokine Growth Factor Rev. 2005;16(3):265-278. (Pubitemid 40910316)
6. Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G. A common precursor for hematopoietic and endothelial cells. Development. 1998;125(4):725-732. (Pubitemid 28108096)
7. Johansson BM, Wiles MV. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol. 1995;15(1):141-151. (Pubitemid 24379910)
8. Beppu H, Kawabata M, Hamamoto T, et al. BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000;221(1):249-258. (Pubitemid 30253588)
9. Moustakas A, Heldin CH. The regulation of TGF-beta signal transduction. Development. 2009; 136(22):3699-3714.
10. Arnold SJ, Maretto S, Islam A, Bikoff EK, Robertson EJ. Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol. 2006;296(1):104-118. (Pubitemid 44061758)
11. Larsson J, Karlsson S. The role of Smad signaling in hematopoiesis. Oncogene. 2005;24(37): 5676-5692. (Pubitemid 43086128)
12. Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development. 1999; 126(8):1631-1642. (Pubitemid 29204328)
13. Yang X, Castilla LH, Xu X, et al. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999;126(8):1571-1580. (Pubitemid 29204322)
14. Lechleider RJ, Ryan JL, Garrett L, et al. Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion. Dev Biol. 2001;240(1): 157-167. (Pubitemid 33141115)
15. Tremblay KD, Dunn NR, Robertson EJ. Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development. 2001;128(18):3609-3621. (Pubitemid 32962727)
16. Dick A, Meier A, Hammerschmidt M. Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo. Dev Dyn. 1999;216(3):285-298. (Pubitemid 29510884)
17. McReynolds LJ, Gupta S, Figueroa ME, Mullins MC, Evans T. Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood. 2007;110(12): 3881-3890. (Pubitemid 350248443)
18. Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell. 2008; 132(4):661-680. (Pubitemid 351260059)
19. Zafonte BT, Liu S, Lynch-Kattman M, et al. Smad1 expands the hemangioblast population within a limited developmental window. Blood. 2007;109(2):516-523. (Pubitemid 46105948)
20. Sun D, Melegari M, Sridhar S, Rogler CE, Zhu L. Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multigene knockdown. Biotechniques. 2006;41(1):59-63. (Pubitemid 46534903)
21. Kennedy M, Keller GM. Hematopoietic commitment of ES cells in culture. Methods Enzymol. 2003;365:39-59. (Pubitemid 37531538)
22. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402-408. (Pubitemid 34164012)
23. Andrews NC, Faller DV. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 1991;19(9):2499.
24. Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 2002;109(1):29-37. (Pubitemid 34327514)
25. Keller GM. In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol. 1995;7(6):862-869.
26. Kattman SJ, Adler ED, Keller GM. Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development. Trends Cardiovasc Med. 2007;17(7):240-246. (Pubitemid 47532729)
27. Sherwood RI, Jitianu C, Cleaver O, et al. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol. 2007;304(2):541-555. (Pubitemid 46527567)
28. Holtzinger A, Rosenfeld GE, Evans T. Gata4 directs development of cardiac-inducing endoderm from ES cells. Dev Biol. 337(1):63-73.
29. Hou J, Charters AM, Lee SC, et al. A systematic screen for genes expressed in definitive endoderm by serial analysis of gene expression (SAGE). BMC Dev Biol. 2007;7:92.
30. Kubo A, Shinozaki K, Shannon JM, et al. Development of definitive endoderm from embryonic stem cells in culture. Development. 2004;131(7): 1651-1662.
31. Adelman CA, Chattopadhyay S, Bieker JJ. The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media. Development. 2002;129(2): 539-549. (Pubitemid 34863818)
32. Lohmann F, Bieker JJ. Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment. Development. 2008;135(12):2071-2082. (Pubitemid 352022521)
33. Zhou L, Nguyen AN, Sohal D, et al. Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood. 2008;112(8):3434-3443.